Chair of Biochemistry and Molecular Biology



    Almut Schulze, Mariia Yuneva, Disease Models & Mechanisms 2018 11: dmm036673 doi: 10.1242/dmm.036673 Published 24 August 2018 (Link)

    Miess, H., Dankworth, B., Gouw, AM., Rosenfeldt, M., Schmitz, W., Jiang, M., Saunders, B., Howell, M., Downward, J., Felsher, DW., Peck, B. and Schulze, A. (2018) The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma, Oncogene 2018 (in press)

    Bartmann, C., Janaki Raman, S.R., Flöter, F., Schulze, A., Bahlke, K., Willingstorfer, J., Strunz, M., Wöckel, A., Klement, R.J., Kapp, M., Djuzenova, C.S., Otto, C., Kämmerer, U. (2018) Beta-hydroxybutyrate (3-OHB) can influence the energetic phenotype of breast cancer cells, but does not impact their proliferation and the response to chemotherapy or radiation, Cancer and Metabolism (accepted for publication)

    Snaebjornsson MT, Schulze A. (2018) Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways, Exp Mol Med. 2018 Apr 16;50(4):34, doi: 10.1038/s12276-018-0065-6.


    Klein-Hessling, S., Muhammad, K., Klein, M., Pusch, T., Rudolf, R., Floter, J., Qureischi, M., Beilhack, A., Vaeth, M., Kummerow, C., Backes, C., Schoppmeyer, R., Hahn, U., Hoth, M., Bopp, T., Berberich-Siebelt, F., Patra, A., Avots, A., Muller, N., Schulze, A. & Serfling, E. (2017) NFATc1 controls the cytotoxicity of CD8+ T cells, Nature Communication 8, 511.

    Ros, S., Flöter, J., Kaymak, I., Da Costa, C., Houddane, A., Dubuis, S., Griffiths, B., Mitter, R., Walz, S., Blake, S., Behrens, A., Brindle, KM., Zamboni, N., Rider, M.H. and Schulze, A., (2017) 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 is essential for p53-null cancer cells, Oncogene, doi: 10.1038/onc.2016.477

    Dubuis, S., Baenke, F., Scherbichler, N., Alexander, L.T., Schulze, A., and Zamboni, N. (2016). Metabotypes of breast cancer cell lines revealed by non-targeted metabolomics. Metab Eng. 10.1016/j.ymben.2016.12.009

    2015 - 2016

    Röhrig, F., and Schulze, A. (2016). The multifaceted roles of fatty acid synthesis in cancer. Nat Rev Cancer, 16, 732-749.

    Peck, B., and Schulze, A. (2016). Lipid Desaturation: the next step in targeting lipogenesis in cancer? FEBS J.

    Peck, B., Schug, Z.T., Zhang, Q., Dankworth, B., Jones, D.T., Smethurst, E., Patel, R., Mason, S., Jiang, M., Saunders, R., Howell, M., Mitter, R., Spencer-Dene, B., Stamp, G., McGarry, L., James, D., Shanks, E., Aboagye, E.O., Critchlow, S.E., Leung, H.Y., Harris, A.L., Wakelam, M.J., Gottlieb, E., and Schulze, A. (2016). Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments. Cancer Metab 4, 6.

    Gatto, F., Schulze, A., and Nielsen, J. (2016). Systematic Analysis Reveals that Cancer Mutations Converge on Deregulated Metabolism of Arachidonate and Xenobiotics. Cell Rep. 16, 878-895.

    Brault, C., and Schulze, A. (2016). The Role of Glucose and Lipid Metabolism in Growth and Survival of Cancer Cells. Recent Results Cancer Res 207, 1-22.

    Schug, Z.T., Peck, B., Jones, D.T., Zhang, Q., Grosskurth, S., Alam, I.S., Goodwin, L.M., Smethurst, E., Mason, S., Blyth, K., McGarry, L., James, D., Shanks, E., Kalna, G., Saunders, R.E., Jiang, M., Howell, M., Lassailly, F., Thin, M.Z., Spencer-Dene, B., Stamp, G., van den Broek, N.J., Mackay, G., Bulusu, V., Kamphorst, J.J., Tardito, S., Strachan, D., Harris, A.L., Aboagye, E.O., Critchlow, S.E., Wakelam, M.J., Schulze, A., and Gottlieb, E. (2015). Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress. Cancer Cell 27, 57-71.

