Publications
2020
Adhikari B, Bozilovic J, Diebold M,Schwarz JD, Hofstetter J, Schröder M, Wanior M, Narain A, Vogt M, DudvarskiStankovic N, Baluapuri A, Schönemann L, Eing L, Bhandare P, Kuster B, SchlosserA, Heinzlmeir S, Sotriffer C, Knapp S* WolfE*, PROTAC-mediated degradation reveals a non-catalytic function ofAURORA-A kinase, Nature Chemical Biology, 2020, https://www.nature.com/articles/s41589-020-00652-y
Wolpaw AJ, Bayliss R, Büchel G, Dang CV, Eilers M, Gustafson WC, Hansen GM, Jura N, Knapp S, Lemmon MA, Levens D, Maris JM, Marmorstein R, Metallo SJ, Park JR, Penn LZ, Rape M, Roussel MF, Shokat KM, Tansey WP, Verba KA, Vos SM, Weiss WA, Wolf E, Mossé YP (2021) Drugging the 'undruggable' MYCN oncogenic transcription factor: Overcoming previous obstacles to impact childhood cancers, Cancer Research, doi: 10.1158/0008-5472.CAN-20-3108
Endres T, Solvie D, Heidelberger J ,Andrioletti V ,Baluapuri A ,Ade CP, Muhar M, Eilers U, Vos SM, Cramer P, Zuber J, Beli P, Popov N, Wolf E, Gallant P, Eilers M: Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters, Molecular Cell, in press
Fröschel C, Komorek J, Attard A, Marsell A, Lopez-Arboleda WA, Le Berre J, Wolf E, Geldner N, Waller F, Korte A, Dröge-Laser W. Plant roots employ cell-layer-specific programs to respond to pathogenic and beneficial microbes, Cell Host Microbe, in press
Jessen C, Kreß JKC, Baluapuri A, Hufnagel A, Schmitz W,Kneitz S, Roth S, Marquardt A, Appenzeller S, Ade CP, Glutsch V, Wobser M,Friedmann-Angeli JP, Mosteo L, Goding CR, Schilling B, Geissinger E, Wolf E, Meierjohann S, The transcriptionfactor NRF2 enhances melanoma malignancy by blocking differentiation andinducing COX2 expression, Oncogene, 2020, doi:10.1038/s41388-020-01477-8
Rajeeve K, Vollmuth N, Janaki-Raman S, Wulff TF, Baluapuri A, Dejure FR, Huber C, Fink J, Schmalhofer M, Schmitz W, Sivadasan R, Wolf E, Eisenreich W, Schulze A, Seibel J, Rudel T: Reprogramming of host glutamine metabolism during Chlamydia trachomatis infection and its key role in peptidoglycan synthesis. Nature Microbiology, 2020, doi: 10.1038/s41564-020-0762-5
Wolf E and Eilers M: Targeting MYC Proteins for Tumor Therapy, Annual Review of Cancer Biology, 2020, 4
Baluapuri, A., Wolf, E., Eilers, M. (2020) Target gene-independent functions of Myc oncoproteins. Nature Reviews Molecular Cell Biology, 2020
Cossa, G., Roeschert, I., Prinz, F., Baluapuri, A., R.S., V., Schülein-Völk, C., Chang, Y.-C., Ade, C. P., Mastrobuoni, G., Girard, C., Wortmann, L., Walz, S., Lührmann, R., Kempa, S., Kuster, B., Wolf, E., Mumberg, D., Eilers, M. (2020) Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription. Molecular Cell, 2020
2019
Baluapuri A*, Hofstetter J*, Dudvarski Stankovic N, Endres T, Bhandare P, Vos SM, Adhikari B, Schwarz JD, Narain A, Vogt M, Wang S-Y, Düster R, Jung LA, Vanselow JT, Wiegering A, Geyer M, Maric HM, Gallant P, Walz S, Schlosser A, Cramer P, Eilers M, Wolf E: MYC recruits SPT5 to RNA polymerase II to promote processive transcription elongation, Molecular Cell, 2019, 74, https://doi.org/10.1016/j.molcel.2019.02.031 *joined first authors
