Biochemistry and cell biology

Gaubatz group Publications


Gründl M, Walz S, Hauf L, Schwab M, Werner KM, Spahr S, Schulte C, Maric HM, Ade CP and Gaubatz S (2020): Interaction of YAP with the Myb-MuvB (MMB) complex defines a transcriptional program to promote the proliferation of cardiomyocytes, PLOS Genetics https://doi.org/10.1371/journal.pgen.1008818

Weinstock G and Gaubatz S (2019): One way to rule them all: G2/M gene regulation by oncogenic YAP1 and B-MYB. Molecular and Cellular Oncology 6:6 doi: 10.1080/23723556.2019.1648026

Pattschull G, Walz S, Gründl M, Schwab M, Rühl E, Baluapuri A, Cindric-Vranesic A, Kneitz S, Wolf E, Ade CP, Rosenwald A, Eyss von B & Gaubatz S (2019): The Myb-MuvB complex is required for YAP-dependent transcription of mitotic genes. Cell Reports  27:3533-3546.e7. doi: 10.1016/j.celrep.2019.05.071.

Hanselmann S, Wolter P, Malkmus J, Gaubatz S (2017) The microtubule-associated protein PRC1 is a potential therapeutic target for lung cancer. Oncotarget: 9:4985-4997. doi: 10.18632/oncotarget.23577. eCollection 2018 Jan 12.

Gründl M, Engel FB, Gaubatz S (2017) GAS2L3: Coordinator of cardiomyocyte cytokinesis? Cell Cycle (doi.org/10.1080/15384101.2017.1372546)

Stopp S, Gründl M, Fackler M, Malkmus J, Leone M, Naumann R, Frantz S, Wolf E, von Eyss B, Engel FB, Gaubatz S (2017) Deletion of Gas2l3 in mice leads to specific defects in cardiomyocyte cytokinesis during development. Proc Natl Acad Sci USA doi: 10.1073/pnas.1703406114

Wolter P, Hanselmann S, Pattschull G, Schruf E, Gaubatz S (2017): Central spindle proteins and mitotic kinesins are direct transcriptional targets of MuvB, B-MYB and FOXM1 in breast cancer cell lines and are potential targets for therapy. Oncotarget.  doi: 10.18632/oncotarget.14466         

Iltzsche F, Simon K, Stopp S, Pattschull G, Francke S, Wolter P, Hauser S, Murphy DJ, Garcia P, Rosenwald A and Gaubatz S (2016):An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinoma. Oncogene, advance online publication 23 May 2016; doi: 10.1038/onc.2016.181 View: 

Kumari G, Ulrich T, Krause M, Finkernagel F, Gaubatz S. (2014): Induction of p21CIP1 and cell cycle arrest after inhibition of Aurora B kinase is attributed to aneuploidy and reactive oxygen species. J Biol Chem. doi:10.1074/jbc.M114.555060.

Fackler, M., Wolter, P. and Gaubatz, S. (2014): The GAR domain of GAS2L3 mediates binding to the chromosomal passenger complex and is required for localization of GAS2L3 to the constriction zone during abscission. FEBS J. 281:2123-2135; DOI: 10.1111/febs.12766. 

Kumari, G., Ulrich, T. and Gaubatz, S. (2013): A role for p38 in transcriptional elongation of p21CIP1 in response to Aurora B inhibition. Cell Cycle 12:2051-60 View: 


Esterlechner, J., Reichert, N., Iltzsche, F., Krause, M., Finkernagel, F., Gaubatz, S. (2013): LIN9, a subunit of the DREAM complex, regulates mitotic gene expression and proliferation of embryonic stem cells. PLOS ONE 8(5): e62882. View: 

Wolter, P., Schmitt, K., Fackler, M., Kremling, H., Probst, L., Hauser, S., Gruss, O. J., and Gaubatz, S. (2012). GAS2L3, a novel target gene of the DREAM complex, is required for proper cytokinesis and genomic stability. J Cell Sci. 125:2393-406 View: 

Hauser S., Ulrich T., Wurster S., Schmitt K., Reichert N. and Gaubatz S. (2011) Loss of LIN9, a member of the DREAM complex, cooperates with SV40 large T antigen to induce genomic instability and anchorage-independent growth. Oncogene 31:1859-68. View: 

Houben R, Adam C, Baeurle A, Hesbacher S, Grimm J, Angermeyer S, Henzel K, Hauser S, Elling R, Bröcker EB, Gaubatz S, Becker JC, Schrama D. (2011) An intact retinoblastoma protein-binding site in Merkel cell polyomavirus large T antigen is required for promoting growth of Merkel cell carcinoma cells. Int J Cancer doi: 10.1002/ijc.26076. View: 

Meierjohann S, Hufnagel A, Wende E, Kleinschmidt MA, Wolf K, Friedl P, Gaubatz S, Schartl M. (2010) MMP13 mediates cell cycle progression in melanocytes and melanoma cells: in vitro studies of migration and proliferation.  Mol Cancer 9:201. View: 

Reichert N, Wurster S, Ulrich T, Schmitt K, Hauser S, Probst L, Götz R, Ceteci F, Moll R, Rapp U, Gaubatz S (2010) Lin9, a subunit of the mammalian DREAM complex, is essential for embryonic development, for survival of adult mice and for tumor suppression. Mol Cell Biol 30:2896-908. View: 

Schmit F, Cremer S, Gaubatz S (2009)  LIN54 is an essential core subunit of the DREAM/ LINC complex that binds to the cdc2 promoter in a sequence-specific manner. FEBS Journal 276:5703-16. View:  

