Priv.-Doz. Dr. Hannes Neuweiler | |
Telefon: | +49 931 31-83872 |
Since 2010 | Lecturer & Group Leader, Department of Biotechnology & Biophysics, University of Würzburg, Germany |
2006–2010 | Marie Curie Fellow (6th framework programme of the EU) and Career Development Fellow in the laboratory of Prof. Alan Fersht, Medical Research Council Centre for Protein Engineering, Cambridge, United Kingdom |
2004–2006 | Postdoctoral Researcher, Department of Applied Laser Physics & Laser Spectroscopy, University of Bielefeld, Germany |
2003–2004 | Postdoctoral Researcher, Department of Biophysical Chemistry, University of Heidelberg, Germany |
1999–2002 | PhD, Department of Physical Chemistry, University of Heidelberg, Germany |
1995–1998 | Study of Chemistry and Diploma, University of Heidelberg, Germany |
1993–1995 | Study of Chemistry, University of Frankfurt/Main, Germany |
List of publications
- [ 2021 ]
- [ 2020 ]
- [ 2019 ]
- [ 2018 ]
- [ 2017 ]
- [ 2016 ]
- [ 2015 ]
- [ 2014 ]
- [ 2013 ]
- [ 2012 ]
- [ 2011 ]
- [ 2010 ]
- [ 2009 ]
- [ 2008 ]
- [ 2007 ]
- [ 2006 ]
- [ 2005 ]
- [ 2004 ]
- [ 2003 ]
- [ 2002 ]
2021[ to top ]
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Allosteric coupling of sub-millisecond clamshell motions in ionotropic glutamate receptor ligand-binding domains in Communications Biology (2021). 4(1) 1056-.
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Two-colour single-molecule photoinduced electron transfer fluorescence imaging microscopy of chaperone dynamics in Nature Communications (2021). 12(1) 6964-.
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Warhead Reactivity Limits the Speed of Inhibition of the Cysteine Protease Rhodesain in ACS Chem. Biol. (2021). 16(4) 661–670.
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Structure, interdomain dynamics, and pH-dependent autoactivation of pro-rhodesain, the main lysosomal cysteine protease from African trypanosomes in Journal of Biological Chemistry (2021). 296 100565-.
2020[ to top ]
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NMR assignments of a dynamically perturbed and dimerization inhibited N-terminal domain variant of a spider silk protein from E. australis in Biomolecular NMR Assignments (2020). 14(1) 67–71.
2019[ to top ]
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On-target restoration of a split T cell-engaging antibody for precision immunotherapy in Nature Communications (2019). 10(1) 5387-.
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Methionine in a protein hydrophobic core drives tight interactions required for assembly of spider silk in Nature Communications (2019). 10(1) 4378-.
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The conserved NxNNWHW motif in Aha-type co-chaperones modulates the kinetics of Hsp90 ATPase stimulation in Nature Communications (2019). 10(1) 1273-.
2018[ to top ]
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Two-step self-assembly of a spider silk molecular clamp in Nature Communications (2018). 9(1) 4779-.
2017[ to top ]
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Conservation of folding and association within a family of spidroin N-terminal domains in Scientific Reports (2017). 7(1) 16789.
2016[ to top ]
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Cooperation of local motions in the Hsp90 molecular chaperone ATPase mechanism in Nat Chem Biol (2016). advance online publication
2015[ to top ]
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β-Structure within the Denatured State of the Helical Protein Domain BBL in Journal of Molecular Biology (2015).
2014[ to top ]
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Microsecond folding and domain motions of a spider silk protein structural switch in Journal of the American Chemical Society (2014). (ja) null.
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PET-FCS: Probing Rapid Structural Fluctuations of Proteins and Nucleic Acids by Single-Molecule Fluorescence Quenching in Methods Mol Biol - Fluorescence Spectroscopy and Microscopy, Y. Engelborghs, A. J. Visser (Hrsg.) (2014). (Bd. 1076) 597–615.
2013[ to top ]
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The N-terminal domains of spider silk proteins assemble ultrafast and protected from charge screening in Nat Commun (2013). 4
2012[ to top ]
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Long-Range Modulation of Chain Motions within the Intrinsically Disordered Transactivation Domain of Tumor Suppressor p53 in Journal of the American Chemical Society (2012). 134(3) 1617–1622.
