AG Diefenbacher
Dr. Markus E. Diefenbacher
Lehrstuhl für Biochemie und Molekularbiologie
Biozentrum
Am Hubland
97074 Würzburg
Raum B 328/329
Tel: 0931 31-88167
Fax: 0931 31-84113
markus.diefenbacher@uni-wuerzburg.de
Curriculum Vitae
Our research focus is the deregulation of protein turnover as a central driver in tumourigenesis.
Research
E3-ligases; the double-edged sword
Deubiquitinases, a novel class of molecules in the limelight
E3-ligases and DUBs in lung cancer
E3-ligases and DUBs in intestinal cancer
Publications
Latest:
Prieto-Garcia, C., Hartmann, O., Reissland, M., Braun, F., Fischer, T., Walz, S., Schülein-Völk, C., Eilers, U., Ade, C.P., Calzado, M.A., Orian, A., Maric, H.M., Münch, C., Rosenfeldt, M., Eilers, M., Diefenbacher, M.E. Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells. EMBO Mol Med. 2020 Mar 4:e11101. doi: 10.15252/emmm.201911101. [Epub ahead of print] PubMed PMID: 32128997.
Ruiz, E. J., Diefenbacher, M. E., Nelson, J. K., Sancho, R., Pucci, F., Chakraborty, A., . . . Behrens, A. (2019). LUBAC determines chemotherapy resistance in squamous cell lung cancer. J Exp Med. doi: 10.1084/jem.20180742
Ungewiss, H., Rotzer, V., Meir, M., Fey, C., Diefenbacher, M. E., Schlegel, N., & Waschke, J. (2018). Dsg2 via Src-mediated transactivation shapes EGFR signaling towards cell adhesion. Cell Mol Life Sci, 75(22), 4251-4268. doi: 10.1007/s00018-018-2869-x
Diefenbacher, M. E., & Orian, A. (2017). Stabilization of nuclear oncoproteins by RNF4 and the ubiquitin system in cancer. Mol Cell Oncol, 4(1), e1260671. doi: 10.1080/23723556.2016.1260671
Lab news and activities
Lab protocols
Funding
Emil Hilb Programm
"Targeting protein stability in lung squamous cell carcinoma"
"Establishing a human colorectal cancer organoid bank" Collaboration with Armin Wiegering
"Unmasking E3-ligase-DUB pairs in colorectal cancer"
