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    Chair of Biochemistry and Molecular Biology

    Welcome to our Department

    Our research focuses on the control of cell growth and proliferation and its deregulation in human tumors.

    We study transcription factors such as Myc and SREBP proteins that control gene expression programs involved in central biological processes such as cell cycle progression, apoptosis, protein translation and metabolism.

    Our work aims to understand how these factors work and how they are regulated and to use this knowledge for novel strategies for tumor therapy.

    The department is part of the
    CCCM
    Comprehensive Cancer Center Mainfranken.

    Mildred Scheel Junior Research Center
    Ten million euros for cancer research
    Broadcast by Bayrischer Rundfunk

    Event Announcements

    CCC Seminarreihe

    Disruptinggene regulation via pharmacologic protein degradation
    Referent: Georg Winter, CeMM Research Center for Molecular Medicine, Wien
    Ort: Biozentrum Universität Würzburg, Hörsaal A 102
    18. Oktober 2018 17:00 c.t.
    Organisator: GSLS - CCC - FOR 2314 Seminarreihe

    MYC oncogene is a master regulator of the immune response
    Referent: Dean W. Felsher, Stanford University
    Ort: Biozentrum Universität Würzburg, Hörsaal A 101
    14. November 2018 17:00 c.t.
    Organisator: GSLS - CCC - FOR 2314 Seminarreihe

    T cell metabolic fitness in tumors
    Referent: Peter Siska Universitätsklinikum Regensburg
    Ort: Biozentrum Universität Würzburg, Hörsaal A 102
    13. Dezember 2018 17:00 c.t.
    Organisator: GSLS - CCC - FOR 2314 Seminarreihe

    New Publications

    Yanku, Y., Bitman-Lotan, E., Zohar, Y., Kurant, E., Zilke, N., Eilers, M. and Orian, A. (2018) Drosophila HUWE1 ubiquitin ligase regulates endoreplication and antagonizes JNK signaling during salivary gland development. Cells 2018,7 151 doi:10.3390/cells7100151

    Almut Schulze, Mariia Yuneva, Disease Models & Mechanisms 2018 11: dmm036673 doi: 10.1242/dmm.036673 Published 24 August 2018

    Miess, H., Dankworth, B., Gouw, AM., Rosenfeldt, M., Schmitz, W., Jiang, M., Saunders, B., Howell, M., Downward, J., Felsher, DW., Peck, B. and Schulze, A. (2018) The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma, Oncogene 2018 (in press)

    Snaebjornsson MT, Schulze A. (2018) Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways, Exp Mol Med. 2018 Apr 16;50(4):34, doi: 10.1038/s12276-018-0065-6.

    Pedrotti L, Weiste C, Nägele T, Wolf E, Lorenzin F, DietrichK, Mair A, Weckwerth W, Teige M, Baena-González E, Dröge-Laser W (2018) Snf1-RELATEDKINASE1-Controlled C/S1-bZIP Signaling Activates Alternative MitochondrialMetabolic Pathways to Ensure Plant Survival in Extended Darkness. The Plantcell

    Rickman,D. S., Schulte, J. H., Eilers,M. (2017) The expanding world of N-Myc driven tumors. Cancer Discovery, Feb;8(2):150-163. doi: 10.1158/2159-8290.CD-17-0273. Epub 2018 Jan 22.

    Dejure,F.R., Eilers, M. (2017)MYC and tumor metabolism: chicken and egg. EMBO J. Nov 10. pii: e201796438.doi: 10.15252/embj.201796438. [Epub ahead of print] Review. PubMed PMID:29127156.

    Büchel, G., Carstensen, A., Mak, K.Y., Roeschert, I., Leen, E., Sumara, O., Hofstetter, J., Herold, S., Kalb, J., Baluapuri, A., Poon, E., Kwok, C., Chesler, L., Maric H. M., Rickman, D. S., Wolf, E., Bayliss, R., Walz, S., Eilers, M. Association with Aurora-A controls N-MYC-dependent promoter escape and pause release of RNA polymerase II during cell cycle, Cell Reports Dec 19;21(12):3483-3497. doi:10.1016/j.celrep.2017.11.090.

    Open Positions

    If you are interested in working with us, please contact our administrative assistant, Sandra Stoudek, or contact the person you would like to work with directly.

    Prof. Dr. Martin Eilers

    Dr. Markus E. Diefenbacher

    Dr. Peter Gallant

    Prof. Dr. Almut Schulze

    PD Dr. Armin Wiegering

    Dr. Elmar Wolf

    Contact

    Lehrstuhl für Biochemie und Molekularbiologie
    Am Hubland
    97074 Würzburg

    Phone: +49 931 31-84112
    Email

    Find Contact

    Hubland Süd, Geb. B1 Hubland Nord, Geb. 32 Julius-von-Sachs-Platz 2 Fabrikschleichach Hubland Süd, Geb. B2 Campus Medizin