Lehrstuhl für Neurobiologie und Genetik

    Publikationen Förster

    • 1.
      Bertolini, E., and Helfrich-Förster, C. (2021) -Sleep and the Circadian Clock in Insects☆. In Reference Module in Neuroscience and Biobehavioral Psychology, Elsevier.
    • 2.
      Vaze, K. M., and Helfrich-Förster, C. (2021) The Neuropeptide PDF Is Crucial for Delaying the Phase of Drosophila’s Evening Neurons Under Long Zeitgeber Periods, Journal of Biological Rhythms.
    • 3.
      Pauls, D., Selcho, M., Räderscheidt, J., Amatobi, K. M., Fekete, A., Krischke, M., Hermann-Luibl, C., Ozbek-Unal, A. G., Ehmann, N., Itskov, P. M., Kittel, R. J., Helfrich-Förster, C., Kühnlein, R. P., Mueller, M. J., and Wegener, C. (2021) Endocrine signals fine-tune daily activity patterns in Drosophila, Current Biology.
    • 4.
      Colizzi, F. S., Beer, K., Cuti, P., Deppisch, P., Martínez Torres, D., Yoshii, T., and Helfrich-Förster, C. (2021) Antibodies Against the Clock Proteins Period and Cryptochrome Reveal the Neuronal Organization of the Circadian Clock in the Pea Aphid, Frontiers in Physiology 12, 988.
    • 5.
      Wehr, T. A., and Helfrich-Förster, C. (2021) Longitudinal observations call into question the scientific consensus that humans are unaffected by lunar cycles, BioEssays n/a, 2100054.
    • 6.
      Helfrich-Förster, C., Monecke, S., Spiousas, I., Hovestadt, T., Mitesser, O., and Wehr, T. A. (2021) Women temporarily synchronize their menstrual cycles with the luminance and gravimetric cycles of the Moon, Science Advances 7.
    • 7.
      Breitenbach, T., Helfrich-Förster, C., and Dandekar, T. (2021) An effective model of endogenous clocks and external stimuli determining circadian rhythms, Scientific Reports 11, 16165.
    • 8.
      Menegazzi, P., Beer, K., Grebler, V., Schlichting, M., Schubert, F. K., and Helfrich-Förster, C. (2020) A Functional Clock Within the Main Morning and Evening Neurons of D. melanogaster Is Not Sufficient for Wild-Type Locomotor Activity Under Changing Day Length, Frontiers in Physiology 11, 229.
    • 9.
      Schabler, S., Amatobi, K. M., Horn, M., Rieger, D., Helfrich-Förster, C., Mueller, M. J., Wegener, C., and Fekete, A. (2020) Loss of function in the Drosophila clock gene period results in altered intermediary lipid metabolism and increased susceptibility to starvation, Cellular and Molecular Life Sciences.
    • 10.
      Schubert, F. K., Helfrich-Förster, C., and Rieger, D. (2020) Single-cell resolution long-term luciferase imaging in cultivated <i>Drosophila</i> brains, microPublication Biology.
    • 11.
      Beer, K., and Helfrich-Förster, C. (2020) Post-embryonic Development of the Circadian Clock Seems to Correlate With Social Life Style in Bees, Frontiers in Cell and Developmental Biology 8, 1325.
    • 12.
      Scheiner, R., Frantzmann, F., Jäger, M., Mitesser, O., Helfrich-Förster, C., and Pauls, D. (2020) A Novel Thermal-Visual Place Learning Paradigm for Honeybees (Apis mellifera), Frontiers in Behavioral Neuroscience 14, 56.
    • 13.
      Pegoraro, M., Flavell, L. M. M., Menegazzi, P., Colombi, P., Dao, P., Helfrich-Förster, C., and Tauber, E. (2020) The genetic basis of diurnal preference in Drosophila melanogaster, BMC Genomics 21, 596.
    • 14.
      Fernandez-Chiappe, F., Hermann-Luibl, C., Peteranderl, A., Reinhard, N., Senthilan, P. R., Hieke, M., Selcho, M., Yoshii, T., Shafer, O. T., Muraro, N. I., and Helfrich-Förster, C. (2020) Dopamine signaling in wake promoting clock neurons is not required for the normal regulation of sleep in Drosophila, Journal of Neuroscience, Society for Neuroscience.
    • 15.
      Beer, K., and Helfrich-Förster, C. (2020) Model and Non-model Insects in Chronobiology, Frontiers in Behavioral Neuroscience 14, 221.
    • 16.
      Helfrich-Förster, C. (2019) Polarization Vision: Targets of Polarization-Sensitive Photoreceptors in the Drosophila Visual System, Current Biology 29, R839 - R842.
    • 17.
      Schlichting, M., Menegazzi, P., Rosbash, M., and Helfrich-Förster, C. (2019) A distinct visual pathway mediates high light intensity adaptation of the circadian clock in Drosophila, Journal of Neuroscience.
    • 18.
      Senthilan, P. R., Grebler, R., Reinhard, N., Rieger, D., and Helfrich-Förster, C. (2019) Role of Rhodopsins as Circadian Photoreceptors in the Drosophila melanogaster, Biology 8, 6.
    • 19.
