piwik-script

English
    Lehrstuhl für Botanik I - Pflanzenphysiologie und Biophysik

    Publikationen

    Xiaodong Duan, Georg Nagel, Shiqiang Gao (2019) Mutated Channelrhodopsins with Increased Sodium and Calcium Permeability. Appl. Sci. 2019, 9, 664; doi:10.3390/app9040664
     

    Tian Y, Gao S, von der Heyde EL, Hallmann A, Nagel G (2018). Two-component cyclase opsins of green algae are ATP-dependent and light-inhibited guanylyl cyclases. BMC Biol. 2018 Dec 6;16(1):144. doi: 10.1186/s12915-018-0613-5.
     
    Beck Sebastian, Jing Yu-Strzelczyk, Dennis Pauls, Oana M. Constantin, Christine E. Gee, Nadine Ehmann, Robert J. Kittel, Georg Nagel, Shiqiang Gao Synthetic Light-Activated Ion Channels for Optogenetic Activation and Inhibition (2018) Front Neurosci. 12: 643. Published online 2018 Oct 2. doi: 10.3389/fnins.2018.00643
    PMCID:    PMC6176052
     
    Scheib U, Broser M, Constantin O M, Yang S, Gao S, Mukherjee S, Stehfest K, Nagel G, Gee C E, Hegemann P (2018) Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 Å structure of the adenylyl cyclase domain. Nature Communications 9(1):2046. doi: 10.1038/s41467-018-04428-w.
     
    Tian Y, Gao S, Yang S, Nagel G. (2018) A novel rhodopsin phosphodiesterase from Salpingoeca rosetta shows light-enhanced substrate affinity. Biochem J. 475(6):1121-1128. doi: 10.1042/BCJ20180010.
     
    Bergs A, Schultheis C, Fischer E, Tsunoda SP, Erbguth K, Husson SJ, Govorunova E, Spudich JL, Nagel G, Gottschalk A, Liewald JF. (2018) Rhodopsin optogenetic toolbox v2.0 for light-sensitive excitation and inhibition in Caenorhabditis elegans. PLoS One. 13(2):e0191802.

    Scholz N, Guan C, Nieberler M, Grotemeyer A, Maiellaro I, Gao S, Beck S, Pawlak M, Sauer M, Asan E, Rothemund S, Winkler J, Prömel S, Nagel G, Langenhan T, Kittel RJ. (2017) Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons. Elife. 2017 Aug 8;6. pii: e28360. doi: 10.7554/eLife.28360.

    Gao S, Nagpal J, Schneider MW, Kozjak-Pavlovic V, Nagel G, Gottschalk A. (2015) Optogenetic manipulation of cGMP in cells and animals by the tightly light-regulated guanylyl-cyclase opsin CyclOp. Nat Commun. 6:8046. doi: 10.1038/ncomms9046 (2015)

    Adamantidis A, Arber S, Bains JS, Bamberg E, Bonci A, Buzsáki G, Cardin JA, Costa RM, Dan Y, Goda Y, Graybiel AM, Häusser M, Hegemann P, Huguenard JR, Insel TR, Janak PH, Johnston D, Josselyn SA, Koch C, Kreitzer AC, Lüscher C, Malenka RC, Miesenböck G, Nagel G, Roska B, Schnitzer MJ, Shenoy KV, Soltesz I, Sternson SM, Tsien RW, Tsien RY, Turrigiano GG, Tye KM, Wilson RI. (2015). Optogenetics: 10 years after ChR2 in neurons--views from the community. Nat Neurosci 18:1202-12.

