• Immunofluorescence of the SMN protein
Chair of Biochemistry

Fischer, Utz, Prof. Dr.

Prof. Dr. Utz Fischer

Phone:  +49 931 - 31 84029

Room:   B128


Curriculum vitae


Prof. Dr. Utz Fischer



Professor and Chairman



Chair of Biochemistry, Theodor-Boveri-Institute at the Biocentre
University of Würzburg
Am Hubland
97074 Würzburg
Phone +49 931 - 31 84029











Studies in Biochemistry at the Free University of Berlin, Germany, Diploma degree



Dissertation at the Philipps-University Marburg in the group of Prof. R. Lührmann



Post-Doc, Institute of Molecular Biology and Tumor Research, University of Marburg, Germany



AIDS Scholar at the HHMI, University of Pennsylvania, Philadelphia (PA, USA)



Group leader at the MPI of Biochemistry, Martinsried, Germany


since 2003

Professor and Chair of Biochemistry, University of Würzburg, Germany



Speaker of the Biocentre/Theodor-Boveri-Institute, University of Würzburg, Germany







Research Fields


Structure and Function of macromolecular machines

RNA-metabolism and neuronal diseases





Professional Activities

Since 2007: Speaker of the DFG-Forschergruppe FOR855 “Cytoplasmic regulation of gene expression”








1989: Dissertation award of Hoechst Industries
1993: AIDS Scholar of the DKFZ (Heidelberg)
1993: Falcon Research Award of the German Society of Cell Biology
1998: Rhone-Poulenc Rorer Research Award
1999: Gerhard Hess Award of the DFG




Key publications:

The Ribosome Cooperates with the Assembly Chaperone pICln to Initiate Formation of snRNPs.

Paknia E, Chari A, Stark H, Fischer U.

Cell Reports 16(12):3103-3112 (2016)

Reconstitution of the human U snRNP assembly machinery reveals stepwise Sm protein organization

Neuenkrichen, N., Englbrecht, C., Ohmer, J., Ziegenhals, T., Chari, A., and Fischer, U.

EMBO Journal 34(14):1925-41 (2015)

Structural Basis of Assembly Chaperone- Mediated snRNP Formation

Grimm C, Chari A, Pelz J, Kuper J, Kisker C, Diederichs K, Stark H, Schindelin H, Fischer U

Molecular Cell 49(4):692-703 (2013)

Intronic miR-26b controls neuronal differentiation by repressing its host transcript, ctdsp2

Dill H, Linder B, Fehr A, Fischer U

Genes & Development 26(1):25-30 (2012)

An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs

Chari A, Golas M, Neuenkirchen N, Klingenhäger M, Sander B, Englbrecht C, Sickmann A, Stark H, Fischer U

Cell 135:497-509 (2008)

Reduced RNP assembly causes motor axon degeneration in an animal model for spinal muscular atrophy

Winkler C, Eggert C, Gradl D, Meister G, Giegerich M, Wedlich D, Fischer U

Genes & Development 19:2320-2330 (2005)

A multiprotein complex mediates the ATP-dependent assembly of spliceosomal U snRNPs

Meister G, Bühler D, Pillai R, Lottspeich F, Fischer U

Nature Cell Biology 3:945-949 (2001)

The SMN-SIP1 complex has an essential role in spliceosomal U snRNP biogenesis

Fischer U, Lui Q, Dreyfuss G

Cell 90:1023-1029 (1997)

The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs

Fischer U, Huber J, Boelens W, Mattaj IW, Lührmann R

Cell 82, 475-483(1995)

Fischer, U. and Lührmann, R.

An essential signalling role for the m3G cap in the transport of U1 snRNP to the nucleus.

Science 249: 786-790 (1990)

Key reviews:

Chari, A. und Fischer, U.

Cellular strategies for the assembly of molecular machines.

Trends in Biochemical Sciences (TIBS) 35(12):676-83 (2010)

Gehring N, Wahle E, Fischer U.

Decipering the mRNP code: RNA-bound determinants of post-transcriptional gene regulation.

Trends in Biochemical Sciences (TIBS), DOI:10.1016/tibs.2017.02.004 (2017)

For a complete list please click here.