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    Chair of Biochemistry

    Selected Publications

     

    Fischer, U., Bartuli, J. & Grimm, C*. Structure and function of the poxvirus transcription machinery. (2021) in The Enzymes (Academic Press), Book chapter

    Grimm, C.*, J. Bartuli, B. Boettcher, A. A. Szalay, and U. Fischer (2021). Structural basis of the complete poxvirus transcription initiation process  (2021). NSMB, accepted,  Preprint available.

    Veepaschit, J., A. Viswanathan, R. Bordonné, C. Grimm*, and U. Fischer. (2021). Identification and structural analysis of the Schizosaccharomyces pombe SMN complex, Nucleic Acids Res.

    Grimm, C.*., J. P. Pelz, C. Schneider, K. Schäffler, and U. Fischer. 2020. 'Crystal Structure of a Variant PAM2 Motif of LARP4B Bound to the MLLE Domain of PABPC1', Biomolecules, 10: 872.

    Grimm, C, H S Hillen, K Bedenk, J Bartuli, S Neyer, Q Zhang, A Hüttenhofer, M Erlacher, C Dienemann, A Schlosser, H Urlaub, B Böttcher, A A Szalay, P Cramer,  Fischer, U. (2019). Structural Basis of Poxvirus Transcription: Vaccinia RNA Polymerase Complexes, Cell, 179: 1537-1550 Download .pdf

    Hillen, H S, J Bartuli, C Grimm, C Dienemann, K Bedenk, A A Szalay, U Fischer, and P Cramer (2019). Structural Basis of Poxvirus Transcription: Transcribing and Capping Vaccinia Complexes, Cell, 179: 1525-1536

    Kraus, M.   C. Grimm*  and  J. Seibel (2018). 'Reversibility of a Point Mutation Induced Domain Shift: Expanding the Conformational Space of a Sucrose Phosphorylase', Sci Rep, 8: 10490.

    Bertleff-Zieschang, N., J. Bechold, C. Grimm*, M. Reutlinger, P. Schneider, G. Schneider, and J. Seibel. 2017. 'Exploring the Structural Space of the Galectin-1-Ligand Interaction', Chembiochem, 18: 1477-81.

    Kraus, M.   C. Grimm*  and  J. Seibel (2017). 'Switching enzyme specificity from phosphate to resveratrol glucosylation', Chem Commun (Camb), 53: 12181-84.

    Hipp, K., C. Grimm, H. Jeske, and B. Bottcher. 2017. Near-Atomic Resolution Structure of a Plant Geminivirus Determined by Electron Cryomicroscopy, Structure, 25: 1303-1309

    Weiss, M. S., K. Diederichs, R. J. Read, S. Panjikar, G. D. Van Duyne, A. G. Matera, U. Fischer, and C. Grimm*. (2016). A critical examination of the recently reported crystal structures of the human SMN protein, Hum Mol Genet, 25: 4717–25.

    Kraus, M., C. Grimm*, and J. Seibel. 2016. 'Redesign of the Active Site of Sucrose Phosphorylase through a Clash-Induced Cascade of Loop Shifts', Chembiochem, 17: 33-6

    Pelz, J. P., H. Schindelin, K. van Pee, J. Kuper, C. Kisker, K. Diederichs, U. Fischer, and C. Grimm*. 2015. 'Crystallizing the 6S and 8S spliceosomal assembly intermediates: a complex project', Acta Crystallogr D Biol Crystallogr, 71: 2040-53.

    Fischer, U., S. Hertlein, and C. Grimm*. 2015. 'The structure of apo ArnA features an unexpected central binding pocket and provides an explanation for enzymatic cooperativity', Acta Crystallogr D Biol Crystallogr, 71: 687-96

    Grimm C, Chari A, Pelz JP, Kuper J, Kisker C, Diederichs K, Stark H, Schindelin H, Fischer U. Structural Basis of Assembly Chaperone- Mediated snRNP Formation. Mol Cell. (2013). Mol Cell, 49: 692-703.

    Grimm C*, Chari A, Reuter K and Fischer U (2010): A crystallization screen based on alternative polymeric precipitants. Acta Crystallogr D  66: 685-697.  Download .pdf

    Grimm C, Matos R, Ly-Hartig N, Steuerwald U, Lindner D, Rybin V, Müller J and Müller CW (2009): Molecular recognition of histone lysine methylation by the Polycomb group repressor dSfmbt. Embo J 28(13): 1965-1977.

    Grimm, C., A. G. de Ayala Alonso, V. Rybin, U. Steuerwald, N. Ly-Hartig, W. Fischle, J. Muller, and C. W. Muller. 2007. 'Structural and functional analyses of methyl-lysine binding by the malignant brain tumour repeat protein Sex comb on midleg', EMBO Rep, 8: 1031-7.

    Grimm, C., R. Ficner, T. Sgraja, P. Haebel, G. Klebe, and K. Reuter. 2006. 'Crystal structure of Bacillus subtilis S-adenosylmethionine:tRNA ribosyltransferase-isomerase', Biochem Biophys Res Commun, 351: 695-701.

    Grimm, C., A. Evers, M. Brock, C. Maerker, G. Klebe, W. Buckel, and K. Reuter. 2003. 'Crystal structure of 2-methylisocitrate lyase (PrpB) from Escherichia coli and modelling of its ligand bound active centre', J Mol Biol, 328: 609-21

    Grimm, C., E. Maser, E. Mobus, G. Klebe, K. Reuter, and R. Ficner. 2000. 'The crystal structure of 3alpha -hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni shows a novel oligomerization pattern within the short chain dehydrogenase/reductase family', J Biol Chem, 275: 41333-9.

    Grimm, C., G. Klebe, R. Ficner, and K. Reuter. 2000. 'Screening orthologs as an important variable in crystallization: preliminary X-ray diffraction studies of the tRNA-modifying enzyme S-adenosyl-methionine:tRNA ribosyl transferase/isomerase', Acta Crystallogr D Biol Crystallogr, 56: 484-8.

    *Corresponding author