AG Eilers
Prof. Dr. Martin Eilers

Lehrstuhl für Biochemie und Molekularbiologie
Biozentrum
Am Hubland
97074 Würzburg
Tel: 0931 31-84111
Fax: 0931 31-84113
martin.eilers@biozentrum.uni-wuerzburg.de
Many cancers are life-threatening diseases and there is an urgent need for novel therapeutic strategies. Our group works on the human MYC protein family, which is involved in the development of the majority of all human cancers. Our aim is both to understand the function of MYC proteins and explore new strategies to inhibit their function.
Publications
Latest:
Roeschert, I., Poon, E., Henssen, A.G., Dorado Garcia, H., Gatti, M., Giansanti, C., Jamin, Y., Ade, C.P., Gallant, P., Schülein-Völk, C., Beli, P., Richards, M., Rosenfeldt, M., Altmeyer, M., Anderson, J., Eggert, A., Dobbelstein, M., Bayliss, R., Chesler, L., Büchel, G., Eilers, M. (2021) Combined inhibition of Aurora-A and ATR kinase resultsin regression of MYCN-amplifiedneuroblastoma, Nature Cancer doi: 10.1038/s43018-020-00171-8
Endres, T., Solvie, D., Heidelberger, J., Andrioletti, V., Baluapuri, A., Ade, CP., Muhar, M., Eilers, U., Vos, SM., Cramer, P., Zuber, J., Beli, P., Popov, N., Wolf, E., Gallant, P., Eilers, M. (2021) Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters, Mol Cell 81(4):830-844.e13. doi: 10.1016/j.molcel.2020.12.035
Toboso-Navasa, A., Gunawan, A., Morlino, G., Nakagawa, R., Taddei, A., Damry, D., Patel, Y., Chakravarty, P., Janz. M., Kassiotis, G., Brink, R., Eilers, M., Calado, DP. (2020) Restriction of memory B cell differentiation at the 1 germinal center B cellpositive selection stage 23. J Exp Med. 217(7). pii: e20191933. doi: 10.1084/jem.20191933.
Baluapuri, A., Wolf, E., Eilers, M. (2020) Target gene-independent functions of Myc oncoproteins. Nat Rev Mol Cell Biol.21(5):255-267 doi: 10.1038/ s41580-020-0215-2. [Epub ahead of print] Review
Cossa, G., Roeschert, I., Prinz, F., Baluapuri, A., R.S., V., Schülein-Völk, C., Chang, Y.-C., Ade, C. P., Mastrobuoni, G., Girard, C., Wortmann, L., Walz, S., Lührmann, R., Kempa, S., Kuster, B., Wolf, E., Mumberg, D., Eilers, M. (2020) Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription. Mol Cell.77(6):1322-1339.e11. doi: 10.1016/ j.molcel.2020.01.008. [Epub ahead of print]
Schmidt, S., Gay, D., Uthe, F. W., Denk, S., Paauwe, M., Matthes, N., Diefenbacher, M. E., Bryson, S., Warrander, F. C., Erhard, F., Ade, C. P., Baluapuri, A., Walz, S., Jackstadt, R. F., Vlachogiannis, G., Valeri, N., Otto, C., Schülein-Völk, C., Maurus, K., Schmitz, W., Knight, J. R. P., Wolf, E., Strathdee, D., Schulze, A., Germer, C-T., Rosenwald, A., Sansom, O. J., Eilers, M., Wiegering, A. (2019) A MYC/GCN2/eIF2a negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer. Nature Cell Biology.21(11):1413-1424 doi:10.1038/ s41556-019-0408-0
Herold, S., Kalb, J., Buchel, G., Ade, C. P., Baluapuri, A., Xu, J., Koster, J., Solvie, D., Carstensen, A., Klotz, C., Rodewald, S., Schulein-Volk, C., Dobbelstein, M., Wolf, E., Molenaar, J., Versteeg, R., Walz, S., Eilers, M. (2019). Recruitment of BRCA1 limits MYCN-driven accumulation of stalled RNA Polymerase. Nature. 567(7749):545-549. doi: 10.1038/s41586-019-1030-9
Baluapuri, A., Hofstetter, J., Dudvarski Stankovic, N., Endres, T., Bhandare, P., Vos, S.M., Adhikari, B., Schwarz, J.D., Narain, A., Vogt, M., Wang, S.Y., Düster, R., Jung, L.A., Vanselow, J.T., Wiegering, A., Geyer, M., Maric, H.M., Gallant, P., Walz, S., Schlosser, A., Cramer, P., Eilers, M., Wolf, E. (2019) MYC recruits SPT5 to RNA polymerase II to promote processive transcription elongation. Mol Cell. 74(4):674-687.e11.
doi:10.1016/j.molcel.2019.02.031.
Haikala,H., Anttila, J., Marques, E., Raatikainen, T., Ilander, M., Hakanen, H., Ala-Hongisto, H., Savelius, M., Balboa, D., von Eyss, B., Eskelinen, V., Munne, P., Nieminen, A., Otonkoski, T., Schüler, J., Laajala, T., Aittokallio, T., Sihto, H., Mattson, J., Heikkilä, P., Leidenius, M., Joensuu, H., Mustjoki, S., Kovanen, P., Eilers, M., Leverson, J., and Klefström, J. (2019) Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy Nat Commun 10: 620
Link to all Publications in PubMed