Veröffentlichungen
2023
Analysis of ageing-dependent thiol oxidation reveals early oxidation of proteins involved in core proteostasis functions
Jonak, K., Suppanz, I., Bender, J., Chacinska, A., Warscheid, B., Topf, U.
https://doi.org/10.1101/2023.05.08.539783
Protein homeostasis is maintained by proteasomes containing PSMB9 induced by EEF1A2 upon mitochondrial stress
Kim, M., Samluk, L., Stępkowski, T.M., Suppanz, I., Serwa, R., Kodroń, A., Warscheid, B., Chacinska, A.
https://doi.org/10.1101/2021.12.23.473808
Quantitative proteomics and lipidomics of TFG-deficient B cells provide insights into mechanisms of autophagic flux and plasma cell biology
Steinmetz, T.D., Reimann, L., Schulz, S.R., Thomas, J., Himmelreich, A.K., Golombek, F., Castiglione, K., Jäck, H.M., Brodesser, S., Warscheid, B., Mielenz, D.
https://doi.org/10.1101/2022.09.01.506221
Pseudokinase HPO-11 inhibits nonsense-mediated decay to ensures genome stability in C. elegans
Zhao, Q., Gromoff, E.D., Yang, W., Schwarz, J., Tittel, L., Schulze, E., Warscheid, B., Baumeister, R., Qi, W.
https://doi.org/10.1101/2022.09.04.506508
A Msp1-containing complex removes orphaned proteins in the mitochondrial outer membrane of trypanosomes
Gerber, M., Suppanz, I, Oeljeklaus, O., Niemann, M., Käser, S., Warscheid, B.*, Schneider, A.1*, Dewar, C.E.*
https://doi.org/10.1101/2023.03.07.531462
Analysis of Yeast Peroxisomes via Spatial Proteomics.
Das H, Zografakis A, Oeljeklaus S, Warscheid B.
Methods Mol Biol. 2023;2643:13-31.
doi: 10.1007/978-1-0716-3048-8_2. PMID: 36952175.
The Mba1 homologue of Trypanosoma brucei is involved in the biogenesis of oxidative phosphorylation complexes.
Wenger C, Harsman A, Niemann M, Oeljeklaus S, von Känel C, Calderaro S, Warscheid B, Schneider A.
Mol Microbiol. 2023 May;119(5):537-550.
doi: 10.1111/mmi.15048. Epub 2023 Mar 10. PMID: 36829306.
Phosphoproteomics Profiling Defines a Target Landscape of the Basophilic Protein Kinases AKT, S6K, and RSK in Skeletal Myotubes.
Fricke AL, Mühlhäuser WWD, Reimann L, Zimmermann JP, Reichenbach C, Knapp B, Peikert CD, Heberle AM, Faessler E, Schäuble S, Hahn U, Thedieck K, Radziwill G, Warscheid B.
J Proteome Res. 2023 Mar 3;22(3):768-789.
doi: 10.1021/acs.jproteome.2c00505. Epub 2023 Feb 10. PMID: 36763541.
2022
Mistargeting of aggregation prone mitochondrial proteins activates a nucleus-mediated posttranscriptional quality control pathway in trypanosomes
Dewar CE, Oeljeklaus S, Mani J, Mühlhäuser WWD, von Känel C, Zimmermann J, Ochsenreiter T, Warscheid B, Schneider A.
Nat Commun. 2022 Jun 2;13(1):3084.
https://doi.org/10.1038%2Fs41467-022-30748-z
Phosphorylation of the receptor protein Pex5p modulates import of proteins into peroxisomes.
Fischer S, Bürgi J, Gabay-Maskit S, Maier R, Mastalski T, Yifrach E, Obarska-Kosinska A, Rudowitz M, Erdmann R, Platta HW, Wilmanns M, Schuldiner M, Zalckvar E, Oeljeklaus S, Drepper F, Warscheid B.
Biol Chem. 2022 Sep 21;404(2-3):135-155.
doi: 10.1515/hsz-2022-0168. PMID: 36122347; PMCID: PMC9929924.
A newly identified secreted larval antigen elicits basophil-dependent protective immunity against N. brasiliensis infection.
Thuma N, Döhler D, Mielenz D, Sticht H, Radtke D, Reimann L, Warscheid B, Voehringer D.
Front Immunol. 2022 Aug 25;13:979491.
doi: 10.3389/fimmu.2022.979491. PMID: 36091065; PMCID: PMC9453252.
p166 links membrane and intramitochondrial modules of the trypanosomal tripartite attachment complex.
Schimanski B, Aeschlimann S, Stettler P, Käser S, Gomez-Fabra Gala M, Bender J, Warscheid B, Vögtle FN, Schneider A.
PLoS Pathog. 2022 Jun 16;18(6):e1010207.
doi: 10.1371/journal.ppat.1010207. PMID: 35709300; PMCID: PMC9242489.
The endoplasmic reticulum membrane protein complex localizes to the mitochondrial - endoplasmic reticulum interface and its subunits modulate phospholipid biosynthesis in Trypanosoma brucei.
Iyer A, Niemann M, Serricchio M, Dewar CE, Oeljeklaus S, Farine L, Warscheid B, Schneider A, Bütikofer P.
PLoS Pathog. 2022 May 2;18(5):e1009717.
doi: 10.1371/journal.ppat.1009717. PMID: 35500022; PMCID: PMC9113592.
Characterization of a highly diverged mitochondrial ATP synthase Fo subunit in Trypanosoma brucei.
Dewar CE, Oeljeklaus S, Wenger C, Warscheid B, Schneider A.
J Biol Chem. 2022 Apr;298(4):101829.
doi: 10.1016/j.jbc.2022.101829. Epub 2022 Mar 12. PMID: 35293314; PMCID: PMC9034290.
Regulating peroxisome-ER contacts via the ACBD5-VAPB tether by FFAT motif phosphorylation and GSK3β.
Kors S, Hacker C, Bolton C, Maier R, Reimann L, Kitchener EJA, Warscheid B, Costello JL, Schrader M.
J Cell Biol, 2022; 221 (3)
http://dx.doi.org/10.1083/jcb.202003143
MaxQuant and MSstats in Galaxy Enable Reproducible Cloud-Based Analysis of Quantitative Proteomics Experiments for Everyone.
Pinter N, Glätzer D, Fahrner M, Fröhlich K, Johnson J, Grüning BA, Warscheid B, Drepper F, Schilling O, Föll MC
J Proteome Res, 2022
http://dx.doi.org/10.1021/acs.jproteome.2c00051
2021
Subcellular proteomics.
Christopher JA, Stadler C, Martin CE, Morgenstern M, Pan Y, Betsinger CN, Rattray DG, Mahdessian D, Gingras AC, Warscheid B, Lehtiö J, Cristea IM, Foster LJ, Emili A, Lilley KS.
Nat Rev Methods Primers. 2021;1:32.
doi: 10.1038/s43586-021-00029-y. Epub 2021 Apr 29. PMID: 34549195; PMCID: PMC8451152.
DNA Repair Protein APE1 Degrades Dysfunctional Abasic mRNA in Mitochondria Affecting Oxidative Phosphorylation.
Barchiesi A, Bazzani V, Jabczynska A, Borowski LS, Oeljeklaus S, Warscheid B, Chacinska A, Szczesny RJ, Vascotto C
J Mol Biol, 2021; 433 (18) : 167125-167125
http://dx.doi.org/10.1016/j.jmb.2021.167125
Quantitative proteomics identifies the universally conserved ATPase Ola1p as a positive regulator of heat shock response in Saccharomyces cerevisiae.
Dannenmaier S, Desroches Altamirano C, Schüler L, Zhang Y, Hummel J, Milanov M, Oeljeklaus S, Koch HG, Rospert S, Alberti S, Warscheid B
J Biol Chem, 2021; 297 (5) : 101050-101050
http://dx.doi.org/10.1016/j.jbc.2021.101050
2nSILAC for Quantitative Proteomics of Prototrophic Baker's Yeast.