    Lewis, C.A., Brault, C., Peck, B., Bensaad, K., Griffiths, B., Mitter, R., Chakravarty, P., East, P., Dankworth, B., Alibhai, D., Harris, A.L., and Schulze, A. (2015). SREBP maintains lipid biosynthesis and viability of cancer cells under lipid- and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiforme. Oncogene 34, 5128-5140.

    Gatto, F., Miess, H., Schulze, A., and Nielsen, J. (2015). Flux balance analysis predicts essential genes in clear cell renal cell carcinoma metabolism. Scientific Reports 5, 10738.

    Baenke, F., Dubuis, S., Brault, C., Weigelt, B., Dankworth, B., Griffiths, B., Jiang, M., Mackay, A., Saunders, B., Spencer-Dene, B., Ros, S., Stamp, G., Reis-Filho, J.S., Howell, M., Zamboni, N., and Schulze, A. (2015). Functional screening identifies MCT4 as a key regulator of breast cancer cell metabolism and survival. The Journal of Pathology.

    2013 - 2014

    Yizhak, K., Le Devedec, S.E., Rogkoti, V.M., Baenke, F., de Boer, V.C., Frezza, C., Schulze, A., van de Water, B., and Ruppin, E. (2014). A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration. Mol Syst Biol 10, 744.

    Peck, B., and Schulze, A. (2014). Cholesteryl esters: fueling the fury of prostate cancer. Cell Metabolism 19, 350-352.

    Bensaad, K., Favaro, E., Lewis, C.A., Peck, B., Lord, S., Collins, J.M., Pinnick, K.E., Wigfield, S., Buffa, F.M., Li, J.L., Zhang, Q., Wakelam, M.J., Karpe, F., Schulze, A., and Harris, A.L. (2014). Fatty acid uptake and lipid storage induced by HIF-1alpha contribute to cell growth and survival after hypoxia-reoxygenation. Cell Rep 9, 349-365.

    Ros, S., and Schulze, A. (2013a). Balancing glycolytic flux: the role of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatases in cancer metabolism. Cancer Metab 1, 8.

    Ros, S., and Schulze, A. (2013b). Glycolysis back in the limelight: systemic targeting of HK2 blocks tumor growth. Cancer Discovery 3, 1105-1107.

    Peck, B., Ferber, E.C., and Schulze, A. (2013). Antagonism between FOXO and MYC Regulates Cellular Powerhouse. Frontiers in Oncology 3, 96.

    Griffiths, B., Lewis, C.A., Bensaad, K., Ros, S., Zhang, Q., Ferber, E.C., Konisti, S., Peck, B., Miess, H., East, P., Wakelam, M., Harris, A.L., and Schulze, A. (2013). Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth. Cancer Metab 1, 3.

    Eijkelenboom, A., Mokry, M., de Wit, E., Smits, L.M., Polderman, P.E., van Triest, M.H., van Boxtel, R., Schulze, A., de Laat, W., Cuppen, E., and Burgering, B.M. (2013). Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling. Molecular Systems Biology 9, 638.

    Currie, E., Schulze, A., Zechner, R., Walther, T.C., and Farese, R.V., Jr. (2013). Cellular fatty acid metabolism and cancer. Cell Metabolism 18, 153-161.

    Baenke, F., Peck, B., Miess, H., and Schulze, A. (2013). Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development. Disease Models & Mechanisms 6, 1353-1363.

    2011 - 2012

    Schulze, A., and Harris, A.L. (2012). How cancer metabolism is tuned for proliferation and vulnerable to disruption. Nature 491, 364-373.

    Santos, C.R., and Schulze, A. (2012). Lipid metabolism in cancer. FEBS J 279, 2610-2623.

    Ros, S., and Schulze, A. (2012). Linking glycogen and senescence in cancer cells. Cell Metabolism 16, 687-688.

    Ros, S., Santos, C.R., Moco, S., Baenke, F., Kelly, G., Howell, M., Zamboni, N., and Schulze, A. (2012). Functional metabolic screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival. Cancer Discovery 2, 328-343.

