Chair of Biochemistry

Selected Publications

Selected Publications

Weibel S, Raab V, Yong Y, Worschech A, Wang E, et al. (2011): Viral-mediated oncolysis is the most critical factor in the late-phase of the tumor regression process upon vaccinia virus infection. BMC Cancer 11: 68.


Hofmann E, Grummt F and Szalay AA (2011): Vaccinia virus GLV-1h237 carrying a Walker A motif mutation of mouse Cdc6 protein enhances human breast tumor therapy in mouse xenografts. International Journal of Oncology doi: 10.3892/ijo.2011.910.


Seubert C*, Stritzker J*, Marian von Hof J, Donat U, Krewer B, Chen N, Tietze LF, Gentschev I and Szalay AA (2011): Enhanced vaccinia virus mediated oncolytic tumor therapy using a beta-galactosidase activatable prodrug. Cancer GeneTherapy 18: 42-52.
*these authors contributed equally to this work

Gentschev I*, Ehrig K*, Donat U, Hess M, Rudolf S, Yu YA, Chen N, Zhang Q, Bullerdiek J, Nolte I, Stritzker J and Szalay AA (2010): Significant growth inhibition of canine mammary carcinoma xenografts following treatment with oncolytic vaccinia virus GLV-1h68. J Oncol 2010: 736907.
*these authors contributed equally to this work

Stritzker J, Weibel S, Seubert C, Götz A, Tresch A, van Rooijen N, Oelschlaeger TA, Hill PJ, Gentschev I and Szalay AA (2010): Enterobacterial tumor colonization in mice depends on bacterial metabolism and macrophages but is independent of chemotaxis and motility. IJMM 300: 449-56.  

Gentschev I*, Donat U*, Hofmann E, Raab V, Weibel S, Adelfinger M, Heisig M, Yu YA, Chen N, Stritzker J and Szalay AA (2010): Regression of human prostate tumors and metastases in nude mice following treatment with the recombinant oncolytic vaccinia virus GLV-1h68. Journal of Biomedicine and Biotechnology Volume 2010, Article ID 489759.
*these authors contributed equally to this work

Stritzker J, Hill PJ, Gentschev I and Szalay AA. (2010): Myristylation negative msbBE. coli Nissle 1917 retain tumor specific colonization properties but show less side effects in immunocompetent mice. Bioengineered Bugs 1:2, 139-145.

Frentzen A, Yu YA, Chen N, Zhang Q, Weibel S, Raab V and Szalay AA (2009):

Anti-VEGF single-chain antibody GLAF-1 encoded by oncolytic vaccinia virus significantly enhances antitumor therapy

. Proc Natl Acad Sci USA 106: 12915-12920.

Worschech A, Chen N, Yu YA, Zhang Q, Pos Z, Weibel S, Raab V, Sabatino M, Monaco A, Liu H, Monsurró V, Buller RM, Stroncek DF, Wang E, Szalay AA and Marincola FM (2009):

Systemic treatment of xenografts with vaccinia virus GLV-1h68 reveals the immunologic facet of oncolytic therapy

. BMC Genomics 10: 301.

Gentschev I, Stritzker J, Hofmann E, Weibel S, Yu YA, Chen N, Zhang Q, Bullerdiek J, Nolte  I and Szalay AA (2009): Use of an oncolytic vaccinia virus for treatment of canine breast cancer in nude mice: preclinical development of a therapeutic agent. Cancer Gene Therapy 16:  320-328.

Weibel S, Stritzker J, Eck M, Goebel W and Szalay AA (2008): Colonization of experimental murine breast tumors by E. coli K12 significantly alters the tumor environment. Cell Microbiol 10(6): 1235-48.

Brader P*, Stritzker J*,  Riedl CC, Zanzonico P, Cai S, Burnazi EM, Ghani ER, Hricak H, Szalay AA, Fong Y, Blasberg R. (2008): E.coli Nissle 1917 facilitates tumor detection by PET and optical imaging. Clin Cancer Res 14(8): 2295-302.
*these authors contributed equally to this work

Stritzker J*, Weibel S*, Hill PJ, Oelschlaeger TA, Goebel W and Szalay AA (2007): Tumor-specific colonization, tissue distribution, and gene induction by probiotic Escherichia coli Nissle 1917 in live mice. Int J Med Microbiol 297(3): 151-62.
*these authors contributed equally to this work