Team
Prof. Dr. Bettina Wascheid
Chair of the Department
Biozentrum, Am Hubland
97074
Würzburg
Deutschland
Building:
B1
Room:
108 a
Phone:
+49 931 31-86772
Office hours after registration by e-mail
Name | Bettina Warscheid |
Born | 20.08.1971 |
Institution | Institute of Biology II, University of Würzburg, Biozentrum, Am Hubland, 97074 Würzburg, Germany |
Contact | phone: +49 931 31-86772 e-mail: bettina.warscheid@uni-wuerzburg.de |
Position | Professor (W3) of Biochemistry and Functional Proteomics |
ORCID | https://orcid.org/0000-0001-5096-1975 |
Academic education | |
1991 - 1997 | Study of Chemistry, TU Dortmund and Leiden University (NL), Diploma |
1997 - 2002 | PhD, Analytical Chemistry, Leibniz-Institute of Analytical Sciences, TU Dortmund |
Stellen | |
seit 2023 | Full Professor (W3) of Biochemistry and Functional Proteomics, Faculty of Biology, University of Würzburg |
2010 - 2023 | Full Professor (W3) of Biochemistry and Functional Proteomics, Faculty of Biology, University of Freiburg, Germany |
2009 - 2010 | Professor (W2) for Clinical and Cellular Proteomics, Faculty of Medicine and Center for Medical Biotechnology, University of Duisburg-Essen |
2004 - 2009 | Junior Professor (W1) for Protein Mass Spectrometry, Molecular Medicine, Faculty of Medicine, University of Bochum |
2003 - 2010 | Group Leader, Medical Proteome Center, University of Bochum |
2002 - 2003 | Postdoc University of Maryland, College Park und Johns Hopkins University, School of Medicine, Baltimore, MD, USA |
bioRxiv preprints
- Pex14p phosphorylation modulates import of citrate synthase 2 into peroxisomes in Saccharomyces cerevisiae
Schummer A*, Maier R*, Gabay-Maskit S, Hansen T, Mühlhäuser WWD, Suppanz I, Fadel A, Schuldiner M, Girzalsky W, Oeljeklaus S, Zalckvar E, Erdmann R, Warscheid B.
bioRxiv preprint first; doi.org/10.1101/2020.07.03.186833
*shared first authorship
- Towards the molecular architecture of the peroxisomal receptor docking complex
Lill P*, Hansen T*, Wendscheck D*, Klink BU, Jeziorek, T, Miehling, J, Bender J, Drepper F, Girzalsky W, Warscheid B°, Erdmann R°, Gatsogiannis C.
bioRxiv preprint first; doi.org/10.1101/854497
*shared first authorship; °equal contribution
Selected publications (2007-2020)
- Phosphoproteomics identifies dual-site phosphorylation in an extended basophilic motif regulating FILIP1-mediated degradation of filamin-C.
Reimann L*, Schwäble AN*, Fricke A, Muehlhaeuser W, Leber Y, Lohanadan K, Puchinger M, Schäuble S, Fässler E Wiese, H, Reichenbach C, Knapp B, Peikert CD, Drepper F, Hahn U, Kreutz C, van der Ven PFM, Radziwill G, Djinović-Carugo K, Fürst DO, Warscheid B (2020).
Commun Biol, 3:253.
- Defining the substrate spectrum of the TIM22 complex identifies pyruvate carrier subunits as unconventional cargos
Gomkale R, Cruz-Zaragoza LD, Suppanz I, Guiard B, Montoya J, Pacheu-Grau D, Warscheid B, Rehling P (2020).
Curr Biol, 30(6):1119-1127.
- Ubx2 monitors the mitochondrial protein entry gate.
Mårtensson CU, Priesnitz C, Song J, Ellenrieder L, Doan KN, Boos F, Floerchinger A, Zufall N, Oeljeklaus S, Warscheid B, Becker T (2019).
Nature, 569:679-683. Feature Article in News & Views; Nature, 569:635-637.
- Mitochondrial proteins: from biogenesis to functional networks.
Pfanner N, Warscheid B, Wiedemann N (2019).
Nat Rev Mol Cell Bio, 20:267-284.
- Quantitative proteomics identifies zinc-based redox switches for global translation modulation by mitochondrially produced reactive oxygen species.
