Forschung AG Gaubatz

Our main interest is transcriptional regulation of the mammalian cell cycle by the DREAM complex and Myb-MuvB (MMB). MMB together with the B-MYB transcription factor is a master activator of genes required for mitosis and cytokinesis.

We use biochemical and genetic methods to understand how DREAM, MuvB, B-MYB and its target genes contribute to normal proliferation, development and tumorigenesis.

Latest: 

Gründl M, Walz S, Hauf L, Schwab M, Werner KM, Spahr S, Schulte C, Maric HM, Ade CP and Gaubatz S (2020): Interaction of YAP with the Myb-MuvB (MMB) complex defines a transcriptional program to promote the proliferation of cardiomyocytes, PLOS Genetics doi:10.1371/journal.pgen.1008818 https://doi.org/10.1371/journal.pgen.1008818

Weinstock G and Gaubatz S (2019): One way to rule them all: G2/M gene regulation by oncogenic YAP1 and B-MYB. Molecular and Cellular Oncology 6:6 doi: 10.1080/23723556.2019.1648026

Pattschull G, Walz S, Gründl M, Schwab M, Rühl E, Baluapuri A, Cindric-Vranesic A, Kneitz S, Wolf E, Ade CP, Rosenwald A, Eyss von B & Gaubatz S (2019): The Myb-MuvB complex is required for YAP-dependent transcription of mitotic genes. Cell Reports  27:3533-3546.e7. doi: 10.1016/j.celrep.2019.05.071.