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  • Molecular chains
  • DNA and cells
Chair of Biochemistry and Molecular Biology

Welcome to our Department

Our research focuses on the control of cell growth and proliferation and its deregulation in human tumors.

We study transcription factors such as Myc and SREBP proteins that control gene expression programs involved in central biological processes such as cell cycle progression, apoptosis, protein translation and metabolism.

Our work aims to understand how these factors work and how they are regulated and to use this knowledge for novel strategies for tumor therapy.

The department is part of the
Comprehensive Cancer Center Mainfranken.

Event Announcements

CCC Seminarreihe

Regulation of mRNA translation via control of elongation in health and disease states
Referent: Anne Willis, MRC Toxicology Unit, Leicester University
Ort: Biozentrum Universität Würzburg, Hörsaal A 101
06. Juni 2018 17:00 c.t.
Organisator: GSLS - CCC - FOR 2314 Seminarreihe

C-ATPase inhibition as a novel option to target cancer cell lipid metabolism
Referent: Karin Bartel, Ludwig-Maximilians-Universität Münschen
Ort: Biozentrum Universität Würzburg, Hörsaal A 102
19. Juni 2018 17:00 c.t.
Organisator: GSLS - CCC - FOR 2314 Seminarreihe

New Publications

Miess, H., Dankworth, B., Gouw, AM., Rosenfeldt, M., Schmitz, W., Jiang, M., Saunders, B., Howell, M., Downward, J., Felsher, DW., Peck, B. and Schulze, A. (2018) The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma, Oncogene 2018 (in press)

Snaebjornsson MT, Schulze A. (2018) Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways, Exp Mol Med. 2018 Apr 16;50(4):34, doi: 10.1038/s12276-018-0065-6.

Pedrotti L, Weiste C, Nägele T, Wolf E, Lorenzin F, DietrichK, Mair A, Weckwerth W, Teige M, Baena-González E, Dröge-Laser W (2018) Snf1-RELATEDKINASE1-Controlled C/S1-bZIP Signaling Activates Alternative MitochondrialMetabolic Pathways to Ensure Plant Survival in Extended Darkness. The Plantcell

Rickman,D. S., Schulte, J. H., Eilers,M. (2017) The expanding world of N-Myc driven tumors. Cancer Discovery, in press

Dejure,F.R., Eilers, M. (2017)MYC and tumor metabolism: chicken and egg. EMBO J. Nov 10. pii: e201796438.doi: 10.15252/embj.201796438. [Epub ahead of print] Review. PubMed PMID:29127156.

Büchel, G., Carstensen, A., Mak, K.Y., Roeschert, I., Leen, E., Sumara, O., Hofstetter, J., Herold, S., Kalb, J., Baluapuri, A., Poon, E., Kwok, C., Chesler, L., Maric H. M., Rickman, D. S., Wolf, E., Bayliss, R., Walz, S., Eilers, M. Association with Aurora-A controls N-MYC-dependent promoter escape and pause release of RNA polymerase II during cell cycle (2017). Cell Reports in press

Jennifer M. Gerlach, Michael Furrer, Maria Gallant, Dirk Birkel, Apoorva Baluapuri, Elmar Wolf, and Peter Gallant (2017) PAF1 complex component Leo1 helps recruit Drosophila Myc to promoters, PNAS, doi: 10.1073/pnas.1705816114

Open Positions

If you are interested in working with us, please contact our administrative assistant, Sandra Stoudek, or contact the person you would like to work with directly.

Prof. Dr. Martin Eilers

Dr. Markus E. Diefenbacher

Dr. Peter Gallant

Prof. Dr. Almut Schulze

PD Dr. Armin Wiegering

Dr. Elmar Wolf

Kontakt

Lehrstuhl für Biochemie und Molekularbiologie
Am Hubland
97074 Würzburg

Tel.: +49 931 31-84112
E-Mail

Suche Ansprechpartner

Hubland Süd, Geb. B1 Hubland Nord, Geb. 32 Julius-von-Sachs-Platz 2 Fabrikschleichach Hubland Süd, Geb. B2 Campus Medizin