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    Chair of Biochemistry and Molecular Biology

    AG Wolf

    Contact

    Prof. Dr. Elmar Wolf
    Lehrstuhl für Biochemie und Molekularbiologie
    Biozentrum
    Am Hubland
    97074 Würzburg
    Raum B 353

    Tel:   0931 31-83259
    Fax:  0931 31-84113
    elmar.wolf@biozentrum.uni-wuerzburg.de

    Emmy Noether group - Cancer Systems Biology

    Lab News

    September 2020

    Our paper on PROTACs for Aurora-A is online at Nature Chemical Biology. Well done, Bikash! See our paper and press release

    September 2020

    Happy to be part of the new cancer center for Bavaria! Würzburg will host one of four new National Centers for Tumor-diseases (NCTs). We are excited to develop novel strategies based on controlled break down of cancer-causing proteins which will open avenues for novel therapies in the research program of this new cancer center! More Details can be found here.

    September 2020
    We have two new lab members! We welcome Lara and Jonas and wish them a lot of success and fun!

    August 2020
    Many congratulations to the lab of Prof Dr Thomas Rudel for their latest paper out now in Nature Microbiology. It was an amazing opportunity to collaborate with them and look forward to similar things in future!

    Archive

    Research



    In ageing Western societies tumors are becoming the most relevant medical problem. A key characteristic of tumors is deregulated signaling pathways that significantly alter the transcriptional profile of tumor cells. Proteins of the MYC family play a prominent role in this oncogenic reprogramming as transcription factors.

    Our vision is to understand the transcriptional changes during carcinogenesis and, in particular, the oncogenic function of Myc to the extent that new pharmaceutical strategies for the fight against cancer can be developed on this basis. To this end, my research group uses genome- and proteome-wide methods to better understand the biology of tumors as well as genetic screens to find potential therapeutic targets of tumor cells. Together with our partners, we have recently developed substances that inhibit the function of Myc. In the next few years, we want to improve these molecules, of the PROTAC substance class, to such an extent that they can be clinically tested and applied.

    Research topic 1: The oncogenic function of MYC

    Research topic 2: Investigation of transcriptional elongation

    Research topic 3: New pharmaceutical concepts in oncology

    Publications

    2020:

    Adhikari B, Bozilovic J, Diebold M,Schwarz JD, Hofstetter J, Schröder M, Wanior M, Narain A, Vogt M, DudvarskiStankovic N, Baluapuri A, Schönemann L, Eing L, Bhandare P, Kuster B, SchlosserA, Heinzlmeir S, Sotriffer C, Knapp S* WolfE*, PROTAC-mediated degradation reveals a non-catalytic function ofAURORA-A kinase, Nature Chemical Biology, 2020, https://www.nature.com/articles/s41589-020-00652-y

    Jessen C, Kreß JKC, Baluapuri A, Hufnagel A, Schmitz W,Kneitz S, Roth S, Marquardt A, Appenzeller S, Ade CP, Glutsch V, Wobser M,Friedmann-Angeli JP, Mosteo L, Goding CR, Schilling B, Geissinger E, Wolf E, Meierjohann S, The transcriptionfactor NRF2 enhances melanoma malignancy by blocking differentiation andinducing COX2 expression, Oncogene, 2020, doi:10.1038/s41388-020-01477-8

    Rajeeve K, Vollmuth N, Janaki-Raman S, Wulff TF, Baluapuri A, Dejure FR, Huber C, Fink J, Schmalhofer M, Schmitz W, Sivadasan R, Wolf E, Eisenreich W, Schulze A, Seibel J, Rudel T: Reprogramming of host glutamine metabolism during Chlamydia trachomatis infection and its key role in peptidoglycan synthesis. Nature Microbiology, 2020, doi: 10.1038/s41564-020-0762-5

    Wolf E and Eilers M: Targeting MYC Proteins for Tumor Therapy, Annual Review of Cancer Biology, 2020, 4

    Baluapuri, A., Wolf, E., Eilers, M(2020) Target gene-independent functions of Myc oncoproteins. Nature Reviews Molecular Cell Biology, 2020

    Cossa, G., Roeschert, I., Prinz, F., Baluapuri, A., R.S., V., Schülein-Völk, C., Chang, Y.-C., Ade, C. P., Mastrobuoni, G., Girard, C., Wortmann, L., Walz, S., Lührmann, R., Kempa, S., Kuster, B., Wolf, E., Mumberg, D., Eilers, M. (2020) Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription. Molecular Cell, 2020

    Show all

    Link to all Publications in PubMed