Priv.-Doz. Dr. Hannes Neuweiler | |
Telefon: | +49 931 31-83872 |
Since 2010 | Lecturer & Group Leader, Department of Biotechnology & Biophysics, University of Würzburg, Germany |
2006–2010 | Marie Curie Fellow (6th framework programme of the EU) and Career Development Fellow in the laboratory of Prof. Alan Fersht, Medical Research Council Centre for Protein Engineering, Cambridge, United Kingdom |
2004–2006 | Postdoctoral Researcher, Department of Applied Laser Physics & Laser Spectroscopy, University of Bielefeld, Germany |
2003–2004 | Postdoctoral Researcher, Department of Biophysical Chemistry, University of Heidelberg, Germany |
1999–2002 | PhD, Department of Physical Chemistry, University of Heidelberg, Germany |
1995–1998 | Study of Chemistry and Diploma, University of Heidelberg, Germany |
1993–1995 | Study of Chemistry, University of Frankfurt/Main, Germany |
List of publications
- [ 2023 ]
- [ 2021 ]
- [ 2020 ]
- [ 2019 ]
- [ 2018 ]
- [ 2017 ]
- [ 2016 ]
- [ 2015 ]
- [ 2014 ]
- [ 2013 ]
- [ 2012 ]
- [ 2011 ]
- [ 2010 ]
- [ 2009 ]
- [ 2008 ]
- [ 2007 ]
- [ 2006 ]
- [ 2005 ]
- [ 2004 ]
- [ 2003 ]
- [ 2002 ]
2023[ to top ]
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Domain swap facilitates structural transitions of spider silk protein C-terminal domains. . In Protein Science, 32(11), S. e4783. 2023.
2021[ to top ]
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Warhead Reactivity Limits the Speed of Inhibition of the Cysteine Protease Rhodesain. . In ACS Chem. Biol., 16(4), S. 661–670. American Chemical Society, 2021.
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Structure, interdomain dynamics, and pH-dependent autoactivation of pro-rhodesain, the main lysosomal cysteine protease from African trypanosomes. . In Journal of Biological Chemistry, 296, S. 100565-. 2021.
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Two-colour single-molecule photoinduced electron transfer fluorescence imaging microscopy of chaperone dynamics. . In Nature Communications, 12(1), S. 6964-. 2021.
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Allosteric coupling of sub-millisecond clamshell motions in ionotropic glutamate receptor ligand-binding domains. . In Communications Biology, 4(1), S. 1056-. 2021.
2020[ to top ]
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NMR assignments of a dynamically perturbed and dimerization inhibited N-terminal domain variant of a spider silk protein from E. australis. . In Biomolecular NMR Assignments, 14(1), S. 67–71. 2020.
2019[ to top ]
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On-target restoration of a split T cell-engaging antibody for precision immunotherapy. . In Nature Communications, 10(1), S. 5387-. 2019.
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Methionine in a protein hydrophobic core drives tight interactions required for assembly of spider silk. . In Nature Communications, 10(1), S. 4378-. 2019.
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The conserved NxNNWHW motif in Aha-type co-chaperones modulates the kinetics of Hsp90 ATPase stimulation. . In Nature Communications, 10(1), S. 1273-. 2019.
2018[ to top ]
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Two-step self-assembly of a spider silk molecular clamp. . In Nature Communications, 9(1), S. 4779-. 2018.
2017[ to top ]
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Conservation of folding and association within a family of spidroin N-terminal domains. . In Scientific Reports, 7(1), S. 16789. Nature Publishing Group, 2017.
2016[ to top ]
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Cooperation of local motions in the Hsp90 molecular chaperone ATPase mechanism. . In Nat Chem Biol, advance online publication. Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved., 2016.
2015[ to top ]
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β-Structure within the Denatured State of the Helical Protein Domain BBL. . In Journal of Molecular Biology. 2015.
2014[ to top ]
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PET-FCS: Probing Rapid Structural Fluctuations of Proteins and Nucleic Acids by Single-Molecule Fluorescence Quenching. . In Methods Mol Biol - Fluorescence Spectroscopy and Microscopy, Bd. 1076, Y. Engelborghs, A. J. Visser (Hrsg.), S. 597–615. Humana Press, 2014.
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Microsecond folding and domain motions of a spider silk protein structural switch. . In Journal of the American Chemical Society, (ja), S. null. 2014.
2013[ to top ]
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The N-terminal domains of spider silk proteins assemble ultrafast and protected from charge screening. . In Nat Commun, 4. Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved., 2013.
2012[ to top ]
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Long-Range Modulation of Chain Motions within the Intrinsically Disordered Transactivation Domain of Tumor Suppressor p53. . In Journal of the American Chemical Society, 134(3), S. 1617–1622. 2012.
2011[ to top ]
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Intrinsic Motions in the N-Terminal Domain of an Ionotropic Glutamate Receptor Detected by Fluorescence Correlation Spectroscopy. . In Journal of Molecular Biology, 414(1), S. 96–105. 2011.
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Backbone-Driven Collapse in Unfolded Protein Chains. . In Journal of Molecular Biology, 409(2), S. 250–262. 2011.
