Chair of Physiological Chemistry

    Gaubatz Group Publications

    Hanselmann S, Wolter P, Malkmus J, Gaubatz S (2017) The microtubule-associated protein PRC1 is a potential therapeutic target for lung cancer. Oncotarget (in press)

    Gründl M, Engel FB, Gaubatz S (2017) GAS2L3: Coordinator of cardiomyocyte cytokinesis? Cell Cycle (doi.org/10.1080/15384101.2017.1372546)

    Stopp S, Gründl M, Fackler M, Malkmus J, Leone M, Naumann R, Frantz S, Wolf E, von Eyss B, Engel FB, Gaubatz S (2017) Deletion of Gas2l3 in mice leads to specific defects in cardiomyocyte cytokinesis during development. Proc Natl Acad Sci USA doi: 10.1073/pnas.1703406114

    Wolter P, Hanselmann S, Pattschull G, Schruf E, Gaubatz S (2017): Central spindle proteins and mitotic kinesins are direct transcriptional targets of MuvB, B-MYB and FOXM1 in breast cancer cell lines and are potential targets for therapy. Oncotarget.  doi: 10.18632/oncotarget.14466         

    Iltzsche F, Simon K, Stopp S, Pattschull G, Francke S, Wolter P, Hauser S, Murphy DJ, Garcia P, Rosenwald A and Gaubatz S (2016):An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinoma. Oncogene, advance online publication 23 May 2016; doi: 10.1038/onc.2016.181 View: http://www.ncbi.nlm.nih.gov/pubmed/27212033

    Kumari G, Ulrich T, Krause M, Finkernagel F, Gaubatz S. (2014): Induction of p21CIP1 and cell cycle arrest after inhibition of Aurora B kinase is attributed to aneuploidy and reactive oxygen species. J Biol Chem. doi:10.1074/jbc.M114.555060.

    Fackler, M., Wolter, P. and Gaubatz, S. (2014): The GAR domain of GAS2L3 mediates binding to the chromosomal passenger complex and is required for localization of GAS2L3 to the constriction zone during abscission. FEBS J. 281:2123-2135; DOI: 10.1111/febs.12766. 

    Kumari, G., Ulrich, T. and Gaubatz, S. (2013): A role for p38 in transcriptional elongation of p21CIP1 in response to Aurora B inhibition. Cell Cycle 12:2051-60 View: 


    Esterlechner, J., Reichert, N., Iltzsche, F., Krause, M., Finkernagel, F., Gaubatz, S. (2013): LIN9, a subunit of the DREAM complex, regulates mitotic gene expression and proliferation of embryonic stem cells. PLOS ONE 8(5): e62882. View: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0062882

    Wolter, P., Schmitt, K., Fackler, M., Kremling, H., Probst, L., Hauser, S., Gruss, O. J., and Gaubatz, S. (2012). GAS2L3, a novel target gene of the DREAM complex, is required for proper cytokinesis and genomic stability. J Cell Sci. 125:2393-406 View: http://www.ncbi.nlm.nih.gov/pubmed/22344256

    Hauser S., Ulrich T., Wurster S., Schmitt K., Reichert N. and Gaubatz S. (2011) Loss of LIN9, a member of the DREAM complex, cooperates with SV40 large T antigen to induce genomic instability and anchorage-independent growth. Oncogene 31:1859-68. View: http://www.ncbi.nlm.nih.gov/pubmed/21860417

    Houben R, Adam C, Baeurle A, Hesbacher S, Grimm J, Angermeyer S, Henzel K, Hauser S, Elling R, Bröcker EB, Gaubatz S, Becker JC, Schrama D. (2011) An intact retinoblastoma protein-binding site in Merkel cell polyomavirus large T antigen is required for promoting growth of Merkel cell carcinoma cells. Int J Cancer doi: 10.1002/ijc.26076. View: http://www.ncbi.nlm.nih.gov/pubmed/21413015