Dannenmaier S, Oeljeklaus S, Warscheid B
Methods Mol Biol, 2021; 2228: 253-270
http://dx.doi.org/10.1007/978-1-0716-1024-4_18
Defining the interactome of the human mitochondrial ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly factors.
Dennerlein S, Poerschke S, Oeljeklaus S, Wang C, Richter-Dennerlein R, Sattmann J, Bauermeister D, Hanitsch E, Stoldt S, Langer T, Jakobs S, Warscheid B, Rehling P
Elife, 2021; 10
http://dx.doi.org/10.7554/eLife.68213
Data-Driven Selection of an Imputation Algorithm.
Egert J, Brombacher E, Warscheid B, Kreutz CDIMA
J Proteome Res, 2021
http://dx.doi.org/10.1021/acs.jproteome.1c00119
Maintaining proteostasis under mechanical stress.
Höhfeld J, Benzing T, Bloch W, Fürst DO, Gehlert S, Hesse M, Hoffmann B, Hoppe T, Huesgen PF, Köhn M, Kolanus W, Merkel R, Niessen CM, Pokrzywa W, Rinschen MM, Wachten D, Warscheid B
Embo Rep, 2021; 22 (8) : e52507-e52507
http://dx.doi.org/10.15252/embr.202152507
Molecular basis of F-actin regulation and sarcomere assembly via myotilin.
Kostan J, Pavšič M, Puž V, Schwarz TC, Drepper F, Molt S, Graewert MA, Schreiner C, Sajko S, van der Ven PFM, Onipe A, Svergun DI, Warscheid B, Konrat R, Fürst DO, Lenarčič B, Djinović-Carugo K
PLOS Biology, 2021; 19 (4) : e3001148-e3001148
http://dx.doi.org/10.1371/journal.pbio.3001148
The Universally Conserved ATPase YchF Regulates Translation of Leaderless mRNA in Response to Stress Conditions.
Landwehr V, Milanov M, Angebauer L, Hong J, Jüngert G, Hiersemenzel A, Siebler A, Schmit F, Öztürk Y, Dannenmaier S, Drepper F, Warscheid B, Koch HG
Front Mol Biosci, 2021; 8: 643696-643696
http://dx.doi.org/10.3389/fmolb.2021.643696
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
Morgenstern M, Peikert CD, Lübbert P, Suppanz I, Klemm C, Alka O, Steiert C, Naumenko N, Schendzielorz A, Melchionda L, Mühlhäuser WWD, Knapp B, Busch JD, Stiller SB, Dannenmaier S, Lindau C, Licheva M, Eickhorst C, Galbusera R, Zerbes RM, Ryan MT, Kraft C, Kozjak-Pavlovic V, Drepper F, Dennerlein S, Oeljeklaus S, Pfanner N, Wiedemann N, Warscheid B
Cell Metab, 2021
http://dx.doi.org/10.1016/j.cmet.2021.11.001
Determinism and contingencies shaped the evolution of mitochondrial protein import.
Rout S, Oeljeklaus S, Makki A, Tachezy J, Warscheid B, Schneider A
P Natl Acad Sci Usa, 2021; 118 (6)
http://dx.doi.org/10.1073/pnas.2017774118
Quantitative proteomics identifies PTP1B as modulator of B cell antigen receptor signaling.
Schwarz JJ, Grundmann L, Kokot T, Kläsener K, Fotteler S, Medgyesi D, Köhn M, Reth M, Warscheid B
Life Sci Alliance, 2021; 4 (11)
http://dx.doi.org/10.26508/lsa.202101084
Order from disorder in the sarcomere: FATZ forms a fuzzy but tight complex and phase-separated condensates with α-actinin.
Sponga A, Arolas JL, Schwarz TC, Jeffries CM, Rodriguez Chamorro A, Kostan J, Ghisleni A, Drepper F, Polyansky A, De Almeida Ribeiro E, Pedron M, Zawadzka-Kazimierczuk A, Mlynek G, Peterbauer T, Doto P, Schreiner C, Hollerl E, Mateos B, Geist L, Faulkner G, Kozminski W, Svergun DI, Warscheid B, Zagrovic B, Gautel M, Konrat R, Djinović-Carugo K
Sci Adv, 2021; 7 (22)
http://dx.doi.org/10.1126/sciadv.abg7653
2020
A combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human tau but minimal levels of other key modifications.
Drepper F, Biernat J, Kaniyappan S, Meyer HE, Mandelkow EM, Warscheid B, Mandelkow E
J Biol Chem, 2020
http://dx.doi.org/10.1074/jbc.RA120.015882
Defining the Substrate Spectrum of the TIM22 Complex Identifies Pyruvate Carrier Subunits as Unconventional Cargos.
Gomkale R, Cruz-Zaragoza LD, Suppanz I, Guiard B, Montoya J, Callegari S, Pacheu-Grau D, Warscheid B, Rehling P
Curr Biol, 2020; 30 (6) : 1119-1127.e5
http://dx.doi.org/10.1016/j.cub.2020.01.024
Towards the molecular architecture of the peroxisomal receptor docking complex.
Lill P, Hansen T, Wendscheck D, Klink BU, Jeziorek T, Vismpas D, Miehling J, Bender J, Schummer A, Drepper F, Girzalsky W, Warscheid B, Erdmann R, Gatsogiannis C
P Natl Acad Sci Usa, 2020
http://dx.doi.org/10.1073/pnas.2009502117
Cullin 3 Is Crucial for Pro-B Cell Proliferation, Interacts with CD22, and Controls CD22 Internalization on B Cells.
Meyer SJ, Böser A, Korn MA, Koller C, Bertocci B, Reimann L, Warscheid B, Nitschke L
J Immunol, 2020; 204 (12) : 3360-3374
http://dx.doi.org/10.4049/jimmunol.1900925
COA6 Facilitates Cytochrome c Oxidase Biogenesis as Thiol-reductase for Copper Metallochaperones in Mitochondria.
Pacheu-Grau D, Wasilewski M, Oeljeklaus S, Gibhardt CS, Aich A, Chudenkova M, Dennerlein S, Deckers M, Bogeski I, Warscheid B, Chacinska A, Rehling P
J Mol Biol, 2020; 432 (7) : 2067-2079
http://dx.doi.org/10.1016/j.jmb.2020.01.036
Phosphoproteomics identifies dual-site phosphorylation in an extended basophilic motif regulating FILIP1-mediated degradation of filamin-C.
Reimann L, Schwäble AN, Fricke AL, Mühlhäuser WWD, Leber Y, Lohanadan K, Puchinger MG, Schäuble S, Faessler E, Wiese H, Reichenbach C, Knapp B, Peikert CD, Drepper F, Hahn U, Kreutz C, van der Ven PFM, Radziwill G, Djinović-Carugo, K, Fürst DO, Warscheid B
Commun Biol, 2020; 3 (1) : 253-253
http://dx.doi.org/10.1038/s42003-020-0982-5
Pex14p Phosphorylation Modulates Import of Citrate Synthase 2 Into Peroxisomes in Saccharomyces cerevisiae.
Schummer A, Maier R, Gabay-Maskit S, Hansen T, Mühlhäuser WWD, Suppanz I, Fadel A, Schuldiner M, Girzalsky W, Oeljeklaus S, Zalckvar E, Erdmann R, Warscheid B
Front Cell Dev Biol, 2020; 8: 549451-549451
http://dx.doi.org/10.3389/fcell.2020.549451
Homologue replacement in the import motor of the mitochondrial inner membrane of trypanosomes.
von Känel C, Muñoz-Gómez SA, Oeljeklaus S, Wenger C, Warscheid B, Wideman JG, Harsman A, Schneider A
Elife, 2020; 9
http://dx.doi.org/10.7554/eLife.52560
2019
The highly diverged trypanosomal MICOS complex is organized in a non-essential integral membrane and an essential peripheral module.