2011[ to top ]
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Intrinsic Motions in the N-Terminal Domain of an Ionotropic Glutamate Receptor Detected by Fluorescence Correlation Spectroscopy in Journal of Molecular Biology (2011). 414(1) 96–105.
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Backbone-Driven Collapse in Unfolded Protein Chains in Journal of Molecular Biology (2011). 409(2) 250–262.
2010[ to top ]
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Kinetics of chain motions within a protein-folding intermediate in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010). 107(51) 22106–22110.
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Carboxyl pK(a) Values and Acid Denaturation of BBL in JOURNAL OF MOLECULAR BIOLOGY (2010). 403(2) 313–327.
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The human peripheral subunit-binding domain folds rapidly while overcoming repulsive Coulomb forces in PROTEIN SCIENCE (2010). 19(9) 1704–1713.
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Hydrogen-Bond Driven Loop-Closure Kinetics in Unfolded Polypeptide Chains in PLOS COMPUTATIONAL BIOLOGY (2010). 6(1)
2009[ to top ]
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Downhill versus Barrier-Limited Folding of BBL 2: Mechanistic Insights from Kinetics of Folding Monitored by Independent Tryptophan Probes in JOURNAL OF MOLECULAR BIOLOGY (2009). 387(4) 975–985.
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Direct observation of ultrafast folding and denatured state dynamics in single protein molecules in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009). 106(44) 18569–18574.
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Reply to Campos et al.: Direct observation versus ambiguous kinetics and thermodynamics in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009). 106(52) E140.
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The Folding Mechanism of BBL: Plasticity of Transition-State Structure Observed within an Ultrafast Folding Protein Family in JOURNAL OF MOLECULAR BIOLOGY (2009). 390(5) 1060–1073.
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Fluorescence Quenching by Photoinduced Electron Transfer: A Reporter for Conformational Dynamics of Macromolecules in CHEMPHYSCHEM (2009). 10(9-10, Sp. Iss. SI) 1389–1398.
2008[ to top ]
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Changes in conformational dynamics of mRNA upon AtGRP7 binding studied by fluorescence correlation spectroscopy in JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008). 130(29) 9507–9513.
2007[ to top ]
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A highly sensitive particle agglutination assay for the detection of P53 autoantibodies in patients with lung cancer in Cancer (2007). 110(11) 2502–2506.
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Probing polyproline structure and dynamics by photoinduced electron transfer provides evidence for deviations from a regular polyproline type II helix in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007). 104(44) 17400–17405.
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Dynamics of unfolded polypeptide chains in crowded environment studied by fluorescence correlation spectroscopy in JOURNAL OF MOLECULAR BIOLOGY (2007). 365(3) 856–869.
2006[ to top ]
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The initial step of DNA hairpin folding: a kinetic analysis using fluorescence correlation spectroscopy in NUCLEIC ACIDS RESEARCH (2006). 34(9) 2516–2527.
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UV Fluorescence Lifetime Imaging Microscopy: A Label-Free Method for Detection and Quantification of Protein Interactions in Analytical Chemistry (2006). 78(3) 663–669.
2005[ to top ]
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Monitoring antibody binding events in homogeneous solution by single-molecule fluorescence spectroscopy in ZEITSCHRIFT FUR PHYSIKALISCHE CHEMIE-INTERNATIONAL JOURNAL OF RESEARCH IN PHYSICAL CHEMISTRY & CHEMICAL PHYSICS (2005). 219(5) 665–678.
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A microscopic view of miniprotein folding: Enhanced folding efficiency through formation of an intermediate in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005). 102(46) 16650–16655.
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Exploring life by single-molecule fluorescence spectroscopy in ANALYTICAL CHEMISTRY (2005). 77(9) 178A-185A.
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A close look at fluorescence quenching of organic dyes by tryptophan in CHEMPHYSCHEM (2005). 6(11) 2277–2285.
2004[ to top ]
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Using photoinduced charge transfer reactions to study conformational dynamics of biopolymers at the single-molecule level in CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2004). 5(3) 285–298.
2003[ to top ]
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Measurement of submicrosecond intramolecular contact formation in peptides at the single-molecule level in JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003). 125(18) 5324–5330.
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Fluorescence quenching of dyes by tryptophan: Interactions at atomic detail from combination of experiment and computer simulation in JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003). 125(47) 14564–14572.
2002[ to top ]
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Detection of Individual p53-Autoantibodies by Using Quenched Peptide-Based Molecular Probes in Angewandte Chemie International Edition (2002). 41(24) 4769–4773.