Other Mg2+ Transporters TRPM7 Mg2+ P2X1 TP PAR1/4 KINASE GPVI P2Y1 P2Y12 IP RHO-A PLC IP3 DAG PI3K Ca2+ PKC SRC AKT a2b3 Aggregation ADPr 5-HT2A AC cAMP PKA VASP ATPr ATP TXA2 THROMBIN COLLAGEN ADP PGI2 5-HT 5-HTr RAP1 ORAI1 TRPC6 TXA2r MAPKC PLA2 IP3R sGC PKG cGMP NO CALDAG STIM1 ARHGEF1 ROCK1 TALIN1 RAC1 Granule release Shape Change shear stress Thrombus growth RGS18 healthy EC layer damage/injury Stress fiber formation Lamellipodia GP1b-IX-V vWF atherosclerosis inflamed EC ROS CD40L IA TNF-a ecto-ADPase aging expression l1 l2 + + + + + + + + + + + + + + + + + + + + + - - - - + - - + + + + + + + + + + + + + + + + + + - + + + + + + - + + - + + + + + - - + + + + + + + + + + + + + - + + - - - + + - + + + + + + + + + + + + + - + + + - - + + + - + -