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Center for Computational and Theoretical Biology

Prof. Dr. Sabine Fischer

Prof. Dr. Sabine Fischer

Professor for Supramolecular and Cellular Simulations
Center for Computational and Theoretical Biology (CCTB)
Klara-Oppenheimer-Weg 32
Campus Hubland Nord
97074 Würzburg
Germany
Phone: +49 931 31-83961
ORCID: https://orcid.org/0000-0001-7237-814X

Google Scholar Profile - Sabine C. Fischer

Research Interests

My research focus is on spatial interactions in biological systems at different length scales. For this, I apply and adjust techniques from data analysis and mathematical modelling such as image analysis, spatial statistics, agent-based modelling and machine learning. I enjoy working in an interdisciplinary environment and utilising the different perspectives for solving interesting research questions. All projects in my group are application- and data-driven and based on close collaborations with experts in the respective field.

Previous PhD students

Alexander Schmitz (2017)

Biena Mathew (2018)

Simon Schardt (2023)

Curriculum Vitae

Since 2018

Professor

Center for Computational and Theoretical Biology (CCTB), University of Würzburg, Würzburg, Germany

2017 - 2018

Development engineer

h.a.l.m. Elektronik GmbH, Frankfurt, Germany    

2011 - 2017

Senior postdoc 

Group of Ernst. H. K. Stelzer, Buchmann Institute of Molecular Life Science (BMLS), Goethe University, Frankfurt am Main, Germany

2009 - 2011

Postdoc

Group of Alfonso Martinez Arias, Department of Genetics, University of Cambridge, UK

Project: “Modelling the cooperative behaviour of sheets of cells during embryogenesis”

2006 - 2009

PhD in Mathematics

School of Mathematical Sciences, University of Nottingham, UK

Thesis: “Modelling planar cell polarity”

Supervisors: Markus Owen and Nick Monk

2000 - 2005

Diploma in Mathematics

Faculty of Mathematics and Computer Science, Julius-Maximilians-University, Würzburg, Germany

Thesis: "Filtermethoden für gemischte Komplementaritätsprobleme"

