Dr. Hans Michael Maric

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List of publications

2021[ to top ]
  • Schulte, C., & Maric, H. M. Expanding GABAAR pharmacology via receptor-associated proteins. Current Opinion in Pharmacology, 57, 98-106. https://doi.org/https://doi.org/10.1016/j.coph.2021.01.004
  • Bartling, C. R. O., Jensen, T. M. T., Henry, S. M., Colliander, A. L., Sereikaite, V., Wenzler, M., Jain, P., Maric, H. M., Harpsøe, K., Pedersen, S. W., Clemmensen, L. S., Haugaard-Kedström, L. M., Gloriam, D. E., Ho, A., & Strømgaard, K. Targeting the APP-Mint2 Protein–Protein Interaction with a Peptide-Based Inhibitor Reduces Amyloid-β Formation. J. Am. Chem. Soc., 143(2), 891-901. https://doi.org/10.1021/jacs.0c10696
  • Moreno-Yruela, C., Bæk, M., Vrsanova, A.-E., Schulte, C., Maric, H. M., & Olsen, C. A. Hydroxamic acid-modified peptide microarrays for profiling isozyme-selective interactions and inhibition of histone deacetylases. Nature Communications, 12(1), 62-. https://doi.org/10.1038/s41467-020-20250-9
  • Schulte, C., Khayenko, V., Nordblom, N. F., Tippel, F., Peck, V., Gupta, A. J., & Maric, H. M. High-throughput determination of protein affinities using unmodified peptide libraries in nanomolar scale. IScience, 24(1), 101898-. https://doi.org/https://doi.org/10.1016/j.isci.2020.101898
2020[ to top ]
  • Gründl, M., Walz, S., Hauf, L., Schwab, M., Werner, K. M., Spahr, S., Schulte, C., Maric, H. M., Ade, C. P., & Gaubatz, S. Interaction of YAP with the Myb-MuvB (MMB) complex defines a transcriptional program to promote the proliferation of cardiomyocytes. PLOS Genetics, 16(5), e1008818-. https://doi.org/10.1371/journal.pgen.1008818
  • Langlhofer, G., Schaefer, N., Maric, H. M., Keramidas, A., Zhang, Y., Baumann, P., Blum, R., Breitinger, U., Strømgaard, K., Schlosser, A., Kessels, M. M., Koch, D., Qualmann, B., Breitinger, H.-G., Lynch, J. W., & Villmann, C. A Novel Glycine Receptor Variant with Startle Disease Affects Syndapin I and Glycinergic Inhibition. J. Neurosci., 40(25), 4954-. https://doi.org/10.1523/JNEUROSCI.2490-19.2020
  • Prieto-Garcia, C., Hartmann, O., Reissland, M., Braun, F., Fischer, T., Walz, S., Schülein-Völk, C., Eilers, U., Ade, C. P., Calzado, M. A., Orian, A., Maric, H. M., Münch, C., Rosenfeldt, M., Eilers, M., & Diefenbacher, M. E. Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells. EMBO Molecular Medicine, 12(4), e11101-. https://doi.org/10.15252/emmm.201911101
2019[ to top ]
  • Sdelci, S., Rendeiro, A. F., Rathert, P., You, W., Lin, J.-M. G., Ringler, A., Hofstätter, G., Moll, H. P., Gürtl, B., Farlik, M., Schick, S., Klepsch, F., Oldach, M., Buphamalai, P., Schischlik, F., Májek, P., Parapatics, K., Schmidl, C., Schuster, M., Penz, T., Buckley, D. L., Hudecz, O., Imre, R., Wang, S.-Y., Maric, H. M., Kralovics, R., Bennett, K. L., Müller, A. C., Mechtler, K., Menche, J., Bradner, J. E., Winter, G. E., Klavins, K., Casanova, E., Bock, C., Zuber, J., & Kubicek, S. MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation. Nature Genetics, 51(6), 990-998. https://doi.org/10.1038/s41588-019-0413-z
  • Baluapuri, A., Hofstetter, J., Dudvarski Stankovic, N., Endres, T., Bhandare, P., Vos, S. M., Adhikari, B., Schwarz, J. D., Narain, A., Vogt, M., Wang, S.-Y., Düster, R., Jung, L. A., Vanselow, J. T., Wiegering, A., Geyer, M., Maric, H. M., Gallant, P., Walz, S., Schlosser, A., Cramer, P., Eilers, M., & Wolf, E. MYC Recruits SPT5 to RNA Polymerase II to Promote Processive Transcription Elongation. Molecular Cell, 74(4), 674-687.e11. https://doi.org/https://doi.org/10.1016/j.molcel.2019.02.031
  • Kasaragod, V. B., Hausrat, T. J., Schaefer, N., Kuhn, M., Christensen, N. R., Tessmer, I., Maric, H. M., Madsen, K. L., Sotriffer, C., Villmann, C., Kneussel, M., & Schindelin, H. Elucidating the Molecular Basis for Inhibitory Neurotransmission Regulation by Artemisinins. Neuron, 101(4), 673-689.e11. https://doi.org/https://doi.org/10.1016/j.neuron.2019.01.001
  • Khayenko, V., & Maric, H. M. Targeting GABAAR-Associated Proteins: New Modulators, Labels and Concepts. Frontiers in Molecular Neuroscience, 12, 162-. https://www.frontiersin.org/article/10.3389/fnmol.2019.00162
