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    Chair of Biochemistry and Molecular Biology

    AG Eilers

    Prof. Dr. Martin Eilers

    Lehrstuhl für Biochemie und Molekularbiologie
    Biozentrum
    Am Hubland
    97074 Würzburg

    Tel:   0931 31-84111
    Fax:  0931 31-84113
    martin.eilers@biozentrum.uni-wuerzburg.de

    Many cancers are life-threatening diseases and there is an urgent need for novel therapeutic strategies. Our group works on the human MYC protein family, which is involved in the development of the majority of all human cancers. Our aim is both to understand the function of MYC proteins and explore new strategies to inhibit their function.

    Research

    Understanding MYC function

    Targeting N-MYC/AURORA for tumor therapy

    MYC and Ubiquitin

    Publications

    Latest:

    Löffler, MC, Mayer, AE, Trujillo Viera, J, Loza Valdes, A, El-Merahbi, E, Ade, CP, Karwen, T, Schmitz, W, Slotta, A, Erk, M, Janaki-Raman, S, Matesanz, N, Torres, JL, Marcos, M, Sabio, G, Eilers, M, Schulze, A & Sumara G (2018) Protein kinase D1 deletion in adipocytes enhances energy dissipation and protects against adiposity. EMBO Journal, DOI 10.15252/embj.201899182

    Yanku, Y., Bitman-Lotan, E., Zohar, Y., Kurant, E., Zilke, N., Eilers, M. and Orian, A. (2018) Drosophila HUWE1 ubiquitin ligase regulates endoreplication and antagonizes JNK signaling during salivary gland development. Cells 2018,7 151 doi:10.3390/cells7100151

    Büchel, G., Carstensen, A., Mak, K.Y., Roeschert, I., Leen, E., Sumara, O., Hofstetter, J., Herold, S., Kalb, J., Baluapuri, A., Poon, E., Kwok, C., Chesler, L., Maric H. M., Rickman, D. S., Wolf, E., Bayliss, R., Walz, S., Eilers, M. (2017) Association with Aurora-A controls N-MYC-dependent promoter escape and pause release of RNA polymerase II during cell cycle. Cell Reports Dec 19;21(12):3483-3497. doi:10.1016/j.celrep.2017.11.090.

    Rickman,D. S., Schulte, J. H., Eilers,M. (2017) The expanding world of N-Myc driven tumors. Cancer Discovery, Feb;8(2):150-163. doi: 10.1158/2159-8290.CD-17-0273. Epub 2018 Jan 22.

    Dejure,F.R., Eilers, M. (2017)MYC and tumor metabolism: chicken and egg. EMBO J. Nov 10. pii: e201796438.doi: 10.15252/embj.201796438. [Epub ahead of print] Review. PubMed PMID:29127156.

    Show all

    Link to all Publications in PubMed

    Kontakt

    Lehrstuhl für Biochemie und Molekularbiologie
    Am Hubland
    97074 Würzburg

    Tel.: +49 931 31-84112
    E-Mail

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    Hubland Süd, Geb. B1
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