AG Diefenbacher
Dr. Markus E. Diefenbacher
Lehrstuhl für Biochemie und Molekularbiologie
Biozentrum
Am Hubland
97074 Würzburg
Raum B 328/329
Tel: 0931 31-88167
Fax: 0931 31-84113
markus.diefenbacher@uni-wuerzburg.de
Curriculum Vitae
Our research focus is the deregulation of protein turnover as a central driver in tumourigenesis.
Research
E3-ligases; the double-edged sword
Deubiquitinases, a novel class of molecules in the limelight
E3-ligases and DUBs in lung cancer
E3-ligases and DUBs in intestinal cancer
Press Release
https://www.uni-wuerzburg.de/en/news-and-events/news/detail/news/tracking-down-false-parkers-in-cancer-cells/
Twitter-Feed
23 days ago
When finishing our Xmas cleaning this year - we also found the best motive for a Xmas card ;) Another year of cloning - another year with great #science and lots of fun🎉 Merry Xmas everyone https://t.co/Ix1xyxwrKE
Lab News
‘’July 2021: Check out our work on the exquisite dependence of PTEN mutant Non-Small Cell Lung Cancer for ATM to evade radiotherapy, available as preprint via BioRxiv: https://www.biorxiv.org/content/10.1101/2021.07.24.453632v1
“June 2021: Coming soon! We are recruiting a PhD student in tumourigenesis with a background in biochemistry or biomedicine.”
“May 2021: Our graduate college “Understanding Ubiquitylation: From Molecular Mechanisms to Diseases” was granted a second funding period by the DFG for another 4,5 years starting in October 2021!”
“Feb 2021: Dr. Camina Fuss started as a new member of our lab. As a clinican scientist, her research work will focus on modelling adrenocortical cancer and identification of so far unexplored dependencies and vulnerabilities for therapy.
Publications
Latest:
Prieto-Garcia, C., Hartmann, O., Reissland, M., Braun, F., Fischer, T., Walz, S., Schülein-Völk, C., Eilers, U., Ade, C.P., Calzado, M.A., Orian, A., Maric, H.M., Münch, C., Rosenfeldt, M., Eilers, M., Diefenbacher, M.E. Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells. EMBO Mol Med. 2020 Mar 4:e11101. doi: 10.15252/emmm.201911101. [Epub ahead of print] PubMed PMID: 32128997.
Ruiz, E. J., Diefenbacher, M. E., Nelson, J. K., Sancho, R., Pucci, F., Chakraborty, A., . . . Behrens, A. (2019). LUBAC determines chemotherapy resistance in squamous cell lung cancer. J Exp Med. doi: 10.1084/jem.20180742
Ungewiss, H., Rotzer, V., Meir, M., Fey, C., Diefenbacher, M. E., Schlegel, N., & Waschke, J. (2018). Dsg2 via Src-mediated transactivation shapes EGFR signaling towards cell adhesion. Cell Mol Life Sci, 75(22), 4251-4268. doi: 10.1007/s00018-018-2869-x
Diefenbacher, M. E., & Orian, A. (2017). Stabilization of nuclear oncoproteins by RNF4 and the ubiquitin system in cancer. Mol Cell Oncol, 4(1), e1260671. doi: 10.1080/23723556.2016.1260671
Funding
Emil Hilb Programm
"Targeting protein stability in lung squamous cell carcinoma"
"Establishing a human colorectal cancer organoid bank" Collaboration with Armin Wiegering
"Unmasking E3-ligase-DUB pairs in colorectal cancer"
