Center for Computational and Theoretical Biology

    Prof. Dr. Sabine Fischer

    Professor for Supramolecular and Cellular Simulations

    Center for Computational and Theoretical Biology (CCTB)

    Campus Hubland Nord 32

    Universität Würzburg

    97074 Würzburg, Germany

    Tel: 0931 - 31 83961

    email: sabine.fischer@uni-wuerzburg.de

    Previous PhD students

    Alexander Schmitz (2017)

    Biena Mathew (2018)

    Curriculum Vitae

    Since 2018


    Center for Computational and Theoretical Biology (CCTB), University of Würzburg, Würzburg, Germany

    2017 - 2018

    Development engineer

    h.a.l.m. Elektronik GmbH, Frankfurt, Germany    

    2011 - 2017

    Senior postdoc 

    Group of Ernst. H. K. Stelzer, Buchmann Institute of Molecular Life Science (BMLS), Goethe University, Frankfurt am Main, Germany

    2009 - 2011


    Group of Alfonso Martinez Arias, Department of Genetics, University of Cambridge, UK

    Project: “Modelling the cooperative behaviour of sheets of cells during embryogenesis”

    2006 - 2009

    PhD in Mathematics

    School of Mathematical Sciences, University of Nottingham, UK

    Thesis: “Modelling planar cell polarity”

    Supervisors: Markus Owen and Nick Monk

    2000 - 2005

    Diploma in Mathematics

    Faculty of Mathematics and Computer Science, Julius-Maximilians-University, Würzburg, Germany

    Thesis: "Filtermethoden für gemischte Komplementaritätsprobleme"

    Supervisor: Christian Kanzow


    [ 2020 ] [ 2019 ] [ 2018 ] [ 2017 ] [ 2016 ] [ 2015 ] [ 2014 ] [ 2013 ] [ 2011 ] [ 2010 ]

    2020 [ to top ]

    • The transition from local to global patterns governs the differentiation of mouse blastocysts. Fischer, Sabine C.; Corujo-Simon, Elena; Lilao-Garzon, Joaquin; Stelzer, Ernst H. K.; Muñoz-Descalzo, Silvia in PLOS ONE (2020). 15(5) 1-29.
    • Cell fate clusters in ICM organoids arise from cell fate heredity and division: a modelling approach. Liebisch, Tim; Drusko, Armin; Mathew, Biena; Stelzer, Ernst H. K.; Fischer, Sabine C.; Matthäus, Franziska in Scientific Reports (2020). 10(1) 22405--.

    2019 [ to top ]

    • Immersive Analysis of 3D Multi-cellular In-Vitro and In-Silico Cell Cultures. Knote, Andreas; Fischer, Sabine C.; Cussat-Blanc, Sylvain; Niebling, Florian; Bernard, David; Cogoni, Florian; von Mammen, Sebastian in 2019 IEEE International Conference on Artificial Intelligence and Virtual Reality (AIVR) (2019). 82-89.
    • Cell Fate Clusters in ICM Organoids Arise from Cell Fate Heredity & Division – a Modelling Approach. Liebisch, T.; Drusko, A.; Mathew, B.; Stelzer, E.H.K.; Fischer, S.C.; Matthäus, F. in bioRxiv (2019).
    • An Introduction to Image-Based Systems Biology of Multicellular Spheroids for Experimentalists and Theoreticians. Fischer, Sabine C. in Computational Biology, H. Husi (red.) (2019).
    • A GABAergic and peptidergic sleep neuron as a locomotion stop neuron with compartmentalized Ca2+ dynamics. Steuer Costa, Wagner; Van der Auwera, Petrus; Glock, Caspar; Liewald, Jana F.; Bach, Maximilian; Schüler, Christina; Wabnig, Sebastian; Oranth, Alexandra; Masurat, Florentin; Bringmann, Henrik; Schoofs, Liliane; Stelzer, Ernst H.K.; Fischer, Sabine C.; Gottschalk, Alexander in Nature Communications (2019). 10(4095)

    2018 [ to top ]