    Jones, N.P., and Schulze, A. (2012). Targeting cancer metabolism--aiming at a tumour's sweet-spot. Drug Discovery Today 17, 232-241.

    Ferber, E.C., Peck, B., Delpuech, O., Bell, G.P., East, P., and Schulze, A. (2012). FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression. Cell Death and Differentiation 19, 968-979.

    Schulze, A., and Downward, J. (2011). Flicking the Warburg switch-tyrosine phosphorylation of pyruvate dehydrogenase kinase regulates mitochondrial activity in cancer cells. Molecular Cell 44, 846-848.

    Schulze, A. (2011). A fresh look at cancer metabolism in a historical setting. EMBO Reports 12, 289-291.

    Peck, B., and Schulze, A. (2011). A role for the cancer-associated miR-106b~25 cluster in neuronal stem cells. Aging 3, 329-331.

    Lewis, C.A., Griffiths, B., Santos, C.R., Pende, M., and Schulze, A. (2011a). Regulation of the SREBP transcription factors by mTORC1. Biochemical Society Transactions 39, 495-499.

    Lewis, C.A., Griffiths, B., Santos, C.R., Pende, M., and Schulze, A. (2011b). Genetic ablation of S6-kinase does not prevent processing of SREBP1. Advances in Enzyme Regulation 51, 280-290.

    2005 - 2010

    Alfano, D., Votta, G., Schulze, A., Downward, J., Caputi, M., Stoppelli, M.P., and Iaccarino, I. (2010). Modulation of cellular migration and survival by c-Myc through the downregulation of urokinase (uPA) and uPA receptor. Molecular and Cellular Biology 30, 1838-1851.

    Porstmann, T., Santos, C.R., Lewis, C., Griffiths, B., and Schulze, A. (2009). A new player in the orchestra of cell growth: SREBP activity is regulated by mTORC1 and contributes to the regulation of cell and organ size. Biochemical Society Transactions 37, 278-283.

    Porstmann, T., Santos, C.R., Griffiths, B., Cully, M., Wu, M., Leevers, S., Griffiths, J.R., Chung, Y.L., and Schulze, A. (2008). SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth. Cell Metabolism 8, 224-236.

    Hui, R.C., Gomes, A.R., Constantinidou, D., Costa, J.R., Karadedou, C.T., Fernandez de Mattos, S., Wymann, M.P., Brosens, J.J., Schulze, A., and Lam, E.W. (2008). The forkhead transcription factor FOXO3a increases phosphoinositide-3 kinase/Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression. Molecular and Cellular Biology 28, 5886-5898.

    Delpuech, O., Griffiths, B., East, P., Essafi, A., Lam, E.W., Burgering, B., Downward, J., and Schulze, A. (2007). Induction of Mxi1-SR alpha by FOXO3a contributes to repression of Myc-dependent gene expression. Molecular and Cellular Biology 27, 4917-4930.

    van den Heuvel, A.P., Schulze, A., and Burgering, B.M. (2005). Direct control of caveolin-1 expression by FOXO transcription factors. The Biochemical Journal 385, 795-802.

    Porstmann, T., Griffiths, B., Chung, Y.L., Delpuech, O., Griffiths, J.R., Downward, J., and Schulze, A. (2005). PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP. Oncogene 24, 6465-6481.

    Nicke, B., Bastien, J., Khanna, S.J., Warne, P.H., Cowling, V., Cook, S.J., Peters, G., Delpuech, O., Schulze, A., Berns, K., Mullenders, J., Beijersbergen, R.L., Bernards, R., Ganesan, T.S., Downward, J., and Hancock, D.C. (2005). Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells. Molecular Cell 20, 673-685.

     - 2004

    Schulze, A., Nicke, B., Warne, P.H., Tomlinson, S., and Downward, J. (2004). The transcriptional response to Raf activation is almost completely dependent on Mitogen-activated Protein Kinase Kinase activity and shows a major autocrine component. Molecular Biology of the Cell 15, 3450-3463.

