Chair of Biochemistry and Molecular Biology

    AG Wiegering

    PD Dr. Armin Wiegering

    Lehrstuhl für Biochemie und Molekularbiologie
    Am Hubland
    97074 Würzburg

    Tel:   0931 31-89369
    Fax:  0931 31-84113


    Colorectal cancer (CRC) is the most common gastrointestinal malignancy. There are approximately 664,000 new cases each year worldwide. Half of these patients will die from this carcinoma. Currently, standard treatment is primary surgery and depending on the tumour stage, additional chemotherapy. Due to the high recurrence rate, new potential targets and prognostic markers are needed to identify patients that are likely to benefit from additional therapy.


    Define components that are in a synthetic lethal relationship to mutation or loss of the tumor suppressor APC

    Dissect the posttranscriptional regulation of c-Myc in CRC



    Schmidt, S., Gay, D., Uthe, F.W. et al. A MYC–GCN2–eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer. Nat Cell Biol (2019) doi:10.1038/s41556-019-0408-0

    The impact of pulmonary metastasectomy in patients with previously resected colorectal cancer liver metastases.
    Wiegering A, Riegel J, Wagner J, Kunzmann V, Baur J, Walles T, Dietz U, Loeb S, Germer CT, Steger U, Klein I.
    PLoS One. 2017 Mar 22;12(3):e0173933. doi: 10.1371/journal.pone.0173933. eCollection 2017 Mar 22.

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    Link to all Publications on PubMed