Lehrstuhl für Biochemie und Molekularbiologie
Raum B 308
Tel: 0931 31-88814
Fax: 0931 31-84113
The transcription factor Myc was initially identified as a potent proto-oncogene in vertebrates. Later it was shown to control a variety of physiological processes during normal development, most notably cellular growth and proliferation. These different activities of Myc can be largely explained by the nature of its transcriptional targets that have been identified in recent years. Much less is known, however, about the molecular mechanisms how Myc controls the expression of these targets in vivo.
Jennifer M. Gerlach, Michael Furrer, Maria Gallant, Dirk Birkel, Apoorva Baluapuri, Elmar Wolf, and Peter Gallant (2017) PAF1 complex component Leo1 helps recruit Drosophila Myc to promoters, PNAS, doi: 10.1073/pnas.1705816114