    • The molecular recognition of phosphatidic acid by an amphipathic helix in Opi1. Hofbauer, H F; Gecht, M; Fischer, S C; Seybert, A; Frangakis, A S; Stelzer, E H K; Covino, R; Hummer, G; Ernst, R in J Cell Biol (2018). 217(9) 3109-3126.
    • Mouse ICM organoids reveal three-dimensional cell fate clustering. Mathew, Biena; Muñoz-Descalzo, Silvia; Corujo Simon, Elena; Schröter, Christian; Stelzer, Ernst H.K; Fischer, Sabine C. in Biophysical Journal (2018). 116 127-141.
    • Electroluminescence imaging and automatic cell classification in mass production of silicon solar cells. Alt, M; Fischer, S; Schenk, S; Zimmermann, S; Ramspeck, K; Meixner, M in 2018 IEEE 7th World Conference on Photovoltaic Energy Conversion (WCPEC) (A Joint Conference of 45th IEEE PVSC, 28th PVSEC 34th EU PVSEC) (2018). 3298-3304.
    • E-cadherin, actin, microtubules and FAK dominate different spheroid formation phases and important elements of tissue integrity. Smyrek, I.; Mathew, B.; Fischer, S. C.; Lissek, S. M.; Becker, S.; Stelzer, E. H. K. in Biology Open (2018). bio.037051.

    2017 [ to top ]

    • Three-dimensional cell neighbourhood impacts differentiation in the inner mass cells of the mouse blastocyst. Fischer, Sabine C.; Corujo-Simon, Elena; Lilao-Garzon, Joaquin; Stelzer, Ernst H. K.; Munoz-Descalzo, Silvia in bioRxiv (2017).
    • Multiscale image analysis reveals structural heterogeneity of the cell microenvironment in homotypic spheroids. Schmitz, Alexander; Fischer, Sabine C.; Mattheyer, Christian; Pampaloni, Francesco; Stelzer, Ernst H. K. in Scientific Reports (2017). 7 43693.

    2016 [ to top ]

    • Identifying the necrotic zone boundary in tumour spheroids with pair-correlation functions. Dini, S.; Binder, B. J.; Fischer, S. C.; Mattheyer, C.; Schmitz, A.; Stelzer, E. H. K.; Bean, N. G.; Green, J. E. F. in Journal of The Royal Society Interface (2016). 13 20160649.

    2015 [ to top ]

    • Robust and automated three-dimensional segmentation of densely packed cell nuclei in different biological specimens with Lines-of-Sight decomposition. Mathew, Biena; Schmitz, Alexander; Muñoz-Descalzo, Silvia; Ansari, Nariman; Pampaloni, Francesco; Stelzer, Ernst Hans Karl; Fischer, Sabine Christine in BMC Bioinformatics (2015). 16 187.
    • Lateral assembly of N-cadherin drives tissue integrity by stabilizing adherens junctions. Garg, S.; Fischer, S. C.; Schuman, E. M.; Stelzer, E. H. K. in Journal of The Royal Society Interface (2015). 12 20141055.

    2014 [ to top ]

    • Contractile and Mechanical Properties of Epithelia with Perturbed Actomyosin Dynamics. Fischer, Sabine C.; Blanchard, Guy B.; Duque, Julia; Adams, Richard J.; Arias, Alfonso Martinez; Guest, Simon D.; Gorfinkiel, Nicole in PLOS ONE (2014). 9(4) 1-12.

    2013 [ to top ]

    • Is a Persistent Global Bias Necessary for the Establishment of Planar Cell Polarity? Fischer, Sabine; Houston, Paul; Monk, Nicholas A. M.; Owen, Markus R. in PLOS ONE (2013). 8(4) 1-12.

    2011 [ to top ]

    • Integrative approaches to morphogenesis: lessons from dorsal closure. Gorfinkiel, N; Schamberg, S; Blanchard, G B in Genesis (2011). 49(7) 522-533.
    • Endocytic and recycling endosomes modulate cell shape changes and tissue behaviour during morphogenesis in Drosophila. Mateus, A M; Gorfinkiel, N; Schamberg, S; Martinez Arias, A in PLoS One (2011). 6(4)

    2010 [ to top ]

    • Modelling and Analysis of Planar Cell Polarity. Schamberg, S.; Houston, P.; Monk, N. A. M.; Owen, M. R. in Bulletin of Mathematical Biology (2010). 72(3) 645--680.