Eichenberger C, Oeljeklaus S, Bruggisser J, Mani J, Haenni B, Kaurov I, Niemann M, Zuber B, Lukes J, Hashimi H, Warscheid B, Schimanski B, Schneider A
Mol Microbiol, 2019
http://dx.doi.org/10.1111/mmi.14389
The deubiquitination of the PTS1-import receptor Pex5p is required for peroxisomal matrix protein import.
El Magraoui F, Brinkmeier R, Mastalski T, Hupperich A, Strehl C, Schwerter D, Girzalsky W, Meyer HE, Warscheid B, Erdmann R, Platta HW
Bba-mol Cell Res, 2019; 1866 (2) : 199-213
http://dx.doi.org/10.1016/j.bbamcr.2018.11.002
Surface-exposed domains of TatB involved in the structural and functional assembly of the Tat translocase in Escherichia coli.
Frobel J, Blummel AS, Drepper F, Warscheid B, Muller M
J Biol Chem, 2019; 294 (38) : 13902-13914
http://dx.doi.org/10.1074/jbc.RA119.009298
Light-Controlled Affinity Purification of Protein Complexes Exemplified by the Resting ZAP70 Interactome.
Horner M, Eble J, Yousefi OS, Schwarz J, Warscheid B, Weber W, Schamel WWA
Front Immunol, 2019; 10: 226-226
http://dx.doi.org/10.3389/fimmu.2019.00226
Non-competitive binding of PpiD and YidC to the SecYEG translocon expands the global view on the SecYEG interactome in E. coli.
Jauss B, Petriman NA, Drepper F, Franz L, Sachelaru I, Welte T, Steinberg R, Warscheid B, Koch HG
J Biol Chem, 2019
http://dx.doi.org/10.1074/jbc.RA119.010686
Evolutionary divergent PEX3 is essential for glycosome biogenesis and survival of trypanosomatid parasites.
Kalel VC, Li M, Gaussmann S, Delhommel F, Schafer AB, Tippler B, Jung M, Maier R, Oeljeklaus S, Schliebs W, Warscheid B, Sattler M, Erdmann R
Bba-mol Cell Res, 2019; 1866 (12) : 118520-118520
http://dx.doi.org/10.1016/j.bbamcr.2019.07.015
Mitochondrial protein translocation-associated degradation.
Martensson CU, Priesnitz C, Song J, Ellenrieder L, Doan KN, Boos F, Floerchinger A, Zufall N, Oeljeklaus S, Warscheid B, Becker T
Nature, 2019; 569 (7758) : 679-683
http://dx.doi.org/10.1038/s41586-019-1227-y
Mitochondrial proteins: from biogenesis to functional networks.
Pfanner N, Warscheid B, Wiedemann N
Nat Rev Mol Cell Bio, 2019
http://dx.doi.org/10.1038/s41580-018-0092-0
2018
Complete Native Stable Isotope Labeling by Amino Acids of Saccharomyces cerevisiae for Global Proteomic Analysis.
Dannenmaier S, Stiller SB, Morgenstern M, Lubbert P, Oeljeklaus S, Wiedemann N, Warscheid B
Anal Chem, 2018; 90 (17) : 10501-10509
http://dx.doi.org/10.1021/acs.analchem.8b02557
Vps39 Interacts with Tom40 to Establish One of Two Functionally Distinct Vacuole-Mitochondria Contact Sites.
Gonzalez Montoro A, Auffarth K, Honscher C, Bohnert M, Becker T, Warscheid B, Reggiori F, van der Laan M, Frohlich F, Ungermann C
Dev Cell, 2018; 45 (5) : 621-636.e7
http://dx.doi.org/10.1016/j.devcel.2018.05.011
The Diverged Trypanosome MICOS Complex as a Hub for Mitochondrial Cristae Shaping and Protein Import.
Kaurov I, Vancova M, Schimanski B, Cadena LR, Heller J, Bily T, Potesil D, Eichenberger C, Bruce H, Oeljeklaus S, Warscheid B, Zdrahal Z, Schneider A, Lukes J, Hashimi H
Curr Biol, 2018; 28 (21) : 3393-3407.e5
http://dx.doi.org/10.1016/j.cub.2018.09.008
Using Pull Down Strategies to Analyze the Interactome of Peroxisomal Membrane Proteins in Human Cells.
Klumper J, Oeljeklaus S, Warscheid B, Erdmann R, Schliebs W
Subcell Biochem, 2018; 89: 261-285
http://dx.doi.org/10.1007/978-981-13-2233-4_11
The mitochondrial TMEM177 associates with COX20 during COX2 biogenesis.
Lorenzi I, Oeljeklaus S, Aich A, Ronsor C, Callegari S, Dudek J, Warscheid B, Dennerlein S, Rehling P
Bba-mol Cell Res, 2018; 1865 (2) : 323-333
http://dx.doi.org/10.1016/j.bbamcr.2017.11.010
Recruitment of Cytosolic J-Proteins by TOM Receptors Promotes Mitochondrial Protein Biogenesis.
Opalinski L, Song J, Priesnitz C, Wenz LS, Oeljeklaus S, Warscheid B, Pfanner N, Becker T
Cell Rep, 2018; 25 (8) : 2036-2043.e5
http://dx.doi.org/10.1016/j.celrep.2018.10.083
The interaction network of the YidC insertase with the SecYEG translocon, SRP and the SRP receptor FtsY.
Petriman NA, Jauss B, Hufnagel A, Franz L, Sachelaru I, Drepper F, Warscheid B, Koch HG
Sci Rep-uk, 2018; 8 (1) : 578-578
http://dx.doi.org/10.1038/s41598-017-19019-w
Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species.
Topf U, Suppanz I, Samluk L, Wrobel L, Boser A, Sakowska P, Knapp B, Pietrzyk MK, Chacinska A, Warscheid B
Nat Commun, 2018; 9 (1) : 324-324
http://dx.doi.org/10.1038/s41467-017-02694-8
Defining the Mammalian Peroxisomal Proteome.
Yifrach E, Fischer S, Oeljeklaus S, Schuldiner M, Zalckvar E, Warscheid B
Subcell Biochem, 2018; 89: 47-66
http://dx.doi.org/10.1007/978-981-13-2233-4_2
2017
Structural features of the TatC membrane protein that determine docking and insertion of a twin-arginine signal peptide.
Blummel AS, Drepper F, Knapp B, Eimer E, Warscheid B, Muller M, Frobel J
J Biol Chem, 2017
http://dx.doi.org/10.1074/jbc.M117.812560
Phospho-ubiquitin-PARK2 complex as a marker for mitophagy defects.
Callegari S, Oeljeklaus S, Warscheid B, Dennerlein S, Thumm M, Rehling P, Dudek J
Autophagy, 2017; 13 (1) : 201-211
http://dx.doi.org/10.1080/15548627.2016.1254852
The BTG2-PRMT1 module limits pre-B cell expansion by regulating the CDK4-Cyclin-D3 complex
Dolezal E, Infantino S, Drepper F, Borsig T, Singh A, Wossning T, Fiala GJ, Minguet S, Warscheid B, Tarlinton DM, Jumaa H, Medgyesi D, Reth M
Nat Immunol, 2017
http://dx.doi.org/10.1038/ni.3774
Membrane localization of acetylated CNK1 mediates a positive feedback on RAF/ERK signaling.
Fischer A, Muhlhauser WWD, Warscheid B, Radziwill G
Sci Adv, 2017; 3 (8) : e1700475-e1700475
http://dx.doi.org/10.1126/sciadv.1700475
AKT-dependent phosphorylation of the SAM domain induces oligomerization and activation of the scaffold protein CNK1.