      Cederroth, C. R., Albrecht, U., Bass, J., Brown, S. A., Dyhrfjeld-Johnsen, J., Gachon, F., Green, C. B., Hastings, M. H., Helfrich-Förster, C., Hogenesch, J. B., Lévi, F., Loudon, A., Lundkvist, G. B., Meijer, J. H., Rosbash, M., Takahashi, J. S., Young, M., and Canlon, B. (2019) Medicine in the Fourth Dimension, Cell Metabolism 30, 238–250.
    • 20.
      Nagy, D., Cusumano, P., Andreatta, G., Anduaga, A. M., Hermann-Luibl, C., Reinhard, N., Gesto, J., Wegener, C., Mazzotta, G., Rosato, E., Kyriacou, C. P., Helfrich-Förster, C., and Costa, R. (2019) Peptidergic signaling from clock neurons regulates reproductive dormancy in Drosophila melanogaster, PLOS Genetics 15, 1–25.
    • 21.
      Schlichting, M., Weidner, P., Diaz, M., Menegazzi, P., Dalla-Benetta, E., Helfrich-Foerster, C., and Rosbash, M. (2019) Light-mediated circuit switching in the Drosophila neuronal clock network, bioRxiv 515478.
    • 22.
      Helfrich-Förster, C. (2019) Flies’ colour preferences depend on the time of day, Nature 574, 43–44.
    • 23.
      Horn, M., Mitesser, O., Hovestadt, T., Yoshii, T., Rieger, D., and Helfrich-Förster, C. (2019) The Circadian Clock Improves Fitness in the Fruit Fly, Drosophila melanogaster, Frontiers in Physiology 10, 1374.
    • 24.
      Bertolini, E., Schubert, F. K., Zanini, D., Sehadová, H., Helfrich-Förster, C., and Menegazzi, P. (2019) Life at High Latitudes Does Not Require Circadian Behavioral Rhythmicity under Constant Darkness, Current Biology.
    • 25.
      Helfrich-Förster, C. (2019) Light input pathways to the circadian clock of insects with an emphasis on the fruit fly Drosophila melanogaster, Journal of Comparative Physiology A 1–14.
    • 26.
      Helfrich-Förster, C. (2018) Sleep in Insects, Annual Review of Entomology 63.
    • 27.
      Beck, K., Hovhanyan, A., Menegazzi, P., Helfrich-Förster, C., and Raabe, T. (2018) Drosophila RSK Influences the Pace of the Circadian Clock by Negative Regulation of Protein Kinase Shaggy Activity, Frontiers in Molecular Neuroscience 11, 122.
    • 28.
      Beer, K., Kolbe, E., Kahana, N. B., Yayon, N., Weiss, R., Menegazzi, P., Bloch, G., and Helfrich-Förster, C. (2018) Pigment-Dispersing Factor-expressing neurons convey circadian information in the honey bee brain, Open Biology 8, 170224.
    • 29.
      Schubert, F. K., Hagedorn, N., Yoshii, T., Helfrich-Förster, C., and Rieger, D. (2018) Neuroanatomical details of the lateral neurons of Drosophila melanogaster support their functional role in the circadian system, J Comp Neurol 526, 1209–1231.
    • 30.
      Bertolini, E., Kistenpfennig, C., Menegazzi, P., Keller, A., Koukidou, M., and Helfrich-Förster, C. (2018) The characterization of the circadian clock in the olive fly Bactrocera oleae (Diptera: Tephritidae) reveals a Drosophila-like organization, Sci Reports 8, 816.
    • 31.
      Pilorz, V., Helfrich-Förster, C., and Oster, H. (2018) The role of the circadian clock system in physiology, Pflügers Archiv - European Journal of Physiology.
    • 32.
      Kay, J., Menegazzi, P., Mildner, S., Roces, F., and Helfrich-Förster, C. (2018) The Circadian Clock of the Ant Camponotus floridanus Is Localized in Dorsal and Lateral Neurons of the Brain, Journal of biological rhythms 33, 255–271.
    • 33.
      Schlichting, M., Rieger, D., Cusumano, P., Grebler, R., Costa, R., Mazzotta, G., and Helfrich-Förster, C. (2018) Cryptochrome interacts with actin and enhances eye-mediated light sensitivity of the circadian clock in Drosophila melanogaster, Frontiers in Molecular Neuroscience 11, 238.
    • 34.
      Fujiwara, Y., Hermann-Luibl, C., Katsura, M., Sekiguchi, M., Ida, T., Helfrich-Förster, C., and Yoshii, T. (2018) The CCHamide1 neuropeptide expressed in the anterior dorsal neuron 1 conveys a circadian signal to the ventral lateral neurons in Drosophila melanogaster, Frontiers in physiology 9, 1276.
    • 35.
      Helfrich-Förster, C., Bertolini, E., and Menegazzi, P. (2018) Flies as models for circadian clock adaptation to environmental challenges, European Journal of Neuroscience.
    • 36.
      Beauchamp, M., Bertolini, E., Deppisch, P., Steubing, J., Menegazzi, P., and Helfrich-Förster, C. (2018) Closely Related Fruit Fly Species Living at Different Latitudes Diverge in Their Circadian Clock Anatomy and Rhythmic Behavior, Journal of Biological Rhythms 33, 602–613.
    • 37.
