Our main interest is transcriptional regulation of the mammalian cell cycle by the DREAM complex and Myb-MuvB (MMB). MMB together with the B-MYB transcription factor is a master activator of genes required for mitosis and cytokinesis.
We use biochemical and genetic methods to understand how DREAM, MuvB, B-MYB and its target genes contribute to normal proliferation, development and tumorigenesis.
Grit Weinstock and Stefan Gaubatz: One way to rule them all: G2/M gene regulation by oncogenic YAP1 and B-MYB. Molecular & Cellular Oncology
Grit Pattschull et al: The Myb-MuvB complex is required for YAP-dependent transcription of mitotic genes. Cell Reports 2019
New preprint by Marco Gründl et al. posted on Biorxiv:
Interaction of YAP with the Myb-MuvB (MMB) complex defines a transcriptional program to promote the proliferation of cardiomyocytes