Fischer A, Weber W, Warscheid B, Radziwill G
Bba-mol Cell Res, 2017; 1864 (1) : 89-100
http://dx.doi.org/10.1016/j.bbamcr.2016.10.009
Biogenesis of the mitochondrial DNA inheritance machinery in the mitochondrial outer membrane of Trypanosoma brucei.
Kaser S, Willemin M, Schnarwiler F, Schimanski B, Poveda-Huertes D, Oeljeklaus S, Haenni B, Zuber B, Warscheid B, Meisinger C, Schneider A
Plos Pathog, 2017; 13 (12) : e1006808-e1006808
http://dx.doi.org/10.1371/journal.ppat.1006808
Identification of new channels by systematic analysis of the mitochondrial outer membrane.
Kruger V, Becker T, Becker L, Montilla-Martinez M, Ellenrieder L, Vogtle FN, Meyer HE, Ryan MT, Wiedemann N, Warscheid B, Pfanner N, Wagner R, Meisinger C
J Cell Biol, 2017
http://dx.doi.org/10.1083/jcb.201706043
Identification of Novel STAT6-Regulated Proteins in Mouse B Cells by Comparative Transcriptome and Proteome Analysis.
Mokada-Gopal L, Boeser A, Lehmann CHK, Drepper F, Dudziak D, Warscheid B, Voehringer D
J Immunol, 2017; 198 (9) : 3737-3745
http://dx.doi.org/10.4049/jimmunol.1601838
Definition of a High-Confidence Mitochondrial Proteome at Quantitative Scale.
Morgenstern M, Stiller S, Lubbert P, Peikert C, Dannenmaier S, Drepper F, Weill U, Hoss P, Feuerstein R, Gebert M, Bohnert M, van der Laan M, Schuldiner M, Schutze C, Oeljeklaus S, Pfanner N, Wiedemann N, Warscheid B
Cell Rep, 2017; 19 (13) : 2836-2852
http://dx.doi.org/10.1016/j.celrep.2017.06.014
INA complex liaises the F1Fo-ATP synthase membrane motor modules.
Naumenko N, Morgenstern M, Rucktaschel R, Warscheid B, Rehling P
Nat Commun, 2017; 8 (1) : 1237-1237
http://dx.doi.org/10.1038/s41467-017-01437-z
tRNAs and proteins use the same import channel for translocation across the mitochondrial outer membrane of trypanosomes.
Niemann M, Harsman A, Mani J, Peikert CD, Oeljeklaus S, Warscheid B, Wagner R, Schneider A
P Natl Acad Sci Usa, 2017; 114 (37) : E7679-E7687
http://dx.doi.org/10.1073/pnas.1711430114
Charting organellar importomes by quantitative mass spectrometry.
Peikert CD, Mani J, Morgenstern M, Kaser S, Knapp B, Wenger C, Harsman A, Oeljeklaus S, Schneider A, Warscheid B
Nat Commun, 2017; 8: 15272-15272
http://dx.doi.org/10.1038/ncomms15272
Mic10, a Core Subunit of the Mitochondrial Contact Site and Cristae Organizing System, Interacts with the Dimeric F1Fo-ATP Synthase.
Rampelt H, Bohnert M, Zerbes RM, Horvath SE, Warscheid B, Pfanner N, van der Laan M
J Mol Biol, 2017; 429 (8) : 1162-1170
http://dx.doi.org/10.1016/j.jmb.2017.03.006
Myofibrillar Z-discs Are a Protein Phosphorylation Hot Spot with Protein Kinase C (PKCalpha) Modulating Protein Dynamics.
Reimann L, Wiese H, Leber Y, Schwable AN, Fricke AL, Rohland A, Knapp B, Peikert CD, Drepper F, van der Ven PF, Radziwill G, Furst DO, Warscheid B
Mol Cell Proteomics, 2017; 16 (3) : 346-367
http://dx.doi.org/10.1074/mcp.M116.065425
PLK1 (polo like kinase 1) inhibits MTOR complex 1 and promotes autophagy.
Ruf S, Heberle AM, Langelaar-Makkinje M, Gelino S, Wilkinson D, Gerbeth C, Schwarz JJ, Holzwarth B, Warscheid B, Meisinger C, van Vugt MA, Baumeister R, Hansen M, Thedieck K
Autophagy, 2017; 13 (3) : 486-505
http://dx.doi.org/10.1080/15548627.2016.1263781
Study of Peroxisomal Protein Phosphorylation by Functional Proteomics.
Schummer A, Fischer S, Oeljeklaus S, Warscheid B
Methods Mol Biol, 2017; 1595: 267-289
http://dx.doi.org/10.1007/978-1-4939-6937-1_26
A trypanosomal orthologue of an intermembrane space chaperone has a non-canonical function in biogenesis of the single mitochondrial inner membrane protein translocase.
Wenger C, Oeljeklaus S, Warscheid B, Schneider A, Harsman A
Plos Pathog, 2017; 13 (8) : e1006550-e1006550
http://dx.doi.org/10.1371/journal.ppat.1006550
Saccharomyces cerevisiae cells lacking Pex3 contain membrane vesicles that harbor a subset of peroxisomal membrane proteins.
Wroblewska JP, Cruz-Zaragoza LD, Wei Y, Schummer A, Chuartzman SG, de Boer R, Oeljeklaus S, Schuldiner M, Zalckvar E, Warscheid B, Erdmann R, van der Klei IJ
Bba-mol Cell Res, 2017
http://dx.doi.org/10.1016/j.bbamcr.2017.05.021
2016
Pex17p-dependent assembly of Pex14p/Dyn2p-subcomplexes of the peroxisomal protein import machinery.
Chan A, Schummer A, Fischer S, Schroter T, Cruz-Zaragoza LD, Bender J, Drepper F, Oeljeklaus S, Kunau WH, Girzalsky W, Warscheid B, Erdmann R
Eur J Cell Biol, 2016; 95 (12) : 585-597
http://dx.doi.org/10.1016/j.ejcb.2016.10.004
A systems study reveals concurrent activation of AMPK and mTOR by amino acids.
Dalle Pezze P, Ruf S, Sonntag AG, Langelaar-Makkinje M, Hall P, Heberle AM, Razquin Navas P, van Eunen K, Tolle RC, Schwarz JJ, Wiese H, Warscheid B, Deitersen J, Stork B, Fassler E, Schauble S, Hahn U, Horvatovich P, Shanley DP, Thedieck K
Nat Commun, 2016; 7: 13254-13254
http://dx.doi.org/10.1038/ncomms13254
Optogenetic clustering of CNK1 reveals mechanistic insights in RAF and AKT signalling controlling cell fate decisions.
Fischer A, Warscheid B, Weber W, Radziwill G
Sci Rep-uk, 2016; 6: 38155-38155
http://dx.doi.org/10.1038/srep38155
The non-canonical mitochondrial inner membrane presequence translocase of trypanosomatids contains two essential rhomboid-like proteins.
Harsman A, Oeljeklaus S, Wenger C, Huot JL, Warscheid B, Schneider A
Nat Commun, 2016; 7: 13707-13707
http://dx.doi.org/10.1038/ncomms13707
Expanding the archaellum regulatory network - the eukaryotic protein kinases ArnC and ArnD influence motility of Sulfolobus acidocaldarius.
Hoffmann L, Schummer A, Reimann J, Haurat MF, Wilson AJ, Beeby M, Warscheid B, Albers SV
Microbiologyopen, 2016
http://dx.doi.org/10.1002/mbo3.414
The Hsp70 homolog Ssb and the 14-3-3 protein Bmh1 jointly regulate transcription of glucose repressed genes in Saccharomyces cerevisiae.
