Bioinformatics | Small Non-coding RNAs

Research

My main subject of research are small non-coding RNAs.

In a current project I am studying the impact of piwi-interacting RNAs (piRNAs) on genome expansion in different lungfish species. Further I am interested in the involvement of piRNAs and miRNAs in the development of cancer. Another aspect of my research comprises genome-wide selection analyses to identify genes that might potentially be relevant for the adaptation to environmental conditions.

Keywords are the statistical and bioinformatical analysis of high throughput sequencing data, small non-coding RNAs, genome-wide selection analyses and the analysis of data resulting from different sequencing techniques from genomic as well as transcriptomic samples.

Short CV

2011- Research Associate
Department of Biochemistry and Cell Biology, JMU Würzburg
2000-2011 Head of Laboratory
for microarray-applications and bioinformatical analyses of high-throughput methods, Interdisziplinäres  Zentrum für Klinische Forschung (IZKF), JMU Würzburg
1997-2000 PostDoc
Laboratory of Prof. R. Kucherlapatis, Department of Molecular Genetics, Albert Einstein College of Medicine, New York, USA
1995-1996

Reasearch Assistant
Laboratory for Image Analysis, Institute of Virology, JMU Würzburg
1993-1995

PhD Student
Laboratory for Image Analysis, Institute of Virology, JMU Würzburg
1984-1990

Student of Veterinary Medicine
Ludwig-Maximilians University of Munich

Selected Publications

Schartl et al  

 
The genomes of all lungfish inform on genome expansion and tetrapod evolution
 

Nature (2024)

Fetiva et al

Oncogenic YAP mediates changes in chromatin accessibility and activity that drive cell cycle gene expression and cell migration
 

Nucleic Acid Resarch (2023)

Lu et al  

High resolution genomes of multiple Xiphophorus species provide new insights into microevolution, hybrid incompatibility, and epistasis

Genome Research (2023)

Meyer et al  

 
Giant lungfish genome elucidates the conquest of land by vertebrates
 

Nature (2021)

Du et al

 
The sterlet sturgeon genome sequence and the mechanisms of segmental rediploidization
 

Nat Ecol Evol (2020)

Jessen et al

The transcription factor NRF2 enhances melanoma malignancy by blocking differentiation and inducing COX2 expression
 

Oncogene (2020)

Kneitz et al

 
Germ cell and tumor associated piRNAs in the medaka and Xiphophorus melanoma models
 

BMC Genomics (2016)

 

 
Complete
Publication list