Mannefeld M, Klassen E, Gaubatz S (2009) B-MYB is required for recovery from the DNA-damage induced G2 checkpoint in p53 mutant cells. Cancer Research, 69:4073-80. View: 

Kleinschmidt MA, Wagner TU, Liedtke D, Samans D, Gaubatz S (2009) LIN9 is required for mitosis and cell survival during early zebrafish development. JBC, 284:13119-27. View:  

Kehoe SM, Oka M, Hankowski KE, Reichert N, Garcia S, McCarrey JR, Gaubatz S, Terada N (2008) A conserved E2F6-binding element in murine meiosis-specific gene promoters. Biol. Reprod. 79:921-930. View:  

Schmit, F., Korenjak, M., Mannefeld, M., Schmitt, K., Franke, C., von Eyss, B., Gagrica, S., Hanel, F., Brehm, A., and Gaubatz, S. (2007) LINC, a human complex that is related to pRb-containing complexes in invertebrates regulates the expression of G2/M genes. Cell Cycle, 6:1903-13 View: 

Osterloh, L., von Eyss, B., Schmit, F., Rein, L., Hubner, D., Samans, B., Hauser, S., and Gaubatz, S. (2007) The human synMuv-like protein LIN-9 is required for transcription of G2/M genes and for entry into mitosis. EMBO Journal, 26:144-157 View: 

Storre J, Schafer A, Reichert N, Barbero JL, Hauser S, Eilers M, Gaubatz S (2005) Silencing of the meiotic genes SMC1beta and STAG3 in somatic cells by E2F6. J Biol Chem, 280:41380 View:  

Gagrica, S; Hauser, S; Kolfschoten, I; Osterloh, L, Agami, R and Gaubatz, S: Inhibition of oncogenic transformation by mammalian Lin-9, a pRB associated protein. EMBO Journal, 23: 4627-38 (2004) View:  

Giangrande, P.H.; Zhu., W.; Schlisio, S.; Sun, X; Mori, S.; Gaubatz, S.; Nevins, J.R.: A role for E2F6 in distinguishing G1/S and G2/M specific transcription. Genes & Development, 18:2941-51(2004) View:  

Ohtani, N.; Brennan, P., Gaubatz, S.; Ghysadeal, J. ; Rowe, M. and Hara, E.: Epstein-Barr virus LMP1 blocks p16 INK4a/RB-pathway by promoting nuclear export of E2F4/5. Journal Cell Biol. 162(2): 173-83 (2003) View:  

Storre, J.; Elsässer, H-P.; Fuchs, M.; Ullmann, D.; Livingston, D.M. and Gaubatz, S.: Homeotic transformations of the axial skeleton that accompany a targeted deletion of E2F6. EMBO Reports, 3: 695-700 (2002) View:  

Ogawa, H.; Ishiguro, K.; Gaubatz, S.; Livingston, D.M. and Nakatani, Y.: A complex with chromatin modifiers that occupies E2F- and Myc- responsive genes in G0 cells. Science, 296: 1132-1136 (2002) View:  

Dahme, T.; Wood, J., Livingston, D.M.; Gaubatz, S.: Two different E2F6 proteins generated by alternative splicing and internal translation initiation. Eur J. Biochem. 269: 5030-6 (2002). View:             

Gaubatz, S., Lindeman, G.L., Lees, J. and Livingston, D.M.: E2F4 is exported from the nucleus in a crm1-dependent manner. Mol. Cell. Biol. 21: 1384-1392 (2001). View: 

Gaubatz, S., Lindeman, G.L., Ishida, S. Jakoi, L ,Nevins,J.R. Livingston, D.M.Rempel, R.E.: E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control. Mol. Cell, 6: 729-735 (2000). View:  

Elliott K, Sakamuro D, Basu A, Du W, Wunner W, Staller P, Gaubatz S, Zhang H, Prochownik E, Eilers M, Prendergast GC.: Bin1 functionally interacts with Myc and inhibits cell proliferation via multiple mechanisms. Oncogene. 18: 3564-73 (1999). View:  

Gaubatz S., Wood J., Livingston D.M. Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6. Proc Natl Acad Sci USA, 95:9190-9195 (1998). View: 

Lindeman G.J., Dagnino L., Gaubatz S., Xu Y., Bronson R.T., Warren H.B., Livingston D.M. A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting. Genes & Dev12:1092-1098 (1998). View: 

Lindeman G.J., Gaubatz S., Livingston D.M., Ginsberg D. The subcellular localization of E2F-4 is cell-cycle dependent.  Proc Natl Acad Sci USA;  94:5095-5100 (1997). View:    

Desbarats L., Gaubatz S.,  Eilers M. Disrimination between different E-box binding proteins at an endogenous target gene of c-myc. Genes & Dev; 10:447-460 (1996). View:    

Gaubatz S., Imhof A., Dosch R., Werner O., Mitchell P., Buettner R., Eilers M.  Transcriptional activation by Myc is under negative control by the transcription factor AP-2. EMBO J; 14: 1508-1519 (1995). View:  

Gaubatz S., Meichle A., Eilers M. An E-Box element localized in the first intron mediates regulation of the prothymosin a gene by c-myc. Mol. Cell. Biol. ;14: 3853-3862 (1994). View:                                                          

Kües U., Richardson W.V.J., Tymon A.M., Mutasa E.S., Göttgens B., Gaubatz S., Gregoriades A, Casselton LA. The combination of dissimilar alleles of the Aa and Aß gene complexes, whose proteins contain homeo domain motifs, determines sexual development in the mushroom Coprinus cinereus. Genes & Dev; 6:568-577 (1992).