Hubscher V, Mudholkar K, Chiabudini M, Fitzke E, Wolfle T, Pfeifer D, Drepper F, Warscheid B, Rospert S
Nucleic Acids Res, 2016; 44 (12) : 5629-5645
http://dx.doi.org/10.1093/nar/gkw168
Outer membrane protein functions as integrator of protein import and DNA inheritance in mitochondria.
Kaser S, Oeljeklaus S, Tyc J, Vaughan S, Warscheid B, Schneider A
P Natl Acad Sci Usa, 2016; 113 (31) : E4467-E4475
http://dx.doi.org/10.1073/pnas.1605497113
The ribosome-associated Mba1 escorts Cox2 from insertion machinery to maturing assembly intermediates.
Lorenzi I, Oeljeklaus S, Ronsor C, Bareth B, Warscheid B, Rehling P, Dennerlein S
Mol Cell Biol, 2016
http://dx.doi.org/10.1128/MCB.00361-16
Regulation of peroxisome dynamics by phosphorylation.
Oeljeklaus S, Schummer A, Mastalski T, Platta HW, Warscheid B
Bba-mol Cell Res, 2016
http://dx.doi.org/10.1016/j.bbamcr.2015.12.022
Identification of Cell Cycle Dependent Interaction Partners of the Septins by Quantitative Mass Spectrometry.
Renz C, Oeljeklaus S, Grinhagens S, Warscheid B, Johnsson N, Gronemeyer T
Plos One, 2016; 11 (2) : e0148340-e0148340
http://dx.doi.org/10.1371/journal.pone.0148340
Mitochondrial Protein Synthesis Adapts to Influx of Nuclear-Encoded Protein.
Richter-Dennerlein R, Oeljeklaus S, Lorenzi I, Ronsor C, Bareth B, Schendzielorz AB, Wang C, Warscheid B, Rehling P, Dennerlein S
Cell, 2016; 167 (2) : 471-483.e10
http://dx.doi.org/10.1016/j.cell.2016.09.003
Mitochondrial OXA Translocase Plays a Major Role in Biogenesis of Inner-Membrane Proteins.
Stiller SB, Hopker J, Oeljeklaus S, Schutze C, Schrempp SG, Vent-Schmidt J, Horvath SE, Frazier AE, Gebert N, van der Laan M, Bohnert M, Warscheid B, Pfanner N, Wiedemann N
Cell Metab, 2016; 23 (5) : 901-908
http://dx.doi.org/10.1016/j.cmet.2016.04.005
Xilmass: A New Approach toward the Identification of Cross-Linked Peptides.
Yilmaz S, Drepper F, Hulstaert N, Cernic M, Gevaert K, Economou A, Warscheid B, Martens L, Vandermarliere E
Anal Chem, 2016; 88 (20) : 9949-9957
http://dx.doi.org/10.1021/acs.analchem.6b01585
2015
Mitochondrial heat shock protein (Hsp) 70 and Hsp10 cooperate in the formation of Hsp60 complexes.
Bottinger L, Oeljeklaus S, Guiard B, Rospert S, Warscheid B, Becker T
J Biol Chem, 2015; 290 (18) : 11611-11622
http://dx.doi.org/10.1074/jbc.M115.642017
Cox17 Protein Is an Auxiliary Factor Involved in the Control of the Mitochondrial Contact Site and Cristae Organizing System.
Chojnacka M, Gornicka A, Oeljeklaus S, Warscheid B, Chacinska A
J Biol Chem, 2015; 290 (24) : 15304-15312
http://dx.doi.org/10.1074/jbc.M115.645069
MITRAC7 Acts as a COX1-Specific Chaperone and Reveals a Checkpoint during Cytochrome c Oxidase Assembly.
Dennerlein S, Oeljeklaus S, Jans D, Hellwig C, Bareth B, Jakobs S, Deckers M, Warscheid B, Rehling P
Cell Rep, 2015; 12 (10) : 1644-1655
http://dx.doi.org/10.1016/j.celrep.2015.08.009
Differential tyrosine phosphorylation controls the function of CNK1 as a molecular switch in signal transduction.
Fischer A, Brummer T, Warscheid B, Radziwill G
Bba-mol Cell Res, 2015; 1853 (11 Pt A) : 2847-2855
http://dx.doi.org/10.1016/j.bbamcr.2015.08.014
Phytoene Desaturase from Oryza sativa: Oligomeric Assembly, Membrane Association and Preliminary 3D-Analysis.
Gemmecker S, Schaub P, Koschmieder J, Brausemann A, Drepper F, Rodriguez-Franco M, Ghisla S, Warscheid B, Einsle O, Beyer P
Plos One, 2015; 10 (7) : e0131717-e0131717
http://dx.doi.org/10.1371/journal.pone.0131717
Structural Insights into Cargo Recognition by the Yeast PTS1 Receptor.
Hagen S, Drepper F, Fischer S, Fodor K, Passon D, Platta HW, Zenn M, Schliebs W, Girzalsky W, Wilmanns M, Warscheid B, Erdmann R
J Biol Chem, 2015; 290 (44) : 26610-26626
http://dx.doi.org/10.1074/jbc.M115.657973
Redox-activation of the universally conserved ATPase YchF by thioredoxin 1.
Hannemann L, Suppanz I, Ba Q, MacInnes K, Drepper F, Warscheid B, Koch HG
Antioxid Redox Sign, 2015
http://dx.doi.org/10.1089/ars.2015.6272
Assembly of beta-barrel proteins in the mitochondrial outer membrane.
Hohr AI, Straub SP, Warscheid B, Becker T, Wiedemann N
Bba-mol Cell Res, 2015; 1853 (1) : 74-88
http://dx.doi.org/10.1016/j.bbamcr.2014.10.006
Role of membrane contact sites in protein import into mitochondria.
Horvath SE, Rampelt H, Oeljeklaus S, Warscheid B, van der Laan M, Pfanner N
Protein Sci, 2015; 24 (3) : 277-297
http://dx.doi.org/10.1002/pro.2625
p53-regulated networks of protein, mRNA, miRNA and lncRNA expression revealed by integrated pSILAC and NGS analyses.
Hunten S, Kaller M, Drepper F, Oeljeklaus S, Bonfert T, Erhard F, Dueck A, Eichner N, Friedel CC, Meister G, Zimmer R, Warscheid B, Hermeking H
Mol Cell Proteomics, 2015
http://dx.doi.org/10.1074/mcp.M115.050237
Ribosome binding induces repositioning of the signal recognition particle receptor on the translocon.
Kuhn P, Draycheva A, Vogt A, Petriman NA, Sturm L, Drepper F, Warscheid B, Wintermeyer W, Koch HG
J Cell Biol, 2015; 211 (1) : 91-104
http://dx.doi.org/10.1083/jcb.201502103
Mitochondrial protein import receptors in Kinetoplastids reveal convergent evolution over large phylogenetic distances.
Mani J, Desy S, Niemann M, Chanfon A, Oeljeklaus S, Pusnik M, Schmidt O, Gerbeth C, Meisinger C, Warscheid B, Schneider A
Nat Commun, 2015; 6: 6646-6646
http://dx.doi.org/10.1038/ncomms7646
YidC occupies the lateral gate of the SecYEG translocon and is sequentially displaced by a nascent membrane protein.
Sachelaru I, Petriman NA, Kudva R, Kuhn P, Welte T, Knapp B, Drepper F, Warscheid B, Koch HG
J Biol Chem, 2015; 290 (23) : 14492-14492
http://dx.doi.org/10.1074/jbc.A112.446583
Functional proteomics identifies acinus L as a direct insulin- and amino acid-dependent mammalian target of rapamycin complex 1 (mTORC1) substrate.
Schwarz JJ, Wiese H, Toelle RC, Zarei M, Dengjel J, Warscheid B, Thedieck K
Mol Cell Proteomics, 2015
http://dx.doi.org/10.1074/mcp.M114.045807
Structural insights into Ca2+-calmodulin regulation of Plectin 1a-integrin beta4 interaction in hemidesmosomes.
