AG Eilers

Understanding MYC function

Targeting N-MYC/AURORA for tumor therapy

MYC and Ubiquitin

Latest:

Krenz, B., Gebhardt-Wolf, A., Ade, C.P., Gaballa, A., Roehrig, F., Vendelova, E., Baluapuri, A., Eilers, U., Gallant, P., D' Artista, L., Wiegering, A., Gasteiger, G., Rosenfeldt, M.T., Bauer, S., Zender, L., Wolf, E., Eilers, M. (2021) MYC- and MIZ1-dependent vesicular transport of double-strand RNA controls immune evasion in pancreatic ductal adenocarcinoma. Cancer Research doi: 10.1158/0008-5472.CAN-21-1677.

Cossa, G., Parua, P.K., Eilers, M. and Fisher, R.P. (2021) Protein phosphatases in the RNAPII transcription cycle: erasers, sculptors, gatekeepers and potential drug targets. Genes & Development. May 1, 2021; 35 (9-10).

Roeschert, I., Poon, E., Henssen, A.G., Dorado Garcia, H., Gatti, M., Giansanti, C., Jamin, Y., Ade, C.P., Gallant, P., Schülein-Völk, C., Beli, P., Richards, M., Rosenfeldt, M., Altmeyer, M., Anderson, J., Eggert, A., Dobbelstein, M., Bayliss, R., Chesler, L., Büchel, G., Eilers, M. (2021) Combined inhibition of Aurora-A and ATR kinase resultsin regression of MYCN-amplifiedneuroblastoma, Nature Cancer doi: 10.1038/s43018-020-00171-8

Endres, T., Solvie, D., Heidelberger, J., Andrioletti, V., Baluapuri, A., Ade, CP., Muhar, M., Eilers, U., Vos, SM., Cramer, P., Zuber, J., Beli, P., Popov, N., Wolf, E., Gallant, P., Eilers, M. (2021) Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters, Mol Cell 81(4):830-844.e13. doi: 10.1016/j.molcel.2020.12.035

Toboso-Navasa, A., Gunawan, A., Morlino, G., Nakagawa, R., Taddei, A., Damry, D., Patel, Y., Chakravarty, P., Janz. M., Kassiotis, G., Brink, R., Eilers, M., Calado, DP. (2020) Restriction of memory B cell differentiation at the 1 germinal center B cellpositive selection stage 23. J Exp Med. 217(7). pii: e20191933. doi: 10.1084/jem.20191933.

Baluapuri, A., Wolf, E., Eilers, M. (2020) Target gene-independent functions of Myc oncoproteins. Nat Rev Mol Cell Biol.21(5):255-267 doi: 10.1038/ s41580-020-0215-2. [Epub ahead of print] Review

Cossa, G., Roeschert, I., Prinz, F., Baluapuri, A., R.S., V., Schülein-Völk, C., Chang, Y.-C., Ade, C. P., Mastrobuoni, G., Girard, C., Wortmann, L., Walz, S., Lührmann, R., Kempa, S., Kuster, B., Wolf, E., Mumberg, D., Eilers, M. (2020) Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription. Mol Cell.77(6):1322-1339.e11. doi: 10.1016/ j.molcel.2020.01.008. [Epub ahead of print]

Schmidt, S., Gay, D., Uthe, F. W., Denk, S., Paauwe, M., Matthes, N., Diefenbacher, M. E., Bryson, S., Warrander, F. C., Erhard, F., Ade, C. P., Baluapuri, A., Walz, S., Jackstadt, R. F., Vlachogiannis, G., Valeri, N., Otto, C., Schülein-Völk, C., Maurus, K., Schmitz, W., Knight, J. R. P., Wolf, E., Strathdee, D., Schulze, A., Germer, C-T., Rosenwald, A., Sansom, O. J., Eilers, M., Wiegering, A. (2019) A MYC/GCN2/eIF2a negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer. Nature Cell Biology.21(11):1413-1424 doi:10.1038/ s41556-019-0408-0

Herold, S., Kalb, J., Buchel, G., Ade, C. P., Baluapuri, A., Xu, J., Koster, J., Solvie, D., Carstensen, A., Klotz, C., Rodewald, S., Schulein-Volk, C., Dobbelstein, M., Wolf, E., Molenaar, J., Versteeg, R., Walz, S., Eilers, M. (2019). Recruitment of BRCA1 limits MYCN-driven accumulation of stalled RNA Polymerase. Nature. 567(7749):545-549. doi: 10.1038/s41586-019-1030-9

Baluapuri, A., Hofstetter, J., Dudvarski Stankovic, N., Endres, T., Bhandare, P., Vos, S.M., Adhikari, B., Schwarz, J.D., Narain, A., Vogt, M., Wang, S.Y., Düster, R., Jung, L.A., Vanselow, J.T., Wiegering, A., Geyer, M., Maric, H.M., Gallant, P., Walz, S., Schlosser, A., Cramer, P., Eilers, M., Wolf, E. (2019) MYC recruits SPT5 to RNA polymerase II to promote processive transcription elongation. Mol Cell. 74(4):674-687.e11.
doi:10.1016/j.molcel.2019.02.031.

Haikala,H., Anttila, J., Marques, E., Raatikainen, T., Ilander, M., Hakanen, H., Ala-Hongisto, H., Savelius, M., Balboa, D., von Eyss, B., Eskelinen, V., Munne, P., Nieminen, A., Otonkoski, T., Schüler, J., Laajala, T., Aittokallio, T., Sihto, H., Mattson, J., Heikkilä, P., Leidenius, M., Joensuu, H., Mustjoki, S., Kovanen, P., Eilers, M., Leverson, J., and Klefström, J. (2019) Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy Nat Commun 10: 620

Link to all Publications in PubMed