Myc-mediated reprogramming of RNA polymerases.
 

Targeting the oncogenic function of Myc for tumour therapy.
 

Using functional genomics to unravel transcriptional networks in tumour cells.

Selected:

Baluapuri A*, Hofstetter J*, Dudvarski Stankovic N, Endres T, Bhandare P, Vos SM, Adhikari B, Schwarz JD, Narain A, Vogt M, Wang S-Y, Düster R, Jung LA, Vanselow JT, Wiegering A, Geyer M, Maric HM, Gallant P, Walz S, Schlosser A, Cramer P, Eilers M, Wolf E: MYC recruits SPT5 to RNA polymerase II to promote processive transcription elongation, Molecular Cell, published online: https://doi.org/10.1016/j.molcel.2019.02.031 *joined first authors

Steffi Herold*, Jacqueline Kalb*, Gabriele Büchel*, Carsten P. Ade, Apoorva Baluapuri, Jiajia Xu, Jan Koster, Daniel Solvie, Anne Carstensen, Christina Klotz, Sabrina Rodewald, Christina Schülein-Völk, Matthias Dobbelstein, Elmar Wolf, Jan Molenaar, Rogier Versteeg, Susanne Walz & Martin Eilers: Recruitment of BRCA1 limits MYCN-driven accumulation of stalled RNA polymerase, Nature, 2019, 567(7749):545-549 *joined first authors

Pedrotti L, Weiste C, Nägele T, Wolf E, Lorenzin F, DietrichK, Mair A, Weckwerth W, Teige M, Baena-González E, Dröge-Laser W (2018) Snf1-RELATEDKINASE1-Controlled C/S1-bZIP Signaling Activates Alternative MitochondrialMetabolic Pathways to Ensure Plant Survival in Extended Darkness. The Plant Cell

Lorenzin F, Benary U, Baluapuri A, Walz S, Jung LA, von Eyss B, Kisker C, Wolf J, Eilers M, Wolf E, Different promoter affinities account for specificity in MYC-dependent gene regulation, eLife, 2016, e15161

Vo BT*, Wolf E*, Kawauchi D, Gebhardt A, Rehg JE, Finkelstein D, Walz S, Murphy BL, Youn YH, Han YG, Eilers M*, Roussel MF*, The interaction of Myc with Miz1 defines medulloblastoma subgroup identity, Cancer Cell, 2016, 29, 5-16 *joined first and senior authors

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