Song JG, Kostan J, Drepper F, Knapp B, de Almeida Ribeiro E Jr, Konarev PV, Grishkovskaya I, Wiche G, Gregor M, Svergun DI, Warscheid B, Djinovic-Carugo K
Structure, 2015; 23 (3) : 558-570
http://dx.doi.org/10.1016/j.str.2015.01.011
COA6 is a mitochondrial complex IV assembly factor critical for biogenesis of mtDNA-encoded COX2.
Stroud DA, Maher MJ, Lindau C, Vogtle FN, Frazier AE, Surgenor E, Mountford H, Singh AP, Bonas M, Oeljeklaus S, Warscheid B, Meisinger C, Thorburn DR, Ryan MT
Hum Mol Genet, 2015
http://dx.doi.org/10.1093/hmg/ddv265
Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol.
Wrobel L, Topf U, Bragoszewski P, Wiese S, Sztolsztener ME, Oeljeklaus S, Varabyova A, Lirski M, Chroscicki P, Mroczek S, Januszewicz E, Dziembowski A, Koblowska M, Warscheid B, Chacinska A
Nature, 2015; 524 (7566) : 485-488
http://dx.doi.org/10.1038/nature14951
2014
Identification of microRNA targets by pulsed SILAC.
Kaller M, Oeljeklaus S, Warscheid B, Hermeking H
Methods in Molecular Biology, 2014; 1188: 327-349
http://dx.doi.org/10.1007/978-1-4939-1142-4_23
The membrane proteome of sensory cilia to the depth of olfactory receptors.
Kuhlmann K, Tschapek A, Wiese H, Eisenacher M, Meyer HE, Hatt HH, Oeljeklaus S, Warscheid B
Mol Cell Proteomics, 2014; 13 (7) : 1828-1843
http://dx.doi.org/10.1074/mcp.M113.035378
The INA complex facilitates assembly of the peripheral stalk of the mitochondrial F1F0\uc0\u8208 ATP synthase.
Lytovchenko O, Naumenko N, Oeljeklaus S, Schmidt B, von der Malsburg K, Deckers M, Warscheid B, van der Laan M, Rehling P
Embo J, 2014; 33 (15) : 1624-1638
http://dx.doi.org/10.15252/embj.201488076
The Mitochondrial ADP/ATP Carrier Associates with the Inner Membrane Presequence Translocase in a Stoichiometric Manner.
Mehnert CS, Rampelt H, Gebert M, Oeljeklaus S, Schrempp SG, Kochbeck L, Guiard B, Warscheid B, van der Laan M
J Biol Chem, 2014; 289 (39) : 27352-27362
http://dx.doi.org/10.1074/jbc.M114.556498
SILAC labeling of yeast for the study of membrane protein complexes.
Oeljeklaus S, Schummer A, Suppanz I, Warscheid B
Methods Mol Biol, 2014; 1188: 23-46
http://dx.doi.org/10.1007/978-1-4939-1142-4_3
Trypanosomal TAC40 constitutes a novel subclass of mitochondrial beta-barrel proteins specialized in mitochondrial genome inheritance.
Schnarwiler F, Niemann M, Doiron N, Harsman A, Kaser S, Mani J, Chanfon A, Dewar CE, Oeljeklaus S, Jackson CB, Pusnik M, Schmidt O, Meisinger C, Hiller S, Warscheid B, Schnaufer AC, Ochsenreiter T, Schneider A
P Natl Acad Sci Usa, 2014; 111 (21) : 7624-7629
http://dx.doi.org/10.1073/pnas.1404854111
Quantitative phosphoproteomics reveals the protein tyrosine kinase Pyk2 as a central effector of olfactory receptor signaling in prostate cancer cells.
Wiese H, Gelis L, Wiese S, Reichenbach C, Jovancevic N, Osterloh M, Meyer HE, Neuhaus EM, Hatt HH, Radziwill G, Warscheid B
Bba-proteins Proteom, 2014
http://dx.doi.org/10.1016/j.bbapap.2014.09.002
Comparison of alternative MS/MS and bioinformatics approaches for confident phosphorylation site localization.
Wiese H, Kuhlmann K, Wiese S, Stoepel NS, Pawlas M, Meyer HE, Stephan C, Eisenacher M, Drepper F, Warscheid B
J Proteome Res, 2014; 13 (2) : 1128-1137
http://dx.doi.org/10.1021/pr400402s
2013
A complex of Cox4 and mitochondrial Hsp70 plays an important role in the assembly of the cytochrome c oxidase.
Bottinger L, Guiard B, Oeljeklaus S, Kulawiak B, Zufall N, Wiedemann N, Warscheid B, van der Laan M, Becker T
Mol Biol Cell, 2013; 24 (17) : 2609-2619
http://dx.doi.org/10.1091/mbc.E13-02-0106
Mitochondrial translation factors of Trypanosoma brucei: Elongation factor-Tu has a unique subdomain that is essential for its function.
Cristodero M, Mani J, Oeljeklaus S, Aeberhard L, Hashimi H, Ramrath DJ, Lukes J, Warscheid B, Schneider A
Mol Microbiol, 2013
http://dx.doi.org/10.1111/mmi.12397
A Combined Approach of Quantitative Interaction Proteomics and Live-cell Imaging Reveals a Regulatory Role for Endoplasmic Reticulum (ER) Reticulon Homology Proteins in Peroxisome Biogenesis.
David C, Koch J, Oeljeklaus S, Laernsack A, Melchior S, Wiese S, Schummer A, Erdmann R, Warscheid B, Brocard C
Mol Cell Proteomics, 2013; 12 (9) : 2408-2425
http://dx.doi.org/10.1074/mcp.M112.017830
Localization of Rab proteins to peroxisomes: a proteomics and immunofluorescence study.
Gronemeyer T, Wiese S, Grinhagens S, Schollenberger L, Satyagraha A, Huber LA, Meyer HE, Warscheid B, Just WW
Febs Lett, 2013; 587 (4) : 328-338
http://dx.doi.org/10.1016/j.febslet.2012.12.025
The proteome of human liver peroxisomes: identification of five new peroxisomal constituents by a label-free quantitative proteomics survey.
Gronemeyer T, Wiese S, Ofman R, Bunse C, Pawlas M, Hayen H, Eisenacher M, Stephan C, Meyer HE, Waterham HR, Erdmann R, Wanders RJ, Warscheid B
Plos One, 2013; 8 (2) : e57395-e57395
http://dx.doi.org/10.1371/journal.pone.0057395
Mitochondrial inner membrane protease promotes assembly of presequence translocase by removing a carboxy-terminal targeting sequence.
Ieva R, Heisswolf AK, Gebert M, Vogtle FN, Wollweber F, Mehnert CS, Oeljeklaus S, Warscheid B, Meisinger C, van der Laan M, Pfanner N
Nat Commun, 2013; 4: 2853-2853
http://dx.doi.org/10.1038/ncomms3853
A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins.
Jank T, Bogdanovic X, Wirth C, Haaf E, Spoerner M, Bohmer KE, Steinemann M, Orth JH, Kalbitzer HR, Warscheid B, Hunte C, Aktories K
Nat Struct Mol Biol, 2013; 20 (11) : 1273-1280
http://dx.doi.org/10.1038/nsmb.2688
Redox proteomics uncovers peroxynitrite-sensitive proteins that help Escherichia coli to overcome nitrosative stress.
Lindemann C, Lupilova N, Muller A, Warscheid B, Meyer HE, Kuhlmann K, Eisenacher M, Leichert LI
J Biol Chem, 2013; 288 (27) : 19698-19714
http://dx.doi.org/10.1074/jbc.M113.457556
Mitochondrial outer membrane proteome of Trypanosoma brucei reveals novel factors required to maintain mitochondrial morphology.
