Understanding MYC function

Targeting N-MYC/AURORA for tumor therapy

MYC and Ubiquitin

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Haikala,H., Anttila, J., Marques, E., Raatikainen, T., Ilander, M., Hakanen, H., Ala-Hongisto, H., Savelius, M., Balboa, D., von Eyss, B., Eskelinen, V., Munne, P., Nieminen, A., Otonkoski, T., Schüler, J., Laajala, T., Aittokallio, T., Sihto, H., Mattson, J., Heikkilä, P., Leidenius, M., Joensuu, H., Mustjoki, S., Kovanen, P., Eilers, M., Leverson, J., and Klefström, J. (2019) Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy Nat Commun 10: 620

Löffler, MC, Mayer, AE, Trujillo Viera, J, Loza Valdes, A, El-Merahbi, E, Ade, CP, Karwen, T, Schmitz, W, Slotta, A, Erk, M, Janaki-Raman, S, Matesanz, N, Torres, JL, Marcos, M, Sabio, G, Eilers, M, Schulze, A & Sumara G (2018) Protein kinase D1 deletion in adipocytes enhances energy dissipation and protects against adiposity. EMBO Journal, DOI 10.15252/embj.201899182

Yanku, Y., Bitman-Lotan, E., Zohar, Y., Kurant, E., Zilke, N., Eilers, M. and Orian, A. (2018) Drosophila HUWE1 ubiquitin ligase regulates endoreplication and antagonizes JNK signaling during salivary gland development. Cells 2018,7 151 doi:10.3390/cells7100151

Büchel, G., Carstensen, A., Mak, K.Y., Roeschert, I., Leen, E., Sumara, O., Hofstetter, J., Herold, S., Kalb, J., Baluapuri, A., Poon, E., Kwok, C., Chesler, L., Maric H. M., Rickman, D. S., Wolf, E., Bayliss, R., Walz, S., Eilers, M. (2017) Association with Aurora-A controls N-MYC-dependent promoter escape and pause release of RNA polymerase II during cell cycle. Cell Reports Dec 19;21(12):3483-3497. doi:10.1016/j.celrep.2017.11.090.

Rickman,D. S., Schulte, J. H., Eilers,M. (2017) The expanding world of N-Myc driven tumors. Cancer Discovery, Feb;8(2):150-163. doi: 10.1158/2159-8290.CD-17-0273. Epub 2018 Jan 22.

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Link to all Publications in PubMed