Chair of Biochemistry and Molecular Biology

    Important Publications

    Most important publications

    Röhrig, F., and Schulze, A. (2016). The multifaceted roles of fatty acid synthesis in cancer. Nat Rev Cancer. 16, 732-749.

    Peck, B., Schug, Z.T., Zhang, Q., Dankworth, B., Jones, D.T., Smethurst, E., Patel, R., Mason, S., Jiang, M., Saunders, R., Howell, M., Mitter, R., Spencer-Dene, B., Stamp, G., McGarry, L., James, D., Shanks, E., Aboagye, E.O., Critchlow, S.E., Leung, H.Y., Harris, A.L., Wakelam, M.J., Gottlieb, E., and Schulze, A. (2016). Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments. Cancer Metab 4, 6.

    Lewis, C.A., Brault, C., Peck, B., Bensaad, K., Griffiths, B., Mitter, R., Chakravarty, P., East, P., Dankworth, B., Alibhai, D., Harris, A.L., and Schulze, A. (2015). SREBP maintains lipid biosynthesis and viability of cancer cells under lipid- and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiforme. Oncogene 34, 5128-5140.

    Schug ZT, Peck B, Jones DT, Zhang Q, Grosskurth S, Alam IS, Goodwin LM, Smethurst E, Mason S, Blyth K, McGarry L, James D, Shanks E, Kalna G, Saunders B, Jiang M, Howell M, Lassailly F, Zaw Thin M, Spencer-Dene B, Stamp G, van den Broek N, Mackay G, Bulusu V, Kamphorst JJ, Tardito S, Strachan D, Harris AL, Aboagye EO, Critchlow SE, Wakelam MJO, Schulze A and Gottlieb E (2015) Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth Under Metabolic Stress. Cancer Cell 27: 57-71

    Griffiths, B, Lewis, C.A., Bensaad, K., Ros, S., Zhang, Q., Ferber, E.C., Konisti, S., Peck, B., Miess, H., East. P., Wakelam, M., Harris, A.L., and Schulze, A. (2013) Inhibition of SREBP induces ER-stress by altering cellular lipid composition and blocks cancer cell growth. Cancer & Metabolism. 1:3

    Schulze A, Harris AL.  How cancer metabolism is tuned for proliferation and vulnerable to disruption. Nature 2012. 491(7424), 364-73.

    Ros S, Santos CR, Moço S, Baenke F, Kelly G, Howell M, Zamboni N and Schulze A. (2012) Functional screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase (PFKFB4) as an important regulator of prostate cancer cell survival. Cancer Discovery 2:328-343

    Ferber E, Peck B, Delpeuch EO, Bell G, East P and Schulze A. (2011) FOXO3A regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression. Cell Death and Differentiation. doi: 10.1038/cdd.2011.179

    Porstmann, T., Santos, C.R, Griffiths, B., Cully, M., Wu, M. Leevers, S. Griffiths, J.R., Chung, Y.-l. and Schulze A. (2008). SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth. Cell Metabolism, 8(3): 224-236.