Chair of Biochemistry

    Fischer, Utz, Prof. Dr.

    Prof. Dr. Utz Fischer

    Phone:  +49 931 - 31 84029
    E-mail:  utz.fischer@biozentrum.uni-wuerzburg.de

    Room:   B128


    Curriculum vitae


    Prof. Dr. Utz Fischer



    Professor and Chairman



    Chair of Biochemistry, Theodor-Boveri-Institute at the Biocentre
    University of Würzburg
    Am Hubland
    97074 Würzburg
    Phone +49 931 - 31 84029













    Studies in Biochemistry at the Free University of Berlin, Germany, Diploma degree



    Dissertation at the Philipps-University Marburg in the group of Prof. R. Lührmann



    Post-Doc, Institute of Molecular Biology and Tumor Research, University of Marburg, Germany



    AIDS Scholar at the HHMI, University of Pennsylvania, Philadelphia (PA, USA)



    Group leader at the MPI of Biochemistry, Martinsried, Germany


    since 2003

    Professor and Chair of Biochemistry, University of Würzburg, Germany



    Speaker of the Biocentre/Theodor-Boveri-Institute, University of Würzburg, Germany







    Research Fields


    Structure and Function of macromolecular machines

    RNA-metabolism and neuronal diseases





    Professional Activities

    Since 2007: Speaker of the DFG-Forschergruppe FOR855 “Cytoplasmic regulation of gene expression”








    1989: Dissertation award of Hoechst Industries
    1993: AIDS Scholar of the DKFZ (Heidelberg)
    1993: Falcon Research Award of the German Society of Cell Biology
    1998: Rhone-Poulenc Rorer Research Award
    1999: Gerhard Hess Award of the DFG




    Key publications:

    The Ribosome Cooperates with the Assembly Chaperone pICln to Initiate Formation of snRNPs.

    Paknia E, Chari A, Stark H, Fischer U.

    Cell Reports 16(12):3103-3112 (2016)

    Reconstitution of the human U snRNP assembly machinery reveals stepwise Sm protein organization

    Neuenkrichen, N., Englbrecht, C., Ohmer, J., Ziegenhals, T., Chari, A., and Fischer, U.

    EMBO Journal 34(14):1925-41 (2015)

    Structural Basis of Assembly Chaperone- Mediated snRNP Formation

    Grimm C, Chari A, Pelz J, Kuper J, Kisker C, Diederichs K, Stark H, Schindelin H, Fischer U

    Molecular Cell 49(4):692-703 (2013)

    Intronic miR-26b controls neuronal differentiation by repressing its host transcript, ctdsp2

    Dill H, Linder B, Fehr A, Fischer U

    Genes & Development 26(1):25-30 (2012)

    An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs

    Chari A, Golas M, Neuenkirchen N, Klingenhäger M, Sander B, Englbrecht C, Sickmann A, Stark H, Fischer U

    Cell 135:497-509 (2008)

    Reduced RNP assembly causes motor axon degeneration in an animal model for spinal muscular atrophy

    Winkler C, Eggert C, Gradl D, Meister G, Giegerich M, Wedlich D, Fischer U

    Genes & Development 19:2320-2330 (2005)

    A multiprotein complex mediates the ATP-dependent assembly of spliceosomal U snRNPs

    Meister G, Bühler D, Pillai R, Lottspeich F, Fischer U

    Nature Cell Biology 3:945-949 (2001)

    The SMN-SIP1 complex has an essential role in spliceosomal U snRNP biogenesis

    Fischer U, Lui Q, Dreyfuss G

    Cell 90:1023-1029 (1997)

    The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs

    Fischer U, Huber J, Boelens W, Mattaj IW, Lührmann R

    Cell 82, 475-483(1995)

    Fischer, U. and Lührmann, R.

    An essential signalling role for the m3G cap in the transport of U1 snRNP to the nucleus.

    Science 249: 786-790 (1990)

    Key reviews:

    Chari, A. und Fischer, U.

    Cellular strategies for the assembly of molecular machines.

    Trends in Biochemical Sciences (TIBS) 35(12):676-83 (2010)

    Gehring N, Wahle E, Fischer U.

    Decipering the mRNP code: RNA-bound determinants of post-transcriptional gene regulation.

    Trends in Biochemical Sciences (TIBS), DOI:10.1016/tibs.2017.02.004 (2017)

    For a complete list please click here.