AG Wiegering
PD Dr. Armin Wiegering
Lehrstuhl für Biochemie und Molekularbiologie
Biozentrum
Am Hubland
97074 Würzburg
Tel: 0931 31-89369
Fax: 0931 31-84113
wiegering_a@ukw.de
Colorectal cancer (CRC) is the most common gastrointestinal malignancy. There are approximately 664,000 new cases each year worldwide. Half of these patients will die from this carcinoma. Currently, standard treatment is primary surgery and depending on the tumour stage, additional chemotherapy. Due to the high recurrence rate, new potential targets and prognostic markers are needed to identify patients that are likely to benefit from additional therapy.
Research
Define components that are in a synthetic lethal relationship to mutation or loss of the tumor suppressor APC
Dissect the posttranscriptional regulation of c-Myc in CRC
Publications
Latest:
Schmidt, S., Gay, D., Uthe, F.W. et al. A MYC–GCN2–eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer. Nat Cell Biol (2019) doi:10.1038/s41556-019-0408-0
https://www.nature.com/articles/s41556-019-0408-0
The impact of pulmonary metastasectomy in patients with previously resected colorectal cancer liver metastases.
Wiegering A, Riegel J, Wagner J, Kunzmann V, Baur J, Walles T, Dietz U, Loeb S, Germer CT, Steger U, Klein I.
PLoS One. 2017 Mar 22;12(3):e0173933. doi: 10.1371/journal.pone.0173933. eCollection 2017 Mar 22.