Schmidt S, Gay D, Uthe FW … Wolf E, Strathdee D, Schulze A, Germer CT, Rosenwald A, Sansom OJ, Eilers M, Wiegering A: A MYC–GCN2–eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer, Nature Cell Biology, (2019, doi:10.1038/s41556-019-0408-0
Herold S*, Kalb J*, Büchel G*,Ade CP, Baluapuri A, Xu J, Koster J, Solvie D, Carstensen A, Klotz C, Rodewald S, Schülein-Völk C,Dobbelstein M, Wolf E, Molenaar J, Versteeg R,Walz S, Eilers M: Recruitment of BRCA1 limits MYCN-driven accumulation of stalled RNA polymerase, Nature, 2019, 567
Dammert MA, Brägelmann J, Olsen RR, Böhm S, Monhasery N, Whitney CP, Chalishazar MD, Tumbrink HL, Guthrie MR, Klein S, Ireland AS, Ryan J, Schmitt A, Marx A, Ozretic L, Castiglione R, Lorenz C, Jachimowicz RD, Wolf E, Thomas RK, Poirier JT, Büttner R, Sen T, Byers LA, Reinhardt HC, Letai A, Oliver TG, Sos ML: MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer, Nature Communications,2019, 10, doi: 10.1038/s41467-019-11371-x.
Annunziata I, van de Vlekkert D, Wolf E, Finkelstein D, Neale G, Machado E, Mosca R, Campos Y, Tillman H, Roussel MF, Andrew Weesner J, Ellen Fremuth L, Qiu X, Han MJ, Grosveld GC, d'Azzo A, MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat. Nature Communications, 2019, 10, doi: 10.1038/s41467-019-11568-0.
Pattschull G, Walz S, Gründl M, Schwab M, Rühl E, Baluapuri A, Cindric-Vranesic A, Kneitz S, Wolf E, Ade CP, Rosenwald A, von Eyss B, Gaubatz S: The Myb-MuvB Complex Is Required for YAP-Dependent Transcription of Mitotic Genes. Cell Reports, 2019, 27
Targeting bromodomain-containing protein 4 (BRD4) inhibits MYC expression in colorectal cancer cells. Neoplasia, 2019 (11):1110-1120
2018
Pedrotti L, Weiste C, Nägele T, Wolf E, Lorenzin F, DietrichK, Mair A, Weckwerth W, Teige M, Baena-González E, Dröge-Laser W (2018) Snf1-RELATEDKINASE1-Controlled C/S1-bZIP Signaling Activates Alternative MitochondrialMetabolic Pathways to Ensure Plant Survival in Extended Darkness. The Plant Cell
2017
Büchel, G., Carstensen, A., Mak, K.Y., Roeschert, I., Leen, E., Sumara, O., Hofstetter, J., Herold, S., Kalb, J., Baluapuri, A., Poon, E., Kwok, C., Chesler, L., Maric H. M., Rickman, D. S., Wolf, E., Bayliss, R., Walz, S., Eilers, M. Association with Aurora-A controls N-MYC-dependent promoter escape and pause release of RNA polymerase II during cell cycle (2017). Cell Reports in press
Gerlach J. M., Furrer M., Gallant M., Birkel D., Baluapuri A., Wolf E. and Gallant P. (2017) PAF1 complex component Leo1 helps recruit Drosophila Myc to promoters, PNAS doi: 10.1073/pnas.1705816114
Dejure, F.R., Royla, N., Herold, S., Kalb, J., Walz, S., Ade, C.P., Mastrobuoni, G., Vanselow, J., Schlosser, A., Wolf, E., Kempa, S., and Eilers, M. (2017) The 3’-UTR of MYC couples RNA polymerase II function to ribonucleotide levels. EMBO J, Apr 13 doi:10.15252/embj.201796662. [Epub ahead of print]
Stopp S, Gründl M, Fackler M, Malkmus J, Leone M, Naumann R, Frantz S, Wolf E, von Eyss B, Engel FB, Gaubatz S., Deletion of Gas2l3 in mice leads to specific defects in cardiomyocyte cytokinesis during development, PNAS, 2017; 114(30): 8029-8034.
