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19.09.2019Die Wichtigkeit der circadianen Biologie wurde bislang in vorklinschen Studien kaum berücksichtigt. Dabei ist sie ein wichtiger Faktor, der die Wirksamkeit und den Abbau von Medikamenten im Organismus beeinflusst.
Medicine in the Fourth Dimension
The importance of circadian biology has rarely been considered in pre-clinical studies, and even more when translating to the bedside. Circadian biology is becoming a critical factor for improving drug efficacy and diminishing drug toxicity. Indeed, there is emerging evidence showing that some drugs are more effective at nighttime than daytime, whereas for others it is the opposite. This suggests that the biology of the target cell will determine how an organ will respond to a drug at a specific time of the day, thus modulating pharmacodynamics. Thus, it is now time that circadian factors become an integral part of translational research.
Autoren: Ch. R. Cederroth, U. Albrecht, J. Bass, Ch. Helfrich-Förster, et al.
Cell Metabolism 30:238-250 (2019)
