Chair of Biochemistry

    Szalay, Aladár, Prof. Dr.

    Prof. Dr. Aladár Szalay

         +49 931 - 31 84410





    Curriculum vitae


    Prof. Dr. Aladár Szalay






    Chair of Biochemistry, Theodor-Boveri-Institute at the Biocentre
    University of Würzburg
    Am Hubland
    97074 Würzburg
    Phone +49 931 - 31 84010














    M.S. Biochemistry, Institute of Biochemistry, Martin Luther University, Halle/Saale, Germany



    Ph.D. Biochemistry, January 1971, Institute of Biochemistry, Martin Luther University, Halle/Saale, Germany



    Research Scientist, Biological Res. Center Hungarian Academy of Sciences Szeged, Hungary



    Gosney Research Fellow, California Institute of Technology Pasadena, CA, USA



    Research Associate, California Institute of Technology Pasadena, CA, USA



    Adjunct Professor, Division of Biological Sciences, Cornell University, Ithaca, New York, USA

    1977-1988 Associate Biochemistry Group Leader in Molecular Biology, Boyce Thompson Institute, Cornell University Ithaca, NY, USA
    1988-1995 Endowed Chair Professor, University of Alberta Edmonton, Alberta, Canada
    1993-1998 Professor of Microbiology and Molecular Genetics, Director of Molecular Biology and Gene Therapy Center, School of Medicine, Loma Linda University, Loma Linda, CA, USA
    1998-2003 University Professor of Biochemistry, School of Medicine Loma Linda University, Loma Linda, CA, USA
    since 2001 President & CEO, Chairman of the Board of Directors, Founder Genelux Corporation, San Diego, CA, USA
    since 2003 University Professor, Virchow Center for Experimental Biomedicine, Institute for Biochemistry and Institute for Molecular Infection Biology, University of Würzburg, Germany


    since 2009

    Professor, Department of Radiation Oncology, Rebecca and John Moores Comprehensive Cancer Center, University of California, San Diego, CA, USA







    Research Fields


    luciferase and fluorescent proteins
    tumor colonizing microorganisms for diagnosis and therapy



    Selected Awards

    1960-1972: Fellowship of Hungary (Distinguished Undergraduate Fellowship of Hungary)
    1962-1966: Foreign Undergraduate Fellowship, Ministry of Culture of Hungary
    1966-1971: Graduate Student Fellowship in Biochemistry, Awarded by the Hungarian National Academy of Sciences
    1973-1975: Gosney Award, California Institute of Technology, Pasadena, CA
    1985: Theobald Smith medal awarded by Squibb, Merck Corp. and Princeton University
    1985: Alexander von Humboldt Scholar Award, Max Planck Institut, Cologne, Germany
    1989: Award of the Economic Council of Advanced Technology, Edmonton, Canada
    1993: Wilhelm Exner Award – Vienna, Austria (Medal for Excellence in Science)
    1999: Alexander von Humboldt Prize, Bonn, Germany
    2002-2004: Vice President of International Society for Bioluminescence and Chemiluminescence
    2004-2006: President of International Society for Bioluminescence and Chemiluminescence







    Selected Publications


    Haddad D, Chen NG, Zhang Q, Chen CH, Yu YA, Gonzalez L, Carpenter SG, Carson J, Au J, Mittra A, Gonen M, Zanzonico PB, Fong Y, Szalay AA (2011): Insertion of the human sodium iodide symporter to facilitate deep tissue imaging does not alter oncolytic or replication capability of a novel vaccinia virus. J Transl Med 9: 36.

    Frentzen A, Yu YA, Chen N, Zhang Q, Weibel S, Raab V and Szalay AA (2009): Anti-VEGF single chain antibody GLAF-1 encoded by oncolytic vaccinia virus significantly enhances therapy in colonized tumor xenografts. PNAS 106: 12915-20.

    Brader P, Stritzker J, Riedl CC, Zanzonico P, Cai S, Burnazi EM, Ghani ER, Hricak H, Szalay AA, Fong Y and Blasberg R (2008): Escherichia coli Nissle 1917 facilitates tumor detection by positron emission tomography and optical imaging. Clin Cancer Res 14(8): 2295-302.

    Weibel S, Stritzker J, Eck M, Goebel W and Szalay AA (2008): Colonization of experimental murine breast tumours by Escherichia coli K-12 significantly alters the tumour microenvironment. Cell Microbiol 10(6): 1235-48.

    Yu YA, Shabahang S, Timiryasova TM, Zhang Q, Beltz R, Gentschev I, Goebel W and Szalay AA (2004): Visualization of tumors and metastases in live animals with bacteria and vaccinia virus encoding light-emitting proteins. Nat Biotechnol 22(3): 313-20.

    Dietrich G, Bubert A, Gentschev I, Sokolovic Z, Simm A, Catic A, Kaufmann SH, Hess J, Szalay AA and Goebel W (1998): Delivery of antigen-encoding plasmid DNA into the cytosol of macrophages by attenuated suicide Listeria monocytogenes. Nat Biotechnol 16(2): 181-5.

    Escher A, O'Kane DJ, Lee J and Szalay AA (1989): Bacterial luciferase alpha beta fusion protein is fully active as a monomer and highly sensitive in vivo to elevated temperature. Proc Natl Acad Sci USA 86(17): 6528-32.