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    Chair of Biochemistry

    Prof. Dr. Utz Fischer

     
    Phone:  +49 931 - 31 84029
     
     
    E-mail:  utz.fischer@biozentrum.uni-wuerzburg.de


    Room:   B128

     

    Curriculum vitae

    Name

    Prof. Dr. Utz Fischer

     

    Position

    Professor and Chairman

    Affiliation

     

    Chair of Biochemistry, Theodor-Boveri-Institute at the Biocentre
    University of Würzburg
    Am Hubland
    97074 Würzburg
    Phone +49 931 - 31 84029

     

    utz.fischer@biozentrum.uni-wuerzburg.de

    Born

    12.10.1964

     

     

     

     

     

     

    Career

    1983-1988

    Studies in Biochemistry at the Free University of Berlin, Germany, Diploma degree

     

    1989-1992

    Dissertation at the Philipps-University Marburg in the group of Prof. R. Lührmann

     

    1992-1995

    Post-Doc, Institute of Molecular Biology and Tumor Research, University of Marburg, Germany

     

    1995-1997

    AIDS Scholar at the HHMI, University of Pennsylvania, Philadelphia (PA, USA)

     

    1997-2003

    Group leader at the MPI of Biochemistry, Martinsried, Germany

     

    since 2003

    Professor and Chair of Biochemistry, University of Würzburg, Germany

     

    2008-2009

    Speaker of the Biocentre/Theodor-Boveri-Institute, University of Würzburg, Germany

     

     

     

     

     

     

    Research Fields

     

    Structure and Function of macromolecular machines

    RNA-metabolism and neuronal diseases

     

     

     

     

    Professional Activities

    Since 2007: Speaker of the DFG-Forschergruppe FOR855 “Cytoplasmic regulation of gene expression”

     

     

     

     

     

     

    Awards

    1989: Dissertation award of Hoechst Industries
    1993: AIDS Scholar of the DKFZ (Heidelberg)
    1993: Falcon Research Award of the German Society of Cell Biology
    1998: Rhone-Poulenc Rorer Research Award
    1999: Gerhard Hess Award of the DFG

      

      

    Publications

    Key publications:

    The Ribosome Cooperates with the Assembly Chaperone pICln to Initiate Formation of snRNPs.

    Paknia E, Chari A, Stark H, Fischer U.

    Cell Reports 16(12):3103-3112 (2016)

    Reconstitution of the human U snRNP assembly machinery reveals stepwise Sm protein organization

    Neuenkrichen, N., Englbrecht, C., Ohmer, J., Ziegenhals, T., Chari, A., and Fischer, U.

    EMBO Journal 34(14):1925-41 (2015)

    Structural Basis of Assembly Chaperone- Mediated snRNP Formation

    Grimm C, Chari A, Pelz J, Kuper J, Kisker C, Diederichs K, Stark H, Schindelin H, Fischer U

    Molecular Cell 49(4):692-703 (2013)

    Intronic miR-26b controls neuronal differentiation by repressing its host transcript, ctdsp2

    Dill H, Linder B, Fehr A, Fischer U

    Genes & Development 26(1):25-30 (2012)

    An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs

    Chari A, Golas M, Neuenkirchen N, Klingenhäger M, Sander B, Englbrecht C, Sickmann A, Stark H, Fischer U

    Cell 135:497-509 (2008)

    Reduced RNP assembly causes motor axon degeneration in an animal model for spinal muscular atrophy

    Winkler C, Eggert C, Gradl D, Meister G, Giegerich M, Wedlich D, Fischer U

    Genes & Development 19:2320-2330 (2005)

    A multiprotein complex mediates the ATP-dependent assembly of spliceosomal U snRNPs

    Meister G, Bühler D, Pillai R, Lottspeich F, Fischer U

    Nature Cell Biology 3:945-949 (2001)

    The SMN-SIP1 complex has an essential role in spliceosomal U snRNP biogenesis

    Fischer U, Lui Q, Dreyfuss G

    Cell 90:1023-1029 (1997)

    The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs

    Fischer U, Huber J, Boelens W, Mattaj IW, Lührmann R

    Cell 82, 475-483(1995)

    Fischer, U. and Lührmann, R.

    An essential signalling role for the m3G cap in the transport of U1 snRNP to the nucleus.

    Science 249: 786-790 (1990)

    Key reviews:

    Chari, A. und Fischer, U.

    Cellular strategies for the assembly of molecular machines.

    Trends in Biochemical Sciences (TIBS) 35(12):676-83 (2010)

    Gehring N, Wahle E, Fischer U.

    Decipering the mRNP code: RNA-bound determinants of post-transcriptional gene regulation.

    Trends in Biochemical Sciences (TIBS), DOI:10.1016/tibs.2017.02.004 (2017)

    For a complete list please click here.