Niemann M, Wiese S, Mani J, Chanfon A, Jackson C, Meisinger C, Warscheid B, Schneider A
Mol Cell Proteomics, 2013; 12 (2) : 515-528
http://dx.doi.org/10.1074/mcp.M112.023093
Coupling of mitochondrial import and export translocases by receptor-mediated supercomplex formation.
Qiu J, Wenz LS, Zerbes RM, Oeljeklaus S, Bohnert M, Stroud DA, Wirth C, Ellenrieder L, Thornton N, Kutik S, Wiese S, Schulze-Specking A, Zufall N, Chacinska A, Guiard B, Hunte C, Warscheid B, van der Laan M, Pfanner N, Wiedemann N, Becker T
Cell, 2013; 154 (3) : 596-608
http://dx.doi.org/10.1016/j.cell.2013.06.033
YidC occupies the lateral gate of the SecYEG translocon and is sequentially displaced by a nascent membrane protein.
Sachelaru I, Petriman NA, Kudva R, Kuhn P, Welte T, Knapp B, Drepper F, Warscheid B, Koch HG
J Biol Chem, 2013; 288 (23) : 16295-16307
http://dx.doi.org/10.1074/jbc.M112.446583
Comparison of Alternative MS/MS and Bioinformatics Approaches for Confident Phosphorylation Site Localization.
Wiese H, Kuhlmann K, Wiese S, Stoepel NS, Pawlas M, Meyer HE, Stephan C, Eisenacher M, Drepper F, Warscheid B
J Proteome Res, 2013
http://dx.doi.org/10.1021/pr400402s
2012
Role of mitochondrial inner membrane organizing system in protein biogenesis of the mitochondrial outer membrane.
Bohnert M, Wenz LS, Zerbes RM, Horvath SE, Stroud DA, von der Malsburg K, Muller JM, Oeljeklaus S, Perschil I, Warscheid B, Chacinska A, Veenhuis M, van der Klei IJ, Daum G, Wiedemann N, Becker T, Pfanner N, van der Laan M
Mol Biol Cell, 2012; 23 (20) : 3948-3956
http://dx.doi.org/10.1091/mbc.E12-04-0295
Find pairs: the module for protein quantification of the PeakQuant software suite.
Eisenacher M, Kohl M, Wiese S, Hebeler R, Meyer HE, Warscheid B, Stephan C
Omics, 2012; 16 (9) : 457-467
http://dx.doi.org/10.1089/omi.2011.0140
Mgr2 promotes coupling of the mitochondrial presequence translocase to partner complexes.
Gebert M, Schrempp SG, Mehnert CS, Heisswolf AK, Oeljeklaus S, Ieva R, Bohnert M, von der Malsburg K, Wiese S, Kleinschroth T, Hunte C, Meyer HE, Haferkamp I, Guiard B, Warscheid B, Pfanner N, van der Laan M
J Cell Biol, 2012; 197 (5) : 595-604
http://dx.doi.org/10.1083/jcb.201110047
MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation.
Mick DU, Dennerlein S, Wiese H, Reinhold R, Pacheu-Grau D, Lorenzi I, Sasarman F, Weraarpachai W, Shoubridge EA, Warscheid B, Rehling P
Cell, 2012; 151 (7) : 1528-1541
http://dx.doi.org/10.1016/j.cell.2012.11.053
Identification of core components and transient interactors of the peroxisomal importomer by dual-track stable isotope labeling with amino acids in cell culture analysis.
Oeljeklaus S, Reinartz BS, Wolf J, Wiese S, Tonillo J, Podwojski K, Kuhlmann K, Stephan C, Meyer HE, Schliebs W, Brocard C, Erdmann R, Warscheid B
J Proteome Res, 2012; 11 (4) : 2567-2580
http://dx.doi.org/10.1021/pr3000333
SILAC for the study of mammalian cell lines and yeast protein complexes.
Piechura H, Oeljeklaus S, Warscheid B
Methods Mol Biol, 2012; 893: 201-221
http://dx.doi.org/10.1007/978-1-61779-885-6_14
New insights into myosin phosphorylation during cyclic nucleotide-mediated smooth muscle relaxation.
Puetz S, Schroeter MM, Piechura H, Reimann L, Hunger MS, Lubomirov LT, Metzler D, Warscheid B, Pfitzer G
J Muscle Res Cell M, 2012
http://dx.doi.org/10.1007/s10974-012-9306-9
An essential novel component of the noncanonical mitochondrial outer membrane protein import system of trypanosomatids.
Pusnik M, Mani J, Schmidt O, Niemann M, Oeljeklaus S, Schnarwiler F, Warscheid B, Lithgow T, Meisinger C, Schneider A
Mol Biol Cell, 2012; 23 (17) : 3420-3428
http://dx.doi.org/10.1091/mbc.E12-02-0107
Rcf1 mediates cytochrome oxidase assembly and respirasome formation, revealing heterogeneity of the enzyme complex.
Vukotic M, Oeljeklaus S, Wiese S, Vogtle FN, Meisinger C, Meyer HE, Zieseniss A, Katschinski DM, Jans DC, Jakobs S, Warscheid B, Rehling P, Deckers M
Cell Metab, 2012; 15 (3) : 336-347
http://dx.doi.org/10.1016/j.cmet.2012.01.016
Promiscuous targeting of polytopic membrane proteins to SecYEG or YidC by the Escherichia coli signal recognition particle.
Welte T, Kudva R, Kuhn P, Sturm L, Braig D, Muller M, Warscheid B, Drepper F, Koch HG
Mol Biol Cell, 2012; 23 (3) : 464-479
http://dx.doi.org/10.1091/mbc.E11-07-0590
A universally conserved GTPase regulates the oxidative stress response in Escherichia coli.
Wenk M, Ba Q, Erichsen V, Macinnes K, Wiese H, Warscheid B, Koch HG
J Biol Chem, 2012
http://dx.doi.org/10.1074/jbc.M112.413070
Comparative profiling of the peroxisomal proteome of wildtype and Pex7 knockout mice by quantitative mass spectrometry.
Wiese S, Gronemeyer T, Brites P, Ofman R, Bunse Ch, Renz Ch, MeyerH E, Wanders R J A, Warscheid B
Int J Mass Spectrom, 2012; 312: 30-40
http://dx.doi.org/10.1016/j.ijms.2011.09.005
Role of MINOS in mitochondrial membrane architecture: cristae morphology and outer membrane interactions differentially depend on mitofilin domains.
Zerbes RM, Bohnert M, Stroud DA, von der Malsburg K, Kram A, Oeljeklaus S, Warscheid B, Becker T, Wiedemann N, Veenhuis M, van der Klei IJ, Pfanner N, van der Laan M
J Mol Biol, 2012; 422 (2) : 183-191
http://dx.doi.org/10.1016/j.jmb.2012.05.004
2011
PEX14 is required for microtubule-based peroxisome motility in human cells.
Bharti P, Schliebs W, Schievelbusch T, Neuhaus A, David C, Kock K, Herrmann C, Meyer HE, Wiese S, Warscheid B, Theiss C, Erdmann R
J Cell Sci, 2011; 124 (Pt 10) : 1759-1768
http://dx.doi.org/10.1242/jcs.079368
Ubp15p, a ubiquitin hydrolase associated with the peroxisomal export machinery.
Debelyy MO, Platta HW, Saffian D, Hensel A, Thoms S, Meyer HE, Warscheid B, Girzalsky W, Erdmann R
J Biol Chem, 2011; 286 (32) : 28223-28234
http://dx.doi.org/10.1074/jbc.M111.238600
Dual function of Sdh3 in the respiratory chain and TIM22 protein translocase of the mitochondrial inner membrane.