Topf U, Suppanz I, Samluk L, Wrobel L, Böser A, Sakowska P, Knapp B, Pietrzyk MK, Chacinska A, Warscheid B (2018).
Nat Commun, 9:324.
- Complete native stable isotope labeling by amino acids of Saccharomyces cerevisiae for global proteomic analysis.
Dannenmaier S, Stiller S, Morgenstern M, Lübbert P, Oeljeklaus S, Wiedemann N, Warscheid B (2018).
Anal Chem, 90:10501-10509.
- Definition of a high confidence mitochondrial proteome at quantitative scale.
Morgenstern M, Stiller SB, Lübbert P, Peikert CD, Dannenmeier S, Drepper F, Weill U, Höß P, Feuerstein R, Gebert M, Bohnert M, van der Laan M, Schuldiner M, Schütze C, Oeljeklaus S, Pfanner N, Wiedemann N, Warscheid B (2017).
Cell Rep, 9:2836-2852.
- Charting organellar importomes by quantitative mass spectrometry.
Peikert CD, Mani J, Morgenstern M, Sandro K, Knapp B, Wenger C, Harsman A, Oeljeklaus S, Schneider A*, Warscheid B* (2017).
Nat Commun, 8:15272-15272.
*corresponding author
- Myofibrillar Z-discs are a protein phosphorylation hot spot with protein kinase C (PKCα) modulating protein dynamics.
Reimann L, Wiese H, Leber Y, Schwäble AN, Fricke A, Rohland A, Knapp B, Peikert CD, Drepper F, van der Ven PFM, Radziwill G, Fürst DO, Warscheid, B.
Mol Cell Proteomics. 2016;
- Regulation of peroxisome dynamics by phosphorylation.
Oeljeklaus S, Schummer A, Mastalski T, Platta WH, Warscheid B (2016).
Biochim Biophys Acta Mol Cell Res, 1863:1027-1037.
- Pex17p-dependent assembly of Pex14p/Dyn2p-subcomplexes of the peroxisomal protein import machinery.
Chan A, Schummer A, Fischer S, Bender J, Drepper F, Oeljeklaus S, Kunau WH, Girzalsky W, Warscheid B*, Erdmann R* (2016).
Eur J Cell Biol, 95(12):585-597.
*corresponding
- The non-canonical mitochondrial inner membrane presequence translocase of trypanosomatids contains two essential rhomboid-like proteins.
Harsman A, Oeljeklaus S, Wenger C, Huot JL, Warscheid B*, Schneider A*.
Nat Commun. 2016; 7:13707.
*corresponding author
- Mitochondrial protein synthesis adapts to influx of nuclear-encoded protein.
Richter-Dennerlein R, Oeljeklaus S, Lorenzi I, Ronsör C, Bareth B, Schendzielorz AB, Wang C, Warscheid B, Rehling P, Dennerlein S.
Cell. 2016;167(2):471-83.
- Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol. Wrobel L, Topf U, Bragoszewski P, Wiese S, Sztolsztener ME, Oeljeklaus S, Varabyova A, Lirski M, Chroscicki P, Mroczek S, Januszewicz E, Dziembowski A, Koblowska M, Warscheid B*, Chacinska A.* (2015)
Nature. 524(7566):485-8.
*corresponding author
- Structural insights into cargo recognition by the yeast PTS1-receptor.
Hagen S, Drepper F, Fischer S, Fodor K, Passon D, Platta H, Zimmermann B, Schliebs W, Girzalsky W, Wilmanns M, Warscheid B, Erdmann R (2015).
J Biol Chem, 290:26610-26626.
- Functional Proteomics Identifies Acinus L as a Direct Insulin- and Amino Acid-Dependent Mammalian Target of Rapamycin Complex 1 (mTORC1) Substrate.
Schwarz JJ, Wiese H, Tölle RC, Zarei M, Dengjel J, Warscheid B*, Thedieck K* (2015)
Mol Cell Proteomics. 14(8):2042-55
*corresponding author
- Quantitative phosphoproteomics reveals the protein tyrosine kinase Pyk2 as a central effector of olfactory receptor signaling in prostate cancer cells.