    Meierjohann S, Hufnagel A, Wende E, Kleinschmidt MA, Wolf K, Friedl P, Gaubatz S, Schartl M. (2010) MMP13 mediates cell cycle progression in melanocytes and melanoma cells: in vitro studies of migration and proliferation.  Mol Cancer 9:201. View: http://www.ncbi.nlm.nih.gov/pubmed/20667128

    Reichert N, Wurster S, Ulrich T, Schmitt K, Hauser S, Probst L, Götz R, Ceteci F, Moll R, Rapp U, Gaubatz S (2010) Lin9, a subunit of the mammalian DREAM complex, is essential for embryonic development, for survival of adult mice and for tumor suppression. Mol Cell Biol 30:2896-908. View: http://www.ncbi.nlm.nih.gov/pubmed/20404087

    Schmit F, Cremer S, Gaubatz S (2009)  LIN54 is an essential core subunit of the DREAM/ LINC complex that binds to the cdc2 promoter in a sequence-specific manner. FEBS Journal 276:5703-16. View: http://www.ncbi.nlm.nih.gov/pubmed/19725879 

    Mannefeld M, Klassen E, Gaubatz S (2009) B-MYB is required for recovery from the DNA-damage induced G2 checkpoint in p53 mutant cells. Cancer Research, 69:4073-80. View: http://www.ncbi.nlm.nih.gov/pubmed/19383908

    Kleinschmidt MA, Wagner TU, Liedtke D, Samans D, Gaubatz S (2009) LIN9 is required for mitosis and cell survival during early zebrafish development. JBC, 284:13119-27. View: http://www.ncbi.nlm.nih.gov/pubmed/19278998 

    Kehoe SM, Oka M, Hankowski KE, Reichert N, Garcia S, McCarrey JR, Gaubatz S, Terada N (2008) A conserved E2F6-binding element in murine meiosis-specific gene promoters. Biol. Reprod. 79:921-930. View: http://www.ncbi.nlm.nih.gov/pubmed/18667754 

    Schmit, F., Korenjak, M., Mannefeld, M., Schmitt, K., Franke, C., von Eyss, B., Gagrica, S., Hanel, F., Brehm, A., and Gaubatz, S. (2007) LINC, a human complex that is related to pRb-containing complexes in invertebrates regulates the expression of G2/M genes. Cell Cycle, 6:1903-13 View: http://www.ncbi.nlm.nih.gov/pubmed/17671431

    Osterloh, L., von Eyss, B., Schmit, F., Rein, L., Hubner, D., Samans, B., Hauser, S., and Gaubatz, S. (2007) The human synMuv-like protein LIN-9 is required for transcription of G2/M genes and for entry into mitosis. EMBO Journal, 26:144-157 View: http://www.ncbi.nlm.nih.gov/pubmed/17159899

    Storre J, Schafer A, Reichert N, Barbero JL, Hauser S, Eilers M, Gaubatz S (2005) Silencing of the meiotic genes SMC1beta and STAG3 in somatic cells by E2F6. J Biol Chem, 280:41380 View: http://www.ncbi.nlm.nih.gov/pubmed/16236716 

    Gagrica, S; Hauser, S; Kolfschoten, I; Osterloh, L, Agami, R and Gaubatz, S: Inhibition of oncogenic transformation by mammalian Lin-9, a pRB associated protein. EMBO Journal, 23: 4627-38 (2004) View: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC533054/ 

    Giangrande, P.H.; Zhu., W.; Schlisio, S.; Sun, X; Mori, S.; Gaubatz, S.; Nevins, J.R.: A role for E2F6 in distinguishing G1/S and G2/M specific transcription. Genes & Development, 18:2941-51(2004) View: http://www.ncbi.nlm.nih.gov/pubmed/15574595 

    Ohtani, N.; Brennan, P., Gaubatz, S.; Ghysadeal, J. ; Rowe, M. and Hara, E.: Epstein-Barr virus LMP1 blocks p16 INK4a/RB-pathway by promoting nuclear export of E2F4/5. Journal Cell Biol. 162(2): 173-83 (2003) View: http://www.ncbi.nlm.nih.gov/pubmed/12860972 