Gebert N, Gebert M, Oeljeklaus S, von der Malsburg K, Stroud DA, Kulawiak B, Wirth C, Zahedi RP, Dolezal P, Wiese S, Simon O, Schulze-Specking A, Truscott KN, Sickmann A, Rehling P, Guiard B, Hunte C, Warscheid B, van der Laan M, Pfanner N, Wiedemann N
Mol Cell, 2011; 44 (5) : 811-818
http://dx.doi.org/10.1016/j.molcel.2011.09.025
Genome-wide characterization of miR-34a induced changes in protein and mRNA expression by a combined pulsed SILAC and microarray analysis.
Kaller M, Liffers ST, Oeljeklaus S, Kuhlmann K, Roh S, Hoffmann R, Warscheid B, Hermeking H
Mol Cell Proteomics, 2011; 10 (8) : M111.010462-M111.010462
http://dx.doi.org/10.1074/mcp.M111.010462
Cytoscape: software for visualization and analysis of biological networks.
Kohl M, Wiese S, Warscheid B
Methods Mol Biol, 2011; 696: 291-303
http://dx.doi.org/10.1007/978-1-60761-987-1_18
The bacterial SRP receptor, SecA and the ribosome use overlapping binding sites on the SecY translocon.
Kuhn P, Weiche B, Sturm L, Sommer E, Drepper F, Warscheid B, Sourjik V, Koch HG
Traffic, 2011; 12 (5) : 563-578
http://dx.doi.org/10.1111/j.1600-0854.2011.01167.x
Mitochondrial preprotein translocase of trypanosomatids has a bacterial origin.
Pusnik M, Schmidt O, Perry AJ, Oeljeklaus S, Niemann M, Warscheid B, Lithgow T, Meisinger C, Schneider A
Curr Biol, 2011; 21 (20) : 1738-1743
http://dx.doi.org/10.1016/j.cub.2011.08.060
Composition and topology of the endoplasmic reticulum-mitochondria encounter structure.
Stroud DA, Oeljeklaus S, Wiese S, Bohnert M, Lewandrowski U, Sickmann A, Guiard B, van der Laan M, Warscheid B, Wiedemann N
J Mol Biol, 2011; 413 (4) : 743-750
http://dx.doi.org/10.1016/j.jmb.2011.09.012
Welte, T., Kudva, R., Kuhn, P., Sturm, L., Braig, D., Müller, M., Warscheid, B., Drepper, F., Koch, H.-G.
Promiscuous targeting of polytopic membrane proteins to SecYEG or YidC by the Escherichia coli signal recognition particle
Mol Biol Cell, 2011; 23 (3) : 464-79
https://doi.org/10.1091/mbc.e11-07-0590
Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis.
von der Malsburg K, Muller JM, Bohnert M, Oeljeklaus S, Kwiatkowska P, Becker T, Loniewska-Lwowska A, Wiese S, Rao S, Milenkovic D, Hutu DP, Zerbes RM, Schulze-Specking A, Meyer HE, Martinou JC, Rospert S, Rehling P, Meisinger C, Veenhuis M, Warscheid B, van der Klei IJ, Pfanner N, Chacinska A, van der Laan M
Dev Cell, 2011; 21 (4) : 694-707
http://dx.doi.org/10.1016/j.devcel.2011.08.026
2010
Structure and function of intact photosystem 1 monomers from the cyanobacterium Thermosynechococcus elongatus.
El-Mohsnawy E, Kopczak MJ, Schlodder E, Nowaczyk M, Meyer HE, Warscheid B, Karapetyan NV, Rogner M
Biochemistry-us, 2010; 49 (23) : 4740-4751
http://dx.doi.org/10.1021/bi901807p
Immunoscreening of the extracellular proteome of colorectal cancer cells.
Klein-Scory S, Kubler S, Diehl H, Eilert-Micus C, Reinacher-Schick A, Stuhler K, Warscheid B, Meyer HE, Schmiegel W, Schwarte-Waldhoff I
Bmc Cancer, 2010; 10: 70-70
http://dx.doi.org/10.1186/1471-2407-10-70
A proteomic approach towards the identification of the matrix protein content of the two types of microbodies in Neurospora crassa.
Managadze D, Wurtz C, Wiese S, Meyer HE, Niehaus G, Erdmann R, Warscheid B, Rottensteiner H
Proteomics, 2010; 10 (18) : 3222-3234
http://dx.doi.org/10.1002/pmic.201000095
Identification of PEX33, a novel component of the peroxisomal docking complex in the filamentous fungus Neurospora crassa.
Managadze D, Wurtz C, Wiese S, Schneider M, Girzalsky W, Meyer HE, Erdmann R, Warscheid B, Rottensteiner H
Eur J Cell Biol, 2010; 89 (12) : 955-964
http://dx.doi.org/10.1016/j.ejcb.2010.07.003
A salivary serine protease of the haematophagous reduviid Panstrongylus megistus: sequence characterization, expression pattern and characterization of proteolytic activity.
Meiser CK, Piechura H, Meyer HE, Warscheid B, Schaub GA, Balczun C
Insect Mol Biol, 2010; 19 (3) : 409-421
http://dx.doi.org/10.1111/j.1365-2583.2010.01002.x
Kazal-type inhibitors in the stomach of Panstrongylus megistus (Triatominae, Reduviidae).
Meiser CK, Piechura H, Werner T, Dittmeyer-Schafer S, Meyer HE, Warscheid B, Schaub GA, Balczun C
Insect Biochem Molec, 2010; 40 (4) : 345-353
http://dx.doi.org/10.1016/j.ibmb.2010.02.011
Coa3 and Cox14 are essential for negative feedback regulation of COX1 translation in mitochondria.
Mick DU, Vukotic M, Piechura H, Meyer HE, Warscheid B, Deckers M, Rehling P
J Cell Biol, 2010; 191 (1) : 141-154
http://dx.doi.org/10.1083/jcb.201007026
Tmem16b is a calcium-gated chloride channel specifically expressed in the cilia of olfactory sensory neurons
Rasche, S., Toetter, B., Adler, J., Doerner, J.F., Tschapek, A., Kurtenbach, S., Hatt, H., Meyer, H.E., Warscheid, B., Neuhaus, E.M.
Chem Senses, 2010; 35 (3) : 239-245
https://doi.org/10.1093/chemse/bjq007
Top-down de Novo protein sequencing of a 13.6 kDa camelid single heavy chain antibody by matrix-assisted laser desorption ionization-time-of-flight/time-of-flight mass spectrometry.
Resemann A, Wunderlich D, Rothbauer U, Warscheid B, Leonhardt H, Fuchser J, Kuhlmann K, Suckau D
Anal Chem, 2010; 82 (8) : 3283-3292
http://dx.doi.org/10.1021/ac1000515
RhoA regulates peroxisome association to microtubules and the actin cytoskeleton.
Schollenberger L, Gronemeyer T, Huber CM, Lay D, Wiese S, Meyer HE, Warscheid B, Saffrich R, Peranen J, Gorgas K, Just WW
Plos One, 2010; 5 (11) : e13886-e13886
http://dx.doi.org/10.1371/journal.pone.0013886
Uncoupled responses of Smad4-deficient cancer cells to TNFalpha result in secretion of monomeric laminin-gamma2.
Zboralski D, Warscheid B, Klein-Scory S, Malas MB, Becker H, Bockmann M, Meyer HE, Schmiegel W, Simon-Assmann P, Schwarte-Waldhoff I
Mol Cancer, 2010; 9 (1) : 65-65
http://dx.doi.org/10.1186/1476-4598-9-65
Reviews
Mitochondrial proteins: from biogenesis to functional networks.
Pfanner N, Warscheid B, Wiedemann N
Nat Rev Mol Cell Bio, 2019
http://dx.doi.org/10.1038/s41580-018-0092-0