Wiese H, Gelis L, Wiese S, Reichenbach C, Jovancevic N, Osterloh M, Meyer HE, Neuhaus EM, Hatt H, Radziwill G, Warscheid B (2014)
Biochim Biophys Acta, pii: S1570-9639(14)00225-8.
- Comparison of alternative MS/MS and bioinformatics approaches for confident phosphorylation site localization.
Wiese H, Kuhlmann K, Wiese S, Stoepel NS, Pawlas M, Meyer HE, Stephan C, Eisenacher M, Drepper F, Warscheid B (2014)
J Proteome Res. 13(2):1128-1137.
- The membrane proteome of sensory cilia to the depth of olfactory receptors.
Kuhlmann K, Tschapek A, Wiese H, Eisenacher M, Meyer HE, Hatt H, Oeljeklaus S, Warscheid B (2014)
Mol Cell Proteomics, 13:1828-43.
- A combined approach of quantitative interaction proteomics and live-cell imaging reveals a regulatory role for ER reticulon homology proteins in peroxisome biogenesis.
David C, Koch JP, Oeljeklaus S, Laernsack A, Melchior S, Wiese S, Schummer A, Erdmann R, Warscheid B*, Brocard C* (2013) *corresponding authors
Mol Cell Proteomics, 2013 May 20.
- Mitochondrial outer membrane proteome of Trypanosoma brucei reveals novel factors required to maintain mitochondrial morphology.
Niemann M, Wiese S, Mani J, Chanfon A, Jackson C, Meisinger C, Warscheid B*, Schneider A* (2013). *corresponding authors
Mol Cell Proteomics: M112.023093
- Identification of Core Components and Transient Interactors of the Peroxisomal Importomer by Dual-track SILAC Analysis.
Oeljeklaus S, Reinartz BS, Wolf J, Wiese S, Tonillo J, Podwojski K, Kuhlmann K, Stephan C, Meyer HE, Schliebs W, Brocard C, Erdmann R, Warscheid B (2012).
J Proteome Res 11(4):2567-2580.
- MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation.
Mick DU, Dennerlein S, Wiese H, Reinhold R, Pacheau-Grau D, Lorenzi I, Sasarman F, Weraarpachai W, Shoubridge EA, Warscheid B, Rehling P (2012).
Cell 151(7):1528-1541.
- New dimensions in the study of protein complexes using quantitative mass spectrometry.
Oeljeklaus S, Meyer HE, Warscheid B.
FEBS Lett. 2009; 583(11):1674-83.
- Characterization of mouse kidney peroxisomes by tandem mass spectrometry and protein correlation profiling.
Wiese S, Gronemeyer T, Ofman R, Kunze M, Grou CP, Almeida JA, Eisenacher M, Stephan C, Hayen H, Schollenberger L, Korosec T, Waterham, HR, Schliebs W, Erdmann R, Berger J, Meyer HE, Just W, Azevedo JE, Wanders RJA, Warscheid B (2007).
Mol Cell Proteomics 6(12):2045-57.
- Protein labeling by iTRAQ: A new tool for quantitative mass spectrometry in proteome research.
Wiese S, Reidegeld KA, Meyer HE, Warscheid B.
Proteomics. 2007; 7(3):340-50.