    Storre, J.; Elsässer, H-P.; Fuchs, M.; Ullmann, D.; Livingston, D.M. and Gaubatz, S.: Homeotic transformations of the axial skeleton that accompany a targeted deletion of E2F6. EMBO Reports, 3: 695-700 (2002) View: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1084195/ 

    Ogawa, H.; Ishiguro, K.; Gaubatz, S.; Livingston, D.M. and Nakatani, Y.: A complex with chromatin modifiers that occupies E2F- and Myc- responsive genes in G0 cells. Science, 296: 1132-1136 (2002) View: http://www.ncbi.nlm.nih.gov/pubmed/12004135 

    Dahme, T.; Wood, J., Livingston, D.M.; Gaubatz, S.: Two different E2F6 proteins generated by alternative splicing and internal translation initiation. Eur J. Biochem. 269: 5030-6 (2002). View: http://www.ncbi.nlm.nih.gov/pubmed/12383262            

    Gaubatz, S., Lindeman, G.L., Lees, J. and Livingston, D.M.: E2F4 is exported from the nucleus in a crm1-dependent manner. Mol. Cell. Biol. 21: 1384-1392 (2001). View: http://www.ncbi.nlm.nih.gov/pubmed/11158323

    Gaubatz, S., Lindeman, G.L., Ishida, S. Jakoi, L ,Nevins,J.R. Livingston, D.M.Rempel, R.E.: E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control. Mol. Cell, 6: 729-735 (2000). View: http://www.ncbi.nlm.nih.gov/pubmed/11030352 

    Elliott K, Sakamuro D, Basu A, Du W, Wunner W, Staller P, Gaubatz S, Zhang H, Prochownik E, Eilers M, Prendergast GC.: Bin1 functionally interacts with Myc and inhibits cell proliferation via multiple mechanisms. Oncogene. 18: 3564-73 (1999). View: http://www.ncbi.nlm.nih.gov/pubmed/10380878 

    Gaubatz S., Wood J., Livingston D.M. Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6. Proc Natl Acad Sci USA, 95:9190-9195 (1998). View: http://www.pnas.org/content/95/16/9190

    Lindeman G.J., Dagnino L., Gaubatz S., Xu Y., Bronson R.T., Warren H.B., Livingston D.M. A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting. Genes & Dev12:1092-1098 (1998). View: http://www.ncbi.nlm.nih.gov/pubmed/9553039

    Lindeman G.J., Gaubatz S., Livingston D.M., Ginsberg D. The subcellular localization of E2F-4 is cell-cycle dependent.  Proc Natl Acad Sci USA;  94:5095-5100 (1997). View: http://www.pnas.org/content/94/10/5095.short   

    Desbarats L., Gaubatz S.,  Eilers M. Disrimination between different E-box binding proteins at an endogenous target gene of c-myc. Genes & Dev; 10:447-460 (1996). View: http://www.ncbi.nlm.nih.gov/pubmed/8600028   

    Gaubatz S., Imhof A., Dosch R., Werner O., Mitchell P., Buettner R., Eilers M.  Transcriptional activation by Myc is under negative control by the transcription factor AP-2. EMBO J; 14: 1508-1519 (1995). View: http://www.ncbi.nlm.nih.gov/pubmed/7729426 

    Gaubatz S., Meichle A., Eilers M. An E-Box element localized in the first intron mediates regulation of the prothymosin a gene by c-myc. Mol. Cell. Biol. ;14: 3853-3862 (1994). View: http://www.ncbi.nlm.nih.gov/pubmed/8196628                                                         

    Kües U., Richardson W.V.J., Tymon A.M., Mutasa E.S., Göttgens B., Gaubatz S., Gregoriades A, Casselton LA. The combination of dissimilar alleles of the Aa and Aß gene complexes, whose proteins contain homeo domain motifs, determines sexual development in the mushroom Coprinus cinereus. Genes & Dev; 6:568-577 (1992).


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