AG Diefenbacher
Dr. Markus E. Diefenbacher
Lehrstuhl für Biochemie und Molekularbiologie
Biozentrum
Am Hubland
97074 Würzburg
Raum B 328/329
Tel: 0931 31-88167
Fax: 0931 31-84113
markus.diefenbacher@uni-wuerzburg.de
Curriculum Vitae
Our research focus is the deregulation of protein turnover as a central driver in tumourigenesis.
Research
E3-ligases; the double-edged sword
Deubiquitinases, a novel class of molecules in the limelight
E3-ligases and DUBs in lung cancer
E3-ligases and DUBs in intestinal cancer
Press Release
https://www.uni-wuerzburg.de/aktuelles/einblick/single/news/kampf-gegen-die-therapieresistenz/
https://www.uni-wuerzburg.de/aktuelles/einblick/single/news/schwachstelle-bei-plattenepithelkarzinomen/
https://www.uni-wuerzburg.de/en/news-and-events/news/detail/news/tracking-down-false-parkers-in-cancer-cells/
Twitter-Feed
11 days ago
Out now! #ubiquitin ligase #RNF4 in #sarcoma! Check out our paper by the Orian lab from @TechnionLive with help from @OliverHartman14 @crypt_tales @DiefenbacherL @Uni_WUE @MSNZ_wuerzburg @Uniklinikum_Wue funded by @dfg_public @Krebshilfe_Bonn https://t.co/o6TON8hkBH
11 days ago
Very proud that @NikiPahor from @DiefenbacherL @Uni_WUE @grk2243 @Uniklinikum_Wue will present her collaborative work with @Marco_A_Calzado @MuenchLab @DikicLab on #ubiquitin in #NSCLC at the Oxford @Ubiquitomics Symposium @KebleOxford!
20 days ago
Excited to listen to #cancer research at the @EMBOevents #EMBOcellSignaling in #Cavtat https://t.co/todNAazVLd
Lab News
‘’July 2021: Check out our work on the exquisite dependence of PTEN mutant Non-Small Cell Lung Cancer for ATM to evade radiotherapy, available as preprint via BioRxiv: https://www.biorxiv.org/content/10.1101/2021.07.24.453632v1
“June 2021: Coming soon! We are recruiting a PhD student in tumourigenesis with a background in biochemistry or biomedicine.”
“May 2021: Our graduate college “Understanding Ubiquitylation: From Molecular Mechanisms to Diseases” was granted a second funding period by the DFG for another 4,5 years starting in October 2021!”
“Feb 2021: Dr. Camina Fuss started as a new member of our lab. As a clinican scientist, her research work will focus on modelling adrenocortical cancer and identification of so far unexplored dependencies and vulnerabilities for therapy.
Publications
Latest:
2022
Mainz, L., Sarhan, M. A. F. E., Roth, S., Sauer, U., Maurus, K., Hartmann, E. M., Seibert, H.-D., Rosenwald, A., Diefenbacher, M. E. & Rosenfeldt, M. T. (2022) Autophagy Blockage Reduces the Incidence of Pancreatic Ductal Adenocarcinoma in the Context of Mutant Trp53, Frontiers in Cell and Developmental Biology. 10.
Mainz, L., Sarhan, M., Roth, S., Sauer, U., Kalogirou, C., Eckstein, M., Gerhard-Hartmann, E., Seibert, H. D., Voelker, H. U., Geppert, C., Rosenwald, A., Eilers, M., Schulze, A., Diefenbacher, M. & Rosenfeldt, M. T. (2022) Acute systemic knockdown of Atg7 is lethal and causes pancreatic destruction in shRNA transgenic mice, Autophagy, 1-14.
2021
Ruiz, E. J., Lan, L., Diefenbacher, M. E., Riising, E. M., Da Costa, C., Chakraborty, A., Hoeck, J. D., Spencer-Dene, B., Kelly, G., David, J. P., Nye, E., Downward, J. & Behrens, A. (2021) JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer, JCI Insight. 6.
Prieto-Garcia, C., Tomašković, I., Shah, V. J., Dikic, I. & Diefenbacher, M. (2021) USP28: Oncogene or Tumor Suppressor? A Unifying Paradigm for Squamous Cell Carcinoma, Cells. 10, 2652.
Funding
Emil Hilb Programm
"Targeting protein stability in lung squamous cell carcinoma"
"Establishing a human colorectal cancer organoid bank" Collaboration with Armin Wiegering
"Unmasking E3-ligase-DUB pairs in colorectal cancer"
