Biocenter of the University of Würzburg
Department of Biochemistry & Molecular Biology
RNA metabolism in health and disease
We are interested in RNA metabolic events that modulate the stability of the human genome in crosstalk with the DNA damage response. In particular, we aim to understand how the DNA damage response engages RNA metabolic hubs and nuclear bodies in DNA repair. We focus our investigations on RNA-binding proteins and long non-coding transcripts to elucidate RNA-dependent pathways that promote genomic stability in healthy cells and drive tumorigenesis upon deregulation.
In vivo Proximity Labeling of Nuclear and Nucleolar Proteins by a Stably Expressed, DNA Damage-Responsive NONO-APEX2 Fusion Protein. Trifault B, Mamontova V, Burger K. Front Mol Biosci. 2022 Jun 6;9:914873. doi: 10.3389/fmolb.2022.914873.
Compartment-Specific Proximity Ligation Expands the Toolbox to Assess the Interactome of the Long Non-Coding RNA NEAT1. Mamontova V, Trifault B, Burger K. Int J Mol Sci. 2022 Apr 17;23(8):4432. doi: 10.3390/ijms23084432. Review.
Commuting to Work: Nucleolar Long Non-Coding RNA Control Ribosome Biogenesis from Near and Far. Mamontova V, Trifault B, Boten L, Burger K. Non-coding RNA. 2021 Jul 14;7(3):42. doi: 10.3390/ncrna7030042. Review.
Burger K, Schlackow M, Gullerova M (2019). Tyrosine kinase c-Abl couples RNA polymerase II transcription to DNA double-strand breaks. Nucleic Acids Res 47(7):3467-3484. doi: 10.1093/nar/gkz024.
Burger K, Gullerova M (2018). Nuclear re-localization of Dicer in primary mouse embryonic fibroblast nuclei following DNA damage.PLoS Genet 14(2):e1007151. doi: 10.1371/journal.pgen.1007151
Burger K, Schlackow M, Potts M, Hester S, Mohammed S, Gullerova M (2017). Nuclear phosphorylated Dicer processes double-stranded RNA in response to DNA damage. J Cell Biol 216(8):2373-2389. doi: 10.1083/jcb.201612131