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Lehrstuhl für Physiologische Chemie

Research Gaubatz group

Prof. Dr. Stefan Gaubatz

Physiological Chemistry
Biocenter
Am Hubland
97074 Würzburg

Tel.: 0931 31-84138
stefan.gaubatz@biozentrum.uni-wuerzburg.de

 

Research

Our main interest is transcriptional regulation of the mammalian cell cycle by the DREAM complex and Myb-MuvB (MMB). MMB together with the B-MYB transcription factor is a master activator of genes required for mitosis and cytokinesis.

We use biochemical and genetic methods to understand how DREAM, MuvB, B-MYB and its target genes contribute to normal proliferation, development and tumorigenesis.

Publications

Latest: 

Grit Weinstock and Stefan Gaubatz: One way to rule them all: G2/M gene regulation by oncogenic YAP1 and B-MYB. Molecular & Cellular Oncology

 

Grit Pattschull et al: The Myb-MuvB complex is required for YAP-dependent transcription of mitotic genes. Cell Reports 2019

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News:

New preprint by Marco Gründl et al. posted on Biorxiv:

Interaction of YAP with the Myb-MuvB (MMB) complex defines a transcriptional program to promote the proliferation of cardiomyocytes