Publications
2021-
S. Endres, S. Ehrmanntraut, L. Endres, K. Can, C. Kraft, T. Rasmussen, R. Luxenhofer, B. Bottcher, B. Engels and A. C. Poppler (2023) Structural Investigation on How Guest Loading of Poly(2-oxazoline)-Based Micelles Affects the Interaction with Simulated Intestinal Fluids. 10.1021/acsbiomaterials.3c00645
M. S. Haider, A. K. Mahato, A. Kotliarova, S. Forster, B. Bottcher, P. Stahlhut, Y. Sidorova and R. Luxenhofer (2022) Biological Activity In Vitro, Absorption, BBB Penetration, and Tolerability of Nanoformulation of BT44:RET Agonist with Disease-Modifying Potential for the Treatment of Neurodegeneration. 10.1021/acs.biomac.2c00761
V. J. Flegler, T. Rasmussen and B. Bottcher (2022) How Functional Lipids Affect the Structure and Gating of Mechanosensitive MscS-like Channels. 23.
S. Endres, E. Karaev, S. Hanio, J. Schlauersbach, C. Kraft, T. Rasmussen, R. Luxenhofer, B. Bottcher, L. Meinel and A. C. Poppler (2022) Concentration and composition dependent aggregation of Pluronic- and Poly-(2-oxazolin)-Efavirenz formulations in biorelevant media. J Colloid Interface Sci 606, 1179-1192.
A. Seifert, T. Tylek, C. Blum, N. Hemmelmann, B. Bottcher, U. Gbureck and J. Groll (2022) Calcium phosphate-based biomaterials trigger human macrophages to release extracellular traps. Biomaterials 285, 121521.
A. Grauel, J. Kagi, T. Rasmussen, I. Makarchuk, S. Oppermann, A. F. A. Moumbock, D. Wohlwend, R. Muller, F. Melin, S. Gunther, P. Hellwig, B. BÖttcher* and T. Friedrich* (2021) Structure of Escherichia coli cytochrome bd-II type oxidase with bound aurachin D. Nat Commun 12, 6498.
L. T. Alexander, R. Lepore, A. Kryshtafovych, A. Adamopoulos, M. Alahuhta, A. M. Arvin, Y. J. Bomble, B. Böttcher, C. Breyton, V. Chiarini, N. B. Chinnam, W. Chiu, K. Fidelis, R. Grinter, G. D. Gupta, M. D. Hartmann, C. S. Hayes, T. Heidebrecht, A. Ilari, A. Joachimiak, Y. Kim, R. Linares, A. L. Lovering, V. V. Lunin, A. N. Lupas, C. Makbul, K. Michalska, J. Moult, P. K. Mukherjee, W. S. Nutt, S. L. Oliver, A. Perrakis, L. Stols, J. A. Tainer, M. Topf, S. E. Tsutakawa, M. Valdivia-Delgado and T. Schwede (2021) Target highlights in CASP14: analysis of models by structure providers. Proteins
B. Böttcher (2021) Hepatitis B Core Protein Capsids. Subcell Biochem 96, 451-470.
V. J. Flegler, A. Rasmussen, K. Borbil, L. Boten, H. A. Chen, H. Deinlein, J. Halang, K. Hellmanzik, J. Loffler, V. Schmidt, C. Makbul, C. Kraft, R. Hedrich, T. Rasmussen and B. Böttcher (2021) Mechanosensitive channel gating by delipidation. Proc Natl Acad Sci U S A 118, e2107095118.
V. J. Flegler, T. Rasmussen and B. Böttcher (2021) More Than Just Closed and Open: Unraveling a Mechanosensor. Trends Biochem Sci 46, 623-625.
C. Grimm, J. Bartuli, B. Böttcher, A. A. Szalay and U. Fischer (2021) Structural basis of the complete poxvirus transcription initiation process. Nat Struct Mol Biol 28, 779-788.
C. Makbul, V. Khayenko, H. M. Maric and B. Böttcher (2021) Conformational Plasticity of Hepatitis B Core Protein Spikes Promotes Peptide Binding Independent of the Secretion Phenotype. Microorganisms 9, 956.
C. Makbul, C. Kraft, M. Grießmann, T. Rasmussen, K. Katzenberger, M. Lappe, P. Pfarr, C. Stoffer, M. Stöhr, A.-M. Wandinger and B. Böttcher (2021) Binding of a Pocket Factor to Hepatitis B Virus Capsids Changes the Rotamer Conformation of Phenylalanine 97. Viruses 13, 2115.