2018[ to top ]
  • Bleem, A., Christiansen, G., Madsen, D. J., Maric, H., Strømgaard, K., Bryers, J. D., Daggett, V., Meyer, R. L., & Otzen, D. E. Protein Engineering Reveals Mechanisms of Functional Amyloid Formation in Pseudomonas aeruginosa Biofilms. Journal of Molecular Biology, 430(20), 3751-3763. https://doi.org/https://doi.org/10.1016/j.jmb.2018.06.043
  • Hines, R. M., Maric, H. M., Hines, D. J., Modgil, A., Panzanelli, P., Nakamura, Y., Nathanson, A. J., Cross, A., Deeb, T., Brandon, N. J., Davies, P., Fritschy, J.-M., Schindelin, H., & Moss, S. J. Developmental seizures and mortality result from reducing GABAA receptor α2-subunit interaction with collybistin. Nature Communications, 9(1), 3130-. https://doi.org/10.1038/s41467-018-05481-1
2017[ to top ]
  • Büchel, G., Carstensen, A., Mak, K.-Y., Roeschert, I., Leen, E., Sumara, O., Hofstetter, J., Herold, S., Kalb, J., Baluapuri, A., Poon, E., Kwok, C., Chesler, L., Maric, H. M., Rickman, D. S., Wolf, E., Bayliss, R., Walz, S., & Eilers, M. Association with Aurora-A Controls N-MYC-Dependent Promoter Escape and Pause Release of RNA Polymerase II during the Cell Cycle. Cell Reports, 21(12), 3483-3497. https://doi.org/https://doi.org/10.1016/j.celrep.2017.11.090
2016[ to top ]
  • Cheng, J., Sahani, S., Hausrat, T., Yang, J.-W., Ji, H., Schmarowski, N., Endle, H., Liu, X., Li, Y., Böttche, R., Radyushkin, K., Maric, H., Hoerder-Suabedissen, A., Molnár, Z., Prouvot, P.-H., Trimbuch, T., Ninnemann, O., Huai, J., Fan, W., Visentin, B., Sabbadini, R., Strømgaard, K., Stroh, A., Luhmann, H., Kneussel, M., Nitsch, R., & Vogt, J. Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling. Neuron, 92(1), 126-142. https://doi.org/https://doi.org/10.1016/j.neuron.2016.08.035
  • Maric, H. M., Hausrat, T. J., Neubert, F., Dalby, N. O., Doose, S., Sauer, M., Kneussel, M., & Strømgaard, K. Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission. Nature Chemical Biology, 13, 153-. https://doi.org/10.1038/nchembio.2246
2015[ to top ]
  • Maric, H. M., Kasaragod, V. B., Haugaard-Kedström, L., Hausrat, T. J., Kneussel, M., Schindelin, H., & Strømgaard, K. Design and Synthesis of High-Affinity Dimeric Inhibitors Targeting the Interactions between Gephyrin and Inhibitory Neurotransmitter Receptors. Angewandte Chemie International Edition, 54(2), 490-494. https://doi.org/10.1002/anie.201409043
2014[ to top ]
  • Maric, H. M., Kasaragod, V. B., Hausrat, T. J., Kneussel, M., Tretter, V., Strømgaard, K., & Schindelin, H. Molecular basis of the alternative recruitment of GABAA versus glycine receptors through gephyrin. Nature Communications, 5, 5767-. https://doi.org/10.1038/ncomms6767
  • Maric, H. M., Kasaragod, V. B., & Schindelin, H. Modulation of Gephyrin-Glycine Receptor Affinity by Multivalency. ACS Chem. Biol., 9(11), 2554-2562. https://doi.org/10.1021/cb500303a
2012[ to top ]
  • Tretter, V., Mukherjee, J., Maric, H., Schindelin, H., Sieghart, W., & Moss, S. Gephyrin, the enigmatic organizer at GABAergic synapses. Frontiers in Cellular Neuroscience, 6. https://www.frontiersin.org/article/10.3389/fncel.2012.00023
2011[ to top ]
  • Maric, H.-M., Mukherjee, J., Tretter, V., Moss, S. J., & Schindelin, H. Gephyrin-mediated γ-aminobutyric acid type A and glycine receptor clustering relies on a common binding site. The Journal of Biological Chemistry, 286(49), 42105-42114. https://doi.org/10.1074/jbc.M111.303412
  • Mukherjee, J., Kretschmannova, K., Gouzer, G., Maric, H.-M., Ramsden, S., Tretter, V., Harvey, K., Davies, P. A., Triller, A., Schindelin, H., & Moss, S. J. The Residence Time of GABA<sub>A</sub>Rs at Inhibitory Synapses Is Determined by Direct Binding of the Receptor α1 Subunit to Gephyrin. J. Neurosci., 31(41), 14677-. https://doi.org/10.1523/JNEUROSCI.2001-11.2011
  • Tretter, V., Kerschner, B., Milenkovic, I., Ramsden, S. L., Ramerstorfer, J., Saiepour, L., Maric, H.-M., Moss, S. J., Schindelin, H., Harvey, R. J., Sieghart, W., & Harvey, K. Molecular Basis of the γ-Aminobutyric Acid A Receptor α3 Subunit Interaction with the Clustering Protein Gephyrin. Journal of Biological Chemistry, 286(43), 37702-37711. https://doi.org/10.1074/jbc.M111.291336