Our main interest is transcriptional regulation of the mammalian cell cycle by the DREAM complex and Myb-MuvB (MMB). MMB together with the B-MYB transcription factor is a master activator of genes required for mitosis and cytokinesis.
We use biochemical and genetic methods to understand how DREAM, MuvB, B-MYB and its target genes contribute to normal proliferation, development and tumorigenesis. We also study the crosstalk betwen MMB and the Hippo/ YAP signaling pathway in cancer and cell cycle regulation.
Learn more about our research by follwing this link.
Gründl M, Walz S, Hauf L, Schwab M, Werner KM, Spahr S, Schulte C, Maric HM, Ade CP and Gaubatz S (2020): Interaction of YAP with the Myb-MuvB (MMB) complex defines a transcriptional program to promote the proliferation of cardiomyocytes, PLOS Genetics doi:10.1371/journal.pgen.1008818
Pattschull G, Walz S, Gründl M, Schwab M, Rühl E, Baluapuri A, Cindric-Vranesic A, Kneitz S, Wolf E, Ade CP, Rosenwald A, Eyss von B & Gaubatz S (2019): The Myb-MuvB complex is required for YAP-dependent transcription of mitotic genes. Cell Reports 27:3533-3546.e7. doi: 10.1016/j.celrep.2019.05.071.