Dr. Cindrilla Chumduri
Kontakt:
Tel.: +49 (0)931-31 86531
Fax: +49 (0)931-31 84402
Labor:
Büro: C243
EMail: cindrilla.chumduri@uni-wuerzburg.de
Pressemitteilung
Forschungsprojekt:
Academic Career
1998 – 2003 Studies in Biotechnology at the Bangalore University, India; Master of Science and Bachelor of Science
2004 – 2005 Junior Research Fellow, Indian Institute of Science, Bangalore, India.
2005 – 2009 Ph.D at the Max Delbrück Center for Molecular Medicine, Berlin, Dept. Clinical and Molecular Oncology
2010 – 2012 Postdoctoral fellow at the Max Planck Institute for Infection Biology, Berlin
2013 – 2016 Research Scientist at the Max Planck Institute for Biology, Berlin
2017 Group leader at the Max Planck Institute for Infection Biology, Berlin
2018 Group leader at Charité University Medicine, Berlin
since 2019 Group leader at Chair of Microbiology, University of Würzburg
Gurumurthy RK, Koster S, Kumar N, Meyer TF, Chumduri C. Patient-derived and mouse endo-ectocervical organoid generation, genetic manipulation and applications to model infection. Nat Protoc. 2022 May 11. doi: 10.1038/s41596-022-00695-6.
Koster S, Gurumurthy RK, Kumar N, Prakash PG, Dhanraj J, Bayer S, Berger H, Kurian SM, Drabkina M, Mollenkopf HJ, Goosmann C, Brinkmann V, Nagel Z, Mangler M, Meyer TF, Chumduri C. Modelling Chlamydia and HPV co-infection in patient-derived ectocervix organoids reveals distinct cellular reprogramming. Nat Commun. 2022 Feb 24;13(1):1030. doi: 10.1038/s41467-022-28569-1.
Gurumurthy RK, Kumar N, Chumduri C. Optimized protocol for isolation of high-quality single cells from the female mouse reproductive tract tissues for single-cell RNA sequencing.
STAR Protoc. 2021 Nov 17;2(4):100970. doi: 10.1016/j.xpro.2021.100970.
Gurumurthy RK, Kumar N, Chumduri C. Spatial analysis of organ-wide RNA, protein expression, and lineage tracing in the female mouse reproductive tract.
STAR Protoc. 2021 Nov 17;2(4):100969. doi: 10.1016/j.xpro.2021.100969.
Chumduri C, Turco MY. Organoids of the female reproductive tract.
J Mol Med (Berl). 2021 Apr;99(4):531-553. doi: 10.1007/s00109-020-02028-0.
Chumduri C, Gurumurthy RK, Berger H, Dietrich O, Kumar N, Koster S, Brinkmann V, Hoffmann K, Drabkina M, Arampatzi P, Son D, Klemm U, Mollenkopf HJ, Herbst H, Mangler M, Vogel J, Saliba AE, Meyer TF. Opposing Wnt signals regulate cervical squamocolumnar homeostasis and emergence of metaplasia.
Nat Cell Biol. 2021 Feb;23(2):184-197. doi: 10.1038/s41556-020-00619-0.
Zadora PK, Chumduri C, Imami K, Berger H, Mi Y, Selbach M, Meyer TF, Gurumurthy RK.
Integrated Phosphoproteome and Transcriptome Analysis Reveals Chlamydia-Induced Epithelial-to-Mesenchymal Transition in Host Cells.
Cell Rep. 2019 Jan 29;26(5):1286-1302.e8. doi: 10.1016/j.celrep.2019.01.006.
Mi Y, Gurumurthy RK, Zadora PK, Meyer TF, Chumduri C.
Chlamydia trachomatis Inhibits Homologous Recombination Repair of DNA Breaks by Interfering with PP2A Signaling.
MBio. 2018 Nov 6;9(6). pii: e01465-18. doi: 10.1128/mBio.01465-18.
Rother M, Gonzalez E, Teixeira da Costa AR, Wask L, Gravenstein I, Pardo M, Pietzke M, Gurumurthy RK, Angermann J, Laudeley R, Glage S, Meyer M, Chumduri C, Kempa S, Dinkel K, Unger A, Klebl B, Klos A, Meyer TF.
Combined Human Genome-wide RNAi and Metabolite Analyses Identify IMPDH as a Host-Directed Target against Chlamydia Infection.
Cell Host Microbe. 2018 May 9;23(5):661-671.e8. doi: 10.1016/j.chom.2018.04.002. Epub 2018 Apr 26.
Müller A, Gillissen B, Richter A, Richter A, Chumduri C, Daniel PT, Scholz CW.
Pan-class I PI3-kinase inhibitor BKM120 induces MEK1/2-dependent mitotic catastrophe in non-Hodgkin lymphoma leading to apoptosis or polyploidy determined by Bax/Bak and p53.
Cell Death Dis. 2018 Mar 7;9(3):384. doi: 10.1038/s41419-018-0413-4.
Chumduri C, Gurumurthy RK, Zietlow R, Meyer TF.
Subversion of host genome integrity by bacterial pathogens.
Nat Rev Mol Cell Biol. 2016 Oct;17(10):659-73. doi: 10.1038/nrm.2016.100.
Chumduri C, Gillissen B, Richter A, Richter A, Milojkovic A, Overkamp T, Müller A, Pott C, Daniel PT.
Apoptosis resistance, mitotic catastrophe, and loss of ploidy control in Burkitt lymphoma.
J Mol Med (Berl). 2015 May;93(5):559-72. doi: 10.1007/s00109-014-1242-2.
Gurumurthy RK, Chumduri C, Karlas A, Kimmig S, Gonzalez E, Machuy N, Rudel T, Meyer TF.
Dynamin-mediated lipid acquisition is essential for Chlamydia trachomatis development.
Mol Microbiol. 2014 Oct;94(1):186-201. doi: 10.1111/mmi.12751.
Chumduri C, Gurumurthy RK, Zadora PK, Mi Y, Meyer TF.
Chlamydia infection promotes host DNA damage and proliferation but impairs the DNA damage response.
Cell Host Microbe. 2013 Jun 12;13(6):746-58. doi: 10.1016/j.chom.2013.05.010.
Milojkovic A, Hemmati PG, Müer A, Overkamp T, Chumduri C, Jänicke RU, Gillissen B, Daniel PT.
p14ARF induces apoptosis via an entirely caspase-3-dependent mitochondrial amplification loop.
Int J Cancer. 2013 Dec 1;133(11):2551-62. doi: 10.1002/ijc.28279.
Müller A, Zang C, Chumduri C, Dörken B, Daniel PT, Scholz CW.
Concurrent inhibition of PI3K and mTORC1/mTORC2 overcomes resistance to rapamycin induced apoptosis by down-regulation of Mcl-1 in mantle cell lymphoma.
Int J Cancer. 2013 Oct 15;133(8):1813-24. doi: 10.1002/ijc.28206.
