Priv.-Doz. Dr. Sören Doose

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List of publications

2021[ to top ]
  • García-Guerrero, E., Götz, R., Doose, S., Sauer, M., Rodríguez-Gil, A., Nerreter, T., Kortüm, K. M., Pérez-Simón, J. A., Einsele, H., Hudecek, M., & Danhof, S. Upregulation of CD38 expression on multiple myeloma cells by novel HDAC6 inhibitors is a class effect and augments the efficacy of daratumumab. Leukemia, 35(1), 201-214. https://doi.org/10.1038/s41375-020-0840-y
2020[ to top ]
  • Wäldchen, F., Schlegel, J., Götz, R., Luciano, M., Schnermann, M., Doose, S., & Sauer, M. Whole-cell imaging of plasma membrane receptors by 3D lattice light-sheet dSTORM. Nature Communications, 11(1), 887-. https://doi.org/10.1038/s41467-020-14731-0
  • Siddig, S., Aufmkolk, S., Doose, S., Jobin, M.-L., Werner, C., Sauer, M., & Calebiro, D. Super-resolution imaging reveals the nanoscale organization of metabotropic glutamate receptors at presynaptic active zones. Sci Adv, 6(16), eaay7193-. https://doi.org/10.1126/sciadv.aay7193
2019[ to top ]
  • Schlegel, J., Peters, S., Doose, S., Schubert-Unkmeir, A., & Sauer, M. Super-Resolution Microscopy Reveals Local Accumulation of Plasma Membrane Gangliosides at Neisseria meningitidis Invasion Sites. Frontiers in Cell and Developmental Biology, 7, 194-. https://www.frontiersin.org/article/10.3389/fcell.2019.00194
  • Nerreter, T., Letschert, S., Götz, R., Doose, S., Danhof, S., Einsele, H., Sauer, M., & Hudecek, M. Super-resolution microscopy reveals ultra-low CD19 expression on myeloma cells that triggers elimination by CD19 CAR-T. Nature Communications, 10(1), 3137-. https://doi.org/10.1038/s41467-019-10948-w
  • Beliu, G., Kurz, A. J., Kuhlemann, A. C., Behringer-Pliess, L., Meub, M., Wolf, N., Seibel, J., Shi, Z.-D., Schnermann, M., Grimm, J. B., Lavis, L. D., Doose, S., & Sauer, M. Bioorthogonal labeling with tetrazine-dyes for super-resolution microscopy. Communications Biology, 2(1), 261-. https://doi.org/10.1038/s42003-019-0518-z
  • Reinhard, S., Aufmkolk, S., Sauer, M., & Doose, S. Registration and Visualization of Correlative Super-Resolution Microscopy Data. Biophysical Journal, 116(11), 2073-2078. https://doi.org/https://doi.org/10.1016/j.bpj.2019.04.029
2018[ to top ]
  • Neubert, F., Beliu, G., Terpitz, U., Werner, C., Geis, C., Sauer, M., & Doose, S. Bioorthogonal Click Chemistry Enables Site-specific Fluorescence Labeling of Functional NMDA Receptors for Super-Resolution Imaging. Angewandte Chemie International Edition, 57(50), 16364-16369. https://doi.org/10.1002/anie.201808951
  • Brunk, M., Sputh, S., Doose, S., van de Linde, S., & Terpitz, U. HyphaTracker: An ImageJ toolbox for time-resolved analysis of spore germination in filamentous fungi. Scientific Reports, 8(1), 605-. https://doi.org/10.1038/s41598-017-19103-1
  • Sisario, D., Memmel, S., Doose, S., Neubauer, J., Zimmermann, H., Flentje, M., Djuzenova, C. S., Sauer, M., & Sukhorukov, V. L. Nanostructure of DNA repair foci revealed by superresolution microscopy. The FASEB Journal, fj.201701435-. https://doi.org/10.1096/fj.201701435
  • Haselmann, H., Mannara, F., Werner, C., Planagumà, J., Miguez-Cabello, F., Schmidl, L., Grünewald, B., Petit-Pedrol, M., Kirmse, K., Classen, J., Demir, F., Klöcker, N., Soto, D., Doose, S., Dalmau, J., Hallermann, S., & Geis, C. Human Autoantibodies against the AMPA Receptor Subunit GluA2 Induce Receptor Reorganization and Memory Dysfunction. Neuron, 100(1), 91-105.e9. https://doi.org/https://doi.org/10.1016/j.neuron.2018.07.048
