Our main interest is transcriptional regulation of the mammalian cell cycle by the DREAM complex and Myb-MuvB (MMB). MMB together with the B-MYB transcription factor is a master activator of genes required for mitosis and cytokinesis.
We use biochemical and genetic methods to understand how DREAM, MuvB, B-MYB and its target genes contribute to normal proliferation, development and tumorigenesis.
Hanselmann S, Wolter P, Malkmus J, Gaubatz S (2017) The microtubule-associated protein PRC1 is a potential therapeutic target for lung cancer. Oncotarget (in press)
Gründl M, Engel FB, Gaubatz S (2017) GAS2L3: Coordinator of cardiomyocyte cytokinesis? Cell Cycle (doi.org/10.1080/15384101.2017.1372546)
Stopp S, Gründl M, Fackler M, Malkmus J, Leone M, Naumann R, Frantz S, Wolf E, von Eyss B, Engel FB, Gaubatz S (2017) Deletion of Gas2l3 in mice leads to specific defects in cardiomyocyte cytokinesis during development. Proc Natl Acad Sci USA (doi: 10.1073/pnas.1703406114)
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