Here you can find the complete list of my publications
Academic activities, awards and honors | ||
since 2019 | Principal Investigator and Board Member of the Excellence Cluster CIBSS Centre for Integrative Biological Signalling Studies,Coordinator of the Area CIBSS-D "Integrative Signalling Technologies". | |
since 2019 | Principal Investigator of SFB 1381 "Dynamic organization of cell protein machines: from biogenesis and modular assembly to function". | |
May 2018 | Member of the CIBSS review team presenting the CIBSS program "Signaling across scales: from mechanistic understanding to functional control" to the DFG review panel. | |
2018 - 2019 | Vice Dean of the Faculty of Biology, University of Fribourg | |
Seit 2017 | Deputy Vice President of the "German Society for Proteome Research" (DGPF) | |
2016 - 2018 | Dean of the Faculty of Biology, University of Freiburg | |
2016 - 2018 | Member of the Senate, University of Freiburg | |
2014 - 2016 | Dean for Student Affairs, Faculty of Biology, University of Freiburg | |
Seit 2013 | Principal Investigator of TRR 130 "B Cells: Immunity and Autoimmunity" | |
Seit 2011 | Principal Investigator of the "Spemann Graduate School of Biology and Medicine" (SGBM) of the "Excellence Initiative of the German Federal and State Governments", University of Freiburg, Germany | |
December 2011 | Member of the BIOSS speaker team presenting the BIOSS-2 program "Signal Research from Analysis to Synthesis" to the DFG review panel. | |
2010 - 2020 | Board member of the Excellence Cluster BIOSS Centre for Biological Signalling Studies | |
Since 2010 | Principal Investigator of the Excellence Cluster BIOSS | |
2010 | Innovative Research Project Award, Structural and Innovation Fond for Research (SI-BW), a program to support top contracts of the Ministry of Science, Research and the Arts of Baden-Württemberg. | |
2002 - 2003 | DFG grant for research in the laboratories of Prof. Catherine Fenselau at the University of Maryland, College Park, MD, and Prof. Robert Cotter at Johns Hopkins University, School of Medicine, Baltimore, MD, USA | |
1996 | Bachelor scholarship of the German Academic Exchange Program for the research stay at the University of Leiden, NL |
Dr. Silke Oeljeklaus
Senior Scientist
Chair of Biochemistry II
Biocenter, Am Hubland
97074
Würzburg
Germany
Building:
B1
Room:
108 b
Phone:
+49 931 31-86774
Dr. Johann Georg Polleichtner
Subject Advisor
Chair of Biochemistry II
Biocenter, Am Hubland
97074
Würzburg
Germany
Building:
Biocenter
Room:
B090
Phone:
+49 931 31-81815
Office hours: Tue-Thu 10-11:30 am, or by appointment.
Dr. Tomasz Stepkowski
Postdoc
Chair of Biochemistry II
IMOL PAS
The International Institute
of Molecular Mechanisms and Machines
Polish Academy of Sciences
Flisa 6
The International Institute
of Molecular Mechanisms and Machines
Polish Academy of Sciences
Flisa 6
02-247
Warsaw
Poland
Phone:
+49 931 31-84973
Julian Bender
Postdoc
Chair of Biochemistry II
Biocenter, Am Hubland
97074
Würzburg
Germany
Building:
B1
Room:
108 b
Phone:
+49 931 31-88160
Hirakjyoti Das
PhD Student
Chair of Biochemistry II
Biocenter, Am Hubland
97074
Würzburg
Germany
Building:
B1
Room:
107 b
Phone:
+49 931 31-83306
Daniel Wendscheck
PhD Student
Chair of Biochemistry II
Biocenter, Am Hubland
97074
Würzburg
Germany
Building:
B1
Room:
108 d
Phone:
+49 931 31-81865
Johannes Zimmermann
PhD Student
Chair of Biochemistry II
Biocenter, Am Hubland
97074
Würzburg
Germany
Building:
B1
Room:
106
Phone:
+49 931 31-86575
Lakshita Sharma
PHD Student
Biocenter, Am Hubland
97074
Würzburg
Germany
Building:
B1
Room:
107
Phone:
0931 31 83998
Bettina Müller-Jäkel
Secretary
Chair of Biochemistry II
Biocenter, Am Hubland
97074
Würzburg
Germany
Building:
B1
Room:
108 c
Phone:
+49 931 31-84531
Fax:
+49 931 31-845310
Andrea Stephan
Technical assistant
Chair of Biochemistry II
Biocenter, Am Hubland
97074
Würzburg
Germany
Building:
B1
Room:
115
Phone:
+49 931 31-80818
Ann-Kathrin Richard
Technical assistant
Chair of Biochemistry II
Biocenter, Am Hubland
97074
Würzburg
Germany
Building:
B1
Room:
107
Phone:
+49 931 31-81030
Thomas Morgenbrodt
Technical assistant
Chair of Biochemistry II
Biocenter, Am Hubland
97074
Würzburg
Germany
Building:
B1
Room:
106
Phone:
0931 31 88164
Ann-Kathrin Staudt
Hiwi
Chair of Biochemistry II
Biocenter, Am Hubland
97074
Würzburg
Germany
Building:
B1
Room:
108 d