Paper out: Mechanosensitive channel engineering

The mechanosensitive channel of small conductance, YnaI, opens by moving its sensor paddles when the membrane tension becomes very high. We found out how to reengineer the channel properties to make it open more easily with higher conductivity.

Reference:

Flegler, V.J., Rasmussen, A., Hedrich, R. et al. Mechanosensitive channel engineering: A study on the mixing and matching of YnaI and MscS sensor paddles and pores. Nat Commun 16, 7881 (2025). https://doi.org/10.1038/s41467-025-63253-0