2016-2020
V. J. Flegler, A. Rasmussen, S. Rao, N. Wu, R. Zenobi, M. S. P. Sansom, R. Hedrich, T. Rasmussen and B. Bottcher (2020) The MscS-like channel YnaI has a gating mechanism based on flexible pore helices. Proc Natl Acad Sci U S A 117, 28754-28762.
J. Wiest, J. Kehrein, M. Saedtler, K. Schilling, E. Cataldi, C. A. Sotriffer, U. Holzgrabe, T. Rasmussen, B. Bottcher, M. Cronin-Golomb, M. Lehmann, N. Jung, M. Windbergs and L. Meinel (2020) Controlling Supramolecular Structures of Drugs by Light. Mol Pharm 17, 4704-4708.
C. Makbul, M. Nassal and B. Bottcher (2020) Slowly folding surface extension in the prototypic avian hepatitis B virus capsid governs stability. Elife 9,
M. S. Haider, M. M. Lubtow, S. Endres, S. Förster, V. J. Flegler, B. Böttcher, V. O. Aseyev, A. C. Pöppler and R. Luxenhofer (2020) Think beyond the core: The impact of the hydrophilic corona on the drug solubilization using polymer micelles. ACS Appl Mater Interfaces 12, 24531-24543.
L. Hahn, M. Maier, P. Stahlhut, M. Beudert, V. Flegler, S. Forster, A. Altmann, F. Toppke, K. Fischer, S. Seiffert, B. Bottcher, T. Luhmann and R. Luxenhofer (2020) Inverse Thermogelation of Aqueous Triblock Copolymer Solutions into Macroporous Shear-Thinning 3D Printable Inks. ACS Appl Mater Interfaces 12, 12445-12456.
C. Grimm, H. S. Hillen, K. Bedenk, J. Bartuli, S. Neyer, Q. Zhang, A. Huttenhofer, M. Erlacher, C. Dienemann, A. Schlosser, H. Urlaub, B. Bottcher, A. A. Szalay, P. Cramer and U. Fischer (2019) Structural Basis of Poxvirus Transcription: Vaccinia RNA Polymerase Complexes. Cell 179, 1537-1550 .
A. Thesseling, T. Rasmussen, S. Burschel, D. Wohlwend, J. Kagi, R. Muller, B. Bottcher and T. Friedrich (2019) Homologous bd oxidases share the same architecture but differ in mechanism. Nat Commun 10, 5138.
N. Famelis, A. Rivera-Calzada, G. Degliesposti, M. Wingender, N. Mietrach, J. M. Skehel, R. Fernandez-Leiro, B. Bottcher, A. Schlosser, O. Llorca and S. Geibel (2019) Architecture of the mycobacterial type VII secretion system. Nature 576, 321-325
T. Rasmussen, V. J. Flegler, A. Rasmussen and B. Bottcher (2019) Structure of the Mechanosensitive Channel MscS Embedded in the Membrane Bilayer. J Mol Biol 431, 3081-3090
B. Song, J. Lenhart, V. J. Flegler, C. Makbul, T. Rasmussen and B. Bottcher (2019) Capabilities of the Falcon III detector for single-particle structure determination. Ultramicroscopy 203, 145-154.
J. Heger-Stevic, P. Zimmermann, L. Lecoq, B. Bottcher and M. Nassal (2018) Hepatitis B virus core protein phosphorylation: Identification of the SRPK1 target sites and impact of their occupancy on RNA binding and capsid structure. PLoS Pathog 14, e1007488.
B. Böttcher and M. Nassal (2018) Structure of Mutant Hepatitis B Core Protein Capsids with Premature Secretion Phenotype. J Mol Biol 430, 4941–4954.
J. Wiest, M. Saedtler, B. Böttcher, M. Grune, M. Reggane, B. Galli, U. Holzgrabe and L. Meinel (2018) Geometrical and Structural Dynamics of Imatinib within Biorelevant Colloids. Mol Pharm 15, 4470-4480.
K. Hipp, C. Grimm, H. Jeske and B. Bottcher (2017) Near-Atomic Resolution Structure of a Plant Geminivirus Determined by Electron Cryomicroscopy. Structure 25, 1303-1309 e3.
