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    Chair of Biochemistry and Molecular Biology

    Welcome to our Department

    Our research focuses on the control of cell growth and proliferation and its deregulation in human tumors.

    We study transcription factors such as Myc and SREBP proteins that control gene expression programs involved in central biological processes such as cell cycle progression, apoptosis, protein translation and metabolism.

    Our work aims to understand how these factors work and how they are regulated and to use this knowledge for novel strategies for tumor therapy.

    The department is part of the
    CCCM
    Comprehensive Cancer Center Mainfranken.

    Mildred Scheel Junior Research Center
    Ten million euros for cancer research
    Broadcast by Bayrischer Rundfunk

    Event Announcements

    CCC Seminarreihe

    Targeting the H3K4 demethylase KDM5B/JARID1B affects the metabolic landscape and malignant phenotype of melanoma cells
    Referent: Felix Vogel, Universitätsklinikum Essen
    Ort: Biozentrum Universität Würzburg, Hörsaal A 102
    04. April 2019 17:00 c.t.
    Organistor: GSLS - CCC - FOR 2314 Seminarreihe

    New Publications

    Herold, S., Kalb, J., Buchel, G., Ade, C. P., Baluapuri, A., Xu, J., Koster, J., Solvie, D., Carstensen, A., Klotz, C., Rodewald, S., Schulein-Volk, C., Dobbelstein, M., Wolf, E., Molenaar, J., Versteeg, R., Walz, S., Eilers, M. (2019). Recruitment of BRCA1 limits MYCN-driven accumulation of stalled RNA Polymerase. Nature. Mar 20. doi:10.1038/s41586-019-1030-9. [Epub ahead of print] PubMed PMID: 30894746.

    Baluapuri, A., Hofstetter, J., Dudvarski Stankovic, N., Endres, T., Bhandare, P., Vos, S.M., Adhikari, B., Schwarz, J.D., Narain, A., Vogt, M., Wang, S.Y., Düster, R., Jung, L.A., Vanselow, J.T., Wiegering, A., Geyer, M., Maric, H.M., Gallant, P., Walz, S., Schlosser, A., Cramer, P., Eilers, M., Wolf, E. (2019) MYC recruits SPT5 to RNA polymerase II to promote processive transcription elongation. Molecular Cell Mar 21 pii:S1097-2765(19)30142-X. doi: 10.1016/j.molcel.2019.02.031. [Epub ahead of print] PubMed PMID: 30928206.

    Haikala,H., Anttila, J., Marques, E., Raatikainen, T., Ilander, M., Hakanen, H., Ala-Hongisto, H., Savelius, M., Balboa, D., von Eyss, B., Eskelinen, V., Munne, P., Nieminen, A., Otonkoski, T., Schüler, J., Laajala, T., Aittokallio, T., Sihto, H., Mattson, J., Heikkilä, P., Leidenius, M., Joensuu, H., Mustjoki, S., Kovanen, P., Eilers, M., Leverson, J., and Klefström, J. (2019) Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy. Nat Commun 10: 620

    Löffler, MC, Mayer, AE, Trujillo Viera, J, Loza Valdes, A, El-Merahbi, E, Ade, CP, Karwen, T, Schmitz, W, Slotta, A, Erk, M, Janaki-Raman, S, Matesanz, N, Torres, JL, Marcos, M, Sabio, G, Eilers, M, Schulze, A & Sumara G (2018) Protein kinase D1 deletion in adipocytes enhances energy dissipation and protects against adiposity. EMBO Journal, DOI 10.15252/embj.201899182

    Yanku, Y., Bitman-Lotan, E., Zohar, Y., Kurant, E., Zilke, N., Eilers, M. and Orian, A. (2018) Drosophila HUWE1 ubiquitin ligase regulates endoreplication and antagonizes JNK signaling during salivary gland development. Cells 2018,7 151 doi:10.3390/cells7100151

    Almut Schulze, Mariia Yuneva, Disease Models & Mechanisms 2018 11: dmm036673 doi: 10.1242/dmm.036673 Published 24 August 2018

    Miess, H., Dankworth, B., Gouw, AM., Rosenfeldt, M., Schmitz, W., Jiang, M., Saunders, B., Howell, M., Downward, J., Felsher, DW., Peck, B. and Schulze, A. (2018) The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma, Oncogene 2018 Oct;37(40):5435-5450. doi: 10.1038/s41388-018-0315-z.

    Snaebjornsson MT, Schulze A. (2018) Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways, Exp Mol Med. 2018 Apr 16;50(4):34, doi: 10.1038/s12276-018-0065-6.

    Pedrotti L, Weiste C, Nägele T, Wolf E, Lorenzin F, DietrichK, Mair A, Weckwerth W, Teige M, Baena-González E, Dröge-Laser W (2018) Snf1-RELATEDKINASE1-Controlled C/S1-bZIP Signaling Activates Alternative MitochondrialMetabolic Pathways to Ensure Plant Survival in Extended Darkness. The Plantcell Feb;30(2):495-509. doi: 10.1105/tpc.17.00414

    Rickman,D. S., Schulte, J. H., Eilers,M. (2017) The expanding world of N-Myc driven tumors. Cancer Discovery, Feb;8(2):150-163. doi: 10.1158/2159-8290.CD-17-0273. Epub 2018 Jan 22.

    Open Positions

    If you are interested in working with us, please contact our administrative assistant, Sandra Stoudek, or contact the person you would like to work with directly.

    Prof. Dr. Martin Eilers

    Dr. Markus E. Diefenbacher

    Dr. Peter Gallant

    Prof. Dr. Almut Schulze

    PD Dr. Armin Wiegering

    Dr. Elmar Wolf

    Contact

    Lehrstuhl für Biochemie und Molekularbiologie
    Am Hubland
    97074 Würzburg

    Phone: +49 931 31-84112
    Email

    Find Contact

    Hubland Süd, Geb. B1
    Hubland Süd, Geb. B1
    Hubland Nord, Geb. 32
    Hubland Nord, Geb. 32
    Julius-von-Sachs-Platz 2
    Julius-von-Sachs-Platz 2
    Fabrikschleichach
    Fabrikschleichach
    Hubland Süd, Geb. B2
    Hubland Süd, Geb. B2
    Campus Medizin
    Campus Medizin