Lecture 4: Results

1. GSE54839 from GEO
- the underlying experiment investigates the differential expression of genes in a chronic cocaine abuse
- the Illumina HumanHT-12 V3.0 expression beadchip was used
- 2 conditions: control and cocaine addiction

2. GEO2R: DEG analyses
- the gene GBP2 shows the most significant differential expression with an adj.P.Val of 0.000347
- GBP2 has the higher average expression value for condition cocaine addiction showing a logFC of 0.503 (if control vs cocaine addiction was defined)
- the logFC is the logarithmic Fold Change (from log-transformed data) of a gene that expression values are compared between two conditions
- the adj.P.Val is the adjusted (or corrected) p value for multiple comparison testing to control the false discovery rate (FDR)

3. Genevestigator
-  the two main types are: "Which conditions regulate a gene?" and "Which genes are regulated in a chosen condition?"

4. INSR
- the logarithmic average expression of INSR in the rectum is 16.03  
- 630 cancer categories are listed where INSR is involved
- the log2-FC for INSR in the influenza virus condition is 2.41. This means that the expression is higher compared to the control condition