piwik-script

    Chair of Biochemistry and Molecular Biology

    AG Wiegering

    Prof. Dr. Armin Wiegering

    Lehrstuhl für Biochemie und Molekularbiologie
    Biozentrum
    Am Hubland
    97074 Würzburg

    Tel:   0931 31-89369
    Fax:  0931 31-84113

    wiegering_a@ukw.de

    Colorectal cancer (CRC) is the most common gastrointestinal malignancy. Currently, standard treatment is primary surgery and, depending on the tumor stage, additional chemotherapy. Due to the high recurrence rate vulnerabilities and prognostic markers specific for CRC need to be identified. One of those potential targets is the process of mRNA translation which is highly deregulated in many tumor entities including CRC. Therefore, tumors show different dependencies on translation factors, ribosomal proteins and rRNAs. Our group aims at investigating and exploiting these dependencies to identify new tumor-specific therapeutic options for CRC.

    Research

    Current projects:

    1. Role of the MYC IRES for intestinal homeostasis and colorectal tumorigenesis

    2. The eIF2/eIF2B complex as potential therapeutic target in CRC

    3. Mechanism of action of the cardiac glycoside cymarine in CRC

    4. Role of the EWS/WT1 fusion protein in desmoplastic small round cell tumor (DSRCT)

    5. Identification of essential translation factors in CRC using CRISPR screens in intestinal organoids

    6. Role of mRNA processing factors in transcription-replication conflicts in CRC

    Publications

    Latest:

    Kastner, C., Hendricks, A., Deinlein, H., Hankir, M., Germer, C. T., Schmidt, S., & Wiegering, A. (2021). Organoid Models for Cancer Research-From Bed to Bench Side and Back. Cancers13(19), 4812. https://doi.org/10.3390/cancers13194812

    Denk, S., Schmidt, S., Schurr, Y., Schwarz, G., Schote, F., Diefenbacher, M., Armendariz, C., Dejure, F., Eilers, M., & Wiegering, A. (2021). CIP2A regulates MYC translation (via its 5'UTR) in colorectal cancer. International journal of colorectal disease36(5), 911–918. https://doi.org/10.1007/s00384-020-03772-y

    Schmidt, S., Denk, S., & Wiegering, A. (2020). Targeting Protein Synthesis in Colorectal Cancer. Cancers12(5), 1298. https://doi.org/10.3390/cancers12051298

    Schmidt, S., Gay, D., Uthe, F. W., Denk, S., Paauwe, M., Matthes, N., Diefenbacher, M. E., Bryson, S., Warrander, F. C., Erhard, F., Ade, C. P., Baluapuri, A., Walz, S., Jackstadt, R., Ford, C., Vlachogiannis, G., Valeri, N., Otto, C., Schülein-Völk, C., Maurus, K., … Wiegering, A. (2019). A MYC-GCN2-eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer. Nature cell biology21(11), 1413–1424. https://doi.org/10.1038/s41556-019-0408-0