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    Chair of Cell and Developmental Biology (Zoology I)

    Tim Vellmer

    DOT1A-mediated histone methylation and replication regulation in Trypanosoma brucei

    Histone methylation by DOT1 is known to regulate various cellular processes in eukaryotes such as gene expression or DNA repair. DOT1A, one of two DOT1 enzymes in Trypanosoma brucei, mediates the mono- and di-methylation of lysine 76 on histone H3 and appears to be a key player in DNA replication initiation. The mechanisms by which this histone mark regulates the replication process are still unknown. My PhD project aims to identify the molecular components involved in this mechanism and the elements that are involved in DOT1A recruitment to its target sites.

    Room C124

    Tel ++49 93131 89359

    tim.vellmer@uni-wuerzburg.de

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    Lehrstuhl für Zoologie I - Zell- und Entwicklungsbiologie
    Am Hubland
    97074 Würzburg

    Phone: +49 931 31-84250
    Fax: +49 931 31-84252
    Email

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