Forschung AG Gaubatz
Address
Prof. Dr. Stefan Gaubatz
Biochemistry and Cell Biology
Biocenter
Am Hubland Süd
97074 Würzburg
Tel.: 0931 31-84138
stefan.gaubatz@biozentrum.uni-wuerzburg.de
Research
Our main interest is transcriptional regulation of the mammalian cell cycle by the DREAM complex and Myb-MuvB (MMB). MMB together with the B-MYB transcription factor is a master activator of genes required for mitosis and cytokinesis.
We use biochemical and genetic methods to understand how DREAM, MuvB, B-MYB and its target genes contribute to normal proliferation, development and tumorigenesis. We also study the crosstalk betwen MMB and the Hippo/ YAP signaling pathway in cancer and cell cycle regulation.
Learn more about our research by follwing this link.
Publications
Latest:
Gründl M, Walz S, Hauf L, Schwab M, Werner KM, Spahr S, Schulte C, Maric HM, Ade CP and Gaubatz S (2020): Interaction of YAP with the Myb-MuvB (MMB) complex defines a transcriptional program to promote the proliferation of cardiomyocytes, PLOS Genetics doi:10.1371/journal.pgen.1008818
Pattschull G, Walz S, Gründl M, Schwab M, Rühl E, Baluapuri A, Cindric-Vranesic A, Kneitz S, Wolf E, Ade CP, Rosenwald A, Eyss von B & Gaubatz S (2019): The Myb-MuvB complex is required for YAP-dependent transcription of mitotic genes. Cell Reports 27:3533-3546.e7. doi: 10.1016/j.celrep.2019.05.071.