      Selkrig, J., Mohammad, F., Ng, S. H., Chua, J. Y., Tumkaya, T., Ho, J., Chiang, Y. N., Rieger, D., Pettersson, S., Helfrich-Foerster, C., and others. (2018) The Drosophila microbiome has a limited influence on sleep, activity, and courtship behaviors, Scientific reports 8, 10646.
    • 38.
      Grebler, R., Kistenpfennig, C., Rieger, D., Bentrop, J., Schneuwly, S., Senthilan, P. R., and Helfrich-Förster, C. (2017) Drosophila Rhodopsin 7 can partially replace the structural role of Rhodopsin 1, but not its physiological function, Journal of Comparative Physiology A 1–11.
    • 39.
      Menegazzi, P., Benetta, E. D., Beauchamp, M., Schlichting, M., Steffan-Dewenter, I., and Helfrich-Förster, C. (2017) Adaptation of circadian neuronal network to photoperiod in high-latitude European Drosophilids, CURR BIOL 27, 833–839.
    • 40.
      Benna, C., Helfrich-Förster, C., Rajendran, S., Monticelli, H., Pilati, P., Nitti, D., and Mocellin, S. (2017) Genetic variation of clock genes and cancer risk: a field synopsis and meta-analysis, Oncotarget.
    • 41.
      Frenkel, L., Muraro, N. I., González, A. N. B., Marcora, M. S., Bernabó, G., Hermann-Luibl, C., Romero, J. I., Helfrich-Förster, C., Castaño, E. M., Marino-Busjle, C., Calvo, D. J., and Ceriani, M. F. (2017) Organization of Circadian Behavior Relies on Glycinergic Transmission, Cell Reports 19, 72–85.
    • 42.
      Fuchikawa, T., Beer, K., Linke-Winnebeck, C., Ben-David, R., Kotowoy, A., Tsang, V., Warman, G., Winnebeck, E., Helfrich-Förster, C., and Bloch, G. (2017) Neuronal circadian clock protein oscillations are similar in behaviourally rhythmic forager honeybees and in arrhythmic nurses, Open Biology 7, 170047.
    • 43.
      Beer, K., Joschinski, J., Arrazola Sastre, A., Krauss, J., and Helfrich-Förster, C. (2017) A damping circadian clock drives weak oscillations in metabolism and locomotor activity of aphids (Acyrthosiphon pisum), Sci Rep 7, 14906–14906.
    • 44.
      Kistenpfennig, C., Nakayama, M., Nihara, R., Tomioka, K., Helfrich-Förster, C., and Yoshii, T. (2017) A Tug-of-War between Cryptochrome and the Visual System Allows the Adaptation of Evening Activity to Long Photoperiods in Drosophila melanogaster., Journal of biological rhythms 33, 24–34.
    • 45.
      Kistenpfennig, C., Grebler, R., Ogueta, M., Hermann-Luibl, C., Schlichting, M., Stanewsky, R., Senthilan, P. R., and Helfrich-Förster, C. (2017) A new Rhodopsin influences light-dependent daily activity patterns of fruit flies, Journal of biological rhythms 32, 406–422.
    • 46.
      Helfrich-Förster, C. (2017) The Drosophila Clock System. In Biological Timekeeping: Clocks, Rhythms and Behaviour (Kumar, V., Ed.), pp. 133–176, Springer India, New Delhi.
    • 47.
      Senthilan, P. R., and Helfrich-Förster, C. (2016) Rhodopsin 7--The unusual Rhodopsin in Drosophila, PeerJ 4, e2427.
    • 48.
      Fischer, R., Helfrich-Förster, C., and Peschel, N. (2016) GSK-3 Beta does not stabilize cryptochrome in the circadian clock of Drosophila, PLOS ONE 11, 1–17.
    • 49.
      Koch, C. E., Bartlang, M. S., Kiehn, J. T., Lucke, L., Naujokat, N., Helfrich-Förster, C., Reber, S. O., and Oster, H. (2016) Time-of-day-dependent adaptation of the HPA axis to predictable social defeat stress, J Endocrinol 231, 209–221.
    • 50.
      Joschinski, J., Beer, K., Helfrich-Förster, C., and Krauss, J. (2016) Pea aphids (Hemiptera: Aphididae) have diurnal rhythms when raised independently of a host plant, J Insect Sci 16, 31.
    • 51.
      Schlichting, M., Menegazzi, P., Lelito, K. R., Yao, Z., Buhl, E., Dalla Benetta, E., Bahle, A., Denike, J., Hodge, J. J., Helfrich-Förster, C., and others. (2016) A neural network underlying circadian entrainment and photoperiodic adjustment of sleep and activity in Drosophila, J Neurosci 36, 9084–9096.
    • 52.
      Beer, K., Steffan-Dewenter, I., Härtel, S., and Helfrich-Förster, C. (2016) A new device for monitoring individual activity rhythms of honey bees reveals critical effects of the social environment on behavior, J Comp Physiol A 202, 555–565.
    • 53.
      Vaze, K. M., and Helfrich-Förster, C. (2016) Drosophila ezoana uses an hour-glass or highly damped circadian clock for measuring night length and inducing diapause, Physiol Entomol 41, 378–389.
    • 54.
      Eck, S., Helfrich-Förster, C., and Rieger, D. (2016) The timed depolarization of morning and evening oscillators phase shifts the circadian clock of Drosophila, J Biol Rhythms 31, 428–442.
    • 55.
