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Deutsch Intern
    Collaborative Research Centre 1047

    Project A1 Förster

    The circadian clock network of selected insects

    Summary

    The circadian clock modulates many aspects of an animal’s behavior and physiology in a rhythmic manner. Most likely all animals have evolved a common timekeeping mechanism because of the selective pressure induced by daily and seasonal changes in the environment which they are living in.
    Circadian rhythms, such as those in daily activity, are controlled by a master clock consisting of a network of clock neurons in the brain. The principle of molecular rhythm generation is similar between phylogenetically distant groups such as mammals and insects, though there are differences in the core clock components (Hardin, 2011). The same applies for the neuronal organization of the animal master clock in the brain. The brain clock is topographically and functionally structured in different parts containing populations of clock neurons that are heterogeneous in morphology, physiology and neurotransmitter content and fulfill slightly different functions. Per definition a clock neuron generates a self-sustained molecular rhythm through the interaction of clock genes and proteins. In D. melanogaster for example the key players of the molecular clockwork are per (PER), tim(TIM), cyc(CYC), Clk(CLK), vri (VRI) and pdp1 (PDP1).

    Subproject 1: Circadian clock of Drosophila

    The fruit-fly Drosophila melanogaster has been extensively used as a model organism to understand the molecular mechanism of the circadian clocks, the location of the circadian pacemaker neurons, as well as input and output pathways that reach or come from the body oscillators and are translated in rhythmic behavioral phenotypes. Drosophila clock neurons are dispersed throughout the brain –some are located in the dorsal and others in the lateral brain [...]

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    Subproject 2: Circadian clock in other insects

    If on one hand the circadian clock of Drosophila melanogaster has been widely studied over the years, the molecular mechanisms and the neuronal organization of the clock of other insects are still largely unknown. We are interested especially in gathering information, both at the molecular and anatomical level, on the circadian clock of the honey bee Apis mellifera, given its incredible capability to orientate towards the sun in time compensated manner, but also of different ants species (belonging to the genus Camponotus, Cataglyphis, and Atta). So far we know that the molecular clock of these Hymenoptera is more similar to the mammalian one instead of to the one of fruit flies, but our knowledge of the neuronal network underlying the control of behavioral rhythms is still quite poor. [...]

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    Publications

    • Kay, J. (2018) The circadian clock of the carpenter ant Camponotus floridanus, PhD Thesis, University of Wuerzburg.
       
    • Helfrich-Förster, C. (2018) Sleep in Insects, Annual Review of Entomology 63.
       
    • Kistenpfennig, C., Grebler, R., Ogueta, M., Hermann-Luibl, C., Schlichting, M., Stanewsky, R., Senthilan, P. R., and Helfrich-F"orster, C. (2017) A new Rhodopsin influences light-dependent daily activity patterns of fruit flies, Journal of biological rhythms 32, 406--422.
       
    • Frenkel, L., Muraro, N. I., González, A. N. B., Marcora, M. S., Bernabó, G., Hermann-Luibl, C., Romero, J. I., Helfrich-Förster, C., Castaño, E. M., Marino-Busjle, C., Calvo, D. J., and Ceriani, M. F. (2017) Organization of Circadian Behavior Relies on Glycinergic Transmission, Cell Reports 19, 72-85.
       
    • Menegazzi, P., Benetta, E. D., Beauchamp, M., Schlichting, M., Steffan-Dewenter, I., and Helfrich-Förster, C. (2017) Adaptation of circadian neuronal network to photoperiod in high-latitude European Drosophilids, CURR BIOL 27, 833-839.
       
    • Vaze, K. M., and Helfrich-Förster, C. (2016) Drosophila ezoana uses an hour-glass or highly damped circadian clock for measuring night length and inducing diapause, Physiol Entomol 41, 378-389.
       
    • Schlichting, M., Menegazzi, P., Lelito, K. R., Yao, Z., Buhl, E., Dalla Benetta, E., Bahle, A., Denike, J., Hodge, J. J., Helfrich-Förster, C., and others,. (2016) A neural network underlying circadian entrainment and photoperiodic adjustment of sleep and activity in Drosophila, J Neurosci 36, 9084-9096.
       
    • Yoshii, T., Hermann-Luibl, C., and Helfrich-Förster, C. (2016) Circadian light-input pathways in Drosophila, Commun Integr Biol 9, e1102805.
       
    • Schlichting, M. (2015) Light entrainment of the circadian clock: the importance of the visual system for adjusting Drosophila melanogaster’s activity pattern, PhD Thesis, University of Wuerzburg.
       

    Kontakt/Contact

    Prof. Dr. Charlotte Förster
    Lehrstuhl Neurobiologie und Genetik
    Biozentrum der Universität Würzburg
    Am Hubland
    D-97074 Würzburg

    Phone: +49 931 31-84450 (Sekretariat/Office)
    Mail:    sfb1047@uni-wuerzburg.de
    Web:   Homepage von Charlotte Förster