Lehrstuhl für Biochemie und Molekularbiologie
Tel: 0931 31-89369
Fax: 0931 31-84113
Colorectal cancer (CRC) is the most common gastrointestinal malignancy. There are approximately 664,000 new cases each year worldwide. Half of these patients will die from this carcinoma. Currently, standard treatment is primary surgery and depending on the tumour stage, additional chemotherapy. Due to the high recurrence rate, new potential targets and prognostic markers are needed to identify patients that are likely to benefit from additional therapy.
Define components that are in a synthetic lethal relationship to mutation or loss of the tumor suppressor APC
Dissect the posttranscriptional regulation of c-Myc in CRC
Schmidt, S., Gay, D., Uthe, F.W. et al. A MYC–GCN2–eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer. Nat Cell Biol (2019) doi:10.1038/s41556-019-0408-0
The impact of pulmonary metastasectomy in patients with previously resected colorectal cancer liver metastases.
Wiegering A, Riegel J, Wagner J, Kunzmann V, Baur J, Walles T, Dietz U, Loeb S, Germer CT, Steger U, Klein I.
PLoS One. 2017 Mar 22;12(3):e0173933. doi: 10.1371/journal.pone.0173933. eCollection 2017 Mar 22.