Center for Computational and Theoretical Biology

    Philip Kollmannsberger (Prof. Dr.)

    Junior Professor "Computational Image Analysis"

    Center for Computational and Theoretical Biology (CCTB)
    University of Würzburg
    Campus Hubland Nord 32
    97074 Würzburg, Germany
    Tel: 0931 - 31 82375

    eMail: philip.kollmannsberger@uni-wuerzburg.de

    Sprechstunde: nach Vereinbarung



    Curriculum Vitae

    since 03/2016

    Assistant Professor (Juniorprofessor)
    Center for Computational and Theoretical Biology (CCTB)
    University of Würzburg, Germany
    03/2012 - 02/2016

    Postdoc and Lecturer
    ETH Zürich, Laboratory of Applied Mechanobiology (Viola Vogel)
    01/2010 - 12/2011

    Max Planck Institute of Colloids and Interfaces, Golm, Germany
    Department of Biomaterials (Peter Fratzl)
    PhD in Physics
    09/2006 - 11/2006 and
    03/2007 - 05/2007

    Visiting Researcher
    Scripps Institute, La Jolla, USA
    Department of Cell Biology (Waterman/Danuser)
    10/2004 - 10/2009

    Research Assistant and PhD Student
    University of Erlangen, Germany
    Center for Medical Physics and Technology (Ben Fabry)
    Diploma in Physics
    05/2001 - 02/2004

    Student of Physics (Diplom)
    University of Erlangen, Germany
    09/2000 - 04/2001

    ERASMUS fellow
    University of Joensuu, Finland
    11/1998 - 08/2000

    Student of Physics (Vordiplom)
    University of Erlangen, Germany


    • Mrestani, A., Kollmannsberger, P., Pauli, M., Repp, F., Kittel, R.J., Eilers, J., Doose, S., Sauer, M., Sirén, A.-L., Heckmann, M., Paul, M.M. (2019) “Active zone compaction for presynaptic strength”, bioRxiv, available: https://www.biorxiv.org/content/early/2019/10/13/802843.
    • Pauli, M., Paul, M.M., Proppert, S., Sharifi, M., Repp, F., Kollmannsberger, P., Sauer, M., Heckmann, M., Sirén, A.-L. (2019) “Targeted volumetric single-molecule localization microscopy of defined presynaptic structures in brain sections”, bioRxiv, available: http://biorxiv.org/lookup/doi/10.1101/568279.
    • Mostosi, P., Schindelin, H., Kollmannsberger, P., Thorn, A. (2019) “Automated interpretation of Cryo-EM density maps with convolutional neural networks”, bioRxiv, 644476, available: https://www.biorxiv.org/content/10.1101/644476v1.



    • Spindler, M.-C., Redolfi, J., Helmprobst, F., Kollmannsberger, P., Stigloher, C., Benavente, R. (2019) “Electron tomography of mouse LINC complexes at meiotic telomere attachment sites with and without microtubules”, Communications Biology, 2(1), 376--, available: https://doi.org/10.1038/s42003-019-0621-1.
    • Ehrig, S., Bidan, C.M., West, A., Jacobi, C., Lam, K., Kollmannsberger, P., Petersen, A., Tomancak, P., Kommareddy, K., Fischer, F.D., Fratzl, P., Dunlop, J.W.C. (2019) “Surface tension determines tissue shape and growth kinetics”, Science Advances, 5(9), eaav9394, available: https://advances.sciencemag.org/content/5/9/eaav9394?intcmp=trendmd-adv.
    • Weinkamer, R., Kollmannsberger, P., Fratzl, P. (2019) “Towards a Connectomic Description of the Osteocyte Lacunocanalicular Network in Bone”, Current Osteoporosis Reports, available: https://doi.org/10.1007/s11914-019-00515-z.


    • Kaltdorf, K.V., Theiss, M., Markert, S.M., Zhen, M., Dandekar, T., Stigloher, C., Kollmannsberger, P. (2018) “Automated classification of synaptic vesicles in electron tomograms of C. elegans using machine learning”, PLoS one, 13(10), e0205348, available: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0205348.
    • Kollmannsberger, P., Bidan, C.M., Dunlop, J., Fratzl, P., Vogel, V. (2018) “Tensile forces drive a reversible fibroblast-to-myofibroblast transition during tissue growth in engineered clefts”, Science Advances, 4(1), eaao4881.