      Yoshii, T., Hermann-Luibl, C., and Helfrich-Förster, C. (2016) Circadian light-input pathways in Drosophila, Commun Integr Biol 9, e1102805.
    • 56.
      Chen, J., Reiher, W., Hermann-Luibl, C., Sellami, A., Cognigni, P., Kondo, S., Helfrich-Förster, C., Veenstra, J. A., and Wegener, C. (2016) Allatostatin a signalling in Drosophila regulates feeding and sleep and is modulated by PDF, PLOS Genet 12, e1006346.
    • 57.
      Chouhan, N., Wolf, R., Helfrich-Förster, C., and Heisenberg, M. (2015) Flies remember the time of day, CURR BIOL 25, 1619–1624.
    • 58.
      Kmoch, S., Majewski, J., Ramamurthy, V., Cao, S., Fahiminiya, S., Ren, H., MacDonald, I. M., Lopez, I., Sun, V., Keser, V., Khan, A., Stránecký, V., Hartmannová, H., Přistoupilová, A., Hodaňová, K., Piherová, L., Kuchař, L., Baxová, A., Chen, R., Barsottini, O. G., Pyle, A., Griffin, H., Splitt, M., Sallum, J., Tolmie, J. L., Sampson, J. R., Chinnery, P., Canada, C., Banin, E., Sharon, D., Dutta, S., Grebler, R., Helfrich-Foerster, C., Pedroso, J. L., Kretzschmar, D., Cayouette, M., and Koenekoop, R. K. (2015) Mutations in PNPLA6 are linked to photoreceptor degeneration and various forms of childhood blindness, Nat Commun 6, 5614–5614.
    • 59.
      Hermann-Luibl, C., and Helfrich-Förster, C. (2015) Clock network in Drosophila, Curr Opin Insect Sci 7, 65–70.
    • 60.
      Yoshii, T., Hermann-Luibl, C., Kistenpfennig, C., Schmid, B., Tomioka, K., and Helfrich-Förster, C. (2015) Cryptochrome-Dependent and -Independent Circadian Entrainment Circuits in Drosophila, J Neurosci 35, 6131–6141.
    • 61.
      Schlichting, M., Grebler, R., Menegazzi, P., and Helfrich-Förster, C. (2015) Twilight dominates over moonlight in adjusting Drosophila’s activity pattern, J Biol Rhythms 30, 117–128.
    • 62.
      Schlichting, M., Menegazzi, P., and Helfrich-Förster, C. (2015) Normal vision can compensate for the loss of the circadian clock, Proc R Soc Lond B: Biol Sci 282, 20151846.
    • 63.
      Schlichting, M., and Helfrich-Förster, C. (2015) Chapter Five - Photic Entrainment in Drosophila Assessed by Locomotor Activity Recordings. In Circadian Rhythms and Biological Clocks, Part B (Sehgal, A., Ed.), pp. 105–123.
    • 64.
      Bartlang, M. S., Oster, H., and Helfrich-Förster, C. (2015) Repeated Psychosocial Stress at Night Affects the Circadian Activity Rhythm of Male Mice, J Biol Rhythms 30, 228–241.
    • 65.
      Johnsson, A., Helfrich-Förster, C., and Engelmann, W. (2015) How light resets circadian clocks. In Photobiology, pp. 243–297.
    • 66.
      Schlichting, M., and Helfrich-Förster, C. (2015) Photic entrainment in Drosophila assessed by locomotor activity recordings. In Methods Enzymol, pp. 105–123.
    • 67.
      Bartlang, M. S., Savelyev, S. A., Johansson, A.-S., Reber, S. O., Helfrich-Förster, C., and Lundkvist, G. B. (2014) Repeated psychosocial stress at night, but not day, affects the central molecular clock, Chronobiol Int 31, 996–1007.
    • 68.
      Dusik, V., Senthilan, P. R., Mentzel, B., Hartlieb, H., Wülbeck, C., Yoshii, T., Raabe, T., and Helfrich-Förster, C. (2014) The MAP kinase p38 is part of Drosophila melanogaster’s circadian clock, PLoS genetics 10, e1004565.
    • 69.
      Hermann-Luibl, C., Yoshii, T., Senthilan, P. R., Dircksen, H., and Helfrich-Förster, C. (2014) The ion transport peptide is a new functional clock neuropeptide in the fruit fly Drosophila melanogaster, J Neurosci 34, 9522–9536.
    • 70.
      Schlichting, M., Grebler, R., Peschel, N., Yoshii, T., and Helfrich-Förster, C. (2014) Moonlight detection by Drosophila’s endogenous clock depends on multiple photopigments in the compound eyes, J Biol Rhythms 29, 75–86.
    • 71.
      Helfrich-Förster, C. (2014) From neurogenetic studies in the fly brain to a concept in circadian biology, J Neurogenet 28, 329–347.
    • 72.
      Gmeiner, F., Kołodziejczyk, A., Yoshii, T., Rieger, D., Nässel, D. R., and Helfrich-Förster, C. (2013) GABA(B) receptors play an essential role in maintaining sleep during the second half of the night in Drosophila melanogaster, J Exp Biol 216, 3837–3843.
    • 73.
      Kronfeld-Schor, N., Dominoni, D., de la Iglesia, H., Levy, O., Herzog, E. D., Dayan, T., and Helfrich-Forster, C. (2013) Chronobiology by moonlight, Proc R Soc Lond B: Biol Sci 280, 20123088.