    Schulze, A., Lehmann, K., Jefferies, H.B., McMahon, M., and Downward, J. (2001). Analysis of the transcriptional program induced by Raf in epithelial cells. Genes & Development 15, 981-994.

    Schulze, A., and Downward, J. (2001). Navigating gene expression using microarrays--a technology review. Nature Cell Biology 3, E190-195.

    Schulze, A., and Downward, J. (2000). Analysis of gene expression by microarrays: cell biologist's gold mine or minefield? Journal of Cell Science 113 Pt 23, 4151-4156.

    Lehmann, K., Janda, E., Pierreux, C.E., Rytomaa, M., Schulze, A., McMahon, M., Hill, C.S., Beug, H., and Downward, J. (2000). Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells. Genes & Development 14, 2610-2622.

    Vogt, B., Zerfass-Thome, K., Schulze, A., Botz, J.W., Zwerschke, W., and Jansen-Durr, P. (1999). Regulation of cyclin E gene expression by the human papillomavirus type 16 E7 oncoprotein. The Journal of General Virology 80 ( Pt 8), 2103-2113.

    Duro, D., Schulze, A., Vogt, B., Bartek, J., Mittnacht, S., and Jansen-Durr, P. (1999). Activation of cyclin A gene expression by the cyclin encoded by human herpesvirus-8. The Journal of General Virology 80 ( Pt 3), 549-555.

    Schulze, A., Mannhardt, B., Zerfass-Thome, K., Zwerschke, W., and Jansen-Durr, P. (1998). Anchorage-independent transcription of the cyclin A gene induced by the E7 oncoprotein of human papillomavirus type 16. Journal of Virology 72, 2323-2334.

    Zerfass-Thome, K., Schulze, A., Zwerschke, W., Vogt, B., Helin, K., Bartek, J., Henglein, B., and Jansen-Durr, P. (1997). p27KIP1 blocks cyclin E-dependent transactivation of cyclin A gene expression. Molecular and Cellular Biology 17, 407-415.

    Spitkovsky, D., Schulze, A., Boye, B., and Jansen-Durr, P. (1997). Down-regulation of cyclin A gene expression upon genotoxic stress correlates with reduced binding of free E2F to the promoter. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 8, 699-710.

    Hermanns, J., Schulze, A., Jansen-Db1urr, P., Kleinschmidt, J.A., Schmidt, R., and zur Hausen, H. (1997). Infection of primary cells by adeno-associated virus type 2 results in a modulation of cell cycle-regulating proteins. Journal of Virology 71, 6020-6027.

    Zerfass, K., Spitkovsky, D., Schulze, A., Joswig, S., Henglein, B., and Jansen-Durr, P. (1996). Adenovirus E1A activates cyclin A gene transcription in the absence of growth factors through interaction with p107. Journal of Virology 70, 2637-2642.

    Schulze, A., Zerfass-Thome, K., Berges, J., Middendorp, S., Jansen-Durr, P., and Henglein, B. (1996). Anchorage-dependent transcription of the cyclin A gene. Molecular and Cellular Biology 16, 4632-4638.

    Zerfass, K., Schulze, A., Spitkovsky, D., Friedman, V., Henglein, B., and Jansen-Durr, P. (1995). Sequential activation of cyclin E and cyclin A gene expression by human papillomavirus type 16 E7 through sequences necessary for transformation. Journal of Virology 69, 6389-6399.

    Schulze, A., Zerfass, K., Spitkovsky, D., Middendorp, S., Berges, J., Helin, K., Jansen-Durr, P., and Henglein, B. (1995). Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site. PNAS 92, 11264-11268.Spitkovsky, D., Steiner, P., Lukas, J., Lees, E., Pagano, M., Schulze, A., Joswig, S., Picard, D., Tommasino, M., Eilers, M., and et al. (1994). Modulation of cyclin gene expression by adenovirus E1A in a cell line with E1A-dependent conditional proliferation. Journal of Virology 68, 2206-2214.

    Schulze, A., Zerfass, K., Spitkovsky, D., Henglein, B., and Jansen-Durr, P. (1994). Activation of the E2F transcription factor by cyclin D1 is blocked by p16INK4, the product of the putative tumor suppressor gene MTS1. Oncogene 9, 3475-3482.