Chair of Biochemistry and Molecular Biology

    AG Diefenbacher

    Dr. Markus E. Diefenbacher

    Lehrstuhl für Biochemie und Molekularbiologie
    Am Hubland
    97074 Würzburg
    Raum B 328/329

    Tel:   0931 31-88167
    Fax:  0931 31-84113

    Curriculum Vitae

    Our research focus is the deregulation of protein turnover as a central driver in tumourigenesis.


    E3-ligases; the double-edged sword

    Deubiquitinases, a novel class of molecules in the limelight

    E3-ligases and DUBs in lung cancer

    E3-ligases and DUBs in intestinal cancer





    Ruiz, E. J., Diefenbacher, M. E., Nelson, J. K., Sancho, R., Pucci, F., Chakraborty, A., . . . Behrens, A. (2019). LUBAC determines chemotherapy resistance in squamous cell lung cancer. J Exp Med. doi: 10.1084/jem.20180742

    Ungewiss, H., Rotzer, V., Meir, M., Fey, C., Diefenbacher, M. E., Schlegel, N., & Waschke, J. (2018). Dsg2 via Src-mediated transactivation shapes EGFR signaling towards cell adhesion. Cell Mol Life Sci, 75(22), 4251-4268. doi: 10.1007/s00018-018-2869-x

    Diefenbacher, M. E., & Orian, A. (2017). Stabilization of nuclear oncoproteins by RNF4 and the ubiquitin system in cancer. Mol Cell Oncol, 4(1), e1260671. doi: 10.1080/23723556.2016.1260671

    Show all

    Lab news and activities

    Vacant positions

    Lab protocols


    Emil Hilb Programm

    "Targeting protein stability in lung squamous cell carcinoma"

    "Establishing a human colorectal cancer organoid bank" Collaboration with Armin Wiegering

    "Unmasking E3-ligase-DUB pairs in colorectal cancer"