    • 74.
      Mazzotta, G., Rossi, A., Leonardi, E., Mason, M., Bertolucci, C., Caccin, L., Spolaore, B., Martin, A. J., Schlichting, M., Grebler, R., Helfrich-Förster, C., and others. (2013) Fly cryptochrome and the visual system, Proc Natl Acad Sci 110, 6163–6168.
    • 75.
      Menegazzi, P., Vanin, S., Yoshii, T., Rieger, D., Hermann, C., Dusik, V., Kyriacou, C. P., Helfrich-Förster, C., and Costa, R. (2013) Drosophila clock neurons under natural conditions, J Biol Rhythms 28, 3–14.
    • 76.
      Hermann, C., Saccon, R., Senthilan, P. R., Domnik, L., Dircksen, H., Yoshii, T., and Helfrich-Förster, C. (2013) The circadian clock network in the brain of different Drosophila species, J Comp Neurol 521, 367–388.
    • 77.
      Redondo, B. B., Bunz, M., Halder, P., Sadanandappa, M. K., Mühlbauer, B., Erwin, F., Hofbauer, A., Rodrigues, V., VijayRaghavan, K., Ramaswami, M., Rieger, D., Wegener, C., Helfrich-Förster, C., and Buchner, E. (2013) Identification and structural characterization of interneurons of the Drosophila brain by monoclonal antibodies of the Würzburg Hybridoma Library, PLOS ONE 8, 1–9.
    • 78.
      Ahmed, Z., Helfrich-Förster, C., and Dandekar, T. (2013) Integrating Formal UML Designs and HCI Patterns with Spiral SDLC in DroLIGHT Implementation, Recent Patents on Computer Science 6, 85–98.
    • 79.
      Ahmed, Z., and Helfrich-Förster, C. (2013) DroLIGHT: real time embedded system towards endogenous clock synchronization of drosophila. In Front Neuroinform Conference Abstract: Neuroinformatics.
    • 80.
      Ahmed, Z., and Helfrich-Förster, C. (2013) DroLIGHT-2: real time embedded and data management system for synchronizing circadian clock to the light-dark cycles, Recent Patents on Computer Science 6, 191–205.
    • 81.
      Yoshii, T., Rieger, D., and Helfrich-Förster, C. (2012) Two clocks in the brain. In Progress in Brain Research, pp. 59–82, Elsevier BV.
    • 82.
      Kistenpfennig, C., Hirsh, J., Yoshii, T., and Helfrich-Förster, C. (2012) Phase-shifting the fruit fly clock without cryptochrome, J Biol Rhythms 27, 117–125.
    • 83.
      Menegazzi, P., Yoshii, T., and Helfrich-Förster, C. (2012) Laboratory versus Nature The Two Sides of the Drosophila Circadian Clock, J Biol Rhythms 27, 433–442.
    • 84.
      Umezaki, Y., Yoshii, T., Kawaguchi, T., Helfrich-Förster, C., and Tomioka, K. (2012) Pigment-dispersing factor is involved in age-dependent rhythm changes in Drosophila melanogaster, J Biol Rhythms 27, 423–432.
    • 85.
      Bartlang, M. S., Neumann, I. D., Slattery, D. A., Uschold-Schmidt, N., Kraus, D., Helfrich-Förster, C., and Reber, S. O. (2012) Time matters: pathological effects of repeated psychosocial stress during the active, but not inactive, phase of male mice, J Endocrinol 215, 425–437.
    • 86.
      Kauranen, H., Menegazzi, P., Costa, R., Helfrich-Förster, C., Kankainen, A., and Hoikkala, A. (2012) Flies in the north: Locomotor behavior and clock neuron organization of Drosophila montana, J Biol Rhythms 27, 377–387.
    • 87.
      Bywalez, W., Menegazzi, P., Rieger, D., Schmid, B., Helfrich-Förster, C., and Yoshii, T. (2012) The dual-oscillator system of Drosophila melanogaster under natural-like temperature cycles, Chronobiol Int 29, 395–407.
    • 88.
      Hermann, C., Yoshii, T., Dusik, V., and Helfrich-Förster, C. (2012) Neuropeptide F immunoreactive clock neurons modify evening locomotor activity and free-running period in Drosophila melanogaster, J Comp Neurol 520, 970–987.
    • 89.
      Rieger, D., Peschel, N., Dusik, V., Glotz, S., and Helfrich-Förster, C. (2012) The ability to entrain to long photoperiods differs between 3 Drosophila melanogaster wild-type strains and is modified by twilight simulation, J Biol Rhythms 27, 37–47.
    • 90.
      Vieira, J., Jones, A. R., Danon, A., Sakuma, M., Hoang, N., Robles, D., Tait, S., Heyes, D. J., Picot, M., Yoshii, T., Helfrich-Förster, C., and others. (2012) Human cryptochrome-1 confers light independent biological activity in transgenic Drosophila correlated with flavin radical stability, PLoS One 7, e31867.
    • 91.
      Yoshii, T., Rieger, D., and Helfrich-Förster, C. (2012) Chapter 4 - Two clocks in the brain: An update of the morning and evening oscillator model in Drosophila. In The Neurobiology of Circadian Timing (Andries Kalsbeek, M. M., and Foster, R. G., Eds.), pp. 59–82.
