Chair of Biochemistry

    Ivaylo Gentschev, PD Dr.



    PD Dr. Ivaylo Gentschev

    Group: Molecular Oncology
    Phone: +49 931 - 31-89187
    E-mail:  ivaylo.gentschev@uni-wuerzburg.de
    Room: B118








    Curriculum vitae


    PD Dr. Ivaylo Gentschev



    Project leader



    Chair of Biochemistry/CTRC, Theodor-Boveri-Institute at the Biocentre
    University of Würzburg
    Am Hubland
    97074 Würzburg
    Phone +49 931 - 31 89187




    1999 - present

    Private lecturer (PD), Faculty memeber, Faculty of Biology, University of Würzburg, Germany


    2018 - present

    Project leader, Cancer Therapy Research Center (CTRC), University of Würzburg, Germany


    2017 - 2018

    Senior Research fellow - StemImmune Corporation (now Calidi Biotherapeutics), San Diego, USA


    2007 - present

    Principal Investigator, Graduate School of Life Science, University of Würzburg, Germany
      2007 - 2015 Director of veterinary vaccine design and veterinary tumor detection and therapy, Genelux Corporation, San Diego USA


    2002 - 2007

    Senior research fellow and group leader at Institute of Medical Radiation an Cel Research (MRCRI, University of Würzburg, Germany


    1996 - 2002

    Assistant professor and group leader, Dept. of Microbiology, University of Würzburg, Germany  
      1991 - 1999 Venia legendi (Habilitation) Microbiology, University of Würzburg, Germany
      1991 - 1996 Post-Doc, Dept. of Microbiology, University of Würzburg, Germany
      1987 - 1991 Ph.D. Microbiology, Dept. of Microbiology, University of Würzburg, Germany
      1986 - 1987 Research Scientist, Academy of Sciences Sofia, Bulgaria
      1985 M.S. Biochemistry, Martin-Luther-University, Halle/Salle, Germany


    Research Fields

    Development of anti-cancer vaccines and therapeutics on the basis of viruses and bacteria.

    Protein and DNA delivery systems for development of subunit vaccines

    Selected Awards

    Since 2012:   Editorial Board of Bioengineered

    2010 - 2019   Editorial Board of Advances in Preventive Medicine

    2009 - 2011   Editorial Board of Bioengineered Bugs

    2010               Selection for appointment of volunteer faculty member at UCSD Radiation Oncology, San Diego, USA

    1999               Max-von-Pettenkofer Award for vaccine development



    Selected Publications


    Full record: >100 publications: 80 original papers, 19 reviews, 14 published meeting abstracts, 8 book chapters, 4 patents; Google Scholar (h index = 37), For a complete list of publications please click (https://www.google.com/search (ivaylo gentschev google scholar)

    Key publications:

    Tumor colonization and tumor therapy with an intranasally-applied Escherichia coli Nissle 1917 strain is strongly affected by the gut microbiome in tumor-bearing mice. I.Gentschev, M.Ye, I. Petrov, A.Cecil, T. Oelschaeger, AA. Szalay. Cancers submitted

    Canine Adipose-Derived Mesenchymal Stem Cells (cAdMSCs) as a “Trojan Horse” in Vaccinia Virus Mediated Oncolytic Therapy against Canine Soft Tissue Sarcomas. I Petrov, I Gentschev*, A Vyalkova, MI Elashry, MC Klymiuk, S Arnhold, AA Szalay. Viruses 12 (7), 750 (2020)

    Oncolytic virotherapy of canine and feline cancer. I Gentschev, SS Patil, I Petrov, J Cappello, M Adelfinger, AA Szalay. Viruses 6 (5), 2122-2137

    Microorganisms as carriers of nucleotide sequences coding for antigens and protein toxins, process of manufacturing and uses thereof. IN Gentschev, J Fensterle, UR Rapp, W Goebel.US Patent 8,669,091 (2014)

    Preclinical evaluation of oncolytic vaccinia virus for therapy of canine soft tissue sarcoma.I Gentschev, M Adelfinger, R Josupeit, S Rudolph, K Ehrig, U Donat, AA Szalay. PloS one 7 (5), e37239 (2012)

    Cancer immunotherapy based on recombinant Salmonella enterica serovar Typhimurium aroA strains secreting prostate-specific antigen and cholera toxin subunit B.J Fensterle, B Bergmann, C Yone, C Hotz, SR Meyer, S Spreng, W Goebel, UR Rapp, I Gentschev. Cancer gene therapy 15 (2), 85-93 (2008)

    Visualization of tumors and metastases in live animals with bacteria and vaccinia virus encoding light-emitting proteins. AY Yong, S Shabahang, TM Timiryasova, Q Zhang, R Beltz, I Gentschev, AA Szalay. Nature biotechnology 22 (3), 313-320 (2004)

    The E. coli α-hemolysin secretion system and its use in vaccine development.I Gentschev, G Dietrich, W Goebel. Trends in microbiology 10 (1), 39-45(2002)

    The Escherichia coli haemolysin secretion apparatus: a potential universal antigen delivery system in Gram‐negative bacterial vaccine carriers. S Spreng, G Dietrich, W Goebel, I Gentschev. Molecular microbiology 31 (5), 1596-1598 (1999)

    Delivery of antigen-encoding plasmid DNA into the cytosol of macrophages by attenuated suicide L. monocytogenes. G Dietrich, A Bubert, I Gentschev, Z Sokolovic, A Simm, A Catic, Nature biotechnology 16 (2), 181-185(1998)

    Development of antigen-delivery systems, based on the Escherichia coli hemolysin secretion pathway. I Gentschev, H Mollenkopf, Z Sokolovic, J Hess, SHE Kaufmann, W Goebel. Gene 179 (1), 133-140 (1996)

    Superior efficacy of secreted over somatic antigen display in recombinant Salmonella vaccine induced protection against listeriosis. Hess J, Gentschev I, Miko D, Welzel M, Ladel C, Goebel W, Kaufmann SH. Proc Natl Acad Sci U S A. 93(4):1458-63 (1996)

    Topological and functional studies on HlyB of Escherichia coli . I Gentschev, W Goebel. Molecular and General Genetics MGG 232 (1), 40-48 (1992)