2016
Lorenzin F, Benary U, Baluapuri A, Walz S, Jung LA, von Eyss B, Kisker C, Wolf J, Eilers M, Wolf E, Different promoter affinities account for specificity in MYC-dependent gene regulation, eLife, 2016, e15161
Vo BT*, Wolf E*, Kawauchi D, Gebhardt A, Rehg JE, Finkelstein D, Walz S, Murphy BL, Youn YH, Han YG, Eilers M*, Roussel MF*, The interaction of Myc with Miz1 defines medulloblastoma subgroup identity, Cancer Cell, 2016, 29, 5-16 *joined first and senior authors
Jung L A, Gebhardt A, Koelmel W, Ade CP, Walz S, Kuper J, von Eyss B, Letschert S, Redel C, d'Artista L, Biankin A, Zender L, Sauer M, Wolf E, Evan G, Kisker C, Eilers M, OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors, Oncogene, 2016
King B, Boccalatte F, Moran-Crusio K, Wolf E, Wang J, Kayembe C, Lazaris C, Yu X, Aranda-Orgilles B, Lasorella A, Aifantis I, The ubiquitin ligase Huwe1 regulates the maintenance and lymphoid commitment of hematopoietic stem cells, Nature Immunology, 2016; 17
Jaenicke LA, von Eyss B, Carstensen A, Wolf E, Xu W, Greifenberg A, Geyer M, Eilers M, and Popov N (2016). Ubiquitin-dependent turnover of MYC antagonizes MYC/PAF1C complex accumulation to drive transcriptional elongation. Mol Cell, 2016 Jan 7;61(1):54-67. doi: 10.1016/j.molcel.2015.11.007. Epub 2015 Dec 10.
2015
Küspert M, Murakawa Y, Schäffler K, Vanselow JT, Wolf E, Juranek S, Schlosser A, Landthaler M, Fischer U, LARP4B i an AU-rich sequence associated factor that promotes mRNA accumulation and translagtion, RNA, 2015
Herter EK, Stauch M, Gallant M, Wolf E, Raabe T, Gallant P,snoRNAs are a novel class of biologically relevant Myc targets, BMC Biology, 2015, 13
Wiese KE, Haikala HM, von Eyss B, Wolf E, Esnault C, Rosenwald A, Treismann R, Klefström J, Eilers M: Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cells, EMBO J, 2015
Wolf E, Lin CY, Eilers E, Levens DL, Taming of the beast: Shaping Myc-dependent amplification, Trends in Cell Biology, 2015, 25
Weber D, Heisig J, Kneitz S, Wolf E, Eilers M, Gessler M: Mechanisms of epigenetic and cell-type specific regulation of Hey target genes in ES cells and cardiomyocytes, Journal of Molecular and Cellular Cardiology, 2015, 79, 79-88
Elkon R, Loayza-Puch F, Korkmaz G, Lopes R, van Breugel PC, Bleijerveld OB, Altelaar AF, Wolf E, Lorenzin F, Eilers M, Agami R. EMBO reports. 2015; 16(12):1723-36.