  • Tauscher, S., Nakagawa, H., Völker, K., Werner, F., Krebes, L., Potapenko, T., Doose, S., Birkenfeld, A. L., Baba, H. A., & Kuhn, M. β Cell-specific deletion of guanylyl cyclase A, the receptor for atrial natriuretic peptide, accelerates obesity-induced glucose intolerance in mice. Cardiovascular Diabetology, 17, 103. https://doi.org/10.1186/s12933-018-0747-3
2017[ to top ]
  • Maric, H. M., Hausrat, T. J., Neubert, F., Dalby, N. O., Doose, S., Sauer, M., Kneussel, M., & Strømgaard, K. Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission. Nature Chemical Biology, 13, 153-. https://doi.org/10.1038/nchembio.2246
  • Burgert, A., Schlegel, J., Bécam, J., Doose, S., Bieberich, E., Schubert-Unkmeir, A., & Sauer, M. Characterization of Plasma Membrane Ceramides by Super-Resolution Microscopy. Angewandte Chemie. https://doi.org/10.1002/ange.201700570
2016[ to top ]
  • Werner, C., Pauli, M., Doose, S., Weishaupt, A., Haselmann, H., Grünewald, B., Sauer, M., Heckmann, M., Toyka, K. V., Asan, E., Sommer, C., & Geis, C. Human autoantibodies to amphiphysin induce defective presynaptic vesicle dynamics and composition. Brain, 139(2), 365-379. http://dx.doi.org/10.1093/brain/awv324
  • Mateos-Gil, P., Letschert, S., Doose, S., & Sauer, M. Super-resolution imaging of plasma membrane proteins with click chemistry. Frontiers in Cell and Developmental Biology, 4, 98-. http://journal.frontiersin.org/article/10.3389/fcell.2016.00098
2015[ to top ]
  • Burgert, A., Letschert, S., Doose, S., & Sauer, M. Artifacts in single-molecule localization microscopy. Histochemistry and Cell Biology, 144, 123-131. http://dx.doi.org/10.1007/s00418-015-1340-4
2014[ to top ]
  • Letschert, S., Göhler, A., Franke, C., Bertleff-Zieschang, N., Memmel, E., Doose, S., Seibel, J., & Sauer, M. Super-Resolution Imaging of Plasma Membrane Glycans. Angewandte Chemie International Edition, n/a-n/a. https://doi.org/10.1002/anie.201406045
2013[ to top ]
  • Steger, K., Bollmann, S., Noe, F., & Doose, S. Systematic evaluation of fluorescence correlation spectroscopy data analysis on the nanosecond time scale. Phys. Chem. Chem. Phys., -. https://doi.org/10.1039/C3CP50644D
  • Seibel, J., König, S., Göhler, A., Doose, S., Memmel, E., Bertleff, N., & Sauer, M. Investigating infection processes with a workflow from organic chemistry to biophysics: the combination of metabolic glycoengineering, super-resolution fluorescence imaging and proteomics. Expert Rev Proteomics, 10(1), 25-31. https://doi.org/10.1586/epr.12.72
  • Schäfer, P., van de Linde, S., Lehmann, J., Sauer, M., & Doose, S. Methylene blue- and thiol-based oxygen depletion for super-resolution imaging. Analytical Chemistry, 85(6), 3393-3400. https://doi.org/10.1021/ac400035k
2012[ to top ]
  • Yahiatène, I., Doose, S., Huser, T., & Sauer, M. Correlation-Matrix Analysis of Two-Color Coincidence Events in Single-Molecule Fluorescence Experiments. Analytical Chemistry, 84(6), 2729-2736. https://doi.org/10.1021/ac2030283
  • Göhler, A., Büchner, C., André, S., Doose, S., Kaltner, H., & Gabius, H.-J. Analysis of homodimeric avian and human galectins by two methods based on fluorescence spectroscopy: Different structural alterations upon oxidation and ligand binding. Biochimie, 94(12), 2649-2655. https://doi.org/10.1016/j.biochi.2012.08.001
2011[ to top ]
  • Noe, F., Doose, S., Daidone, I., Löllmann, M., Sauer, M., Chodera, J. D., & Smith, J. C. Dynamical fingerprints for probing individual relaxation processes in biomolecular dynamics with simulations and kinetic experiments. Proceedings of the National Academy of Sciences. http://dx.doi.org/10.1073/pnas.1004646108
