AG Burger
Biocenter of the University of Würzburg
Department of Biochemistry & Molecular Biology
Am Hubland
97074 Würzburg
RNA metabolism in health and disease
Research synopsis
We are interested in RNA metabolic events that modulate the stability of the human genome in crosstalk with the DNA damage response. In particular, we aim to understand how the DNA damage response engages RNA metabolic hubs and nuclear bodies in DNA repair. We focus our investigations on RNA-binding proteins and long non-coding transcripts to elucidate RNA-dependent pathways that promote genomic stability in healthy cells and drive tumorigenesis upon deregulation.
Recent publications
Burger K, Schlackow M, Gullerova M (2019). Tyrosine kinase c-Abl couples RNA polymerase II transcription to DNA double-strand breaks. Nucleic Acids Res 47(7):3467-3484. doi: 10.1093/nar/gkz024.
Burger K, Gullerova M (2018). Nuclear re-localization of Dicer in primary mouse embryonic fibroblast nuclei following DNA damage.PLoS Genet 14(2):e1007151. doi: 10.1371/journal.pgen.1007151
Burger K, Schlackow M, Potts M, Hester S, Mohammed S, Gullerova M (2017). Nuclear phosphorylated Dicer processes double-stranded RNA in response to DNA damage. J Cell Biol 216(8):2373-2389. doi: 10.1083/jcb.201612131
Research topics
Structure and function of paraspeckles in health and disease
The role of RNA-binding proteins in genome maintenance
People
Kaspar Burger

Barbara Trifault

Victoria Mamontova

Lea Boten
