• Immunofluorescence of the SMN protein
Chair of Biochemistry

Bartuli, Julia Dr.

Dr. Julia Bartuli

Phone:  +49 931 31-83246

Room:   B131

Curriculum vitae



Dr. Julia Bartuli






Chair of Biochemistry, Theodor-Boveri-Institute at the Biocentre
University of Würzburg
Am Hubland
97074 Würzburg
Phone +49 931 - 31 83246











PhD in Biochemistry, Institute of Chemical Biology and Fundamental Medicine  (ICBFM), Novosibirsk, Russia
Title of dissertation: The structural elements of the proteins rpS15e and eRF1, adjacent to mRNA in the decoding center of human ribosome

Thesis Advisor: Prof. Dr. Galina Karpova, ICBFM SB RAS

  2002 - 2007

Diploma degree in Biochemistry, Novosibirsk State University, Russia
Title of d
iploma thesis: Identification of the fragments of human ribosomal proteins, neighboring with mRNA at the 80S human ribosome by a cross-linking approach

Research Experience 2017 - present

Postdoctoral fellow in the laboratory of Prof. Utz Fischer, Biocentre, University of Würzburg, Germany
Structural and biochemical characterization of Vaccinia virus macromolecular machineries

  2011 - 2016 Researcher at the ICBFM
  2007 - 2011 PhD thesis at the ICBFM, Novosibirsk, Russia




Research Fields

tructure and function of macromolecular complexes

Poxvirus transcription and replication






2016: Grant from the Russian Federation for Young Scientists.

 2013: Winner of the 20th contest of the European Academy for Young Scientists of Russia the in Biology section
 2009: Winner of the 2009 «International Academic Publishing Company Nauka/Interperiodica» for the best publications 






Grimm, C, Hillen, H.S., Bedenk, K., Bartuli, J., Neuer, S., Zhang, Q., Huettenhofer, A., Erlacher, M., Dienemann, C., Schlosser, A., Urlaub H., Böttcher, B., Szalay, A.A., Cramer, P., Fischer, U. (2019). Structural Basis of Poxvirus Transcription: Vaccinia RNA polymerase Complexes. Cell 179,1537-1550.

Hillen, H.S.*, Bartuli, J.*, Grimm, C., Dienemann, C., Bedenk, K., Szalay, A.A., Fischer, U., Cramer, P. (2019). Structural Basis of Poxvirus Transcription: Transcribing and Capping Vaccinia Complexes. Cell 179, 1525-1536. (*Equal contribution). doi:10.1016/j.cell.2019.11.023.

Grimm, C*, Bartuli, J.*, Böttcher, B., Szalay, A.A., Fischer, U. (2021). Structural basis of the complete poxvirus transcription initiation process. Nature Structural & Molecular Biology. In press (*Equal contribution).

Fischer, U., Bartuli, J., Grimm C. (2021). Structure and function of the poxvirus transcription machinery. The Enzyme.

Sharifulin, D.E., Bartuli, Y.S., Meschaninova, M.I., Ven’yaminova, A.G., Graifer, D.M. & Karpova, G.G. (2016). Exploring accessibility of structural elements of the mammalian 40S ribosomal mRNA entry channel at various steps of translation initiation. Biochim Biophys Acta 1864, 1328-1338. doi: 10.1016/j.bbapap.2016.06.011.

Bulygin, K.N., Bartuli, Y.S., Malygin, A.A., Graifer, D.M., Frolova, L.Y. & Karpova G.G.(2015). Chemical footprinting reveals conformational changes of 18S and 28S rRNAs at different steps of translation termination on the human ribosome. RNA 22, 278-289. doi: 10.1261/rna.053801.115.

Sharifulin, D.E., Grosheva, A.S., Bartuli, Y.S., Malygin, A.A., Meschaninova, M.I., Ven’yaminova, A.G., Stahl, J., Graifer D.M. & Karpova G.G. (2015). Molecular contacts of ribose-phosphate backbone of mRNA with human ribosome. Biochim. Biophys. Acta 1849,  930-939. doi: 10.1016/j.bbagrm.2015.06.001.

Sharifulin, D., Babaylova, E., Kossinova, O., Bartuli, Yu., Graifer, D. & Karpova G. (2013). Ribosomal protein S5e is implicated in translation initiation via its interaction with N-terminal domain of initiation factor eIF2a. Chembiochem 14, 2136–2143. doi: 10.1002/cbic.201300318.

Sharifulin, D., Khairulina, Yu., Ivanov, A., Meschaninova, M., Ven’yaminova, A., Graifer, D. & Karpova, G. (2012). A central fragment of ribosomal protein S26 containing the eukaryotespecific motif YxxPKxYxK is a key component of the ribosomal binding site of mRNA region 5’ of the E site codon. Nucleic Acids Res 40, 3056-3065. doi: 10.1093/nar/gkr1212.

Bulygin, K.N.*, Khairulina, Yu.S.*, Kolosov, P.M., Ven’yaminova, A.G., Graifer, D.M., Vorobjev, Yu.N., Frolova, L.Yu. & Karpova, G.G. (2011). Adenine and guanine recognition of stop codon is mediated by different N domain conformations of translation termination factor eRF1. Nucleic Acids Res 39, 7134–7146. (*Equal contribution). doi: 10.1093/nar/gkr376.

Khairulina, J., Graifer, D., Bulygin, K., Ven’yaminova, A., Frolova, L. & Karpova, G.  (2010).  Eukaryote-specific motif of ribosomal protein S15 neighbors A site codon during elongation and termination of translation. Biochimie 92, 820-825. doi: 10.1016/j.biochi.2010.02.031.

Bulygin, K.N.*, Khairulina, Yu.S.*, Kolosov, P.M., Ven’yaminova, A.G., Graifer, D.M., Vorobjev, Yu.N., Frolova, L.Yu., Kisselev, L.L. & Karpova, G.G. (2010). Three distinct peptides from the N domain of translation termination factor eRF1 surround stop codon in the ribosome. RNA 16, 1902–1914. (*Equal contribution). doi: 10.1261/rna.2066910.

Khairulina, Yu.S., Molotkov, M.V., Bulygin, K.N., Graifer, D.M., Ven’yaminova, A.G. & Karpova, G.G. (2008). The C-terminal fragment of ribosomal protein S15 is located in the decoding site of the human ribosome. Mol. Biol. (Mosk) 42, 270-276.

Khairulina, Yu.S., Molotkov, M.V., Bulygin, K.N., Graifer, D.M., Ven’yaminova, A.G., Frolova, L.Yu., Stahl, J. & Karpova G.G. (2008). Protein S3 Fragments Neighboring mRNA during Elongation and Termination of Translation on the Human Ribosome. Bioorg Khim 34, 691-697. Russian.