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Center for Computational and Theoretical Biology

Prof. Dr. Sabine Fischer

Professor for Supramolecular and Cellular Simulations

Center for Computational and Theoretical Biology (CCTB)

University of Würzburg

Campus Hubland Nord 32

97074 Würzburg, Germany

Tel: 0931 - 31 83961

eMail: sabine.fischer@uni-wuerzburg.de

Previous PhD students

Alexander Schmitz (2017)

Biena Mathew (2018)

Curriculum Vitae

Since 2018

Professor

Center for Computational and Theoretical Biology (CCTB), University of Würzburg, Würzburg, Germany

2017 - 2018

Development engineer

h.a.l.m. Elektronik GmbH, Frankfurt, Germany    

2011 - 2017

Senior postdoc 

Group of Ernst. H. K. Stelzer, Buchmann Institute of Molecular Life Science (BMLS), Goethe University, Frankfurt am Main, Germany

2009 - 2011

Postdoc

Group of Alfonso Martinez Arias, Department of Genetics, University of Cambridge, UK

Project: “Modelling the cooperative behaviour of sheets of cells during embryogenesis”

2006 - 2009

PhD in Mathematics

School of Mathematical Sciences, University of Nottingham, UK

Thesis: “Modelling planar cell polarity”

Supervisors: Markus Owen and Nick Monk

2000 - 2005

Diploma in Mathematics

Faculty of Mathematics and Computer Science, Julius-Maximilians-University, Würzburg, Germany

Thesis: "Filtermethoden für gemischte Komplementaritätsprobleme"

Supervisor: Christian Kanzow

Publications

[ under review ] [ 2018 ] [ 2017 ] [ 2016 ] [ 2015 ] [ 2014 ] [ 2013 ] [ 2011 ] [ 2010 ]

under review[ nach oben ]

  • Actin, microtubules and FAK dominate different spheroid formation phases revealing their importance for tissue integrity.Smyrek, I; Mathew, B; Fischer, SC; Lissek, S; Becker, S; Stelzer, EHK (under review).
     

2018[ nach oben ]

  • The molecular recognition of phosphatidic acid by an amphipathic helix in Opi1.Hofbauer, H F; Gecht, M; Fischer, S C; Seybert, A; Frangakis, A S; Stelzer, E H K; Covino, R; Hummer, G; Ernst, R in J Cell Biol (2018). 217(9) 3109-3126.
     
  • Mouse ICM organoids reveal three-dimensional cell fate clustering.Mathew, Biena; Muñoz-Descalzo, Silvia; Corujo Simon, Elena; Schröter, Christian; Stelzer, Ernst H.K; Fischer, Sabine C. in Biophysical Journal (2018).
     

2017[ nach oben ]

  • Three-dimensional cell neighbourhood impacts differentiation in the inner mass cells of the mouse blastocyst.Fischer, Sabine C.; Corujo-Simon, Elena; Lilao-Garzon, Joaquin; Stelzer, Ernst H. K.; Munoz-Descalzo, Silvia in bioRxiv (2017).
     
  • Multiscale image analysis reveals structural heterogeneity of the cell microenvironment in homotypic spheroids.Schmitz, Alexander; Fischer, Sabine C.; Mattheyer, Christian; Pampaloni, Francesco; Stelzer, Ernst H. K. in Scientific Reports (2017). 7 43693--.
     

2016[ nach oben ]

  • Identifying the necrotic zone boundary in tumour spheroids with pair-correlation functions.Dini, S.; Binder, B. J.; Fischer, S. C.; Mattheyer, C.; Schmitz, A.; Stelzer, E. H. K.; Bean, N. G.; Green, J. E. F. in Journal of The Royal Society Interface (2016). 13(123)
     

2015[ nach oben ]

  • Robust and automated three-dimensional segmentation of densely packed cell nuclei in different biological specimens with Lines-of-Sight decomposition.Mathew, Biena; Schmitz, Alexander; Muñoz-Descalzo, Silvia; Ansari, Nariman; Pampaloni, Francesco; Stelzer, Ernst Hans Karl; Fischer, Sabine Christine in BMC Bioinformatics (2015). 16 187.
     
  • Lateral assembly of N-cadherin drives tissue integrity by stabilizing adherens junctions.Garg, S.; Fischer, S. C.; Schuman, E. M.; Stelzer, E. H. K. in Journal of The Royal Society Interface (2015). 12(104)
     

2014[ nach oben ]

  • Contractile and Mechanical Properties of Epithelia with Perturbed Actomyosin Dynamics.Fischer, Sabine C.; Blanchard, Guy B.; Duque, Julia; Adams, Richard J.; Arias, Alfonso Martinez; Guest, Simon D.; Gorfinkiel, Nicole in PLOS ONE (2014). 9(4) 1-12.
     

2013[ nach oben ]

  • Is a Persistent Global Bias Necessary for the Establishment of Planar Cell Polarity?Fischer, Sabine; Houston, Paul; Monk, Nicholas A. M.; Owen, Markus R. in PLOS ONE (2013). 8(4) 1-12.
     

2011[ nach oben ]

  • Integrative approaches to morphogenesis: lessons from dorsal closure.Gorfinkiel, N; Schamberg, S; Blanchard, G B in Genesis (2011). 49(7) 522-533.
     
  • Endocytic and recycling endosomes modulate cell shape changes and tissue behaviour during morphogenesis in Drosophila.Mateus, A M; Gorfinkiel, N; Schamberg, S; Martinez Arias, A in PLoS One (2011). 6(4)
     

2010[ nach oben ]

  • Modelling and Analysis of Planar Cell Polarity.Schamberg, S.; Houston, P.; Monk, N. A. M.; Owen, M. R. in Bulletin of Mathematical Biology (2010). 72(3) 645--680.
     
Kontakt

Center for Computational and Theoretical Biology
Gebäude 32
Campus Hubland Nord
97074 Würzburg

Suche Ansprechpartner

Hubland Nord, Geb. 32
Hubland Nord, Geb. 32