R. Sundaramoorthy, A. L. Hughes, V. Singh, N. Wiechens, D. P. Ryan, H. El-Mkami, M. Petoukhov, D. I. Svergun, B. Treutlein, S. Quack, M. Fischer, J. Michaelis, B. Bottcher, D. G. Norman and T. Owen-Hughes (2017) Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes. Elife 6, e22510
R. L. Cassady-Cain, E. A. Blackburn, H. Alsarraf, E. Dedic, A. G. Bease, B. Bottcher, R. Jorgensen, M. Wear and M. P. Stevens (2016) Biophysical characterization and activity of lymphostatin, a multifunctional virulence factor of attaching & effacing Escherichia coli. J Biol Chem 291, 5803-5816.
S. M. Currie, E. Gwyer Findlay, A. J. McFarlane, P. M. Fitch, B. Bottcher, N. Colegrave, A. Paras, A. Jozwik, C. Chiu, J. Schwarze and D. J. Davidson (2016) Cathelicidins Have Direct Antiviral Activity against Respiratory Syncytial Virus In Vitro and Protective Function In Vivo in Mice and Humans. J Immunol 196, 2699-710.
2011-2015
B. Böttcher, V. Prazak, A. Rasmussen, S. S. Black and T. Rasmussen (2015) The Structure of YnaI Implies Structural and Mechanistic Conservation in the MscS Family of Mechanosensitive Channels. Structure 23, 1705-17014.
H. Dong, P. Li, B. Böttcher, R. M. Elliott and C. Dong (2013) Crystal structure of Schmallenberg orthobunyavirus nucleoprotein-RNA complex reveals a novel RNA sequestration mechanism. RNA 19, 1129-1136.
B. Bradatsch, C. Leidig, S. Granneman, M. Gnadig, D. Tollervey, B. Bottcher, R. Beckmann and E. Hurt (2012) Structure of the pre-60S ribosomal subunit with nuclear export factor Arx1 bound at the exit tunnel. Nat Struct Mol Biol 19, 1234-41.
G. Guedez, K. Hipp, V. Windeisen, B. Derrer, M. Gengenbacher, B. Bottcher, I. Sinning, B. Kappes and I. Tews (2012) Assembly of the Eukaryotic PLP-Synthase Complex from Plasmodium and Activation of the Pdx1 Enzyme. Structure 20, 172-84.
K. Hipp, K. Galani, C. Batisse, S. Prinz and B. Bottcher (2012) Modular architecture of eukaryotic RNase P and RNase MRP revealed by electron microscopy. Nucleic Acids Res 40, 3275-3288.
S. Lebaron, C. Schneider, R. W. van Nues, A. Swiatkowska, D. Walsh, B. Bottcher, S. Granneman, N. J. Watkins and D. Tollervey (2012) Proofreading of pre-40S ribosome maturation by a translation initiation factor and 60S subunits. Nat Struct Mol Biol 19, 744-53.
D. C. Soares, N. J. Bradshaw, J. Zou, C. K. Kennaway, R. S. Hamilton, Z. A. Chen, M. A. Wear, E. A. Blackburn, J. Bramham, B. Bottcher, J. K. Millar, P. N. Barlow, M. D. Walkinshaw, J. Rappsilber and D. J. Porteous (2012) The Mitosis and Neurodevelopment Proteins NDE1 and NDEL1 Form Dimers, Tetramers, and Polymers with a Folded Back Structure in Solution. J Biol Chem 287, 32381-93.
C. Fernandez-Tornero, B. Böttcher, U. J. Rashid and C. W. Muller (2011) Analyzing RNA polymerase III by electron cryomicroscopy. RNA Biol 8, 760-765.
B. Gerlach, J. A. Kleinschmidt and B. Bottcher (2011) Conformational Changes in Adeno-Associated Virus Type 1 Induced by Genome Packaging. J Mol Biol 409, 427-438.
F. Nasertorabi, C. Batisse, M. Diepholz, D. Suck and B. Bottcher (2011) Insights into the structure of the CCR4-NOT complex by electron microscopy. FEBS Lett 585, 2182-6.
F. Sonntag, K. Kother, K. Schmidt, M. Weghofer, C. Raupp, K. Nieto, A. Kuck, B. Gerlach, B. Bottcher, O. J. Muller, K. Lux, M. Horer and J. A. Kleinschmidt (2011) The assembly activating protein (AAP) promotes capsid assembly of different AAV serotypes. J Virol 85, 12686-12697.
2006-2010
B. Bottcher and K. Hipp (2010) Single-particle applications at intermediate resolution. Adv Protein Chem Struct Biol 81, 61-88.
