Chair of Biochemistry and Molecular Biology

    AG Diefenbacher

    Dr. Markus E. Diefenbacher

    Lehrstuhl für Biochemie und Molekularbiologie
    Am Hubland
    97074 Würzburg
    Raum B 328/329

    Tel:   0931 31-88167
    Fax:  0931 31-84113

    Curriculum Vitae

    Our research focus is the deregulation of protein turnover as a central driver in tumourigenesis.


    E3-ligases; the double-edged sword

    Deubiquitinases, a novel class of molecules in the limelight

    E3-ligases and DUBs in lung cancer

    E3-ligases and DUBs in intestinal cancer

    Press Release


    Lab News

    ‘’July 2021: Check out our work on the exquisite dependence of PTEN mutant Non-Small Cell Lung Cancer for ATM to evade radiotherapy, available as preprint via BioRxiv: https://www.biorxiv.org/content/10.1101/2021.07.24.453632v1

    “June 2021: Coming soon! We are recruiting a PhD student in tumourigenesis with a background in biochemistry or biomedicine.”

    “May 2021: Our graduate college “Understanding Ubiquitylation: From Molecular Mechanisms to Diseases” was granted a second funding period by the DFG for another 4,5 years starting in October 2021!”

    “Feb 2021: Dr. Camina Fuss started as a new member of our lab. As a clinican scientist, her research work will focus on modelling adrenocortical cancer and identification of so far unexplored dependencies and vulnerabilities for therapy.



    Prieto-Garcia, C., Hartmann, O., Reissland, M., Braun, F., Fischer, T., Walz, S., Schülein-Völk, C., Eilers, U., Ade, C.P., Calzado, M.A., Orian, A., Maric, H.M., Münch, C., Rosenfeldt, M., Eilers, M., Diefenbacher, M.E. Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells. EMBO Mol Med. 2020 Mar 4:e11101. doi: 10.15252/emmm.201911101. [Epub ahead of print] PubMed PMID: 32128997.

    Ruiz, E. J., Diefenbacher, M. E., Nelson, J. K., Sancho, R., Pucci, F., Chakraborty, A., . . . Behrens, A. (2019). LUBAC determines chemotherapy resistance in squamous cell lung cancer. J Exp Med. doi: 10.1084/jem.20180742

    Ungewiss, H., Rotzer, V., Meir, M., Fey, C., Diefenbacher, M. E., Schlegel, N., & Waschke, J. (2018). Dsg2 via Src-mediated transactivation shapes EGFR signaling towards cell adhesion. Cell Mol Life Sci, 75(22), 4251-4268. doi: 10.1007/s00018-018-2869-x

    Diefenbacher, M. E., & Orian, A. (2017). Stabilization of nuclear oncoproteins by RNF4 and the ubiquitin system in cancer. Mol Cell Oncol, 4(1), e1260671. doi: 10.1080/23723556.2016.1260671

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    Emil Hilb Programm

    "Targeting protein stability in lung squamous cell carcinoma"

    "Establishing a human colorectal cancer organoid bank" Collaboration with Armin Wiegering

    "Unmasking E3-ligase-DUB pairs in colorectal cancer"