Tbet JAK1 STAT1 TCR IL4 GATA3 IFNg IFNgR SOCS1 NFAT IL4R IL10 IL18 IRAK IL18R STAT6 STAT3 IL10R IL12 IL12R STAT4 IL23 STAT5 IL2R IL17 IL6 TGFb TGFbR IL23R IL2 RORgt JAK3 IL6R IFNbR IFNb Foxp3