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    Chair of Biochemistry and Molecular Biology

    AG Wolf

    Contact

    PD Dr. Elmar Wolf
    Lehrstuhl für Biochemie und Molekularbiologie
    Biozentrum
    Am Hubland
    97074 Würzburg
    Raum B 353

    Tel:   0931 31-83259
    Fax:  0931 31-84113
    elmar.wolf@biozentrum.uni-wuerzburg.de

    Emmy Noether group - Cancer Systems Biology

    Lab News

    March 2020
    Our review on
    TARGETING MYC is online at Annual Review of Cancer Biology. Have a look if you like.

    January 2020
    We have a new PhD student - welcome Lorenz!

    November 2019
    We are looking forward to our 1st AG Wolf Retreat from 28th to 30th November 2019!

    We are looking for a HiWi with Felasa-B certificate to support our team. Just drop us an email to Applications.2019.Wolf@gmail.com

    Archive

    Research



    In ageing Western societies tumors are becoming the most relevant medical problem. A key characteristic of tumors is deregulated signaling pathways that significantly alter the transcriptional profile of tumor cells. Proteins of the MYC family play a prominent role in this oncogenic reprogramming as transcription factors.

    Our vision is to understand the transcriptional changes during carcinogenesis and, in particular, the oncogenic function of Myc to the extent that new pharmaceutical strategies for the fight against cancer can be developed on this basis. To this end, my research group uses genome- and proteome-wide methods to better understand the biology of tumors as well as genetic screens to find potential therapeutic targets of tumor cells. Together with our partners, we have recently developed substances that inhibit the function of Myc. In the next few years, we want to improve these molecules, of the PROTAC substance class, to such an extent that they can be clinically tested and applied.

    Research topic 1: The oncogenic function of MYC

    Research topic 2: Investigation of transcriptional elongation

    Research topic 3: New pharmaceutical concepts in oncology

    Publications

    Recent:

    Wolf E and Eilers M: Targeting MYC Proteins for Tumor Therapy, Annual Review of Cancer Biology, 2020, 4

    Baluapuri, A., Wolf, E., Eilers, M(2020) Target gene-independent functions of Myc oncoproteins. Nature Reviews Molecular Cell Biology in press

    Cossa, G., Roeschert, I., Prinz, F., Baluapuri, A., R.S., V., Schülein-Völk, C., Chang, Y.-C., Ade, C. P., Mastrobuoni, G., Girard, C., Wortmann, L., Walz, S., Lührmann, R., Kempa, S., Kuster, B., Wolf, E., Mumberg, D., Eilers, M. (2020) Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription. Molecular Cell in press

    Schmidt S, Gay D, Uthe FW … Wolf E, Strathdee D, Schulze A, Germer CT, Rosenwald A, Sansom OJ, Eilers M, Wiegering A: A MYC–GCN2–eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer, Nature Cell Biology, 2019,  doi:10.1038/s41556-019-0408-0

    Baluapuri A*, Hofstetter J*, Dudvarski Stankovic N, Endres T, Bhandare P, Vos SM, Adhikari B, Schwarz JD, Narain A, Vogt M, Wang S-Y, Düster R, Jung LA, Vanselow JT, Wiegering A, Geyer M, Maric HM, Gallant P, Walz S, Schlosser A, Cramer P, Eilers M, Wolf E: MYC recruits SPT5 to RNA polymerase II to promote processive transcription elongation, Molecular Cell, 2019, 74, https://doi.org/10.1016/j.molcel.2019.02.031 *joined first authors

    Herold S*, Kalb J*, Büchel G*,Ade CP, Baluapuri A, Xu J, Koster J, Solvie D, Carstensen A, Klotz C, Rodewald S, Schülein-Völk C,Dobbelstein M, Wolf E, Molenaar J, Versteeg R,Walz S, Eilers M: Recruitment of BRCA1 limits MYCN-driven accumulation of stalled RNA polymerase, Nature, 2019, 567

    Show all

    Link to all Publications in PubMed