Supervisor: Christian Kanzow

Publications

2023[ to top ]
  • Tissues as networks of cells: towards generative rules of complex organ development. Fischer, Sabine C.; Bassel, George W.; Kollmannsberger, Philip. In Journal of The Royal Society Interface, 20(204), bl 20230115. The Royal Society, 2023.
  • The salt-and-pepper pattern in mouse blastocysts is compatible with signalling beyond the nearest neighbours. Fischer, Sabine; Schardt, Simon; Lilao-Garzon, Joaquin; Munoz-Descalzo, Silvia. In iScience, bl 108106. Elsevier {BV}, 2023.
  • The salt-and-pepper pattern in mouse blastocysts is compatible with signalling beyond the nearest neighbours. Fischer, Sabine; Schardt, Simon; Lilao-Garzon, Joaquin; Munoz-Descalzo, Silvia. In bioRxiv, bl 2023.05.04.539359. Cold Spring Harbor Laboratory, 2023.
  • Recognition and reconstruction of cell differentiation patterns with deep learning. Dirk, Robin; Fischer, Jonas L.; Schardt, Simon; Ankenbrand, Markus J.; Fischer, Sabine C. In PLOS Computational Biology, 19(10), bll 1–29. Public Library of Science, 2023.
  • Adjusting the range of cell--cell communication enables fine-tuning of cell fate patterns from checkerboard to engulfing. Schardt, Simon; Fischer, Sabine C. In Journal of Mathematical Biology, 87(4), bl 54. 2023.
2022[ to top ]
  • Recognition and reconstruction of cell differentiation patterns with deep learning. Dirk, Robin; Fischer, Jonas L.; Schardt, Simon; Ankenbrand, Markus J.; Fischer, Sabine C. In arXiv, bl 2212.10058. 2022.
  • Interactive, Visual Simulation of a Spatio-Temporal Model of Gas Exchange in the Human Alveolus. Schmid, Kerstin; Knote, Andreas; Mück, Alexander; Pfeiffer, Keram; von Mammen, Sebastian; Fischer, Sabine C. In Frontiers in Bioinformatics. Frontiers, 2022.
  • Adjusting the range of cell-cell communication enables fine-tuning of cell fate patterns from checkerboard to engulfing. Schardt, Simon; Fischer, Sabine C. In arXiv, bl 2211.07241. 2022.
2021[ to top ]
  • On-lattice Vicsek model in confined geometries. Kuhn, Andreas; C, Fischer Sabine. In arXiv, bl 2105.08792. 2021.
  • NANOG/GATA6 Interactions Revisited: A Statistical Mechanics Approach towards Cell Fate Decisions. Schardt, Simon; Fischer, S C. In arXiv, bl 2107.04501. 2021.
  • Interactive, visual simulation of a spatio-temporal model of gas exchange in the human alveolus. Schmid, Kerstin; Knote, Andreas; Mück, Alexander; Pfeiffer, Keram; von Mammen, Sebastian; Fischer, Sabine C. In bioRxiv, bl 2021.09.15.460416. 2021.
  • Global cell-cell communication enables spatial segregation of cells in organoids of the inner cell mass. Schardt, Simon; Fischer, SC. In arXiv, bl 2111.01624. 2021.
2020[ to top ]
  • The transition from local to global patterns governs the differentiation of mouse blastocysts. Fischer, Sabine C.; Corujo-Simon, Elena; Lilao-Garzon, Joaquin; Stelzer, Ernst H. K.; Muñoz-Descalzo, Silvia. In PLOS ONE, 15(5), bll 1–29. Public Library of Science, 2020.
  • Cell fate clusters in ICM organoids arise from cell fate heredity and division: a modelling approach. Liebisch, Tim; Drusko, Armin; Mathew, Biena; Stelzer, Ernst H. K.; Fischer, Sabine C.; Matthäus, Franziska. In Scientific Reports, 10(1), bl 22405-. 2020.
2019[ to top ]
  • Mouse ICM organoids reveal three-dimensional cell fate clustering. Mathew, Biena; Muñoz-Descalzo, Silvia; Corujo Simon, Elena; Schröter, Christian; Stelzer, Ernst H.K; Fischer, Sabine C. In Biophysical Journal, 116, bll 127–141. Elsevier, 2019.
  • Immersive Analysis of 3D Multi-cellular In-Vitro and In-Silico Cell Cultures. Knote, Andreas; Fischer, Sabine C.; Cussat-Blanc, Sylvain; Niebling, Florian; Bernard, David; Cogoni, Florian; von Mammen, Sebastian. In 2019 IEEE International Conference on Artificial Intelligence and Virtual Reality (AIVR), bll 82–89. 2019.
  • An Introduction to Image-Based Systems Biology of Multicellular Spheroids for Experimentalists and Theoreticians. Fischer, Sabine C. In Computational Biology, H. Husi (red.). Codon Publications, Brisbane, Australia, 2019.
  • A GABAergic and peptidergic sleep neuron as a locomotion stop neuron with compartmentalized Ca2+ dynamics. Steuer Costa, Wagner; Van der Auwera, Petrus; Glock, Caspar; Liewald, Jana F.; Bach, Maximilian; Schüler, Christina; Wabnig, Sebastian; Oranth, Alexandra; Masurat, Florentin; Bringmann, Henrik; Schoofs, Liliane; Stelzer, Ernst H.K.; Fischer, Sabine C.; Gottschalk, Alexander. In Nature Communications, 10(4095). 2019.
2018[ to top ]
  • The molecular recognition of phosphatidic acid by an amphipathic helix in Opi1. Hofbauer, H F; Gecht, M; Fischer, S C; Seybert, A; Frangakis, A S; Stelzer, E H K; Covino, R; Hummer, G; Ernst, R. In J Cell Biol, 217(9), bll 3109–3126. 2018.
  • Electroluminescence imaging and automatic cell classification in mass production of silicon solar cells. Alt, M; Fischer, S; Schenk, S; Zimmermann, S; Ramspeck, K; Meixner, M. In 2018 IEEE 7th World Conference on Photovoltaic Energy Conversion (WCPEC) (A Joint Conference of 45th IEEE PVSC, 28th PVSEC 34th EU PVSEC), bll 3298–3304. 2018.
  • E-cadherin, actin, microtubules and {FAK} dominate different spheroid formation phases and important elements of tissue integrity. Smyrek, I.; Mathew, B.; Fischer, S. C.; Lissek, S. M.; Becker, S.; Stelzer, E. H. K. In Biology Open, bl bio.037051. The Company of Biologists, 2018.
2017[ to top ]
  • Multiscale image analysis reveals structural heterogeneity of the cell microenvironment in homotypic spheroids. Schmitz, Alexander; Fischer, Sabine C.; Mattheyer, Christian; Pampaloni, Francesco; Stelzer, Ernst H. K. In Scientific Reports, 7, bl 43693. The Author(s), 2017.
2016[ to top ]
  • Identifying the necrotic zone boundary in tumour spheroids with pair-correlation functions. Dini, S.; Binder, B. J.; Fischer, S. C.; Mattheyer, C.; Schmitz, A.; Stelzer, E. H. K.; Bean, N. G.; Green, J. E. F. In Journal of The Royal Society Interface, 13, bl 20160649. The Royal Society, 2016.
2015[ to top ]
  • Robust and automated three-dimensional segmentation of densely packed cell nuclei in different biological specimens with Lines-of-Sight decomposition. Mathew, Biena; Schmitz, Alexander; Muñoz-Descalzo, Silvia; Ansari, Nariman; Pampaloni, Francesco; Stelzer, Ernst Hans Karl; Fischer, Sabine Christine. In BMC Bioinformatics, 16, bl 187. 2015.
  • Lateral assembly of N-cadherin drives tissue integrity by stabilizing adherens junctions. Garg, S.; Fischer, S. C.; Schuman, E. M.; Stelzer, E. H. K. In Journal of The Royal Society Interface, 12, bl 20141055. The Royal Society, 2015.
2014[ to top ]
  • Contractile and Mechanical Properties of Epithelia with Perturbed Actomyosin Dynamics. Fischer, Sabine C.; Blanchard, Guy B.; Duque, Julia; Adams, Richard J.; Arias, Alfonso Martinez; Guest, Simon D.; Gorfinkiel, Nicole. In PLOS ONE, 9(4), bll 1–12. Public Library of Science, 2014.
2013[ to top ]
  • Is a Persistent Global Bias Necessary for the Establishment of Planar Cell Polarity?. Fischer, Sabine; Houston, Paul; Monk, Nicholas A. M.; Owen, Markus R. In PLOS ONE, 8(4), bll 1–12. Public Library of Science, 2013.
2011[ to top ]
  • Integrative approaches to morphogenesis: lessons from dorsal closure. Gorfinkiel, N; Schamberg, S; Blanchard, G B. In Genesis, 49(7), bll 522–533. 2011.
  • Endocytic and recycling endosomes modulate cell shape changes and tissue behaviour during morphogenesis in Drosophila. Mateus, A M; Gorfinkiel, N; Schamberg, S; Martinez Arias, A. In PLoS One, 6(4). 2011.
2010[ to top ]
  • Modelling and Analysis of Planar Cell Polarity. Schamberg, S.; Houston, P.; Monk, N. A. M.; Owen, M. R. In Bulletin of Mathematical Biology, 72(3), bll 645–680. 2010.