Chair of Biochemistry and Molecular Biology



    The impact of pulmonary metastasectomy in patients with previously resected colorectal cancer liver metastases.
    Wiegering A, Riegel J, Wagner J, Kunzmann V, Baur J, Walles T, Dietz U, Loeb S, Germer CT, Steger U, Klein I.
    PLoS One. 2017 Mar 22;12(3):e0173933. doi: 10.1371/journal.pone.0173933. eCollection 2017 Mar 22.

    Reactivating p53 and Inducing Tumor Apoptosis (RITA) Enhances the Response of RITA-Sensitive Colorectal Cancer Cells to Chemotherapeutic Agents 5-Fluorouracil and Oxaliplatin.
    Wiegering A, Matthes N, Mühling B, Koospal M, Quenzer A, Peter S, Germer CT, Linnebacher M, Otto C.
    Neoplasia. 2017 Mar 8;19(4):301-309. doi: 10.1016/j.neo.2017.01.007. [Epub ahead of print]


    Original article: role of adjuvant chemotherapy in a perioperative chemotherapy regimen for gastric cancer. 
    Lichthardt S, Kerscher A, Dietz UA, Jurowich C, Kunzmann V, von Rahden BH, Germer CT, Wiegering A.
    BMC Cancer. 2016 Aug 18;16:650. doi: 10.1186/s12885-016-2708-0.

    Improved survival of patients with colon cancer detected by screening colonoscopy. 
    Wiegering A, Ackermann S, Riegel J, Dietz UA, Götze O, Germer CT, Klein I.
    Int J Colorectal Dis. 2016 May;31(5):1039-45. doi: 10.1007/s00384-015-2501-6. Epub 2016 Jan 14.


    Diagnostic value of preoperative CT scan to stratify colon cancer for neoadjuvant therapy. 
    Wiegering A, Kunz M, Hussein M, Klein I, Wiegering V, Uthe FW, Dietz UA, Jurowich C, Bley T, Dandekar T, Germer CT, Ritter C.
    Int J Colorectal Dis. 2015 Aug;30(8):1067-73. doi: 10.1007/s00384-015-2265-z. Epub 2015 May 22.

    Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer.
    Wiegering A, Uthe FW, Jamieson T, Ruoss Y, Hüttenrauch M, Küspert M, Pfann C, Nixon C, Herold S, Walz S, Taranets L, Germer CT, Rosenwald A, Sansom OJ, Eilers M.
    Cancer Discov. 2015 Jul;5(7):768-81. doi: 10.1158/2159-8290.CD-14-1040. Epub 2015 May 1.


    E7080 (lenvatinib), a multi-targeted tyrosine kinase inhibitor, demonstrates antitumor activities against colorectal cancer xenografts.
    Wiegering A, Korb D, Thalheimer A, Kämmerer U, Allmanritter J, Matthes N, Linnebacher M, Schlegel N, Klein I, Ergün S, Germer CT, Otto C.
    Neoplasia. 2014 Nov 20;16(11):972-81. doi: 10.1016/j.neo.2014.09.008. eCollection 2014 Nov 20.

    Multimodal therapy in treatment of rectal cancer is associated with improved survival and reduced local recurrence - a retrospective analysis over two decades.
    Wiegering A, Isbert C, Dietz UA, Kunzmann V, Ackermann S, Kerscher A, Maeder U, Flentje M, Schlegel N, Reibetanz J, Germer CT, Klein I.
    BMC Cancer. 2014 Nov 6;14:816. doi: 10.1186/1471-2407-14-816.

    Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase. 
    Peter S, Bultinck J, Myant K, Jaenicke LA, Walz S, Müller J, Gmachl M, Treu M, Boehmelt G, Ade CP, Schmitz W, Wiegering A, Otto C, Popov N, Sansom O, Kraut N, Eilers M.
    EMBO Mol Med. 2014 Dec;6(12):1525-41. doi: 10.15252/emmm.201403927.

    The impact of pyrvinium pamoate on colon cancer cell viability.
    Wiegering A, Uthe FW, Hüttenrauch M, Mühling B, Linnebacher M, Krummenast F, Germer CT, Thalheimer A, Otto C.
    Int J Colorectal Dis. 2014 Oct;29(10):1189-98. doi: 10.1007/s00384-014-1975-y. Epub 2014 Jul 26.


    CIP2A influences survival in colon cancer and is critical for maintaining Myc expression. 
    Wiegering A, Pfann C, Uthe FW, Otto C, Rycak L, Mäder U, Gasser M, Waaga-Gasser AM, Eilers M, Germer CT.
    PLoS One. 2013 Oct 1;8(10):e75292. doi: 10.1371/journal.pone.0075292. eCollection 2013 Oct 1.