    • Repp, F., Kollmannsberger, P., Roschger, A., Berzlanovich, A., Gruber, G., Roschger, P., Wagermaier, W., Weinkamer, R. (2017) “Coalignment of osteocyte canaliculi and collagen fibers in human osteonal bone”, Journal of Stuctural Biology, 199, 177-186.
    • Repp, F., Kollmannsberger, P., Roschger, A., Kerschnitzki, M., Berzlanovich, A., Gruber, G.M., Roschger, P., Wagermaier, W., Weinkamer, R. (2017) “Spatial heterogeneity in the canalicular density of the osteocyte network in human osteons”, Bone Reports, 6, 101-108.
    • Kollmannsberger, P., Kerschnitzki, M., Repp, F., Wagermaier, W., Weinkamer, R., Fratzl, P. (2017) “The Small World of Osteocytes: Connectomics of the Lacuno-Canalicular Network in Bone.”, New Journal of Physics, 19, 073019.
    • Kaltdorf, K.V., Schulze, K., Helmprobst, F., Kollmannsberger, P., Dandekar, T., Stigloher, C. (2017) “FIJI Macro 3D ART VeSElecT: 3D Automated Reconstruction Tool for Vesicle Structures of Electron Tomograms”, PLOS Computational Biology, 13(1), 1-21, available: http://dx.doi.org/10.1371%2Fjournal.pcbi.1005317.


    • Yamashita, T., Kollmannsberger, P., Mawatari, K., Kitamori, T., Vogel, V. (2016) “Cell sheet mechanics: How geometrical constraints induce the detachment of cell sheets from concave surfaces”, Acta Biomaterialia, 45, 85 - 97, available: http://www.sciencedirect.com/science/article/pii/S1742706116304408.
    • Bidan, C.M., Kollmannsberger, P., Gering, V., Ehrig, S., Joly, P., Petersen, A., Vogel, V., Fratzl, P., Dunlop, J.W.C. (2016) “Gradual conversion of cellular stress patterns into pre-stressed matrix architecture during in vitro tissue growth”, Journal of The Royal Society Interface, 13(118), available: http://rsif.royalsocietypublishing.org/content/13/118/20160136.
    • Avalos Vizcarra, I., Hosseini, V., Kollmannsberger, P., Meier, S., Weber, S.S., Arnoldini, M., Ackermann, M., Vogel, V. (2016) “How type 1 fimbriae help Escherichia coli to evade extracellular antibiotics”, Scientific Reports, 6, 18109, available: http://dx.doi.org/10.1038/srep18109.


    • Foolen, J., Yamashita, T., Kollmannsberger, P. (2015) “Shaping tissues by balancing active forces and geometric constraints”, Journal of Physics D: Applied Physics, 49(5), 053001.


    • Hosseini, V., Kollmannsberger, P., Ahadian, S., Ostrovidov, S., Kaji, H., Vogel, V., Khademhosseini, A. (2014) “Fiber-Assisted Molding (FAM) of Surfaces with Tunable Curvature to Guide Cell Alignment and Complex Tissue Architecture”, Small, 10(23), 4851--4857.


    • Lukas, C., Ruffoni, D., Lambers, F.M., Schulte, F.A., Kuhn, G., Kollmannsberger, P., Weinkamer, R., Müller, R. (2013) “Mineralization kinetics in murine trabecular bone quantified by time-lapsed in vivo micro-computed tomography”, Bone, 56(1), 55--60.
    • Möller, J., Emge, P., Vizcarra, I.A., Kollmannsberger, P., Vogel, V. (2013) “Bacterial filamentation accelerates colonization of adhesive spots embedded in biopassive surfaces”, New Journal of Physics, 15(12), 125016.
    • Yamashita, T., Kollmannsberger, P., Mawatari, K., Vogel, V., Kitamori, T. (2013) “Curvature-induced spontaneous detachment of vascular smooth muscle cell sheets: towards vascular self assembly in microchannels”, Microsystem Technology in Chemistry and Life Science.
    • Kerschnitzki, M., Kollmannsberger, P., Burghammer, M., Duda, G.N., Weinkamer, R., Wagermaier, W., Fratzl, P. (2013) “Architecture of the osteocyte network correlates with bone material quality”, Journal of Bone and Mineral Research, 28(8), 1837--1845.
    • Bidan, C.M., Kommareddy, K.P., Rumpler, M., Kollmannsberger, P., Fratzl, P., Dunlop, J.W.C. (2013) “Geometry as a factor for tissue growth: towards shape optimization of tissue engineering scaffolds”, Advanced healthcare materials, 2(1), 186--194.


