Lipids (fats) are macronutrients that serve as building blocks for biological membranes, signalling compounds, as well as long-term energy stores. To reach their target cells, they have to be transported in the bloodstream upon food uptake or upon mobilisation from lipid stores. This cycling of lipids can be impaired by modern lifestyle which is often at odds with endogenously driven rhythmicity, and leads to circadian disruption and metabolic syndrome. We are convinced that fruit flies can help to understand the mechanisms behind, yet it was unknown whether and how lipids cycle in the fly blood known as hemolymph.
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