M. A. Brooks, K. Gewartowski, E. Mitsiki, J. Letoquart, R. A. Pache, Y. Billier, M. Bertero, M. Correa, M. Czarnocki-Cieciura, M. Dadlez, V. Henriot, N. Lazar, L. Delbos, D. Lebert, J. Piwowarski, P. Rochaix, B. Bottcher, L. Serrano, B. Seraphin, H. van Tilbeurgh, P. Aloy, A. Perrakis and A. Dziembowski (2010) Systematic bioinformatics and experimental validation of yeast complexes reduces the rate of attrition during structural investigations. Structure 18, 1075-82.
S. Ernst, C. Batisse, N. Zarrabi, B. Böttcher and B. Boersch (2010) Regulatory assembly of the vacuolar proton pump VOV1-ATPase in yeast cells by FLIM-FRET. Proceedings of SPIE 7569,
C. Fernandez-Tornero, B. Bottcher, U. J. Rashid, U. Steuerwald, B. Florchinger, D. P. Devos, D. Lindner and C. W. Muller (2010) Conformational flexibility of RNA polymerase III during transcriptional elongation. EMBO J 29, 3762-72.
D. Flemming, K. Thierbach, P. Stelter, B. Bottcher and E. Hurt (2010) Precise mapping of subunits in multiprotein complexes by a versatile electron microscopy label. Nat Struct Mol Biol 17, 775-8.
J. Batisse, C. Batisse, A. Budd, B. Bottcher and E. Hurt (2009) Purification of nuclear poly(A)-binding protein Nab2 reveals association with the yeast transcriptome and a messenger ribonucleoprotein core structure. J Biol Chem 284, 34911-7.
D. Flemming, P. Sarges, P. Stelter, A. Hellwig, B. Bottcher and E. Hurt (2009) Two structurally distinct domains of the nucleoporin Nup170 cooperate to tether a subset of nucleoporins to nuclear pores. J Cell Biol 185, 387-95.
T. Heitkamp, B. Bottcher and J. C. Greie (2009) Solution structure of the KdpFABC P-type ATPase from Escherichia coli by electron microscopic single particle analysis. J Struct Biol 166, 295-302.
S. Kuhner, V. van Noort, M. J. Betts, A. Leo-Macias, C. Batisse, M. Rode, T. Yamada, T. Maier, S. Bader, P. Beltran-Alvarez, D. Castano-Diez, W. H. Chen, D. Devos, M. Guell, T. Norambuena, I. Racke, V. Rybin, A. Schmidt, E. Yus, R. Aebersold, R. Herrmann, B. Bottcher, A. S. Frangakis, R. B. Russell, L. Serrano, P. Bork and A. C. Gavin (2009) Proteome organization in a genome-reduced bacterium. Science 326, 1235-40.
C. Ulbrich, M. Diepholz, J. Bassler, D. Kressler, B. Pertschy, K. Galani, B. Bottcher and E. Hurt (2009) Mechanochemical removal of ribosome biogenesis factors from nascent 60S ribosomal subunits. Cell 138, 911-22.
M. Cristodero, B. Bottcher, M. Diepholz, K. Scheffzek and C. Clayton (2008) The Leishmania tarentolae exosome: purification and structural analysis by electron microscopy. Mol Biochem Parasitol 159, 24-9.
M. Diepholz, M. Börsch and B. Böttcher (2008) Structural organization of the V-ATPase and its implications for regulatory assembly and disassembly. Biochem Soc Trans 36, 1027-31.
M. Diepholz, D. Venzke, S. Prinz, C. Batisse, B. Flörchinger, M. Rössle, D. I. Svergun, B. Böttcher and J. Fethiere (2008) A different conformation for EGC stator subcomplex in solution and in the assembled yeast V-ATPase: possible implications for regulatory disassembly. Structure 16, 1789-98.
T. Heitkamp, R. Kalinowski, B. Bottcher, M. Borsch, K. Altendorf and J. C. Greie (2008) K+-translocating KdpFABC P-type ATPase from Escherichia coli acts as a functional and structural dimer. Biochemistry 47, 3564-75.
T. Pohl, D. Schneider, R. Hielscher, S. Stolpe, K. Dorner, M. Kohlstadt, B. Bottcher, P. Hellwig and T. Friedrich (2008) Nucleotide-induced conformational changes in the Escherichia coli NADH:ubiquinone oxidoreductase (complex I). Biochem Soc Trans 36, 971-5.