  • van de Linde, S., Krstic, I., Prisner, T., Doose, S., Heilemann, M., & Sauer, M. Photoinduced formation of reversible dye radicals and their impact on super-resolution imaging. Photochem. Photobiol. Sci., 10(4), 499-506. https://doi.org/10.1039/C0PP00317D
  • Bollmann, S., Lollmann, M., Sauer, M., & Doose, S. Dimer formation of organic fluorophores reports on biomolecular dynamics under denaturing conditions. Phys. Chem. Chem. Phys., 13(28), 12874-12882. https://doi.org/10.1039/C1CP21111K
  • Bollmann, S., Burgert, A., Plattner, C., Nagel, L., Sewald, N., Löllmann, M., Sauer, M., & Doose, S. Conformational Flexibility of Glycosylated Peptides. ChemPhysChem, 12(16), 2907-2911. https://doi.org/10.1002/cphc.201100650
  • Gohler, A., Buchner, C., Andre, S., Doose, S., Kaltner, H., & Gabius, H.-J. Sensing ligand binding to a clinically relevant lectin by tryptophan fluorescence anisotropy. Analyst, 136(24), 5270-5276. https://doi.org/10.1039/C1AN15692F
2010[ to top ]
  • Daidone, I., Neuweiler, H., Doose, S., Sauer, M., & Smith, J. C. Hydrogen-Bond Driven Loop-Closure Kinetics in Unfolded Polypeptide Chains. PLOS COMPUTATIONAL BIOLOGY, 6(1), Article 1. http://dx.doi.org/10.1371/journal.pcbi.1000645
  • Goehler, A., Andre, S., Kaltner, H., Sauer, M., Gabius, H.-J., & Doose, S. Hydrodynamic Properties of Human Adhesion/Growth-Regulatory Galectins Studied by Fluorescence Correlation Spectroscopy. BIOPHYSICAL JOURNAL, 98(12), 3044-3053. http://dx.doi.org/10.1016/j.bpj.2010.03.040
2009[ to top ]
  • Doose, S., Neuweiler, H., & Sauer, M. Fluorescence Quenching by Photoinduced Electron Transfer: A Reporter for Conformational Dynamics of Macromolecules. CHEMPHYSCHEM, 10(9-10, Sp. Iss. SI), 1389-1398. http://dx.doi.org/10.1002/cphc.200900238
2008[ to top ]
  • Doose, S. Importance of Backbone and Solvent Properties for Conformational Dynamics in Polypeptides. CHEMPHYSCHEM, 9(18), 2687-2689. http://dx.doi.org/10.1002/cphc.200800545
  • Goodman, R. P., Heilemann, M., Doose, S., Erben, C. M., Kapanidis, A. N., & Turberfield, A. J. Reconfigurable, braced, three-dimensional DNA nanostructures. NATURE NANOTECHNOLOGY, 3(2), 93-96. http://dx.doi.org/10.1038/nnano.2008.3
  • Schuettpelz, M., Schoening, J. C., Doose, S., Neuweiler, H., Peters, E., Staiger, D., & Sauer, M. Changes in conformational dynamics of mRNA upon AtGRP7 binding studied by fluorescence correlation spectroscopy. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130(29), 9507-9513. http://dx.doi.org/10.1021/ja801994z
2007[ to top ]
  • Doose, S. Optical amplification from single excitons in collodial quantum dots. SMALL, 3(11), 1856-1858. http://dx.doi.org/10.1002/smll.200700478
  • Doose, S., Neuweiler, H., Barsch, H., & Sauer, M. Probing polyproline structure and dynamics by photoinduced electron transfer provides evidence for deviations from a regular polyproline type II helix. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 104(44), 17400-17405. http://dx.doi.org/10.1073/pnas.0705605104
  • Doose, S., Heilemann, M., Michalet, X., Weiss, S., & Kapanidis, A. Periodic acceptor excitation spectroscopy of single molecules. European Biophysics Journal, 36(6), 669-674. http://dx.doi.org/10.1007/s00249-007-0133-7
  • Neuweiler, H., Lollmann, M., Doose, S., & Sauer, M. Dynamics of unfolded polypeptide chains in crowded environment studied by fluorescence correlation spectroscopy. JOURNAL OF MOLECULAR BIOLOGY, 365(3), 856-869. http://dx.doi.org/10.1016/j.jmb.2006.10.021