    • 92.
      Schmid, B., Helfrich-Förster, C., and Yoshii, T. (2011) A new ImageJ plug-in “ActogramJ” for chronobiological analyses, J Biol Rhythms 26, 464–467.
    • 93.
      Helfrich-Förster, C., Nitabach, M. N., and Holmes, T. C. (2011) Insect circadian clock outputs, Essays Biochem 49, 87–101.
    • 94.
      Peschel, N., and Helfrich-Förster, C. (2011) Setting the clock--by nature: circadian rhythm in the fruitfly Drosophila melanogaster, FEBS letters 585, 1435–1442.
    • 95.
      Yoshii, T., Hermann, C., and Helfrich-Förster, C. (2010) Cryptochrome-positive and-negative clock neurons in Drosophila entrain differentially to light and temperature, J Biol Rhythms 25, 387–398.
    • 96.
      Benna, C., Bonaccorsi, S., Wülbeck, C., Helfrich-Förster, C., Gatti, M., Kyriacou, C. P., Costa, R., and Sandrelli, F. (2010) Drosophila timeless2 is required for chromosome stability and circadian photoreception, CURR BIOL 20, 346–352.
    • 97.
      Helfrich-Förster, C. (2010) Das neuronale Netzwerk der Inneren Uhr, Neuroforum 16, 151.
    • 98.
      Ritz, T., Yoshii, T., Helfrich-Förster, C., and Ahmad, M. (2010) Cryptochrome: A photoreceptor with the properties of a magnetoreceptor?, Commun Integr Biol 3, 24–27.
    • 99.
      Wülbeck, C., Grieshaber, E., and Helfrich-Förster, C. (2009) Blocking endocytosis in Drosophila’s circadian pacemaker neurons interferes with the endogenous clock in a PDF-dependent way, Chronobiol Int 26, 1307–1322.
    • 100.
      Helfrich-Förster, C., Yoshii, T., Vanin, S., and Costa, R. (2009) The role of PDF in the circadian clock, Sleep Biol Rhythms 7, 130–143.
    • 101.
      Helfrich-Förster, C. (2009) Macht die innere Uhr “mondsüchtig”?, BIOspektrum 5, 491–492.
    • 102.
      Helfrich-Förster, C. (2009) Does the morning and evening oscillator model fit better for flies or mice?, J Biol Rhythms 24, 259–270.
    • 103.
      Johard, H. A., Yoishii, T., Dircksen, H., Cusumano, P., Rouyer, F., Helfrich-Förster, C., and Nässel, D. R. (2009) Peptidergic clock neurons in Drosophila: ion transport peptide and short neuropeptide F in subsets of dorsal and ventral lateral neurons, J Comp Neurol 516, 59–73.
    • 104.
      Helfrich-Förster, C. (2009) Neuropeptide PDF plays multiple roles in the circadian clock of Drosophila melanogaster, Sleep Biol Rhythms 7, 130–143.
    • 105.
      Yoshii, T., Vanin, S., Costa, R., and Helfrich-Förster, C. (2009) Synergic entrainment of Drosophila’s circadian clock by light and temperature, J Biol Rhythms 24, 452–464.
    • 106.
      Rieger, D., Wülbeck, C., Rouyer, F., and Helfrich-Förster, C. (2009) Period gene expression in four neurons is sufficient for rhythmic activity of Drosophila melanogaster under dim light conditions, J Biol Rhythms 24, 271–282.
    • 107.
      Yoshii, T., Ahmad, M., and Helfrich-Förster, C. (2009) Cryptochrome mediates light-dependent magnetosensitivity of Drosophila’s circadian clock, PLoS Biol 7, e1000086.
    • 108.
      Yoshii, T., Wülbeck, C., Sehadova, H., Veleri, S., Bichler, D., Stanewsky, R., and Helfrich-Förster, C. (2009) The neuropeptide pigment-dispersing factor adjusts period and phase of Drosophila’s clock, J Neurosci 29, 2597–2610.
    • 109.
      Kempinger, L., Dittmann, R., Rieger, D., and Helfrich-Förster, C. (2009) The nocturnal activity of fruit flies exposed to artificial moonlight is partly caused by direct light effects on the activity level that bypass the endogenous clock, Chronobiol Int 26, 151–166.
    • 110.
      Yoshii, T., Todo, T., Wülbeck, C., Stanewsky, R., and Helfrich-Förster, C. (2008) Cryptochrome is present in the compound eyes and a subset of Drosophila’s clock neurons, J Comp Neurol 508, 952–966.
    • 111.
      Wülbeck, C., Grieshaber, E., and Helfrich-Förster, C. (2008) Pigment-dispersing factor (PDF) has different effects on Drosophila’s circadian clocks in the accessory medulla and in the dorsal brain, J Biol Rhythms 23, 409–424.
    • 112.
      Helfrich-Förster, C., Yoshii, T., Wülbeck, C., Grieshaber, E., Rieger, D., Bachleitner, W., Cusumano, P., and Rouyer, F. (2007) The Lateral and Dorsal Neurons ofDrosophila melanogaster:New Insights about Their Morphology and Function, Cold Spring Harbor Symposia on Quantitative Biology, Cold Spring Harbor Laboratory Press 72, 517–525.