2010[ to top ]
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Hydrogen-Bond Driven Loop-Closure Kinetics in Unfolded Polypeptide Chains. . In PLOS COMPUTATIONAL BIOLOGY, 6(1). PUBLIC LIBRARY SCIENCE, 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA, 2010.
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The human peripheral subunit-binding domain folds rapidly while overcoming repulsive Coulomb forces. . In PROTEIN SCIENCE, 19(9), S. 1704–1713. JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA, 2010.
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Carboxyl pK(a) Values and Acid Denaturation of BBL. . In JOURNAL OF MOLECULAR BIOLOGY, 403(2), S. 313–327. ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND, 2010.
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Kinetics of chain motions within a protein-folding intermediate. . In PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(51), S. 22106–22110. NATL ACAD SCIENCES, 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA, 2010.
2009[ to top ]
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Reply to Campos et al.: Direct observation versus ambiguous kinetics and thermodynamics. . In PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(52), S. E140. NATL ACAD SCIENCES, 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA, 2009.
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Direct observation of ultrafast folding and denatured state dynamics in single protein molecules. . In PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(44), S. 18569–18574. NATL ACAD SCIENCES, 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA, 2009.
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Fluorescence Quenching by Photoinduced Electron Transfer: A Reporter for Conformational Dynamics of Macromolecules. . In CHEMPHYSCHEM, 10(9-10, Sp. Iss. SI), S. 1389–1398. WILEY-V C H VERLAG GMBH, PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY, 2009.
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The Folding Mechanism of BBL: Plasticity of Transition-State Structure Observed within an Ultrafast Folding Protein Family. . In JOURNAL OF MOLECULAR BIOLOGY, 390(5), S. 1060–1073. ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND, 2009.
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Downhill versus Barrier-Limited Folding of BBL 2: Mechanistic Insights from Kinetics of Folding Monitored by Independent Tryptophan Probes. . In JOURNAL OF MOLECULAR BIOLOGY, 387(4), S. 975–985. ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND, 2009.
2008[ to top ]
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Changes in conformational dynamics of mRNA upon AtGRP7 binding studied by fluorescence correlation spectroscopy. . In JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130(29), S. 9507–9513. AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA, 2008.
2007[ to top ]
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A highly sensitive particle agglutination assay for the detection of P53 autoantibodies in patients with lung cancer. . In Cancer, 110(11), S. 2502–2506. Wiley Subscription Services, Inc., A Wiley Company, 2007.
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Dynamics of unfolded polypeptide chains in crowded environment studied by fluorescence correlation spectroscopy. . In JOURNAL OF MOLECULAR BIOLOGY, 365(3), S. 856–869. ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND, 2007.
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Probing polyproline structure and dynamics by photoinduced electron transfer provides evidence for deviations from a regular polyproline type II helix. . In PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 104(44), S. 17400–17405. NATL ACAD SCIENCES, 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA, 2007.
2006[ to top ]
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UV Fluorescence Lifetime Imaging Microscopy: A Label-Free Method for Detection and Quantification of Protein Interactions. . In Analytical Chemistry, 78(3), S. 663–669. 2006.
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The initial step of DNA hairpin folding: a kinetic analysis using fluorescence correlation spectroscopy. . In NUCLEIC ACIDS RESEARCH, 34(9), S. 2516–2527. OXFORD UNIV PRESS, GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND, 2006.
2005[ to top ]
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A microscopic view of miniprotein folding: Enhanced folding efficiency through formation of an intermediate. . In PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(46), S. 16650–16655. NATL ACAD SCIENCES, 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA, 2005.
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A close look at fluorescence quenching of organic dyes by tryptophan. . In CHEMPHYSCHEM, 6(11), S. 2277–2285. WILEY-V C H VERLAG GMBH, PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY, 2005.
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Exploring life by single-molecule fluorescence spectroscopy. . In ANALYTICAL CHEMISTRY, 77(9), S. 178A-185A. AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA, 2005.
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Monitoring antibody binding events in homogeneous solution by single-molecule fluorescence spectroscopy. . In ZEITSCHRIFT FUR PHYSIKALISCHE CHEMIE-INTERNATIONAL JOURNAL OF RESEARCH IN PHYSICAL CHEMISTRY & CHEMICAL PHYSICS, 219(5), S. 665–678. R OLDENBOURG VERLAG, LEKTORAT MINT, POSTFACH 80 13 60, D-81613 MUNICH, GERMANY, 2005.
2004[ to top ]
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Using photoinduced charge transfer reactions to study conformational dynamics of biopolymers at the single-molecule level. . In CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 5(3), S. 285–298. BENTHAM SCIENCE PUBL LTD, EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES, 2004.
2003[ to top ]
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Fluorescence quenching of dyes by tryptophan: Interactions at atomic detail from combination of experiment and computer simulation. . In JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 125(47), S. 14564–14572. AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA, 2003.
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Measurement of submicrosecond intramolecular contact formation in peptides at the single-molecule level. . In JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 125(18), S. 5324–5330. AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA, 2003.
2002[ to top ]
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Detection of Individual p53-Autoantibodies by Using Quenched Peptide-Based Molecular Probes. . In Angewandte Chemie International Edition, 41(24), S. 4769–4773. WILEY-VCH Verlag, 2002.