    Dawydow A., Gueta R., Ljaschenko D., Ullrich S., Hermann M., Fiala A., Langenhan T., Nagel G., Kittel R.J., (2014) Channelrhodopsin-2-XXL, a powerful optogenetic tool for low-light applications. Proc Natl Acad Sci USA. 111(38):13972-7

    Raffelberg S, Wang L, Gao S, Losi A, Gärtner W, Nagel G. (2013) A LOV-domain-mediated blue-light-activated adenylate (adenylyl) cyclase from the cyanobacterium Microcoleus chthonoplastes PCC 7420. Biochem J; 455(3):359-65

    Hegemann P, Nagel G. (2013) From channelrhodopsins to optogenetics.EMBO Mol Med. 5(2):173-6. doi: 10.1002/emmm.201202387. Epub 2013 Jan 22.

    Ullrich S, Gueta R, Nagel G. (2013) Degradation of channelopsin-2 in the absence of retinal and degradation resistance in certain mutants. Biol Chem. 2013 Feb;394(2):271-80.

    Schultheis C, Liewald JF, Bamberg E, Nagel G, Gottschalk A. (2011) Optogenetic long-term manipulation of behavior and animal development. PLoS. 6(4):18766.

    Yonehara K, Balint K, Noda M, Nagel G, Bamberg E, Roska B. (2011) Spatially asymmetric reorganization of inhibition establishes a motion-sensitive circuit. Nature. 469(7330):407-10.

    Weissenberger S, Schultheis C, Liewald JF, Erbguth K, Nagel G, Gottschalk A. (2011) PACα--an optogenetic tool for in vivo manipulation of cellular cAMP levels, neurotransmitter release, and behavior in Caenorhabditis elegans. J Neurochem. 116(4):616-25.

    Stierl M, Stumpf P, Udwari D, Gueta R, Hagedorn R, Losi A, Gärtner W, Petereit L, Efetova M, Schwarzel M, Oertner TG, Nagel G, Hegemann P. (2011) Light modulation of cellular cAMP by a small bacterial photoactivated adenylyl cyclase, bPAC, of the soil bacterium Beggiatoa. J Biol Chem. 286(2):1181-8.

    Bamann C, Nagel G, Bamberg E. (2010) Microbial rhodopsins in the spotlight. Curr. Opin. Neurobiol. 20(5):610-6.

    Bamann C, Gueta R, Kleinlogel S, Nagel G, Bamberg E. (2010) Structural guidance of the photocycle of channelrhodopsin-2 by an interhelical hydrogen bond. Biochemistry. 49(2):267-78.

    Looser J, Schröder-Lang S, Hegemann P, Nagel G. (2009) Mechanistic insights in light-induced cAMP production by photoactivated adenylyl cyclase alpha (PACalpha). Biol Chem. 390(11):1105-11.

    Radu I, Bamann C, Nack M, Nagel G, Bamberg E, Heberle J. (2009) Conformational Changes of Channelrhodopsin-2. J. Am. Chem. Soc. 131, 7313-7319.

    Caldwell JH, Herin GA, Nagel G, Bamberg E, Scheschonka A, Betz H. (2008) Increases in intracellular calcium triggered by channelrhodopsin-2 potentiate the response of metabotropic glutamate receptor mGluR7. J Biol Chem. 283, 24300-24307.

    C. Bamann, T. Kirsch, G. Nagel, and E. Bamberg (2008) Spectral charcteristics of the photocycle of channelrhodopsin-2 and its implication for channel function. J Mol Biol. 375(3):686-694.

    F. Zhang, L.-P. Wang, M. Brauner, J.F. Liewald, K. Kay, N. Watzke, P.G. Wood, E. Bamberg, G. Nagel, A. Gottschalk, and K. Deisseroth (2007) Multimodal fast optical interrogation of neural circuits. Nature 446:633-639.

    Schröder-Lang, S., M. Schwärzel, R. Seifert, T. Strünker, S. Kateriya, J. Looser, M. Watanabe, U. B. Kaupp, P. Hegemann, G. Nagel (2007) Fast manipulation of cellular cAMP level by light in vivo. Nat Methods 4(1):39-42.

    Schroll C, Riemensperger T, Bucher D, Ehmer J, Voller T, Erbguth K, Gerber B, Hendel T, Nagel G, Buchner E, Fiala A. (2006) Light-induced activation of distinct modulatory neurons triggers appetitive or aversive learning in Drosophila larvae. Curr Biol. 16(17):1741-7.