C. Fernandez-Tornero, B. Bottcher, M. Riva, C. Carles, U. Steuerwald, R. W. Ruigrok, A. Sentenac, C. W. Muller and G. Schoehn (2007) Insights into transcription initiation and termination from the electron microscopy structure of yeast RNA polymerase III. Mol Cell 25, 813-23.
S. Seitz, S. Urban, C. Antoni and B. Bottcher (2007) Cryo-electron microscopy of hepatitis B virions reveals variability in envelope capsid interactions. EMBO J 26, 4160-7.
P. Stelter, R. Kunze, D. Flemming, D. Hopfner, M. Diepholz, P. Philippsen, B. Bottcher and E. Hurt (2007) Molecular basis for the functional interaction of dynein light chain with the nuclear-pore complex. Nat Cell Biol 9, 788-96.
B. Böttcher, M. Vogel, M. Ploss and M. Nassal (2006) High plasticity of the hepatitis B virus capsid revealed by conformational stress. J Mol Biol 356, 812-22.
T. Schafer, B. Maco, E. Petfalski, D. Tollervey, B. Bottcher, U. Aebi and E. Hurt (2006) Hrr25-dependent phosphorylation state regulates organization of the pre-40S subunit. Nature 441, 651-5.
C. Skamel, M. Ploss, B. Böttcher, T. Stehle, R. Wallich, M. M. Simon and M. Nassal (2006) Hepatitis B virus capsid-like particles can display the complete, dimeric outer surface protein C and stimulate production of protective antibody responses against Borrelia burgdorferi infection. J Biol Chem 281, 17474-81.
2001-2005
J. Fethiere, D. Venzke, D. R. Madden and B. Bottcher (2005) Peripheral stator of the yeast V-ATPase: stoichiometry and specificity of interaction between the EG complex and subunits C and H. Biochemistry 44, 15906-14.
S. Kronenberg, B. Bottcher, C. W. von der Lieth, S. Bleker and J. A. Kleinschmidt (2005) A conformational change in the adeno-associated virus type 2 capsid leads to the exposure of hidden VP1 N termini. J Virol 79, 5296-303.
M. Lutzmann, R. Kunze, K. Stangl, P. Stelter, K. F. Toth, B. Bottcher and E. Hurt (2005) Reconstitution of Nup157 and Nup145N into the Nup84 complex. J Biol Chem 280, 18442-51.
D. Venzke, I. Domgall, T. Köcher, J. Fethiere, S. Fischer and B. Böttcher (2005) Elucidation of the stator organization in the V-ATPase of Neurospora crassa. J Mol Biol 349, 659-669.
P. Aloy, B. Bottcher, H. Ceulemans, C. Leutwein, C. Mellwig, S. Fischer, A. C. Gavin, P. Bork, G. Superti-Furga, L. Serrano and R. B. Russell (2004) Structure-based assembly of protein complexes in yeast. Science 303, 2026-9.
B. Böttcher, S. Unseld, H. Ceulemans, R. B. Russell and H. Jeske (2004) Geminate structures of African cassava mosaic virus. J Virol 78, 6758-65.
J. Fethiere, D. Venzke, M. Diepholz, A. Seybert, A. Geerlof, M. Gentzel, M. Wilm and B. Bottcher (2004) Building the stator of the yeast vacuolar-ATPase: specific interaction between subunits E and G. J Biol Chem 279, 40670-6.
T. Friedrich and B. Bottcher (2004) The gross structure of the respiratory complex I: a Lego System. Biochim Biophys Acta 1608, 1-9.
C. Mellwig and B. Böttcher (2003) A unique resting position of the ATP-synthase from chloroplasts. J Biol Chem 278, 18544-9.
P. Aloy, F. D. Ciccarelli, C. Leutwein, A. C. Gavin, G. Superti-Furga, P. Bork, B. Bottcher and R. B. Russell (2002) A complex prediction: three-dimensional model of the yeast exosome. EMBO Rep 3, 628-635.
B. Böttcher, D. Scheide, M. Hesterberg, L. Nagel-Steger and T. Friedrich (2002) A novel, enzymatically active conformation of the Escherichia coli NADH:ubiquinone oxidoreductase (complex I). J Biol Chem 277, 17970-17977.
I. Domgall, D. Venzke, U. Luttge, R. Ratajczak and B. Bottcher (2002) Three-dimensional Map of a Plant V-ATPase Based on Electron Microscopy. J Biol Chem 277, 13115-13121.
