Chair of Biochemistry and Molecular Biology



    Cremona, C. A., Sancho, R., Diefenbacher, M. E., & Behrens, A. (2016). Fbw7 and its counteracting forces in stem cells and cancer: Oncoproteins in the balance. Semin Cancer Biol, 36, 52-61. doi: 10.1016/j.semcancer.2015.09.006


    Diefenbacher, M.E., Chakraborty, A., Blake, S.M., Mitter, R., Popov, N., Eilers, M., and Behrens, A. (2015). Usp28 counteracts Fbw7 in intestinal homeostasis and cancer. Cancer research 75, 1181-1186.

    Chakraborty, A., Diefenbacher, M.E., Mylona, A., Kassel, O., and Behrens, A. (2015). The E3 ubiquitin ligase Trim7 mediates c-Jun/AP-1 activation by Ras signalling. Nature communications 6, 6782.


    Diefenbacher, M.E., Popov, N., Blake, S.M., Schulein-Volk, C., Nye, E., Spencer-Dene, B., Jaenicke, L.A., Eilers, M., and Behrens, A. (2014). The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer. The Journal of clinical investigation 124, 3407-3418.

    Schulein-Volk, C., Wolf, E., Zhu, J., Xu, W., Taranets, L., Hellmann, A., Janicke, L.A., Diefenbacher, M.E., Behrens, A., Eilers, M., et al. (2014). Dual regulation of Fbw7 function and oncogenic transformation by Usp28. Cell reports 9, 1099-1109.

    Diefenbacher, M.E., Reich, D., Dahley, O., Kemler, D., Litfin, M., Herrlich, P., and Kassel, O. (2014). The LIM domain protein nTRIP6 recruits the mediator complex to AP-1-regulated promoters. PloS one 9, e97549.


    Fritsch, R., de Krijger, I., Fritsch, K., George, R., Reason, B., Kumar, M.S., Diefenbacher, M., Stamp, G., and Downward, J. (2013). RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms. Cell 153, 1050-1063.

    Davies, C.C., Chakraborty, A., Diefenbacher, M.E., Skehel, M., and Behrens, A. (2013). Arginine methylation of the c-Jun coactivator RACO-1 is required for c-Jun/AP-1 activation. The EMBO journal 32, 1556-1567.

    Castellano, E., Sheridan, C., Thin, M.Z., Nye, E., Spencer-Dene, B., Diefenbacher, M.E., Moore, C., Kumar, M.S., Murillo, M.M., Gronroos, E., et al. (2013). Requirement for interaction of PI3-kinase p110alpha with RAS in lung tumor maintenance. Cancer cell 24, 617-630.


    Kumar, M.S., Hancock, D.C., Molina-Arcas, M., Steckel, M., East, P., Diefenbacher, M., Armenteros-Monterroso, E., Lassailly, F., Matthews, N., Nye, E., et al. (2012). The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer. Cell 149, 642-655.

    Hauser, R., Pech, M., Kijek, J., Yamamoto, H., Titz, B., Naeve, F., Tovchigrechko, A., Yamamoto, K., Szaflarski, W., Takeuchi, N., Stellberger, T., Diefenbacher, M.E., Nierhaus, K.H., Uetz, P. (2012). RsfA (YbeB) proteins are conserved ribosomal silencing factors. PLoS genetics 8, e1002815.

    Baumann, P., Thiele, W., Cremers, N., Muppala, S., Krachulec, J., Diefenbacher, M., Kassel, O., Mudduluru, G., Allgayer, H., Frame, M., et al. (2012). CD24 interacts with and promotes the activity of c-src within lipid rafts in breast cancer cells, thereby increasing integrin-dependent adhesion. Cellular and molecular life sciences : CMLS 69, 435-448.


    Schreck, I., Al-Rawi, M., Mingot, J.M., Scholl, C., Diefenbacher, M.E., O'Donnell, P., Bohmann, D., and Weiss, C. (2011). c-Jun localizes to the nucleus independent of its phosphorylation by and interaction with JNK and vice versa promotes nuclear accumulation of JNK. Biochemical and biophysical research communications 407, 735-740.


    Sancho, R., Jandke, A., Davis, H., Diefenbacher, M.E., Tomlinson, I., and Behrens, A. (2010). F-box and WD repeat domain-containing 7 regulates intestinal cell lineage commitment and is a haploinsufficient tumor suppressor. Gastroenterology 139, 929-941.

    Roder, I.V., Choi, K.R., Reischl, M., Petersen, Y., Diefenbacher, M.E., Zaccolo, M., Pozzan, T., and Rudolf, R. (2010). Myosin Va cooperates with PKA RIalpha to mediate maintenance of the endplate in vivo. Proceedings of the National Academy of Sciences of the United States of America 107, 2031-2036.

    Diefenbacher, M.E., Litfin, M., Herrlich, P., and Kassel, O. (2010). The nuclear isoform of the LIM domain protein Trip6 integrates activating and repressing signals at the promoter-bound glucocorticoid receptor. Molecular and cellular endocrinology 320, 58-66.


    Diefenbacher, M., Sekula, S., Heilbock, C., Maier, J.V., Litfin, M., van Dam, H., Castellazzi, M., Herrlich, P., and Kassel, O. (2008). Restriction to Fos family members of Trip6-dependent coactivation and glucocorticoid receptor-dependent trans-repression of activator protein-1. Molecular endocrinology 22, 1767-1780.