    • Bidan, C.M., Kommareddy, K.P., Rumpler, M., Kollmannsberger, P., Bréchet, Y.J.M., Fratzl, P., Dunlop, J.W.C. (2012) “How Linear Tension Converts to Curvature: Geometric Control of Bone Tissue Growth”, PloS one, 7(5), e36336.


    • Kollmannsberger, P., Bidan, C.M., Dunlop, J.W.C., Fratzl, P. (2011) “The physics of tissue patterning and extracellular matrix organisation: how cells join forces”, Soft Matter, 7(20), 9549--9560.
    • Kollmannsberger, P., Mierke, C.T., Fabry, B. (2011) “Nonlinear viscoelasticity of adherent cells is controlled by cytoskeletal tension”, Soft Matter, 7(7), 3127--3132.
    • Lukas, C., Kollmannsberger, P., Ruffoni, D., Roschger, P., Fratzl, P., Weinkamer, R. (2011) “The Heterogeneous Mineral Content of Bone—Using Stochastic Arguments and Simulations to Overcome Experimental Limitations”, Journal of Statistical Physics, 144(2), 316--331.
    • Kollmannsberger, P., Fabry, B. (2011) “Linear and nonlinear rheology of living cells”, Annual Review of Materials Research, 41, 75--97.


    • Mierke, C.T., Kollmannsberger, P., Zitterbart, D.P., Diez, G., Koch, T.M., Marg, S., Ziegler, W.H., Goldmann, W.H., Fabry, B. (2010) “Vinculin facilitates cell invasion into three-dimensional collagen matrices”, Journal of Biological Chemistry, 285(17), 13121--13130.


    • Diez, G., Kollmannsberger, P., Mierke, C.T., Koch, T.M., Vali, H., Fabry, B., Goldmann, W.H. (2009) “Anchorage of vinculin to lipid membranes influences cell mechanical properties”, Biophysical journal, 97(12), 3105--3112.
    • Kollmannsberger, P., Fabry, B. (2009) “Active soft glassy rheology of adherent cells”, Soft Matter, 5(9), 1771--1774.
    • Kasza, K.E., Nakamura, F., Hu, S., Kollmannsberger, P., Bonakdar, N., Fabry, B., Stossel, T.P., Wang, N., Weitz, D.A. (2009) “Filamin A is essential for active cell stiffening but not passive stiffening under external force”, Biophysical journal, 96(10), 4326--4335.
    • Lorenz, C., Brunner, J.G., Kollmannsberger, P., Jaafar, L., Fabry, B., Virtanen, S. (2009) “Effect of surface pre-treatments on biocompatibility of magnesium”, Acta biomaterialia, 5(7), 2783--2789.


    • Mierke, C.T., Zitterbart, D.P., Kollmannsberger, P., Raupach, C., Schlötzer-Schrehardt, U., Goecke, T.W., Behrens, J., Fabry, B. (2008) “Breakdown of the endothelial barrier function in tumor cell transmigration”, Biophysical journal, 94(7), 2832--2846.
    • Rösel, D., Brábek, J., Tolde, O., Mierke, C.T., Zitterbart, D.P., Raupach, C., Bicanová, K.`yna, Kollmannsberger, P., Pavnková, D., Vesel`y, P., others, (2008) “Up-regulation of Rho/ROCK signaling in sarcoma cells drives invasion and increased generation of protrusive forces”, Molecular Cancer Research, 6(9), 1410--1420.
    • Mierke, C.T., Kollmannsberger, P., Paranhos Zitterbart, D., Smith, J., Fabry, B., Goldmann, W.H. (2008) “Mechano-coupling and regulation of contractility by the vinculin tail domain”, Biophysical journal, 94(2), 661--670.


    • Kollmannsberger, P., Fabry, B. (2007) “High-force magnetic tweezers with force feedback for biological applications”, Review of Scientific Instruments, 78(11), 114301--114301.