S. Kronenberg, J. A. Kleinschmidt and B. Bottcher (2001) Electron cryo-microscopy and image reconstruction of adeno-associated virus type 2 empty capsids. EMBO Rep 2, 997-1002.
C. Mellwig and B. Bottcher (2001) Dealing with particles in different conformational states by electron microscopy and image processing. J Struct Biol 133, 214-20.
2000 and before
G. Beterams, B. Bottcher and M. Nassal (2000) Packaging of up to 240 subunits of a 17 kDa nuclease into the interior of recombinant hepatitis B virus capsids. FEBS Lett 481, 169-76.
B. Böttcher (2000) ATP synthase Is revolution effective? EMBO Reports 1, 223-224.
B. Böttcher, I. Bertsche, R. Reuter and P. Gräber (2000) Direct visualisation of conformational changes in EF0F1 by electron microscopy. J Mol Biol 296, 449-57.
B. Böttcher and P. Gräber (2000) The structure of the H+-ATP synthase from chloroplasts and its subcomplexes as revealed by electron microscopy. Biochim Biophys Acta 1458, 404-16.
P. A. Kratz, B. Bottcher and M. Nassal (1999) Native display of complete foreign protein domains on the surface of hepatitis B virus capsids. Proc Natl Acad Sci U S A 96, 1915-20.
B. Böttcher, L. Schwarz and P. Gräber (1998) Direct indication for the existence of a double stalk in CF0F1. J Mol Biol 281, 757-62.
B. Böttcher, N. Tsuji, H. Takahashi, M. R. Dyson, S. Zhao, R. A. Crowther and K. Murray (1998) Peptides that block hepatitis B virus assembly: analysis by cryomicroscopy, mutagenesis and transfection. Embo J 17, 6839-45.
B. Böttcher, N. A. Kiselev, V. Y. Stel'Mashchuk, N. A. Perevozchikova, A. V. Borisov and R. A. Crowther (1997) Three-dimensional structure of infectious bursal disease virus determined by electron cryomicroscopy. J Virol 71, 325-30.
B. Bottcher, S. A. Wynne and R. A. Crowther (1997) Determination of the fold of the core protein of hepatitis B virus by electron cryomicroscopy. Nature 386, 88-91.
B. Böttcher, S. A. Wynne and R. A. Crowther (1997) The fold of the core protein of hepatitis B virus determined by electron cryomicroscopy. Hitachi instrument news 32, 3-8.
C. Menendez, A. Otto, G. Igloi, P. Nick, R. Brandsch, B. Schubach and B. Bottcher (1997) Molybdate-uptake genes and molybdopterin-biosynthesis genes on a bacterial plasmid--characterization of MoeA as a filament-forming protein with adenosinetriphosphatase activity. Eur J Biochem 250, 524-31.
B. Böttcher and R. A. Crowther (1996) Difference imaging reveals ordered regions of RNA in turnip yellow mosaic virus. Structure 4, 387-94.
Böttcher (1995) Electron cryo-microscopy of graphite in amorphous ice. Ultramicroscopy 58, 417-424.
B. Bottcher, P. Graber, E. J. Boekema and U. Lucken (1995) Electron cryomicroscopy of two-dimensional crystals of the H+-ATPase from chloroplasts. FEBS Letters 373, 262-264.
B. Böttcher, U. Lücken and P. Gräber (1995) The structure of the H+-ATPase from chloroplasts by electron cryomicroscopy. Biochemical Society Transactions 23, 780-785.
R. A. Crowther, N. A. Kiselev, B. Bottcher, J. A. Berriman, G. P. Borisova, V. Ose and P. Pumpens (1994) Three-Dimensional Structure of Hepatitis B Virus Core Particles Determined by Electron Cryomicroscopy. Cell 77, 943-950.
E. J. Boekema and B. Bottcher (1992) The Structure of Atp Synthase from Chloroplasts - Conformational-Changes of Cf1 Studied by Electron-Microscopy. Biochimica Et Biophysica Acta 1098, 131-143.
B. Böttcher, P. Gräber and E. J. Boekema (1992) The structure of Photosystem I from the thermophilic cyanobacterium Synechococcus sp. determined by electron microscopy of two-dimensional crystals. Biochim Biophys Acta 1100, 125-36.
Böttcher, Lücken, Boekema and Gräber (1990) On the structure of the ATP-Synthase from Chloroplasts. Cur.Res.i.Photosynth 9, 33-36.