  • Vogelsang, J., Doose, S., Sauer, M., & Tinnefeld, P. Single-Molecule Fluorescence Resonance Energy Transfer in Nanopipets: Improving Distance Resolution and Concentration Range. ANALYTICAL CHEMISTRY, 79(19), 7367-7375. http://dx.doi.org/10.1021/ac071176n
  • Doose, S., Barsch, H., & Sauer, M. Polymer properties of polythymine as revealed by translational diffusion. BIOPHYSICAL JOURNAL, 93(4), 1224-1234. http://dx.doi.org/10.1529/biophysj.107.107342
2006[ to top ]
  • Kim, J., Doose, S., Neuweiler, H., & Sauer, M. The initial step of DNA hairpin folding: a kinetic analysis using fluorescence correlation spectroscopy. NUCLEIC ACIDS RESEARCH, 34(9), 2516-2527. http://dx.doi.org/10.1093/nar/gkl221
  • Tsay, J., Doose, S., & Weiss, S. Rotational and translational diffusion of peptide-coated CdSe/CdS/ZnS nanorods studied by fluorescence correlation spectroscopy. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 128(5), 1639-1647. http://dx.doi.org/10.1021/ja056162i
  • Pinaud, F., Michalet, X., Bentolila, L., Tsay, J., Doose, S., Li, J., Iyer, G., & Weiss, S. Advances in fluorescence imaging with quantum dot bio-probes. BIOMATERIALS, 27(9), 1679-1687. http://dx.doi.org/10.1016/j.biomaterials.2005.11.018
2005[ to top ]
  • Neuweiler, H., Doose, S., & Sauer, M. A microscopic view of miniprotein folding: Enhanced folding efficiency through formation of an intermediate. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(46), 16650-16655. http://dx.doi.org/10.1073/pnas.0507351102
  • Tsay, J., Doose, S., Pinaud, F., & Weiss, S. Enhancing the photoluminescence of peptide-coated nanocrystals with shell composition and UV irradiation. JOURNAL OF PHYSICAL CHEMISTRY B, 109(5), 1669-1674. http://dx.doi.org/10.1021/jp046828f
  • Michalet, X., Pinaud, F., Bentolila, L., Tsay, J., Doose, S., Li, J., Sundaresan, G., Wu, A., Gambhir, S., & Weiss, S. Quantum dots for live cells, in vivo imaging, and diagnostics. SCIENCE, 307(5709), 538-544. http://dx.doi.org/10.1126/science.1104274
  • Kapanidis, A., Margeat, E., Laurence, T., Doose, S., Ho, S., Mukhopadhyay, J., Kortkhonjia, E., Mekler, V., Ebright, R., & Weiss, S. Retention of transcription initiation factor sigma(70) in transcription elongation: Single-molecule analysis. MOLECULAR CELL, 20(3), 347-356. http://dx.doi.org/10.1016/j.molcel.2005.10.012
  • Doose, S., Tsay, J., Pinaud, F., & Weiss, S. Comparison of photophysical and colloidal properties of biocompatible semiconductor nanocrystals using fluorescence correlation spectroscopy. ANALYTICAL CHEMISTRY, 77(7), 2235-2242. http://dx.doi.org/10.1021/ac050035n
  • Doose, S., Neuweiler, H., & Sauer, M. A close look at fluorescence quenching of organic dyes by tryptophan. CHEMPHYSCHEM, 6(11), 2277-2285. http://dx.doi.org/10.1002/cphc.200500191
2004[ to top ]
  • Kapanidis, A., Lee, N., Laurence, T., Doose, S., Margeat, E., & Weiss, S. Fluorescence-aided molecule sorting: Analysis of structure and interactions by alternating-laser excitation of single molecules. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101(24), 8936-8941. http://dx.doi.org/10.1073/pnas.0401690101
2003[ to top ]
  • Michalet, X., Kapanidis, A., Laurence, T., Pinaud, F., Doose, S., Pflughoefft, M., & Weiss, S. The power and prospects of fluorescence microscopies and spectroscopies. ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, 32, 161-182. http://dx.doi.org/10.1146/annurev.biophys.32.110601.142525