Prof. Dr. Sabine Fischer
Professor for Supramolecular and Cellular Simulations
Center for Computational and Theoretical Biology (CCTB)
Campus Hubland Nord 32
Universität Würzburg
97074 Würzburg, Germany
Tel: 0931 - 31 83961
Previous PhD students
Alexander Schmitz (2017)
Biena Mathew (2018)
Simon Schardt (2023)
Curriculum Vitae
Since 2018 | Professor Center for Computational and Theoretical Biology (CCTB), University of Würzburg, Würzburg, Germany |
2017 - 2018 | Development engineer h.a.l.m. Elektronik GmbH, Frankfurt, Germany |
2011 - 2017 | Senior postdoc Group of Ernst. H. K. Stelzer, Buchmann Institute of Molecular Life Science (BMLS), Goethe University, Frankfurt am Main, Germany |
2009 - 2011 | Postdoc Group of Alfonso Martinez Arias, Department of Genetics, University of Cambridge, UK Project: “Modelling the cooperative behaviour of sheets of cells during embryogenesis” |
2006 - 2009 | PhD in Mathematics School of Mathematical Sciences, University of Nottingham, UK Thesis: “Modelling planar cell polarity” Supervisors: Markus Owen and Nick Monk |
2000 - 2005 | Diploma in Mathematics Faculty of Mathematics and Computer Science, Julius-Maximilians-University, Würzburg, Germany Thesis: "Filtermethoden für gemischte Komplementaritätsprobleme" Supervisor: Christian Kanzow |
Publications
- [ 2023 ]
- [ 2022 ]
- [ 2021 ]
- [ 2020 ]
- [ 2019 ]
- [ 2018 ]
- [ 2017 ]
- [ 2016 ]
- [ 2015 ]
- [ 2014 ]
- [ 2013 ]
- [ 2011 ]
- [ 2010 ]
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The salt-and-pepper pattern in mouse blastocysts is compatible with signalling beyond the nearest neighbours. in bioRxiv (2023). 2023.05.04.539359.
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Recognition and reconstruction of cell differentiation patterns with deep learning in arXiv (2022). 2212.10058.
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Interactive, Visual Simulation of a Spatio-Temporal Model of Gas Exchange in the Human Alveolus in Frontiers in Bioinformatics (2022).
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Adjusting the range of cell-cell communication enables fine-tuning of cell fate patterns from checkerboard to engulfing in arXiv (2022). 2211.07241.
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On-lattice Vicsek model in confined geometries in arXiv (2021). 2105.08792.
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NANOG/GATA6 Interactions Revisited: A Statistical Mechanics Approach towards Cell Fate Decisions in arXiv (2021). 2107.04501.
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Interactive, visual simulation of a spatio-temporal model of gas exchange in the human alveolus in bioRxiv (2021). 2021.09.15.460416.
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Global cell-cell communication enables spatial segregation of cells in organoids of the inner cell mass in arXiv (2021). 2111.01624.
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The transition from local to global patterns governs the differentiation of mouse blastocysts in PLOS ONE (2020). 15(5) 1–29.
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Cell fate clusters in ICM organoids arise from cell fate heredity and division: a modelling approach in Scientific Reports (2020). 10(1) 22405-.
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Mouse ICM organoids reveal three-dimensional cell fate clustering in Biophysical Journal (2019). 116 127–141.
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Immersive Analysis of 3D Multi-cellular In-Vitro and In-Silico Cell Cultures in 2019 IEEE International Conference on Artificial Intelligence and Virtual Reality (AIVR) (2019). 82–89.
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An Introduction to Image-Based Systems Biology of Multicellular Spheroids for Experimentalists and Theoreticians in Computational Biology, H. Husi (red.) (2019).
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A GABAergic and peptidergic sleep neuron as a locomotion stop neuron with compartmentalized Ca2+ dynamics in Nature Communications (2019). 10(4095)
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The molecular recognition of phosphatidic acid by an amphipathic helix in Opi1 in J Cell Biol (2018). 217(9) 3109–3126.
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Electroluminescence imaging and automatic cell classification in mass production of silicon solar cells in 2018 IEEE 7th World Conference on Photovoltaic Energy Conversion (WCPEC) (A Joint Conference of 45th IEEE PVSC, 28th PVSEC 34th EU PVSEC) (2018). 3298–3304.
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E-cadherin, actin, microtubules and {FAK} dominate different spheroid formation phases and important elements of tissue integrity in Biology Open (2018). bio.037051.
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Multiscale image analysis reveals structural heterogeneity of the cell microenvironment in homotypic spheroids in Scientific Reports (2017). 7 43693.
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Identifying the necrotic zone boundary in tumour spheroids with pair-correlation functions in Journal of The Royal Society Interface (2016). 13 20160649.
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Robust and automated three-dimensional segmentation of densely packed cell nuclei in different biological specimens with Lines-of-Sight decomposition in BMC Bioinformatics (2015). 16 187.
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Lateral assembly of N-cadherin drives tissue integrity by stabilizing adherens junctions in Journal of The Royal Society Interface (2015). 12 20141055.
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Contractile and Mechanical Properties of Epithelia with Perturbed Actomyosin Dynamics in PLOS ONE (2014). 9(4) 1–12.
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Is a Persistent Global Bias Necessary for the Establishment of Planar Cell Polarity? in PLOS ONE (2013). 8(4) 1–12.
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Integrative approaches to morphogenesis: lessons from dorsal closure in Genesis (2011). 49(7) 522–533.
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Endocytic and recycling endosomes modulate cell shape changes and tissue behaviour during morphogenesis in Drosophila in PLoS One (2011). 6(4)
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Modelling and Analysis of Planar Cell Polarity in Bulletin of Mathematical Biology (2010). 72(3) 645–680.