    • 113.
      Bachleitner, W., Kempinger, L., Wülbeck, C., Rieger, D., and Helfrich-Förster, C. (2007) Moonlight shifts the endogenous clock of Drosophila melanogaster, Proc Natl Acad Sci 104, 3538–3543.
    • 114.
      Veleri, S., Rieger, D., Helfrich-Förster, C., and Stanewsky, R. (2007) Hofbauer-Buchner Eyelet Affects Circadian Photosensitivity and Coordinates TIM and PER Expression in Drosophila Clock Neurons, J Biol Rhythms 22, 29–42.
    • 115.
      Hamasaka, Y., Rieger, D., Parmentier, M.-L., Grau, Y., Helfrich-Förster, C., and Nässel, D. R. (2007) Glutamate and its metabotropic receptor inDrosophilaclock neuron circuits, J Comp Neurol 505, 32–45.
    • 116.
      Rieger, D., Fraunholz, C., Popp, J., Bichler, D., Dittmann, R., and Helfrich-Förster, C. (2007) The fruit fly Drosophila melanogaster favors dim light and times its activity peaks to early dawn and late dusk, J Biol Rhythms 22, 387–399.
    • 117.
      Helfrich-Förster, C. (2007) Immunohistochemistry in Drosophila. In Methods in Molecular Biology, pp. 533–547, Springer Nature.
    • 118.
      Wülbeck, C., and Helfrich-Förster, C. (2007) RNA in situ hybridizations on Drosophila whole mounts, Circadian Rhythms: Methods and Protocols, Springer 495–511.
    • 119.
      Helfrich-Förster, C. (2006) The neural basis of Drosophila’s circadian clock, Sleep Biol Rhythms 4, 224–234.
    • 120.
      Helfrich-Förster, C., Shafer, O. T., Wülbeck, C., Grieshaber, E., Rieger, D., and Taghert, P. (2006) Development and morphology of the clock-gene-expressing lateral neurons of Drosophila melanogaster, J Comp Neurol 500, 47–70.
    • 121.
      Shafer, O. T., Helfrich-Förster, C., Renn, S. C. P., and Taghert, P. H. (2006) Reevaluation of Drosophila melanogaster’s neuronal circadian pacemakers reveals new neuronal classes, J Comp Neurol 498, 180–193.
    • 122.
      Rieger, D., Shafer, O. T., Tomioka, K., and Helfrich-Förster, C. (2006) Functional analysis of circadian pacemaker neurons in Drosophila melanogaster, J Neurosci 26, 2531–2543.
    • 123.
      Helfrich-Förster, C. (2005) PDF has found its receptor, Neuron 48, 161–163.
    • 124.
      Helfrich-Förster, C. (2005) Organization of endogenous clocks in insects, Portland Press Limited.
    • 125.
      Wülbeck, C., Szabo, G., Shafer, O. T., Helfrich-Förster, C., and Stanewsky, R. (2005) The Novel Drosophila timblind Mutation Affects Behavioral Rhythms but Not Periodic Eclosion, Genetics 169, 751–766.
    • 126.
      Helfrich-Förster, C. (2005) Neurobiology of the fruit fly’s circadian clock, Genes Brain Behav 4, 65–76.
    • 127.
      Helfrich-Förster, C. (2005) Techniques that revealed the network of the circadian clock of Drosophila, Methods in enzymology, Elsevier 393, 439–451.
    • 128.
      Helfrich-Förster, C. (2004) The circadian clock in the brain: a structural and functional comparison between mammals and insects, J Comp Physiol A 190.
    • 129.
      Park, J. H., Schroeder, A. J., Helfrich-Förster, C., Jackson, F. R., and Ewer, J. (2003) Targeted ablation of CCAP neuropeptide-containing neurons of Drosophila causes specific defects in execution and circadian timing of ecdysis behavior, Development 130, 2645–2656.
    • 130.
      Rieger, D., Stanewsky, R., and Helfrich-Förster, C. (2003) Cryptochrome, compound eyes, Hofbauer-Buchner eyelets, and ocelli play different roles in the entrainment and masking pathway of the locomotor activity rhythm in the fruit fly Drosophila melanogaster, J Biol Rhythms 18, 377–391.
    • 131.
      Helfrich-Förster, C. (2003) The neuroarchitecture of the circadian clock in the brain of Drosophila melanogaster, Microsc Res Tech 62, 94–102.
    • 132.
      Veleri, S., Brandes, C., Helfrich-Förster, C., Hall, J. C., and Stanewsky, R. (2003) A self-sustaining, light-entrainable circadian oscillator in the Drosophila brain, Curr Biol 13, 1758–1767.
    • 133.
      Helfrich-Förster, C., Edwards, T., Yasuyama, K., Wisotzki, B., Schneuwly, S., Stanewsky, R., Meinertzhagen, I. A., and Hofbauer, A. (2002) The extraretinal eyelet of Drosophila: development, ultrastructure, and putative circadian function, J Neurosci 22, 9255–9266.
    • 134.
      Helfrich-Förster, C., and Engelmann, W. (2002) Photoreceptors for the circadian clock of the fruitfly. In Biological rhythms, pp. 94–106, Springer.
    • 135.
      Helfrich-Förster, C. (2002) The circadian system of Drosophila melanogaster and its light input pathways1, Zoology 105, 297–312.