2014
Schülein-Völk C, Wolf E, Zhu J, Xu W, Taranets L, Hellmann A, Diefenbacher M, Behrens A, Eilers M, Popov N: Dual regulation of Fbw7 function and oncogenic transformation by Usp28, Cell Reports, 2014, 9, 1099-1109
Muthalagu N, Junttila MR, Wiese KE, Wolf E, Morton J, Bauer B, Evan GI, Eilers M, Murphy DJ: BIM Is the Primary Mediator of MYC-Induced Apoptosis in Multiple Solid Tissues, Cell Reports, 2014, 8, 1347-1353
Walz S, Lorenzin F, Morton J, Wiese KE, von Eyss B, Herold S, Rycak L, Dumay-Odelot H, Karim S, Bartkuhn M, Roels F, Wuestefeld T, Fischer M, Teichmann M, Zender L, Wei CL, Sansom O, Wolf E*, Eilers M*: Activation and repression by oncogenic Myc shape tumour-specific gene expression profiles, Nature, 2014, 511, 483-487 *these authors contributed equally , shared senior-authorship
Baumgart S, Chen NM, Siveke JT, Koenig A, Zhang JS, Singh SK, Wolf E, Bartkuhn M, Esposito I, Heßmann E, Reinecke J, Nikorowitsch J, Brunner M, Singh G, Fernandez-Zapico ME, Smyrk T, Bamlet WR, Eilers M, Neesse A, Gress TM, Billadeau DD, Tuveson DA, Urrutia R, Ellenrieder V: Inflammation induced NFATc1-STAT3 Transcription Complex Promotes Pancreatic Cancer initiation by KrasG12D, Cancer Discovery, 2014, 4, 688-701
Sanz-Moreno A, Fuhrmann D, Wolf E, von Eyss B, Eilers M, Elsässer HP: Miz1 deficiency in the mammary gland causes a lactation defect by attenuated stat5 expression and phosphorylation, PLos One, 2014, 9, e89187
2013
Wiese KE, Walz S, von Eyss B, Wolf E, Athineos D, Sansom O, Eilers M: The role of MIZ-1 in MYC-dependent tumorigenesis, Cold Spring Harb Perspect Med, 2013, 3, a014290
Wolf E*, Gebhardt A*, Kawauchi D, Walz S, von Eyss B, Wagner N, Renninger C, Krohne G, Asan E, Roussel MF, Eilers M: Miz1 is required to maintain autophagic flux, Nature Communications, 2013, ncomms3535, *these authors contributed equally
2012
Wolf E, Kastner B, Lührmann R: Antisense-targeted immuno-EM localization of the pre-mRNA path in the spliceosomal C complex, RNA, 2012, 18, 1347-1357
Hönnemann J, Sanz-Moreno A, Wolf E, Eilers M, Elsässer HP: Miz1 Is a Critical Repressor of cdkn1a during Skin Tumorigenesis, PLoS One, 2012, 7, e34885
Heisig J, Weber D, Englberger E, Winkler A, Kneitz S, Sung WK, Wolf E, Eilers M, Wei CL, Gessler M: Target Gene Analysis by Microarrays and Chromatin Immunoprecipitation Identifies HEY Proteins as Highly Redundant bHLH Repressors, PLoS Genetics, 2012, 8, e1002728
2011
Agafonov DE, Deckert J, Wolf E, Odenwälder P, Bessonov S, Will CL, Urlaub H, Lührmann R: Semiquantitative proteomic analysis of the human spliceosome via a novel two-dimensional gel electrophoresis method, Molecular and cellular biology, 2011, 31, 2667-2682
2010
Golas MM, Sander B, Bessonov S, Grote M, Wolf E, Kastner B, Stark H, Lührmann R: 3D cryo-EM structure of an active step I spliceosome and localization of its catalytic core, Molecular Cell, 2010, 40, 927-938
Grote M, Wolf E, Will CL, Lemm I, Agafonov DE, Schomburg A, Fischle W, Urlaub H, Lührmann R: Molecular architecture of the human Prp19/CDC5L complex, Molecular and cellular biology, 2010, 30, 2105-2119
2009
Wolf E, Kastner B, Deckert J, Merz C, Stark H, Lührmann R: Exon, intron and splice site locations in the spliceosomal B complex, EMBO J, 2009, 28, 2283-2292
Herold N, Will CL, Wolf E, Kastner B, Urlaub H, Lührmann L: Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes, Molecular and cellular biology, 2009, 29, 281-301
2008
Häcker I, Sander B, Golas MM, Wolf E, Karagöz E, Kastner B, Stark H, Fabrizio P, Lührmann R: Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy, Nature structural and molecular biology, 2008, 15, 1206-1212
Kastner B, Fischer N, Golas MM, Sander B, Dube P, Boehringer D, Hartmuth K, Deckert J, Hauer F, Wolf E, Uchtenhagen H, Urlaub H, Pörschke D, Lührmann R, Stark H: GraFix: Sample preparation for singleparticle electron cryomicroscopy, Nature Methods, 2008, 5, 53-55
2005
Cheng Y, Wolf E, Larvie M, Zak O, Aisen P, Grigorieff N, Harrison SC, Walz T: Single particle reconstructions of the Transferrin–Transferrin receptor complex obtained with different specimen preparation techniques, Journal of Molecular Biology, 2005, 355, 1048-1065