    Zimmermann D, Terpitz U, Zhou A, Reuss R, Müller K, Sukhorukov VL, Gessner P, Nagel G, Zimmermann U, Bamberg E. (2006) Biophysical characterisation of electrofused giant HEK293-cells as a novel electrophysiological expression system. Biochem Biophys Res Commun. 348(2):673-81.

    Nagel, G., P. Barbry, H. Chabot, E. Brochiero, K. Hartung and R. Grygorczyk. (2005) CFTR fails to inhibit the epithelial sodium channel ENaC expressed in Xenopus laevis oocytes. J Physiol (Lond) 564: 671-682.

    Nagel, G., T. Szellas, S. Kateriya, N. Adeishvili, P. Hegemann, E. Bamberg. Channelrhodopsins: directly light-gated cation channels. Biochemical Society Transactions (2005) 33(4): 863-866.

    Boyden, E.S., F. Zhang, E. Bamberg, G. Nagel, K. Deisseroth (2005) Millisecond-timescale, genetically targeted optical control of neural activity. Nature Neuroscience 8(9):1263-8.

    Nagel, G., M. Brauner, J.F. Liewald, N. Adeishvili, E. Bamberg, A. Gottschalk (2005) Light-activation of Channelrhodopsin-2 in excitable cells of Caenorhabditis elegans triggers rapid behavioral responses. Current Biology 15(24):2279-84.

    Bettina Himmel & Georg Nagel (2004) Protein kinase-independent activation of CFTR by phosphatidylinositol phosphates. EMBO reports 5, 85–90.

    Nagel, G. (2004) CFTR, investigated with the two-electrode voltage-clamp technique: the importance of knowing the series resistance. Journal of Cystic Fibrosis 3: 109– 111.

    Kateriya S, Nagel G, Bamberg E, Hegemann P. (2004) "Vision" in single-celled algae. News Physiol Sci. 19:133-137.

    Nagel, G, T. Szellas, W. Huhn, S. Kateriya, N. Adeishvili, P. Berthold, D. Ollig, P. Hegemann, E. Bamberg. (2003) Channelrhodopsin-2, a directly Light-gated Cation-selective Membrane Channel. Proc Natl Acad Sci U.S.A. 100:13940-13945.

    Szellas, T. & G. Nagel (2003) Apparent affinity of CFTR for ATP is increased by continuous kinase activity.  FEBS Letters 535: 141-146. 

    Hippler-Mreyen, Silke, Johann P. Klare, Ansgar A. Wegener, Ralf Seidel, Christian Herrmann, Georg Schmies, Georg Nagel, Ernst Bamberg, and M. Engelhard (2003) Probing the Sensory Rhodopsin II Binding Domain of its Cognate Transducer by Calorimetry and Electrophysiology. J. Mol. Biol. 330, 1203–1213.

    Volk, C., V. Gorboulev, T. Budiman, G. Nagel, H. Koepsell. (2003) Different Affinities of Inhibitors to the Outwardly and Inwardly Directed Substrate Binding Site of Organic Cation Transporter 2. Molecular Pharmacology 64:1037-1047.

    Nagel G., D. Ollig, M. Fuhrmann, S. Kateriya, A.M. Musti, E. Bamberg, P. Hegemann (2002). Channelrhodopsin-1: a light-gated proton channel in green algae. Science 296: 2395-2398.

    Powe A, Zhou Z, Hwang T-C, Nagel G (2002). Quantitative Analysis of ATP-Dependent Gating of CFTR. Methods in Molecular Medicine 70:67-98.

    Haase A, Kappl M, Nagel G, Wood PG, Hartung K. (2002) The Ca/Ca Exchange Mode of the Na/Ca Exchanger Investigated by Photolytic Ca2+ Concentration Jumps.  Ann N Y Acad Sci. 976:113-116.