    • 136.
      Helfrich-Förster, C., Wulf, J., and De Belle, J. S. (2002) Mushroom body influence on locomotor activity and circadian rhythms in Drosophila melanogaster, J Neurogenet 16, 73–109.
    • 137.
      Helfrich-Förster, C. (2001) The locomotor activity rhythm of Drosophila melanogaster is controlled by a dual oscillator system, J Insect Physiol 47, 877–887.
    • 138.
      Foster, R. G., and Helfrich-Förster, C. (2001) The regulation of circadian clocks by light in fruitflies and mice, Philos Trans R Soc Lond B Biol Sci 356, 1779–1789.
    • 139.
      Helfrich-Förster, C., Winter, C., Hofbauer, A., Hall, J. C., and Stanewsky, R. (2001) The circadian clock of fruit flies is blind after elimination of all known photoreceptors, Neuron 30, 249–261.
    • 140.
      Helfrich-Förster, C., Täuber, M., Park, J. H., Mühlig-Versen, M., Schneuwly, S., and Hofbauer, A. (2000) Ectopic expression of the neuropeptide pigment-dispersing factor alters behavioral rhythms in Drosophila melanogaster, J Neurosci 20, 3339–3353.
    • 141.
      Park, J. H., Helfrich-Forster, C., Lee, G., Liu, L., Rosbash, M., and Hall, J. C. (2000) Differential regulation of circadian pacemaker output by separate clock genes in Drosophila, Proc Natl Acad Sci 97, 3608–3613.
    • 142.
      Helfrich-Förster, C. (2000) Differential control of morning and evening components in the activity rhythm of Drosophila melanogaster-sex-specific differences suggest a different quality of activity, J Biol Rhythms 15, 135–154.
    • 143.
      Emery, P., Stanewsky, R., Helfrich-Förster, C., Emery-Le, M., Hall, J. C., and Rosbash, M. (2000) Drosophila CRY is a deep brain circadian photoreceptor, Neuron 26, 493–504.
    • 144.
      Hao, H., Glossop, N. R., Lyons, L., Qiu, J., Morrish, B., Cheng, Y., Helfrich-Förster, C., and Hardin, P. (1999) The 69 bp Circadian Regulatory Sequence (CRS) Mediatesper-Like Developmental, Spatial, and Circadian Expression and Behavioral Rescue in Drosophila, J Neurosci 19, 987–994.
    • 145.
      Helfrich-Förster, C., Stengl, M., and Homberg, U. (1998) Organization of the Circadian System in Insects, Chronobiol Int 15, 567–594.
    • 146.
      Helfrich-Förster, C. (1998) Robust circadian rhythmicity of Drosophila melanogaster requires the presence of lateral neurons: a brain-behavioral study of disconnected mutants, J. Comp. Physiol. A 182, 435–453.
    • 147.
      Antkowiak, B., and Helfrich-Förster, C. (1998) Effects of small concentrations of volatile anesthetics on action potential firing of neocortical neurons In vitro, Anesthesiology 88, 1592–1605.
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      Helfrich-Förster, C. (1997) Development of pigment-dispersing hormone-immunoreactive neurons in the nervous system of drosophila melanogaster, J Comp Neurol 380, 335–354.
    • 149.
      Kaneko, M., Helfrich-Förster, C., and Hall, J. C. (1997) Spatial and temporal expression of the period andtimeless genes in the developing nervous system of Drosophila: newly identified pacemaker candidates and novel features of clock gene product cycling, J Neurosci 17, 6745–6760.
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      Helfrich-Förster, C. (1996) Drosophila rhythms: from brain to behavior, Semin Cell Dev Biol 7, 791–802.
    • 151.
      Helfrich-Förster, C. (1995) The period clock gene is expressed in central nervous system neurons which also produce a neuropeptide that reveals the projections of circadian pacemaker cells within the brain of Drosophila melanogaster., Proc Natl Acad Sci 92, 612–616.
    • 152.
      Helfrich-Förster, C., and Homberg, U. (1993) Pigment-dispersing hormone-immunoreactive neurons in the nervous system of wild-type Drosophila melanogaster and of several mutants with altered circadian rhythmicity, Journal of Comparative Neurology, Wiley-Blackwell 337, 177–190.
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      Helfrich, C., and Engelmann, W. (1987) Evidences for circadian rhythmicity in the per0 mutant of Drosophila melanogaster, J Biosci 42, 1335–1338.
    • 154.
      Helfrich-Förster, C. (1987) Use of Drosophila melanogaster brain mutants for the localization of the pacemaker of circadian locomotor activity rhythm, J Neurogenet 4, 137–140.
    • 155.
      Helfrich, C. (1986) Role of the Optic Lobes in the Regulation of the Locomotor Activity Rhythm of Drosophila melanogaster: Behavioral Analysis of Neural Mutants, J Neurogenet 3, 321–343.
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      Helfrich, C., Cymborowski, B., and Engelmann, W. (1985) Circadian activity rhythm of the house fly continues after optic tract severance and lobectomy, Chronobiol Int 2, 19–32.
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      Helfrich-Förster, C., and Engelmann, W. (1983) Circadian rhythm of the locomotor activity in Drosophila melanogaster and its mutants ‘sine oculis’ and ‘small optic lobes’, Physiol Entomol 8, 257–272.