AG Diefenbacher

Dr. Markus E. Diefenbacher

Lehrstuhl für Biochemie und Molekularbiologie
Biozentrum
Am Hubland
97074 Würzburg
Raum B 328/329

Tel: 0931 31-88167
Fax: 0931 31-84113
markus.diefenbacher@uni-wuerzburg.de

Curriculum Vitae

Our research focus is the deregulation of protein turnover as a central driver in tumourigenesis.

Research

E3-ligases; the double-edged sword

Deubiquitinases, a novel class of molecules in the limelight

E3-ligases and DUBs in lung cancer

E3-ligases and DUBs in intestinal cancer

Press Release

https://www.uni-wuerzburg.de/aktuelles/einblick/single/news/kampf-gegen-die-therapieresistenz/
https://www.uni-wuerzburg.de/aktuelles/einblick/single/news/schwachstelle-bei-plattenepithelkarzinomen/
https://www.uni-wuerzburg.de/en/news-and-events/news/detail/news/tracking-down-false-parkers-in-cancer-cells/

I am a very proud 'DoktorVater' and still amazed by the very excellent presentation and viva by @CristianPG_mlg here @Uni_WUE @GSLSUniWue. Thank you to the co-supervisors @iDikic2 and Martin Eilers @MYCGyvers, Stefan Gaubatz and the chair Alexander Buchberger. Pictures to come 😃

51 days ago

Excited! Just applied to the open call @bmel on advances in #animalsinresearch and alternatives thereof with our #CRISPR #NSCLC models. Check out https://t.co/MQlQGV2Mfd how we implemented @NC3Rs @TVVde by gene editing to reduce and refine our research models

51 days ago

Today is a special day, apart from #MayThe4th 😃We are looking forward to the viva of my #firstPhDstudent @CristianPG_mlg who conducted #groundbreaking work on #USP28 together with lots of friends an colleagues @MuenchLab @DikicLab @Marco_A_Calzado @DiefenbacherL and many more

Lab News

‘’July 2021: Check out our work on the exquisite dependence of PTEN mutant Non-Small Cell Lung Cancer for ATM to evade radiotherapy, available as preprint via BioRxiv: https://www.biorxiv.org/content/10.1101/2021.07.24.453632v1

“June 2021: Coming soon! We are recruiting a PhD student in tumourigenesis with a background in biochemistry or biomedicine.”

“May 2021: Our graduate college “Understanding Ubiquitylation: From Molecular Mechanisms to Diseases” was granted a second funding period by the DFG for another 4,5 years starting in October 2021!”

“Feb 2021: Dr. Camina Fuss started as a new member of our lab. As a clinican scientist, her research work will focus on modelling adrenocortical cancer and identification of so far unexplored dependencies and vulnerabilities for therapy.

Group Members

Publications

Latest:

2022

Mainz, L., Sarhan, M. A. F. E., Roth, S., Sauer, U., Maurus, K., Hartmann, E. M., Seibert, H.-D., Rosenwald, A., Diefenbacher, M. E. & Rosenfeldt, M. T. (2022) Autophagy Blockage Reduces the Incidence of Pancreatic Ductal Adenocarcinoma in the Context of Mutant Trp53, Frontiers in Cell and Developmental Biology. 10.

Mainz, L., Sarhan, M., Roth, S., Sauer, U., Kalogirou, C., Eckstein, M., Gerhard-Hartmann, E., Seibert, H. D., Voelker, H. U., Geppert, C., Rosenwald, A., Eilers, M., Schulze, A., Diefenbacher, M. & Rosenfeldt, M. T. (2022) Acute systemic knockdown of Atg7 is lethal and causes pancreatic destruction in shRNA transgenic mice, Autophagy, 1-14.

2021

Ruiz, E. J., Lan, L., Diefenbacher, M. E., Riising, E. M., Da Costa, C., Chakraborty, A., Hoeck, J. D., Spencer-Dene, B., Kelly, G., David, J. P., Nye, E., Downward, J. & Behrens, A. (2021) JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer, JCI Insight. 6.

Prieto-Garcia, C., Tomašković, I., Shah, V. J., Dikic, I. & Diefenbacher, M. (2021) USP28: Oncogene or Tumor Suppressor? A Unifying Paradigm for Squamous Cell Carcinoma, Cells. 10, 2652.